EKS-GAA-00280

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00280

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	372.5	1.6E-111	70	362	293

Status

Unreviewed

Ensembl Protein

ENSGACP00000006553

UniProt Accession

G3NMJ0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000004903	ENSGACP00000006553	ENSGACT00000006570

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

394

Protein Sequence
(FASTA)

MQKRRKPEPI QLNPIPDGNT INGTGATETN LEALQKKLEE LELDEQQRKR LEAFLTQKQK 60

VGELKDDDFE KICELGAGNG GVVFKVSHRP SGLIMARKLI HLEIKPAIRN QIIRELQVLH 120

ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQSLKKAG NIPEQILGKV SIAVIKGLAY 180

LREKHKIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240

YSVQSDIWSM GLSLVEMAIG RFPIPPPDAK ELEQIFGSPA EGEGACSESS PKPQPPGRPG 300

SSHGSDRPPM AIFELLDYIV NEPPPKLPGI FSAEFQDFVN KCLIKNPAER ADLKHLTVHA 360

FIKLSEAEQV DFAGWLCSTI GLNQPVTPTH STAM 394

Nucleotide Sequence
(FASTA)

ATGCAGAAGA GAAGGAAGCC GGAGCCGATC CAGCTCAACC CGATCCCCGA TGGAAACACC 60

ATCAACGGCA CCGGAGCCAC AGAAACAAAT CTAGAGGCTC TGCAGAAGAA GCTGGAAGAG 120

CTCGAGTTGG ACGAGCAGCA GCGGAAACGT CTGGAGGCCT TTCTGACACA GAAGCAGAAG 180

GTGGGCGAGC TCAAGGACGA TGACTTTGAG AAGATCTGCG AGCTGGGTGC CGGCAACGGA 240

GGAGTCGTCT TCAAGGTCTC CCACCGACCC TCTGGTCTGA TTATGGCGAG GAAGCTGATC 300

CACCTGGAGA TCAAACCGGC CATTCGGAAC CAGATCATTA GGGAGCTGCA GGTGCTGCAC 360

GAGTGCAACT CCCCTTACAT TGTGGGCTTC TATGGAGCGT TCTACAGCGA CGGAGAAATC 420

AGCATCTGCA TGGAGCATAT GGACGGCGGC TCCCTGGACC AGTCGCTGAA GAAGGCAGGC 480

AACATCCCAG AGCAGATCCT CGGCAAAGTC AGCATCGCTG TGATTAAAGG CCTCGCCTAC 540

CTGAGGGAGA AACACAAGAT CATGCACAGA GATGTCAAGC CGTCCAACAT ACTCGTGAAT 600

TCCCGAGGTG AGATCAAGCT GTGTGACTTC GGCGTGAGCG GCCAGCTCAT AGACTCCATG 660

GCCAACTCCT TTGTGGGAAC CCGCTCCTAC ATGTCGCCCG AGCGTTTGCA GGGAACACAT 720

TACTCCGTTC AGTCGGACAT CTGGAGTATG GGTCTGTCCC TGGTTGAAAT GGCGATCGGG 780

CGCTTTCCAA TCCCACCGCC TGATGCCAAG GAACTGGAAC AGATTTTTGG TTCTCCTGCA 840

GAGGGGGAGG GTGCATGCAG CGAGTCGTCC CCGAAGCCGC AGCCTCCCGG GCGACCAGGC 900

AGCTCACACG GATCTGACAG ACCACCAATG GCCATATTTG AGCTGCTTGA TTACATCGTC 960

AATGAGCCTC CACCAAAGCT GCCCGGGATA TTCAGCGCTG AATTTCAAGA CTTTGTGAAC 1020

AAATGCTTGA TTAAGAATCC TGCAGAGCGA GCGGACCTGA AACATTTGAC GGTGCATGCG 1080

TTCATCAAGC TGTCTGAAGC AGAGCAGGTG GACTTTGCTG GCTGGTTGTG CAGTACCATT 1140

GGCCTCAATC AGCCTGTGAC CCCCACCCAC AGCACGGCAA TGTGA 1185

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek+ elGaGnggvV kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 70    EKICELGAGNGGVVFKVSHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  128

         7899*************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+ lkk    +++ipe++lgk+++av+k+l+yl+ek

Q: 129   GFYGAFYSDGEISICMEHMDGGSLDQSLKK----AGNIPEQILGKVSIAVIKGLAYLREK  184

         **************************9988....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 185   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  243

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gr+p++++++

Q: 244   QSDIWSMGLSLVEMAIGRFPIPPPDAkeleqifgspaegegacsesspkpqppgrpgssh  303

         ***********************9999*********************************

S: 208   ........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

                 i+ell++ivne+ppklp   fs efq+fv+kCl+k+++eR++lk+l+ hafi

Q: 304   gsdrppmaIFELLDYIVNEPPPKLP-GIFSAEFQDFVNKCLIKNPAERADLKHLTVHAFI  362

         ************************9.59******************************97

Domain Sequence
(FASTA)

EKICELGAGN GGVVFKVSHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQSLKKA GNIPEQILGK VSIAVIKGLA YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAI GRFPIPPPDA KELEQIFGSP AEGEGACSES SPKPQPPGRP GSSHGSDRPP 240

MAIFELLDYI VNEPPPKLPG IFSAEFQDFV NKCLIKNPAE RADLKHLTVH AFI 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013