EKS-GAA-00474

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00474

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	361.0	6.0E-108	597	851	255

Status

Unreviewed

Ensembl Protein

ENSGACP00000007190

UniProt Accession

G3NPC6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000005435	ENSGACP00000007190	ENSGACT00000007208

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1095

Protein Sequence
(FASTA)

QRSLRVVYVL NDGLKSVMAS SPESGALQCL QRACDAESAL LTTVTFGRLD FGETSVLDSF 60

YDADIAVVDM SDVFRQPSLF YHLGVRESFD MANNVILYHD TDPDTAQSLK DMVAQKNTAS 120

SGNYYFIPYI VTPNHEYMCC ESDAQRRASE YMQPSWDNLL GPLCVPLTDR FTGLLKDIHV 180

TSCASFKDTL LNDIRKAREK YQGEELAKEL SRIKLRIDNT EVLTQDIVMN LLFSYRDIQD 240

YDAMVKLVQT LEMLPTCDLA TQPMIQFHYA FALNRRNSPG DREQALGVML QVLQSCEHPA 300

PDMFCLCGRI YKDIFLDSDC KDMKNRDNAI QWYRKGFELQ PTLYSGINLA VLLIVAGQQF 360

ESSMELRKIG VRLNSLLGRK GSLEKMNNYW DVGQFFTVGM LASDIPKATQ AAEKLFKLKP 420

PLWYLRSVVQ NLQLILRFKK QSVEHSPQRE RLNFWMDIIV EATQGTTKRL RFPVLILEPT 480

KVYQPSYVSI NNEAEEKNVS IWHVSPAETK GIHEWNFTAM SIKGISISKF DERCCFLYVH 540

DNSDDFQIYF STEEQCGRFC SMVKEMISDG TGNAVELEGE GDGDTLEYEY DTDETGDRVV 600

LGRGTYGVVY AGRDVSNQVR IAIKEIPERD SRYSQPLHEE IALHKYLKHR NIVQYLGSVS 660

ENGYIKIFME QVPGGSLSAL LRSKWGPLKE ATIIFYTRQI LEGLRYLHEN QIVHRDIKGD 720

NVLVNTYSGV LKISDFGTSK RLAGVNPCTE TFTGTLQYMA PEIIDKGPRG YGAPADIWSL 780

GCTIIEMATG KPPFHELGEP QAAMFKVGMF KIHPEIPESL SLEAKSFILR CFEPDPNKRA 840

ITSDLLRDTF VRQNSKGKKS KIAFKPSDYI HSVSLPVQLQ CEAIGSSSSE PGSMSPDCDS 900

KHDVFFLKKK SPDSENPLKP PNSSYLSSVP DEGSASYDRS APPSPEDRDG GLFLLKKDSE 960

RRAILFKVLN DDQAKVISNL KENHIQQGIE ELQLSVDHIK QIICILRDFI HSPERRVMAA 1020

TISKLKLDLD FDSTSINQIQ LVLFGFQDSV NKVLRNHHIK PHWMFAMDNI IRRAVQAAIT 1080

ILIPELQTHF GPASE 1095

Nucleotide Sequence
(FASTA)

CAGCGTTCCC TGCGGGTGGT GTACGTCCTG AACGACGGGC TGAAGTCGGT GATGGCCAGC 60

AGCCCCGAAT CCGGTGCGCT CCAGTGTCTG CAGAGAGCGT GCGACGCGGA GAGCGCGCTG 120

CTCACCACCG TCACCTTCGG ACGGCTGGAC TTCGGAGAAA CGTCCGTGCT GGACAGCTTC 180

TACGACGCAG ACATCGCGGT TGTGGACATG AGCGACGTGT TTCGGCAGCC CTCCTTGTTC 240

TACCACCTGG GCGTGAGGGA GAGCTTCGAC ATGGCCAACA ACGTCATCCT GTACCACGAC 300

ACCGACCCCG ACACCGCGCA GTCGCTGAAG GATATGGTGG CGCAGAAAAA CACAGCGTCC 360

AGCGGTAACT ACTACTTCAT CCCCTACATC GTGACGCCCA ACCACGAGTA CATGTGCTGC 420

GAGAGCGACG CCCAGCGCAG GGCCAGCGAG TACATGCAGC CCAGCTGGGA CAACCTGCTG 480

GGGCCGCTGT GCGTGCCCCT CACGGACCGC TTCACCGGCC TGCTGAAGGA CATCCACGTC 540

ACGTCCTGTG CCTCTTTTAA GGACACCCTG CTGAACGACA TCAGGAAGGC CAGAGAGAAG 600

TACCAGGGAG AGGAGCTGGC CAAGGAGCTC TCCCGCATTA AACTCAGGAT CGACAACACG 660

GAGGTTCTCA CCCAGGACAT CGTGATGAAC CTGCTGTTTT CTTACCGGGA CATACAGGAC 720

TACGACGCCA TGGTGAAGCT GGTGCAGACT TTGGAGATGC TGCCGACTTG TGATCTGGCG 780

ACGCAGCCCA TGATCCAGTT CCACTACGCG TTCGCCCTCA ACAGGAGGAA CAGTCCCGGG 840

GACCGGGAGC AGGCTCTCGG AGTGATGCTG CAGGTGCTGC AGTCGTGCGA ACACCCGGCG 900

CCGGACATGT TCTGCCTGTG CGGACGGATA TACAAGGACA TCTTCCTGGA CTCGGACTGC 960

AAGGACATGA AGAACAGGGA CAACGCCATA CAGTGGTACA GAAAGGGGTT TGAGCTGCAG 1020

CCAACGCTCT ACTCTGGCAT CAACCTGGCC GTCCTCCTCA TAGTTGCGGG GCAACAGTTT 1080

GAGAGCTCCA TGGAACTGAG GAAAATAGGC GTGAGGCTGA ACAGCCTGCT CGGCCGCAAA 1140

GGTTCCCTGG AGAAGATGAA CAACTACTGG GACGTGGGCC AGTTCTTCAC TGTCGGCATG 1200

CTCGCCAGCG ACATCCCCAA AGCCACTCAG GCTGCAGAGA AGCTCTTCAA ACTCAAGCCG 1260

CCTCTCTGGT ATTTGCGGTC GGTGGTGCAG AACCTGCAGC TGATCCTGAG GTTCAAGAAG 1320

CAGTCGGTGG AACATTCTCC ACAGCGGGAG AGACTCAACT TCTGGATGGA CATCATCGTG 1380

GAAGCCACGC AGGGAACCAC CAAGCGGCTG CGCTTTCCGG TGTTGATTCT GGAGCCCACT 1440

AAGGTTTACC AGCCCTCGTA TGTGTCCATC AACAACGAGG CGGAGGAGAA GAACGTCTCC 1500

ATCTGGCACG TTTCTCCCGC TGAAACGAAA GGGATCCACG AGTGGAACTT CACCGCTATG 1560

TCCATCAAAG GCATCAGCAT AAGTAAGTTC GATGAGCGGT GCTGCTTCCT CTACGTCCAC 1620

GACAACTCGG ATGATTTCCA GATCTACTTC TCCACCGAGG AGCAGTGCGG TCGGTTCTGC 1680

TCGATGGTGA AGGAGATGAT ATCCGACGGT ACGGGCAACG CCGTGGAACT GGAGGGGGAA 1740

GGAGACGGAG ACACGCTGGA GTACGAGTAT GACACGGACG AGACAGGGGA CAGGGTGGTG 1800

TTGGGCCGGG GCACCTACGG AGTGGTGTAC GCCGGCAGGG ACGTCAGCAA CCAGGTCCGA 1860

ATCGCCATCA AAGAGATCCC CGAGAGGGAC AGCAGATACT CGCAGCCCCT CCACGAGGAG 1920

ATCGCCCTCC ACAAGTACCT GAAGCACAGG AACATTGTTC AGTATCTGGG CTCCGTTTCG 1980

GAGAACGGAT ACATCAAGAT CTTCATGGAG CAAGTGCCCG GAGGAAGCCT GTCCGCGTTG 2040

CTGCGCTCCA AATGGGGCCC GCTGAAGGAG GCCACCATCA TCTTCTACAC CCGACAGATC 2100

CTGGAGGGGC TCCGGTACCT GCACGAGAAC CAGATCGTCC ACCGGGACAT CAAGGGGGAT 2160

AACGTGTTGG TGAACACCTA CAGCGGCGTC CTGAAGATCT CCGACTTTGG AACCTCCAAG 2220

CGGTTGGCGG GAGTGAACCC GTGCACGGAG ACGTTCACCG GCACTCTGCA GTACATGGCT 2280

CCGGAAATCA TCGACAAGGG CCCTCGAGGC TACGGGGCCC CGGCCGACAT CTGGTCCCTG 2340

GGGTGCACCA TCATAGAGAT GGCCACTGGG AAACCGCCCT TCCACGAGTT GGGAGAACCA 2400

CAGGCGGCCA TGTTCAAGGT GGGAATGTTC AAGATCCACC CGGAGATCCC CGAGTCGCTG 2460

TCCCTGGAGG CCAAGTCGTT CATCTTGCGC TGCTTCGAGC CGGACCCCAA CAAGAGAGCC 2520

ATCACCTCGG ACCTCCTCAG AGACACGTTT GTCCGACAGA ACAGCAAAGG CAAGAAGAGC 2580

AAGATCGCCT TCAAGCCATC AGACTACATC CACAGCGTGT CGCTGCCGGT GCAGCTGCAG 2640

TGCGAGGCCA TCGGCAGCAG CAGCAGCGAG CCGGGTTCCA TGAGCCCGGA CTGCGACTCC 2700

AAACACGACG TGTTCTTCCT GAAGAAGAAG AGCCCCGACT CCGAGAACCC GCTCAAGCCG 2760

CCCAACTCCA GCTACCTGAG CAGTGTTCCG GACGAGGGTT CGGCGTCGTA CGACCGCAGC 2820

GCGCCCCCGT CCCCCGAGGA CAGGGACGGC GGTCTGTTCC TGCTGAAGAA GGACAGCGAG 2880

AGGCGGGCCA TTCTGTTCAA GGTGCTCAAC GACGACCAGG CGAAGGTCAT CTCCAACCTG 2940

AAGGAGAACC ACATCCAGCA GGGCATTGAA GAGCTCCAGC TCTCTGTCGA TCACATCAAG 3000

CAGATCATCT GCATCCTCCG AGACTTCATC CATTCCCCGG AGAGGCGCGT CATGGCGGCC 3060

ACCATCTCCA AGCTCAAGCT GGACCTGGAC TTCGACTCCA CCTCCATCAA CCAGATCCAG 3120

CTGGTGCTCT TCGGCTTCCA GGACTCGGTA AACAAAGTCC TGAGGAACCA TCACATCAAA 3180

CCTCACTGGA TGTTTGCGAT GGATAACATC ATCCGCCGAG CCGTGCAGGC CGCGATCACC 3240

ATCCTCATTC CAGAGCTGCA GACCCACTTC GGCCCGGCGT CCGAG 3285

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+g+G++g vya++dv+++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 597   DRVVLGRGTYGVVYAGRDVSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  651

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+l+e +i +yt+qilegl+yLHe++

Q: 652   IVQYLGSVSENGYIKIFMEQVPGGSLSALLRsKWGPLKEATIIFYTRQILEGLRYLHENQ  711

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k+

Q: 712   IVHRDIKGDNVLVNTySGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDKGP  768

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf+el+e++a+mfkvg+ k++Peipe+ls e+k+f+

Q: 769   RGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSLEAKSFI  828

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          +c+e dp+kr+ +++LL+++f+

Q: 829   LRCFEPDPNKRAITSDLLRDTFV  851

         ********************996

Domain Sequence
(FASTA)

DRVVLGRGTY GVVYAGRDVS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSENGYIK IFMEQVPGGS LSALLRSKWG PLKEATIIFY TRQILEGLRY LHENQIVHRD 120

IKGDNVLVNT YSGVLKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDK GPRGYGAPAD 180

IWSLGCTIIE MATGKPPFHE LGEPQAAMFK VGMFKIHPEI PESLSLEAKS FILRCFEPDP 240

NKRAITSDLL RDTFV 255

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013