EKS-GAA-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	349.2	1.6E-104	72	326	255

Status

Unreviewed

Ensembl Protein

ENSGACP00000008104

UniProt Accession

G3NRY7;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006112	ENSGACP00000008104	ENSGACT00000008123

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1230

Protein Sequence
(FASTA)

MAAVSSGGAA GSAAAGITHS ARPTHAGMGS QNRAQPSSGI NHPSRTGTAP GSIASPGHTS 60

ATRPPPARVG HYEIERTIGK GNFAVVKLAT HIITKAKVAI KIVDKTQLDQ QNLKKIFREV 120

PIMKVLEHPP IIRLYEVMET ERMIYLVTEY ASGGEIFART DHLVAHGRMA EKDARKKFKQ 180

IVAAVHFCHC RNIVHRDLKA ENLLLDHNLN IKIADFGFSN LFARGQLLKT WCGSPPYAAP 240

ELFEGKEYDG PKVDIWSLGV VLYVLVCGAL PFDGSTLQNL RARVLSGKFR IPFFMSTDCE 300

YLIRHMLVLE PSRRLTLEQI CKNKWMRLGD PDPDFDRLIA ECEQVKTERE VELINEQVLK 360

AMCEMGLDRE RTLQSLQTDA YDHYSAIYSL LADRLKKHKT LLVAPPKPRS INYPLSAVQG 420

NPVSMTVPHV QLINPENQIV EPDGSMALDS DEGEEPSPEA MARYLSMRRH TVGVPDQRTD 480

MQEDLQKLPP GFPRGAVPQP PFPSLVPNMG QTHTLMPAQS LQPTQQLEYK EQSLLQPPTL 540

QLLNGMGPLG RRASDGGANI QLHAQLLKRP RGPSPLVASP HPIPAVAPVD EEGSDGEPDQ 600

EAVQRSSYKD CNTLHLPMER FSPVRRFSDG AATIQAFKAH LEHSSLIKQL KQECEQLQKM 660

YAAQQDERFL EHTQQQHILY QQEQQILHQQ IQGLSLGHGE SQPSHLTHQL QRLRIQPSSP 720

PPTHPSNHLF RQPNQSPPPC SAGMMQGHGG PSPVQYQHGA PALYQGQSGS PPPRASLPTN 780

QQAASAHPSV ALAQGVPQQQ QVTIQVQEVE LGGVAQRQGG FLSTPGHRVL GKQLSADNAE 840

THSRSLGRFT SAYDQAHFNP HLFSGDVASR VVGPYNHYLQ GASLNVPGLE EYQSGAVGTG 900

TYGPPSALQQ ALLSPTPFEC RPAQHHVTPT LQGLLSPRHS LTGHADPRLP PQDLAALLKR 960

QSPRPCPSTP ALPSGAPQEY GEILVLRQLN QGEGLELQAP QGAAGGQHYH HLLQIRPPEV 1020

QPQQHLAQAP CPGLPHSESM EEDEAPPGYP HPHEGLLAKA ADGHELLGPP LGGTPPYNSP 1080

THRHGGYARN VPPARESEHV DCRPQGQAME VPDHNGVGYS AAPQSDAYRS RGQLQRHHTI 1140

QTCDDAYDQA EPMSGMSLLA GKALSSARMS DILSQTSLTG SQQLHQRGES ACDVEEELHA 1200

AACYPSSCTS DMLLSYKPPD LQYSMEQAGV 1230

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTCAAGCGG AGGTGCTGCT GGGTCCGCTG CGGCCGGGAT TACGCACTCT 60

GCCCGACCGA CCCACGCAGG CATGGGCTCC CAGAACCGAG CCCAGCCGTC CTCCGGCATC 120

AACCACCCCA GTCGCACCGG CACGGCCCCC GGGAGCATCG CCAGTCCTGG CCACACTTCG 180

GCCACCAGGC CCCCCCCAGC CCGAGTGGGC CACTACGAAA TCGAGCGGAC CATCGGCAAG 240

GGAAATTTCG CGGTTGTCAA ACTAGCCACA CACATCATTA CCAAAGCGAA GGTGGCTATA 300

AAAATAGTGG ATAAAACCCA GCTGGACCAA CAGAACCTGA AAAAGATTTT CAGAGAGGTG 360

CCAATCATGA AGGTGCTGGA GCACCCCCCC ATCATCCGCC TCTACGAGGT GATGGAGACT 420

GAGCGGATGA TCTATCTGGT AACGGAGTAC GCCAGCGGTG GAGAGATATT CGCGCGCACA 480

GACCACCTGG TGGCCCACGG GCGCATGGCG GAAAAGGACG CCCGGAAGAA GTTCAAACAG 540

ATTGTGGCAG CGGTCCATTT CTGTCACTGC CGCAACATCG TCCACAGAGA CCTGAAGGCG 600

GAGAATCTGC TGCTGGACCA CAACCTCAAC ATCAAAATCG CAGATTTTGG CTTCAGCAAC 660

CTGTTTGCTC GAGGACAGCT GTTGAAGACG TGGTGCGGCA GCCCCCCCTA CGCCGCGCCA 720

GAGCTCTTCG AGGGCAAGGA GTACGACGGG CCGAAAGTCG ACATATGGAG CTTAGGTGTG 780

GTGTTGTACG TGCTGGTGTG CGGCGCCCTG CCTTTTGACG GCAGCACCCT GCAGAATTTG 840

CGGGCGCGCG TCCTCAGCGG CAAGTTCCGC ATCCCCTTCT TCATGTCCAC AGACTGCGAG 900

TACCTGATCA GACACATGTT GGTGCTGGAG CCCAGCAGAC GGTTGACCTT GGAGCAGATC 960

TGTAAGAACA AGTGGATGAG ACTAGGAGAT CCGGACCCGG ACTTCGACAG GTTGATAGCG 1020

GAGTGTGAGC AGGTGAAGAC GGAGAGGGAG GTCGAGCTCA TCAATGAGCA GGTTCTGAAA 1080

GCAATGTGCG AGATGGGCCT GGATCGAGAA CGCACACTTC AGTCCCTACA AACGGATGCA 1140

TACGATCACT ACAGCGCCAT CTACAGTTTG CTGGCCGACC GCCTCAAGAA ACACAAGACC 1200

CTGCTTGTTG CTCCGCCCAA GCCGCGCTCC ATCAACTATC CTCTTAGCGC CGTGCAGGGT 1260

AATCCCGTTA GCATGACCGT TCCCCACGTC CAGCTCATCA ACCCAGAGAA CCAGATCGTC 1320

GAGCCGGACG GCAGCATGGC GCTGGACAGC GATGAAGGGG AGGAGCCATC CCCCGAGGCC 1380

ATGGCTCGCT ATCTGTCAAT GAGGCGGCAC ACCGTGGGAG TACCAGACCA AAGGACAGAC 1440

ATGCAGGAGG ACCTCCAGAA ACTGCCGCCA GGTTTCCCTC GCGGTGCGGT TCCCCAGCCC 1500

CCTTTCCCCT CACTGGTCCC CAACATGGGC CAAACTCACA CTCTCATGCC CGCACAGAGC 1560

TTGCAGCCCA CACAGCAGCT GGAGTACAAG GAGCAGTCCT TGCTGCAGCC CCCCACCCTC 1620

CAGCTGCTCA ACGGCATGGG GCCTCTCGGT CGAAGGGCTT CCGACGGCGG GGCCAACATT 1680

CAACTACACG CTCAGCTCCT CAAGCGGCCC CGGGGGCCCT CACCGCTTGT TGCCAGCCCG 1740

CACCCAATCC CCGCAGTAGC TCCGGTGGAT GAGGAAGGTT CAGACGGAGA GCCGGACCAG 1800

GAGGCAGTAC AGAGATCCAG CTATAAGGAC TGTAACACCC TTCATCTCCC CATGGAGCGC 1860

TTCTCACCCG TCAGGCGCTT TTCTGACGGC GCCGCCACCA TCCAGGCCTT CAAGGCTCAT 1920

CTAGAGCACA GCAGCCTCAT TAAGCAACTC AAACAGGAGT GCGAGCAGCT CCAGAAAATG 1980

TACGCTGCCC AGCAGGATGA GCGGTTCCTG GAGCACACAC AGCAGCAGCA TATCCTCTAC 2040

CAGCAAGAGC AACAGATCCT CCACCAGCAA ATCCAGGGTC TGTCTTTAGG CCACGGAGAG 2100

AGCCAGCCCA GTCACCTGAC CCACCAGCTC CAGAGGTTGC GCATCCAGCC TTCCAGTCCT 2160

CCGCCAACTC ATCCCAGCAA CCACCTCTTC AGACAGCCCA ACCAGAGCCC CCCGCCTTGC 2220

TCTGCAGGCA TGATGCAAGG GCACGGAGGT CCCTCACCAG TGCAGTACCA GCACGGGGCT 2280

CCTGCACTCT ATCAAGGCCA GAGTGGCAGC CCGCCTCCGC GAGCCTCTCT ACCGACCAAT 2340

CAGCAGGCAG CATCCGCCCA CCCCAGCGTA GCGCTGGCGC AGGGTGTACC TCAACAACAG 2400

CAGGTGACCA TTCAGGTTCA AGAGGTGGAG CTGGGAGGCG TGGCGCAGAG ACAGGGCGGC 2460

TTTTTGTCCA CGCCGGGGCA CCGAGTCCTC GGGAAGCAGC TGAGCGCGGA CAACGCCGAG 2520

ACGCACAGTC GCAGCCTCGG CCGCTTCACA TCGGCTTACG ACCAAGCTCA CTTTAACCCC 2580

CACCTCTTCT CGGGCGACGT CGCCTCCCGG GTGGTCGGCC CCTACAACCA CTACCTGCAG 2640

GGAGCCTCCC TCAACGTGCC GGGCCTGGAG GAGTACCAGA GCGGGGCGGT CGGGACCGGC 2700

ACCTACGGCC CCCCCTCCGC ACTACAGCAG GCCCTGCTGT CCCCGACTCC TTTTGAGTGC 2760

CGCCCCGCAC AGCATCACGT CACCCCCACC CTGCAGGGCC TCCTGTCGCC CCGCCACTCT 2820

CTAACAGGCC ACGCCGACCC CAGGCTGCCG CCCCAAGACC TGGCAGCCCT GCTCAAGAGG 2880

CAGAGCCCCC GGCCGTGCCC GTCGACCCCC GCCCTGCCCA GCGGCGCGCC CCAAGAGTAC 2940

GGAGAGATTC TGGTCCTCCG CCAGCTGAAC CAGGGGGAAG GCTTGGAGCT GCAGGCGCCG 3000

CAGGGCGCCG CCGGGGGCCA ACACTACCAC CACCTCCTCC AGATCCGGCC CCCCGAGGTC 3060

CAGCCGCAGC AGCACCTGGC CCAGGCTCCC TGCCCCGGCT TACCCCACTC GGAGAGCATG 3120

GAGGAGGACG AAGCGCCGCC CGGCTACCCC CACCCGCACG AGGGCCTGCT GGCCAAGGCG 3180

GCAGACGGTC ACGAGCTGCT GGGGCCCCCC CTAGGAGGCA CCCCGCCCTA CAACTCCCCT 3240

ACACACCGGC ACGGCGGCTA CGCGAGGAAC GTTCCGCCGG CGAGAGAATC GGAGCATGTC 3300

GACTGCAGGC CCCAAGGGCA GGCCATGGAG GTGCCCGATC ACAACGGCGT GGGCTATTCA 3360

GCAGCTCCCC AGAGTGACGC CTATAGGTCC CGTGGACAGC TACAGCGCCA CCACACCATC 3420

CAGACCTGCG ACGACGCCTA CGACCAGGCG GAGCCCATGT CGGGAATGAG CCTGCTGGCC 3480

GGGAAGGCGC TGAGCTCGGC TCGCATGTCG GACATTCTGA GCCAGACGTC GCTGACGGGA 3540

AGCCAGCAGC TGCATCAGCG GGGAGAGTCG GCGTGTGACG TGGAGGAGGA GCTCCATGCG 3600

GCGGCCTGCT ACCCCTCCTC CTGCACCAGT GACATGCTCC TCAGCTACAA GCCCCCCGAC 3660

CTGCAGTACA GCATGGAGCA GGCCGGTGTT TAG 3693

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g+f+ Vkla+h  tk kva+Ki++k++l++++l+ki+rE+ i+k l+hp i

Q: 72    YEIERTIGKGNFAVVKLATHIITKAKVAIKIVDKTQLDQQNLKKIFREVPIMKVLEHPPI  131

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLf...dyieekgrlkekearklfkqlvsavkYlhsk  117

         i+l+ev+et++++ylv+eyasgge+f   d+++++gr+ ek+ark fkq+v+av+++h +

Q: 132   IRLYEVMETERMIYLVTEYASGGEIFartDHLVAHGRMAEKDARKKFKQIVAAVHFCHCR  191

         *************************9666799****************************

S: 118   givHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegp  177

         +ivHrDlK+eNllld++ nikiaDFG++nlf +g+ll+t+cGsppYaaPel++gk+Y+gp

Q: 192   NIVHRDLKAENLLLDHNLNIKIADFGFSNLFARGQLLKTWCGSPPYAAPELFEGKEYDGP  251

         ************************************************************

S: 178   kvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdp  237

         kvD+WslGvvLy+lv+g+lPfd+++l++l++++l+gk++ip+ +s+++e L+r++Lv +p

Q: 252   KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTDCEYLIRHMLVLEP  311

         ************************************************************

S: 238   ekRatieeilkhewl  252

         ++R+t+e+i k++w+

Q: 312   SRRLTLEQICKNKWM  326

         **************8

Domain Sequence
(FASTA)

YEIERTIGKG NFAVVKLATH IITKAKVAIK IVDKTQLDQQ NLKKIFREVP IMKVLEHPPI 60

IRLYEVMETE RMIYLVTEYA SGGEIFARTD HLVAHGRMAE KDARKKFKQI VAAVHFCHCR 120

NIVHRDLKAE NLLLDHNLNI KIADFGFSNL FARGQLLKTW CGSPPYAAPE LFEGKEYDGP 180

KVDIWSLGVV LYVLVCGALP FDGSTLQNLR ARVLSGKFRI PFFMSTDCEY LIRHMLVLEP 240

SRRLTLEQIC KNKWM 255

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013