EKS-GAA-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	448.6	1.2E-134	207	494	288

Status

Unreviewed

Ensembl Protein

ENSGACP00000007677

UniProt Accession

G3NQR1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000005810	ENSGACP00000007677	ENSGACT00000007696

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

MTVRGVLLLA LIALVLPCSS LEVEEVKPPT KEEHDCVCEG SSCDKEKRCK GHQCFSSLTL 60

SAGSLVYQKG CFKVYEQSTL TCKTPPSRDQ IVECCHGHLC NLNSTVALPV AAAELSSYSV 120

TTLAVVIVAP VIILIVLSAV AILVFRRIHN NQMERLTLRD AEYGTIDGLI ASNVGESTLA 180

DLLDHSCTSG SGSGLPFLVQ RTVARQITLN ECVGKGRYGE VWRGQWQGES VAVKIFSSRD 240

EKSWFRETEI YNTVLLRHEN ILGFIASDMT SRNSSTQLWL ITHFHEMGSL YDYLQLSTLD 300

AAGCLRMALS IASGLAHLHV EIFGTQGKPA IAHRDLKSKN ILVQKNGHCC IADLGLAVMH 360

FQDTNELDVG NNPKVGTKRY MAPEVLDDSI QMDCFESFKR VDIWALGLVL WEIARRTVSN 420

GIVEDYKPPF HDVVPSDPSF EDMKKVVCVD QQRPNIPNRW FSDPTLTSMA KLMKECWYQN 480

PSARLTALRI KKTLTKIDNS LDKIKTDI 508

Nucleotide Sequence
(FASTA)

ATGACGGTGA GAGGCGTGTT GCTTTTGGCT TTGATCGCCC TGGTCCTTCC CTGTTCAAGC 60

TTGGAAGTGG AGGAAGTAAA GCCCCCGACC AAGGAGGAGC ATGACTGTGT ATGTGAGGGC 120

AGCTCCTGTG ACAAAGAGAA ACGCTGCAAG GGCCACCAGT GTTTCTCCTC CCTGACGCTC 180

AGCGCCGGCT CCCTGGTCTA CCAGAAAGGC TGCTTCAAGG TCTACGAGCA GAGCACGCTG 240

ACCTGCAAGA CCCCACCTTC CAGGGACCAG ATTGTGGAGT GCTGCCACGG GCACCTGTGC 300

AACCTGAACA GCACCGTGGC GCTACCCGTC GCAGCCGCCG AGCTATCCAG CTACAGTGTG 360

ACCACACTGG CTGTCGTCAT CGTGGCGCCC GTCATCATCC TCATCGTCCT CTCCGCCGTC 420

GCGATCCTCG TGTTCAGGCG CATCCACAAC AACCAAATGG AGAGACTGAC GTTGCGAGAC 480

GCAGAATATG GAACCATCGA CGGCCTTATA GCCTCCAACG TGGGAGAGAG CACTCTGGCG 540

GATCTCCTTG ATCATTCCTG CACTTCAGGA AGCGGCTCGG GACTCCCTTT CCTCGTTCAG 600

AGAACTGTTG CACGACAAAT CACGCTCAAC GAGTGTGTAG GTAAGGGCCG TTACGGTGAA 660

GTGTGGAGGG GTCAGTGGCA GGGAGAGAGT GTCGCCGTCA AAATCTTCTC CTCCAGAGAC 720

GAGAAGTCCT GGTTCAGAGA GACTGAGATC TACAACACCG TGCTGCTGAG GCATGAGAAC 780

ATCCTGGGCT TCATAGCTTC GGACATGACC TCGAGGAACT CCAGCACTCA GTTGTGGCTG 840

ATCACACACT TCCATGAGAT GGGCTCCCTG TACGACTACC TTCAACTCAG CACCCTGGAC 900

GCAGCCGGCT GCCTCCGCAT GGCGCTTTCC ATCGCGAGCG GCCTGGCGCA CCTCCATGTG 960

GAGATCTTCG GCACTCAGGG CAAGCCGGCC ATTGCCCACC GGGACCTCAA GAGCAAAAAC 1020

ATATTGGTGC AAAAGAACGG ACATTGCTGC ATTGCTGACC TCGGTCTGGC CGTGATGCAT 1080

TTTCAAGACA CCAACGAGCT GGATGTGGGG AACAACCCCA AAGTGGGCAC CAAGCGCTAC 1140

ATGGCCCCCG AGGTGCTGGA CGACTCCATC CAGATGGATT GCTTCGAGTC CTTCAAGAGG 1200

GTGGACATCT GGGCCCTGGG CCTCGTCCTG TGGGAGATCG CCAGGAGGAC AGTCAGCAAT 1260

GGCATCGTGG AGGACTACAA GCCACCTTTT CACGACGTGG TCCCAAGCGA TCCCAGTTTT 1320

GAGGATATGA AGAAGGTTGT GTGTGTGGAT CAGCAGAGGC CCAACATCCC AAACAGATGG 1380

TTTTCAGACC CTACATTGAC CTCCATGGCT AAACTCATGA AGGAGTGCTG GTACCAGAAT 1440

CCGTCTGCCA GACTCACAGC GTTGCGCATC AAAAAGACTC TCACGAAGAT CGACAACTCT 1500

CTGGACAAAA TCAAGACAGA CATTTGA 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrhenil+fia

Q: 207   ITLNECVGKGRYGEVWRGQWQGESVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIA  266

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t++he+gsL+dyL+ +tld+  +lr+als+asGlahLH ei+gt+

Q: 267   SDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDAAGCLRMALSIASGLAHLHVEIFGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilv+k++ cciaDlGLa+++ ++++eld+ +n +vGtkRYmaPE

Q: 327   G--KPAIAHRDLKSKNILVQKNGHCCIADLGLAVMHFQDTNELDVGNNPKVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++++++fe+fkr+D+++lgLvlWE+a+R+ + +++ve+yk+pf++vv+sdPs+e+m

Q: 385   VLDDSIQMDCFESFKRVDIWALGLVLWEIARRTVS-NGIVEDYKPPFHDVVPSDPSFEDM  443

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+++++rP+ip++w ++++l++++kl++ecW+++p+aRltalr+kk+l

Q: 444   KKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

ITLNECVGKG RYGEVWRGQW QGESVAVKIF SSRDEKSWFR ETEIYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHFHE MGSLYDYLQL STLDAAGCLR MALSIASGLA HLHVEIFGTQ 120

GKPAIAHRDL KSKNILVQKN GHCCIADLGL AVMHFQDTNE LDVGNNPKVG TKRYMAPEVL 180

DDSIQMDCFE SFKRVDIWAL GLVLWEIARR TVSNGIVEDY KPPFHDVVPS DPSFEDMKKV 240

VCVDQQRPNI PNRWFSDPTL TSMAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013