EKS-GAA-00412

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00412

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	299.8	2.3E-89	21	287	267

Status

Unreviewed

Ensembl Protein

ENSGACP00000006822

UniProt Accession

G3NNA8;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3A

Gene Synonyms/Alias

MYO3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000005155	ENSGACP00000006822	ENSGACT00000006839

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1637

Protein Sequence
(FASTA)

MFPQPGKSIV FDNFPDPTEA WDIIETIGKG TYGKVYKVLN KLDGSKAAVK ILDPVHDIDE 60

EIEAEYNILK ALSDHANVVK FFGMYYKKDV KCGDQLWLVL ELCNGGSVTD LAKGMLKRGD 120

RMDEAVVAYI LHEALMGLQH LHVHKTIHRD VKGNNILLTT HGGVKLVDFG VSAQLTNTRL 180

RRNTSVGTPF WMAPEVIACE QQLDSTYDAR CDVWSLGITA IELGDGDPPL SELHPMRALF 240

KIPRNPPPTL HQPELWSDGF NDFICKCLIK DFELRPNVLD LLQHVFIKAS IGREKILQKQ 300

LIELIDLNQQ IGIIDKTRHE RIHTKRGGHM KTQSDLDEVD DLATLEVLDE NTVTEQLQRR 360

YGRDQIYTYV GDILIAVNPF HGMQIYGPQC TKMYIGAKRT ANPPHIFAVA DIAYQSMVSF 420

NTDQCVVISG ESGAGKTESA HLLVQQLTVL GKANNQTLQE KILLVNSLVE AFGNACTVIN 480

DNSSRFGKYL EMKFTCGGTV VGAQISEYLL EKSRVIHQAA GERNFHIFYY LYAGLADRKK 540

LAHYKLSRQQ NTQVGGNPRP RRMLLGNQGD VPLSAVNPCL SLLQELGSVY STLAAILNSG 600

DVEFSPVASE HQTDKSDISN TSVLENVASL LCIRSDELQE ALTSHCVVAR GETIVRPNTV 660

DKAAEVRDAM GKALYGRLFS WIVNRINALL RPDGNLGEDE KGLNIGILDI FGFENFKKNS 720

FEQLCINIAN EQIQFYFNQH IFAWEQDEYL NEEVDARMIE YEDNRPLLDL FLQKPMGMLS 780

LLDEESRFPQ ATDQTLVGEF VLLDDSEKFE DNLKTKSFWR PKRVDLGFGI HHYAGKVVIY 840

SAAGFLAKNR DALPADIVLL LRSSENELTR KLVTHPLTKT GNLAHTKGKG ANTMRTPTRS 900

LTFAKPGEPG DAPYHPRETT NMRTQTVASY FRYSLMDLLS KMVAGQPHFV RCIKPNNDRQ 960

ANRFDREKVL VQLRYTGVLE TAKIRRQGYS HRIVFANFIK RYYMVAFPAH EEPPVTQETC 1020

AAILENAKLE NWAMGKTKAS QWCLLVFLKY HHVEHLNLMV QQATQRIILL QAFVRGWMGA 1080

KRYRQLLKDR ERSALVLQSV CRGYVAKKKY RQLVEEKNKA ATKIQARYRG HKERKSFKRK 1140

RKKFKERKRT AAGAQSESPP DAAVQPEAGR ESAGRESGND DEDESTYEAE ENDDSDHTQV 1200

PDTEEEEGVE GGDAGQAEPA EDGKEESGQE EAAEGDAVNE EEQTRAATVL QSNFRGHKER 1260

KRLQDEGKIP ARKQEARSPP GEEDGPGDQT PAAEVGDEAT GRGGGGRTVD VSSSDQDEAR 1320

AAVVLQSNFR GHKERKRLEE EGKIPKKTQK KKNEAADRSA ENPGGADEEK AATVLQSNFR 1380

GHRDRKKLRA DREAREKTAE EEEEAREEAP DVADIQSNFR GHKDRKNLKA NKQKARTEAA 1440

RLESFSKQIT KTSEDFAALQ TKLNEIIQAH HSNPENNGIV ARVWHNHQKR HRLIILIDCR 1500

ISADKRQSRS PRRTQEPKTL NTPEDATYYN LIHRSVQDDK RKPRKEDPGK LLDVDDHYYR 1560

TLSSSRSEPC LFPEDASPYG APERRPSLGG SVDGGMYNEP LPPATASRPT RERADNPFDF 1620

RHLLRKTSQR RRLIKQY 1637

Nucleotide Sequence
(FASTA)

ATGTTTCCAC AACCGGGGAA ATCCATCGTC TTCGACAACT TCCCGGATCC CACCGAGGCC 60

TGGGACATCA TCGAGACCAT CGGCAAGGGG ACCTACGGAA AAGTCTACAA GGTGCTCAAC 120

AAGCTCGACG GCAGCAAAGC GGCCGTGAAG ATACTGGACC CCGTCCACGA TATCGACGAG 180

GAGATCGAAG CGGAGTACAA CATCCTCAAA GCGCTGTCCG ACCACGCCAA TGTGGTGAAG 240

TTCTTCGGGA TGTACTACAA GAAGGATGTG AAATGCGGCG ACCAGCTGTG GCTGGTGCTG 300

GAGCTCTGCA ATGGCGGCTC TGTGACAGAC CTGGCCAAAG GGATGCTGAA GAGGGGGGAC 360

CGCATGGACG AAGCCGTCGT TGCCTACATC CTGCACGAGG CCCTCATGGG CCTGCAGCAC 420

CTGCACGTCC ACAAGACCAT CCACCGCGAC GTCAAGGGCA ACAACATCCT GCTGACGACG 480

CACGGAGGCG TCAAACTGGT GGACTTCGGT GTCTCGGCCC AGCTGACGAA CACGCGTCTG 540

AGGAGGAACA CCTCGGTGGG GACTCCCTTC TGGATGGCTC CGGAGGTGAT CGCCTGCGAG 600

CAGCAGCTGG ACTCGACCTA CGACGCTCGC TGTGACGTCT GGTCCCTCGG CATTACGGCC 660

ATAGAGCTCG GAGACGGAGA CCCCCCCCTC TCCGAACTCC ACCCAATGAG AGCGCTCTTC 720

AAAATCCCCA GAAATCCCCC GCCGACCCTC CACCAGCCGG AGCTCTGGTC CGACGGCTTT 780

AACGACTTCA TCTGCAAATG TCTGATCAAG GACTTTGAGC TGAGGCCCAA CGTGCTGGAC 840

CTGCTGCAGC ACGTCTTCAT CAAAGCCAGC ATCGGCAGAG AGAAGATCCT GCAGAAGCAG 900

CTGATCGAGC TCATCGATCT CAACCAGCAA ATAGGAATCA TTGATAAAAC CAGGCATGAA 960

CGCATCCACA CCAAGCGAGG AGGCCACATG AAGACGCAGA GCGACCTCGA CGAGGTGGAC 1020

GACCTCGCCA CCCTGGAGGT TCTGGACGAG AACACGGTCA CGGAGCAGCT GCAGCGCCGC 1080

TACGGGCGCG ATCAAATCTA CACGTACGTG GGAGACATCC TCATCGCGGT CAACCCGTTC 1140

CACGGCATGC AGATATACGG CCCTCAGTGC ACCAAGATGT ACATCGGAGC CAAGCGCACG 1200

GCCAACCCCC CTCACATCTT CGCCGTGGCT GACATCGCCT ACCAGTCCAT GGTGTCGTTT 1260

AATACAGACC AGTGCGTGGT GATCAGCGGG GAAAGCGGAG CCGGGAAGAC GGAGAGCGCT 1320

CATCTGTTGG TGCAGCAGCT GACGGTGCTC GGAAAGGCCA ACAACCAGAC GCTGCAGGAG 1380

AAGATCCTGC TGGTCAACAG CCTGGTGGAA GCGTTCGGAA ACGCCTGCAC CGTCATCAAC 1440

GACAACTCCA GCCGCTTCGG CAAGTACCTG GAGATGAAGT TCACCTGCGG AGGCACGGTG 1500

GTGGGAGCGC AGATATCCGA GTACCTGCTG GAGAAGTCCA GGGTCATCCA CCAGGCGGCG 1560

GGGGAGAGGA ACTTCCACAT CTTCTACTAC CTGTACGCCG GCCTGGCAGA CAGGAAGAAG 1620

CTGGCTCACT ACAAGCTCTC ACGACAGCAA AACACCCAAG TGGGTGGCAA CCCGAGGCCG 1680

CGCCGGATGC TATTGGGCAA TCAGGGCGAC GTCCCGCTGT CTGCGGTGAA TCCCTGTCTG 1740

TCACTCCTGC AGGAGCTGGG CAGCGTCTAC AGCACCCTGG CTGCCATCCT CAACTCCGGC 1800

GACGTGGAGT TCTCTCCGGT CGCCTCGGAG CACCAGACCG ACAAGAGCGA CATCTCCAAC 1860

ACGTCGGTCC TGGAGAACGT GGCGTCGCTG CTGTGCATCC GCTCGGACGA GCTGCAGGAA 1920

GCCCTGACCT CCCACTGCGT GGTCGCCCGC GGGGAGACCA TCGTCAGGCC CAACACGGTG 1980

GACAAGGCGG CGGAGGTGAG GGACGCCATG GGCAAGGCGC TCTACGGCCG CCTCTTCAGC 2040

TGGATCGTCA ACCGCATCAA CGCGCTGCTG CGGCCCGACG GAAACCTCGG GGAGGACGAG 2100

AAGGGCCTGA ACATCGGCAT CCTGGACATC TTCGGTTTCG AGAACTTCAA GAAGAACTCC 2160

TTCGAGCAGC TCTGCATCAA CATCGCCAAC GAGCAGATCC AGTTCTACTT CAACCAGCAC 2220

ATCTTCGCCT GGGAGCAGGA CGAGTACCTG AACGAGGAGG TGGACGCCCG GATGATCGAG 2280

TACGAGGACA ACCGGCCCCT CCTGGACCTG TTCCTGCAGA AGCCCATGGG GATGCTGTCG 2340

CTGCTGGATG AGGAGAGTCG CTTCCCGCAG GCCACCGACC AGACGCTCGT AGGCGAGTTT 2400

GTTTTATTGG ACGATTCAGA GAAATTCGAA GACAACCTGA AGACCAAAAG CTTCTGGCGA 2460

CCGAAGCGGG TGGACCTGGG CTTCGGTATC CACCACTACG CCGGAAAGGT AGTGATCTAC 2520

AGCGCCGCCG GCTTCTTGGC CAAGAACCGG GACGCGCTGC CGGCCGACAT CGTGCTGCTG 2580

CTGAGGTCGT CGGAAAACGA GCTCACCCGC AAGCTGGTCA CCCATCCGCT CACCAAGACG 2640

GGTAACCTCG CCCACACTAA GGGGAAAGGC GCGAACACCA TGCGGACCCC GACGCGCAGC 2700

CTCACCTTCG CCAAGCCGGG CGAACCGGGA GACGCGCCGT ACCACCCGAG AGAAACCACC 2760

AACATGAGGA CACAGACGGT GGCCTCCTAC TTCAGATACT CTCTGATGGA TCTGCTGTCC 2820

AAGATGGTGG CGGGGCAGCC TCACTTTGTG CGCTGCATCA AACCCAACAA CGACCGCCAA 2880

GCCAACAGGT TCGACCGGGA GAAGGTCCTG GTCCAGCTGC GATACACCGG CGTCCTGGAG 2940

ACCGCCAAGA TCAGGCGGCA GGGCTACTCG CACCGAATCG TGTTCGCCAA CTTCATAAAG 3000

AGGTACTACA TGGTGGCGTT CCCCGCTCAC GAGGAGCCGC CCGTCACCCA GGAAACGTGC 3060

GCCGCCATTC TGGAGAATGC CAAGCTGGAG AACTGGGCCA TGGGGAAGAC GAAGGCGAGT 3120

CAGTGGTGCT TGCTGGTGTT CCTCAAGTAC CACCACGTGG AACATCTGAA CCTGATGGTG 3180

CAGCAGGCCA CGCAGCGCAT CATCCTGCTG CAGGCCTTCG TCCGCGGCTG GATGGGAGCC 3240

AAACGGTACC GCCAGCTGTT AAAGGACCGA GAACGCAGCG CGCTGGTGCT GCAGTCAGTC 3300

TGCAGGGGCT ACGTGGCCAA AAAGAAATAC AGGCAGTTGG TGGAGGAGAA GAACAAAGCT 3360

GCAACCAAGA TTCAGGCTCG CTACAGAGGC CACAAGGAGA GGAAAAGCTT CAAAAGGAAA 3420

CGGAAAAAGT TTAAAGAGAG AAAGAGGACG GCGGCCGGGG CCCAATCGGA GTCACCGCCG 3480

GATGCAGCGG TGCAACCAGA AGCCGGGCGA GAGTCCGCCG GCAGAGAGTC GGGGAATGAC 3540

GACGAAGACG AGAGCACGTA CGAAGCGGAG GAGAATGACG ATAGCGATCA CACGCAGGTG 3600

CCAGACACCG AAGAGGAAGA GGGGGTCGAA GGAGGAGATG CCGGCCAAGC GGAGCCGGCG 3660

GAGGACGGGA AGGAGGAGAG CGGACAAGAG GAGGCTGCAG AGGGAGACGC TGTGAATGAA 3720

GAAGAACAGA CCAGGGCCGC CACGGTCCTC CAGAGCAACT TCAGGGGTCA CAAGGAGAGG 3780

AAGAGGCTGC AGGACGAAGG CAAGATCCCC GCTCGGAAAC AGGAAGCAAG GAGTCCGCCG 3840

GGCGAGGAGG ACGGGCCCGG AGATCAAACT CCAGCAGCGG AAGTTGGCGA CGAGGCGACA 3900

GGAAGGGGAG GAGGAGGAAG AACAGTAGAT GTTTCCTCGA GCGACCAAGA CGAGGCCAGA 3960

GCAGCCGTGG TGCTTCAGAG CAACTTCCGC GGCCACAAAG AGCGCAAGCG GCTCGAGGAG 4020

GAAGGAAAGA TCCCCAAGAA GACGCAGAAG AAGAAGAACG AGGCGGCGGA CCGTTCGGCG 4080

GAGAACCCGG GGGGAGCGGA CGAGGAAAAG GCCGCCACTG TCCTCCAGAG TAACTTCAGA 4140

GGCCACCGGG ACCGGAAGAA GCTGAGAGCC GACCGAGAAG CGCGGGAGAA GACGGCGGAG 4200

GAAGAGGAGG AAGCCAGAGA GGAGGCACCG GACGTCGCCG ACATCCAGAG CAACTTCAGA 4260

GGCCACAAGG ACCGAAAGAA CCTCAAAGCC AACAAGCAAA AAGCGAGGAC GGAAGCTGCA 4320

CGCCTGGAGA GCTTCTCCAA GCAGATCACA AAGACCTCTG AGGACTTTGC GGCCCTGCAG 4380

ACCAAGTTGA ACGAGATCAT CCAGGCCCAT CATTCAAACC CCGAGAACAA CGGCATTGTT 4440

GCACGTGTGT GGCACAACCA TCAGAAACGC CACCGTCTGA TCATTCTCAT CGACTGTCGC 4500

ATTTCAGCCG ACAAGAGACA GTCGAGGAGC CCCCGCAGGA CGCAGGAGCC GAAGACCCTC 4560

AACACGCCGG AGGACGCCAC CTACTACAAC TTGATTCACC GCTCCGTCCA GGACGATAAA 4620

CGCAAGCCCA GGAAAGAGGA TCCGGGGAAG CTGCTGGATG TGGATGACCA CTATTACCGG 4680

ACGCTGTCCA GCAGCAGGTC CGAGCCCTGC CTCTTCCCGG AGGACGCGTC GCCGTACGGG 4740

GCCCCCGAGA GGAGGCCGTC TCTCGGGGGC TCCGTGGACG GTGGGATGTA CAACGAGCCC 4800

CTCCCCCCGG CCACGGCCAG CAGACCGACC CGAGAGAGGG CCGACAACCC GTTTGACTTC 4860

AGACATCTGC TGAGGAAGAC CTCCCAGAGA CGAAGGCTCA TCAAACAGTA C 4911

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         ++++e+igkG++gkvy+  +k  g+++a+k+++  + +  ee++ e+++lk l++  n+v

Q: 21    WDIIETIGKGTYGKVYKVLNKLDGSKAAVKILDPVH-DIDEEIEAEYNILKALSDhANVV  79

         7899*****************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lwlv+e+++gGs++dl+k   ++ ++++E  +ayil+e+l +L+

Q: 80    KFFGMYYKkdvkcGDQLWLVLELCNGGSVTDLAKgmLKRGDRMDEAVVAYILHEALMGLQ  139

         ********9999999*******************66677899******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH +k+iHrd+k++niLlt++g VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 140   HLHVHKTIHRDVKGNNILLTTHGGVKLVDFGVSAQLTNTRLRRNTSVGTPFWMAPEVIAC  199

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D+wslGItaiel +g+pP+++l+p++al+ki++n+pp+l++++ +s+

Q: 200   EqqlDSTYDARCDVWSLGITAIELGDGDPPLSELHPMRALFKIPRNPPPTLHQPELWSDG  259

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f+ kcl k++e Rp++ +ll+h F+

Q: 260   FNDFICKCLIKDFELRPNVLDLLQHVFI  287

         **************************97

Domain Sequence
(FASTA)

WDIIETIGKG TYGKVYKVLN KLDGSKAAVK ILDPVHDIDE EIEAEYNILK ALSDHANVVK 60

FFGMYYKKDV KCGDQLWLVL ELCNGGSVTD LAKGMLKRGD RMDEAVVAYI LHEALMGLQH 120

LHVHKTIHRD VKGNNILLTT HGGVKLVDFG VSAQLTNTRL RRNTSVGTPF WMAPEVIACE 180

QQLDSTYDAR CDVWSLGITA IELGDGDPPL SELHPMRALF KIPRNPPPTL HQPELWSDGF 240

NDFICKCLIK DFELRPNVLD LLQHVFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 5.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 7.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 7.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013