EKS-GAA-00487

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00487

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	506.6	1.9E-152	410	675	266

Status

Unreviewed

Ensembl Protein

ENSGACP00000007033

UniProt Accession

G3NNW9;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000005304	ENSGACP00000007033	ENSGACT00000007050

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

737

Protein Sequence
(FASTA)

LTISTTTVES QPVTIEVEGL PTFIHQPEHR NVTRNAPFTL SCDAVGPPDP VRIRWLRDGL 60

HYRDCQNSSS SCSVSGVDKY TQFSCEAHNS KGVTTSREAN INIKVLPGPV SDVAVTERQP 120

NKLLLSWSPG HDGFSPLTKC HIRVKEVSRR KGEVTTTRFV NATVPPFQCE VPGLQAMTWY 180

NVSVSCSNEV GASPVTTWIQ SNTTEGVPSV YPRNVTAQLN ESWLVIRWKP PPDDKINGIL 240

SGYDVIIEKW GEKGCCKRVK FQIHSYNTVA FVDVQEFNTT YSVEVAACTQ AGSGMVSPRV 300

WLFVPADKSV VPPSSSPGTR APDSSTVVVV VVVSIAVLLI IIPGAIYFRN RTSTSWFGRL 360

FEGEKQQPFV QYNTQRSYNR SAIGVTFVNL GVSEELQAKL QDVMVARNLL TIGKILGEGE 420

FGSVMEGHLR RPDGTSERVA VKTMKLDSFS QREIDEFLNE AACMKDFDHL NVIKLLGVCM 480

EEGAGHFPKP MVILPYMSHG DLHSFLLRSR LGESPAFLPT QTLLKFMVDI ALGMEYLSGR 540

NFLHRDLAAR NCMLRDDLTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI AVESLADRVF 600

TIKSDVWAFG VTMWEIATRG MTPYPGIQNH EIYDYLYEGN RLKQPGDCLD ELYELMYSCW 660

RTDPLDRPSF PQLREMLEKL TEKLPESFSK DDIIYINTSF PEEDANGATS AQHPRFSLSP 720

SCSHQAAENS VVIADIH 737

Nucleotide Sequence
(FASTA)

CTGACCATCA GCACCACGAC GGTGGAGTCT CAGCCCGTCA CAATCGAGGT GGAAGGTCTG 60

CCGACATTTA TCCATCAGCC GGAGCACAGG AATGTAACGA GAAACGCGCC TTTCACATTG 120

TCGTGCGATG CGGTCGGACC TCCGGACCCC GTTCGAATCC GCTGGCTCCG CGATGGGTTG 180

CATTATCGAG ACTGTCAGAA CTCCAGCAGC AGCTGCTCTG TGTCAGGTGT GGACAAGTAC 240

ACTCAGTTCA GTTGTGAAGC TCACAACTCG AAGGGTGTCA CCACTTCCAG AGAAGCAAAT 300

ATCAACATCA AAGTGCTTCC CGGGCCGGTA TCTGATGTTG CCGTGACGGA GAGGCAACCC 360

AATAAGTTAC TGTTGAGCTG GAGCCCCGGA CATGATGGTT TCTCTCCACT AACCAAGTGC 420

CACATCAGGG TGAAGGAGGT GAGCCGGAGG AAAGGGGAAG TGACGACCAC CAGGTTCGTT 480

AATGCCACAG TGCCGCCATT TCAGTGTGAA GTCCCCGGGC TGCAGGCGAT GACGTGGTAC 540

AACGTGAGCG TTTCGTGCAG CAATGAGGTG GGAGCTTCTC CGGTCACCAC GTGGATCCAG 600

AGCAACACCA CAGAGGGAGT TCCATCAGTT TATCCCCGAA ACGTCACTGC ACAGCTGAAT 660

GAGTCTTGGC TGGTGATCAG GTGGAAACCT CCTCCAGATG ATAAGATAAA TGGCATCCTG 720

AGTGGCTACG ATGTTATTAT TGAGAAATGG GGAGAGAAGG GATGTTGCAA ACGTGTAAAA 780

TTTCAGATCC ACAGTTACAA CACCGTGGCC TTTGTAGATG TGCAGGAATT CAACACGACC 840

TACAGTGTGG AGGTGGCTGC GTGCACGCAG GCTGGGAGCG GCATGGTCAG CCCACGAGTC 900

TGGCTGTTTG TGCCAGCGGA CAAATCGGTG GTGCCCCCAT CGTCCAGCCC TGGCACCAGG 960

GCTCCAGACT CCTCCACTGT TGTGGTGGTC GTGGTGGTTA GCATCGCTGT CCTGCTGATT 1020

ATCATCCCTG GAGCCATCTA TTTCCGCAAC AGGACTTCTA CATCTTGGTT TGGGCGGTTG 1080

TTCGAAGGTG AAAAGCAGCA GCCTTTCGTG CAGTACAACA CCCAGAGGTC CTACAACCGA 1140

TCAGCCATAG GAGTCACATT TGTGAACCTC GGTGTTAGTG AGGAACTCCA GGCCAAGCTT 1200

CAGGACGTGA TGGTCGCGAG GAATTTGCTC ACCATAGGGA AGATTCTTGG AGAGGGTGAA 1260

TTTGGCTCTG TGATGGAGGG ACATTTGAGA CGACCAGATG GAACATCGGA GAGAGTTGCT 1320

GTAAAGACAA TGAAACTGGA CAGCTTCTCT CAAAGGGAGA TTGACGAATT CCTGAATGAG 1380

GCGGCCTGCA TGAAGGATTT TGATCATCTT AATGTCATCA AATTGCTCGG TGTGTGCATG 1440

GAAGAAGGCG CAGGACATTT TCCCAAGCCG ATGGTCATCC TGCCGTACAT GTCGCACGGC 1500

GATCTTCACA GCTTCTTGCT GCGCTCACGC CTGGGAGAAA GTCCAGCCTT CTTGCCCACT 1560

CAGACACTTC TGAAGTTCAT GGTCGACATC GCTTTGGGTA TGGAGTATCT CAGTGGTCGG 1620

AACTTTCTGC ACCGTGACCT GGCGGCTCGC AACTGCATGC TGCGGGACGA CCTGACTGTG 1680

TGTGTAGCAG ACTTTGGTCT ATCGAAGAAG ATCTACAGTG GAGATTATTA CAGGCAGGGG 1740

AGAATAGCCA AAATGCCTGT AAAATGGATT GCAGTCGAGA GTCTGGCAGA CAGAGTTTTT 1800

ACCATAAAGA GTGATGTGTG GGCATTTGGC GTTACCATGT GGGAGATTGC TACACGAGGC 1860

ATGACGCCGT ACCCCGGCAT CCAGAACCAT GAAATTTACG ACTACCTTTA TGAAGGAAAC 1920

CGACTGAAGC AGCCAGGAGA CTGTTTGGAT GAGCTGTACG AGCTCATGTA CAGCTGCTGG 1980

AGGACCGATC CGCTCGACCG TCCCTCCTTT CCCCAGCTGC GAGAAATGTT GGAAAAGCTC 2040

ACAGAAAAGC TGCCGGAGTC TTTCAGCAAG GACGACATCA TCTATATCAA CACCAGCTTT 2100

CCTGAAGAGG ACGCAAACGG AGCGACATCT GCACAGCATC CTAGATTTAG CTTGTCGCCT 2160

TCCTGCAGCC ATCAGGCAGC AGAGAATTCC GTGGTCATTG CGGACATTCA C 2211

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l++gk+lgegefgsvmeg+l++ dg++ +vavkt+kld ++++ei+efl+eaacmk+fdh

Q: 410   LTIGKILGEGEFGSVMEGHLRRPDGTSERVAVKTMKLDSFSQREIDEFLNEAACMKDFDH  469

         589*********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

          nvi+l+gv++e  + g++pkp+vilp+m +gdlh+fll srlge+p +lp+qtl+kfmv

Q: 470   LNVIKLLGVCMEEGA-GHFPKPMVILPYMSHGDLHSFLLRSRLGESPAFLPTQTLLKFMV  528

         ***********9876.56******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls rnf+hrdlaarncml++d+tvcvadfglskkiysgdyyrqgriak+pvk

Q: 529   DIALGMEYLSGRNFLHRDLAARNCMLRDDLTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  588

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wia+esladrv+t ksdvwafgvtmweiatrg+tpy+g++n+eiydyl +gnrlkqp dc

Q: 589   WIAVESLADRVFTIKSDVWAFGVTMWEIATRGMTPYPGIQNHEIYDYLYEGNRLKQPGDC  648

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlre  267

         ldely+lmy+cw++dp drpsf +lre

Q: 649   LDELYELMYSCWRTDPLDRPSFPQLRE  675

         ***********************9995

Domain Sequence
(FASTA)

LTIGKILGEG EFGSVMEGHL RRPDGTSERV AVKTMKLDSF SQREIDEFLN EAACMKDFDH 60

LNVIKLLGVC MEEGAGHFPK PMVILPYMSH GDLHSFLLRS RLGESPAFLP TQTLLKFMVD 120

IALGMEYLSG RNFLHRDLAA RNCMLRDDLT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAVESLADRV FTIKSDVWAF GVTMWEIATR GMTPYPGIQN HEIYDYLYEG NRLKQPGDCL 240

DELYELMYSC WRTDPLDRPS FPQLRE 266

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013