EKS-GAA-00186

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00186

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	603.9	5.0E-182	409	687	279

Status

Unreviewed

Ensembl Protein

ENSGACP00000006653

UniProt Accession

G3NMU0;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1 (1 of 2)

Gene Synonyms/Alias

TLK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000005028	ENSGACP00000006653	ENSGACT00000006670

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

717

Protein Sequence
(FASTA)

MDELNSLDPR RQELLEARFM GGVGGSTGGS TGSTSAGTKG LTNNECSNQS FGSLGSSSDK 60

ESETPEKKQS ETPRGRKRKP ELQSESSQGK SIARGPKISD YFDFQAGNGS SPVRGLPPVI 120

RSPQNSHSLS AQGINVGQNS SPPTSLSFGD HLTQPKQLAV KFVQTDLTVL KLAALESTKN 180

LDLEKKEGRI DDLLRANCDL RRQIDEQQKL LEKYKERLNK CITMSKKLLI EKSTQEKQAC 240

REKSMQDRLR LGHFTTVRHG ASFTEQWTDG YAFQNLVKQQ ECTNQQREEI ERQRKLLAKR 300

KPPSSTNAQA PTTNSEPKQR KTKAVNGAES DPFLKPSLPQ LLTLAEYHEQ EEIFKLRLGH 360

LKKEEAEIQA ELERLERVRN LHIRELKRIN NEDSSHQRFK DHPTLNERYL LLHLLGRGGF 420

SEVYKAFDLI EQRYAAVKIH QLNKNWREEK KENYHKHACR EYRIHKELDH PRIVKLYDYF 480

SLDTDTFCTV MEYCEGNDLD FYLKQHKLMS EKEARSIVMQ IVNALRYLNE IKPPIIHYDL 540

KPGNILLVDG TACGEIKITD FGLSKIMDDD NYGVDGMDLT SQGAGTYWYL PPECFVVGKE 600

PPKISNKVDV WSVGVIFFQC LYGRKPFGHN QSQQDILQEN TILKATDVQF PVKPVSSNEA 660

KAFIRRCLAY RKEDRIDVHQ MGSDPYLLPH MRRSSSSGNL QINAAGLGPA SSSIVSY 717

Nucleotide Sequence
(FASTA)

ATGGACGAGC TGAACAGCCT GGACCCCCGG AGACAGGAGC TGCTGGAGGC GCGCTTTATG 60

GGCGGGGTGG GCGGCAGCAC AGGAGGCAGC ACTGGCAGCA CAAGTGCAGG AACCAAAGGA 120

TTGACCAATA ATGAATGTTC AAATCAAAGT TTTGGAAGCC TTGGATCCTC AAGTGACAAG 180

GAGTCAGAGA CTCCGGAGAA GAAACAGTCA GAAACACCTA GAGGCAGAAA AAGGAAACCT 240

GAGCTCCAGT CAGAGAGCAG CCAAGGGAAA TCAATTGCGC GAGGACCCAA AATAAGTGAT 300

TATTTTGATT TTCAGGCAGG AAATGGCTCC AGTCCTGTCC GAGGTCTCCC ACCAGTGATT 360

CGATCGCCCC AGAACTCCCA TTCCCTCTCC GCTCAGGGTA TCAATGTTGG ACAAAATAGT 420

TCACCTCCTA CTAGTCTGTC TTTTGGGGAC CACCTGACGC AGCCAAAGCA ACTAGCAGTC 480

AAATTTGTTC AGACCGACCT CACAGTGTTA AAGCTGGCTG CCCTGGAAAG CACTAAGAAC 540

CTTGACCTCG AAAAGAAGGA GGGGAGAATA GATGACTTGC TTCGGGCAAA CTGTGATCTC 600

AGGAGACAGA TAGATGAACA ACAAAAATTA CTTGAAAAGT ACAAGGAACG CTTGAATAAA 660

TGCATTACTA TGAGCAAGAA GTTGCTCATA GAAAAGAGCA CACAGGAGAA GCAGGCCTGC 720

CGGGAGAAAA GCATGCAAGA TCGACTTCGT TTAGGCCATT TCACTACAGT GAGACATGGA 780

GCGTCATTCA CAGAGCAGTG GACTGATGGC TATGCCTTCC AGAACCTTGT GAAACAGCAA 840

GAGTGTACAA ACCAACAGAG AGAGGAAATT GAGAGGCAGA GAAAACTTCT AGCCAAGAGG 900

AAACCTCCAT CCTCTACCAA CGCCCAAGCA CCAACCACAA ACTCTGAGCC AAAGCAACGC 960

AAAACAAAGG CGGTGAATGG CGCAGAGAGC GACCCCTTTC TAAAACCCAG CCTACCTCAG 1020

CTGCTGACCC TAGCAGAATA CCACGAACAG GAAGAGATCT TCAAACTGCG ACTCGGACAT 1080

CTTAAGAAGG AAGAGGCTGA GATCCAGGCG GAGCTGGAGC GTCTGGAGAG AGTGCGCAAC 1140

CTTCACATTC GGGAGCTGAA GAGAATAAAT AATGAGGACA GTTCACACCA AAGATTTAAA 1200

GATCATCCAA CGTTGAATGA ACGATATCTG CTCCTACACC TTCTGGGAAG AGGGGGCTTT 1260

AGTGAAGTTT ACAAGGCCTT TGACTTGATT GAGCAACGAT ATGCTGCTGT AAAAATCCAT 1320

CAACTTAACA AGAACTGGAG AGAGGAGAAA AAGGAGAACT ATCACAAACA TGCGTGCCGA 1380

GAGTACAGAA TACACAAGGA GCTGGACCAC CCCAGAATAG TGAAACTTTA TGACTACTTC 1440

TCATTGGACA CCGACACGTT TTGCACCGTC ATGGAGTACT GCGAAGGCAA TGACTTGGAT 1500

TTCTACTTGA AACAGCATAA GCTAATGTCC GAGAAGGAGG CGCGGTCTAT CGTCATGCAG 1560

ATTGTGAACG CATTAAGATA CCTGAATGAA ATCAAACCTC CCATCATCCA TTACGACCTT 1620

AAGCCAGGCA ATATCTTGTT GGTGGATGGC ACGGCCTGTG GGGAAATCAA AATCACTGAC 1680

TTCGGTCTGT CAAAAATCAT GGATGATGAC AACTACGGCG TGGATGGGAT GGACCTGACA 1740

TCACAGGGCG CAGGCACCTA TTGGTACTTG CCTCCTGAAT GTTTTGTCGT TGGCAAAGAA 1800

CCTCCAAAGA TCTCCAATAA GGTGGACGTG TGGTCTGTGG GTGTCATCTT TTTTCAGTGT 1860

CTGTATGGAA GGAAGCCTTT TGGCCACAAT CAGTCCCAAC AGGACATCCT GCAAGAGAAC 1920

ACCATACTGA AAGCCACGGA TGTTCAGTTC CCTGTCAAGC CTGTTTCCAG CAATGAGGCA 1980

AAGGCCTTCA TCAGGCGGTG CTTGGCATAC AGGAAGGAGG ACCGGATCGA CGTTCACCAG 2040

ATGGGAAGCG ACCCGTACCT GCTCCCTCAC ATGCGAAGGT CAAGCTCCTC TGGAAATCTG 2100

CAGATAAACG CGGCGGGTCT GGGACCGGCC TCCTCCAGCA TCGTTTCATA CTGA 2154

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl eqry+avkihqlnk+w++ekkeny+kha+reyrihkel

Q: 409   YLLLHLLGRGGFSEVYKAFDLIEQRYAAVKIHQLNKNWREEKKENYHKHACREYRIHKEL  468

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctv+ey+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 469   DHPRIVKLYDYFSLDTDTFCTVMEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  528

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimddd+y++d g++ltsqgagty

Q: 529   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDNYGVD-GMDLTSQGAGTY  587

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkat+

Q: 588   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATD  647

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpv s+eakafirrclayrkedridv+q+ +d+yl

Q: 648   VQFPVKPVSSNEAKAFIRRCLAYRKEDRIDVHQMGSDPYL  687

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LIEQRYAAVK IHQLNKNWRE EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVMEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDNYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATDV 240

QFPVKPVSSN EAKAFIRRCL AYRKEDRIDV HQMGSDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013