EKS-GAA-00463

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00463

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	322.2	3.1E-96	88	324	237

Status

Unreviewed

Ensembl Protein

ENSGACP00000008198

UniProt Accession

G3NS81;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K13

Gene Synonyms/Alias

MAP3K13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006196	ENSGACP00000008198	ENSGACT00000008217

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

872

Protein Sequence
(FASTA)

FDNSVLQLQE HEQEEAGSPA SCEHGGCGSG IDDIKLHFQR AGPGSGGFLE GLFGCLRPVW 60

NIIGKTYSTE YKLQQQDTWE VPFEEISELQ WLGSGAQGAV FLGKFRSEEV AIKKVREQKE 120

TDIKPLRKLK HPNIISFKGV CTQAPCYCII MEYCAQGQLY EVLRAGRKVT PRMLVDWATG 180

IASGMNYLHL HKIIHRDLKS PNVLVTSNDT VKISDFGTSK ELSDKSTKMS FAGTVAWMAP 240

EVIRNEPVSE KVDIWSFGVV LWELLTGEIP YKDVDSSAII WGVGSNSLHL PVPSTCPDGF 300

KILMKQTWQS KPRNRPSFRQ ILLHLDIASA DVLGAPQETY FKSQSEWREE VKKHFEKIKS 360

EGTCIHRLDE ELIRRRRDEL RHALDIREHY ERKLERANNL YMELSAIMLQ LEVREKDLMK 420

REQTVEKKYP GTYKRHLVRP IVRTNAVEKL IKKKGSMSHK PGMPPTKRPD LLRSDGIPSL 480

DPLPSPLSAS PKLSTPPGKA RHRSKPRHRR ANSKGSHGEF SGLLRPLAAA LEDTQSLQEQ 540

PFLLHQHHHH PQTEAPFLPL KGREQAVVNC ANNLRYFGPA APLRSPQTDH LQRRVSEPSP 600

DLISTAVDAD TRLRTSPAGP DPVPGAGAGT LCPCCQAHPF PGCLHCQETP PASSHPELPH 660

YSLLNTQEGT ASSLGAPGKD AASDGEATKK AQPQEQQASQ RAHTLLTALP RTLRPLRKGG 720

DESSEEEEGE VDSEVEFPRR QRPHRCMSSF QSYSTFSSEN LSVSDGEEGN TSDHSHSGPL 780

ERLSASQEEH LDELLSHTPE IPIDISTQSD GLSDKECAVR RVKTQISLGK LCSDEHSYEN 840

PLQFGDSDGD TSEAECSDAT IRNNKVGAPS SW 872

Nucleotide Sequence
(FASTA)

TTTGACAACA GCGTGCTGCA GCTGCAGGAG CACGAGCAGG AGGAAGCGGG ATCGCCGGCC 60

TCCTGTGAGC ACGGCGGGTG CGGCAGCGGG ATCGACGACA TCAAGCTGCA CTTCCAGAGG 120

GCGGGGCCCG GGTCGGGTGG CTTCTTAGAG GGGCTGTTCG GTTGCCTTCG GCCCGTGTGG 180

AACATCATCG GGAAGACGTA CTCAACTGAA TACAAGCTCC AGCAGCAAGA CACGTGGGAG 240

GTTCCATTCG AGGAGATCTC TGAGTTGCAG TGGTTGGGCA GCGGTGCACA GGGAGCCGTC 300

TTCTTGGGAA AGTTCCGCTC TGAGGAGGTG GCCATCAAGA AGGTGCGTGA GCAGAAGGAG 360

ACGGACATTA AACCCCTGCG AAAACTCAAG CATCCCAATA TCATCAGCTT CAAGGGGGTG 420

TGCACCCAGG CGCCTTGTTA CTGCATCATC ATGGAGTACT GTGCGCAGGG CCAGCTGTAC 480

GAGGTGCTGA GGGCGGGGAG GAAAGTGACT CCCAGGATGC TGGTGGACTG GGCCACAGGC 540

ATCGCCAGCG GCATGAACTA CCTTCACCTG CACAAGATCA TCCACAGGGA TCTCAAGTCT 600

CCCAATGTTT TGGTCACCTC CAACGACACC GTGAAAATCT CCGACTTTGG AACGTCCAAA 660

GAGCTCAGTG ACAAAAGTAC AAAGATGTCC TTTGCGGGTA CAGTGGCCTG GATGGCCCCG 720

GAAGTCATAA GAAACGAGCC CGTGTCTGAA AAAGTAGACA TCTGGTCATT TGGAGTTGTG 780

TTGTGGGAAC TTCTGACCGG AGAGATTCCC TACAAAGATG TGGACTCCTC GGCCATCATT 840

TGGGGTGTTG GCAGCAACAG TCTTCACCTC CCGGTCCCCT CGACCTGCCC GGACGGCTTC 900

AAAATCCTCA TGAAACAAAC ATGGCAGAGC AAGCCCAGGA ATAGGCCTTC ATTTCGTCAG 960

ATCCTCCTAC ACCTCGACAT CGCCTCTGCT GATGTCTTAG GAGCTCCTCA GGAGACCTAC 1020

TTCAAGTCTC AGTCAGAATG GAGAGAGGAA GTGAAGAAAC ATTTTGAGAA GATCAAAAGT 1080

GAAGGCACCT GTATCCACAG GCTGGACGAG GAGCTGATCC GACGCAGGCG GGATGAACTC 1140

AGGCACGCTC TGGACATCCG GGAGCACTAT GAGAGGAAAC TGGAGAGAGC CAACAACCTC 1200

TACATGGAGC TCAGTGCCAT CATGCTGCAG CTGGAGGTCC GAGAGAAGGA CCTAATGAAG 1260

CGAGAGCAAA CCGTGGAGAA GAAATATCCA GGGACCTACA AGCGACACCT CGTCAGACCC 1320

ATTGTCAGGA CCAACGCTGT AGAGAAGCTC ATCAAGAAGA AAGGAAGCAT GTCCCACAAA 1380

CCAGGGATGC CCCCCACTAA AAGACCGGAC CTGCTTCGTT CCGATGGCAT CCCCAGCCTC 1440

GACCCACTCC CCTCCCCTCT ATCGGCCAGC CCCAAGCTCT CCACGCCTCC CGGAAAGGCC 1500

CGCCACCGCA GCAAGCCGCG CCACCGCCGG GCCAACAGCA AAGGAAGCCA CGGCGAGTTC 1560

TCCGGGCTGC TGAGGCCTCT CGCCGCGGCA TTGGAAGACA CCCAGTCCCT CCAGGAGCAG 1620

CCGTTTCTCC TCCACCAACA CCACCACCAC CCGCAGACCG AGGCGCCGTT CCTCCCCTTA 1680

AAGGGCCGGG AGCAGGCCGT CGTAAACTGT GCCAACAACC TGCGCTACTT CGGCCCCGCC 1740

GCTCCGCTGC GTAGCCCTCA GACGGACCAC CTCCAGCGAC GCGTTTCTGA ACCCAGCCCC 1800

GACCTCATTT CCACCGCTGT GGATGCGGAC ACGCGACTGC GCACGTCGCC CGCCGGCCCC 1860

GACCCGGTTC CCGGTGCCGG CGCTGGCACT TTGTGTCCCT GCTGCCAGGC TCACCCCTTC 1920

CCTGGCTGCC TACACTGCCA GGAGACCCCA CCTGCGTCAA GCCATCCGGA GTTGCCCCAC 1980

TACTCCCTAC TCAACACCCA GGAAGGCACT GCGTCTTCTC TCGGGGCTCC GGGCAAAGAT 2040

GCAGCCTCGG ACGGAGAGGC CACAAAGAAG GCTCAGCCAC AAGAACAACA GGCGTCCCAG 2100

CGCGCTCACA CCCTGCTCAC TGCACTGCCC CGCACTCTCA GGCCCCTCAG GAAGGGTGGC 2160

GACGAGTCAT CTGAAGAGGA AGAGGGGGAG GTGGATAGTG AAGTGGAGTT TCCGAGGAGA 2220

CAAAGACCTC ATCGCTGTAT GAGCAGCTTC CAGTCCTACT CCACCTTCAG CTCGGAGAAC 2280

CTGTCGGTGT CTGACGGAGA GGAGGGAAAC ACCAGTGACC ACTCCCACAG CGGGCCCCTG 2340

GAGAGGCTGA GCGCCAGTCA GGAGGAACAT CTGGACGAGC TGCTGTCTCA CACGCCGGAA 2400

ATCCCCATCG ACATCTCCAC CCAGTCAGAC GGCCTCTCCG ACAAGGAGTG CGCGGTGCGC 2460

AGGGTGAAGA CCCAGATCTC TCTGGGGAAA CTGTGCTCCG ACGAACACAG CTACGAGAAT 2520

CCACTGCAGT TTGGGGATTC AGACGGCGAT ACGTCGGAGG CGGAGTGCTC CGATGCCACC 2580

ATCAGAAACA ACAAAGTCGG GGCCCCTTCC TCCTGGTGA 2619

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k l+kl+hpnii ++

Q: 88    ELQWLGSGAQGAVFLGKFRSEEVAIKKVREQKET---------DIKPLRKLKHPNIISFK  138

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r++++++lv+wa+ iA+Gm+YLh +   ki

Q: 139   GVCTQAPCYCIIMEYCAQGQLYEVLRA--GRKVTPRMLVDWATGIASGMNYLHLH---KI  193

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++t+ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 194   IHRDLKSPNVLV-TSNDTVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  252

         ************.******************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 253   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  312

         ************************************************************

S: 242   ekRpsfseivks  253

         ++Rpsf++i+ +

Q: 313   RNRPSFRQILLH  324

         *********876

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRS EEVAIKKVRE QKETDIKPLR KLKHPNIISF KGVCTQAPCY 60

CIIMEYCAQG QLYEVLRAGR KVTPRMLVDW ATGIASGMNY LHLHKIIHRD LKSPNVLVTS 120

NDTVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQILLH 237

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013