EKS-GAA-00454

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00454

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	408.6	1.2E-122	242	495	254

Status

Unreviewed

Ensembl Protein

ENSGACP00000008369

UniProt Accession

G3NSQ1;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006319	ENSGACP00000008369	ENSGACT00000008388

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MEFQKRLSSC WESFLRCFKK PNQPVAKTRG DKDLVIGNPE FDGRDEPTPL APAIPGVYYI 60

AQYNYSARTE EDLSFHAGDT LEALDKSHGD WWLAKALTGV SASHQGYIPA NYVAPLESVD 120

AEAWYFPDTK RLDAEKMLLA EGNQHGAFLI RNCESQQGER SLSVLDAGKV KHYKLKKLAN 180

GHYYVSRNRS FETIRELVEH YSNHSDGLCV RLCEPCKKME APQTHGLSYN TVDQWEIERK 240

SIKLLKKLGA GQFGEVFEGR WNETTSVAVK TLKPGTMDAE DFLREAQLMK RLRHPKLIQL 300

YAVCTMEEPI YIITELMNNG SLLEYLNKDK GVTLGISQQI EMAAQVAAGM AFLELQNYIH 360

RDLAARNVLV GENNVCKVAD FGLARVFMKE NENVYEAKEG SKFPVKWTAP EAINDHKFTI 420

KSDVWSFGIL LYEIMTFGQM PYPAMSNYQV VHQVPQGYRM PNPPNCPKVM YDIMADCWKE 480

KENDRPTFET LQWKLEDLIF DQDVTSYDDA SRY 513

Nucleotide Sequence
(FASTA)

ATGGAGTTCC AGAAGAGGCT TTCCTCCTGC TGGGAGAGCT TTTTGCGTTG TTTTAAAAAG 60

CCGAACCAGC CCGTGGCCAA AACCCGCGGG GACAAAGACT TAGTTATAGG AAATCCCGAA 120

TTTGACGGTC GTGATGAACC AACGCCGCTT GCACCTGCGA TTCCCGGCGT TTATTACATC 180

GCCCAGTACA ACTACTCGGC GCGCACCGAA GAGGACCTGA GCTTCCACGC GGGGGACACT 240

TTGGAGGCTC TCGATAAAAG TCACGGCGAT TGGTGGTTGG CGAAAGCCCT GACCGGGGTC 300

TCCGCGTCCC ACCAGGGATA CATCCCGGCT AACTATGTGG CGCCCCTGGA GAGCGTCGAC 360

GCTGAAGCAT GGTATTTTCC CGACACGAAG AGGCTTGATG CCGAGAAGAT GCTGTTGGCA 420

GAAGGGAATC AGCATGGTGC CTTCCTCATC CGAAATTGTG AAAGTCAGCA GGGGGAGCGC 480

TCCCTCTCGG TGCTGGATGC TGGGAAGGTG AAGCATTATA AGCTTAAAAA ACTGGCGAAC 540

GGTCACTACT ACGTGTCGAG GAACCGATCC TTTGAAACAA TAAGGGAGCT TGTGGAACAT 600

TACTCCAACC ATTCCGATGG CCTCTGTGTG CGTCTCTGCG AGCCTTGCAA AAAGATGGAG 660

GCTCCACAGA CTCACGGCCT CTCCTACAAC ACGGTGGACC AATGGGAGAT TGAACGCAAA 720

TCCATCAAGC TCCTAAAGAA GCTTGGAGCT GGTCAGTTTG GCGAAGTGTT CGAGGGCCGG 780

TGGAACGAAA CCACATCGGT CGCGGTGAAG ACCCTGAAAC CGGGTACAAT GGACGCGGAG 840

GACTTCCTAA GAGAGGCTCA GCTCATGAAG AGGCTGCGGC ATCCTAAGCT GATCCAGCTG 900

TATGCAGTCT GCACTATGGA GGAGCCCATA TACATCATCA CAGAGCTGAT GAACAACGGC 960

AGCTTACTGG AGTACCTCAA TAAGGATAAG GGCGTCACGC TGGGTATCTC CCAACAGATT 1020

GAGATGGCGG CCCAGGTTGC CGCGGGCATG GCTTTCCTGG AGTTGCAGAA CTACATTCAC 1080

AGAGACCTGG CAGCCAGGAA CGTCCTGGTC GGCGAGAACA ACGTCTGCAA AGTTGCCGAC 1140

TTTGGCCTCG CAAGGGTCTT CATGAAAGAG AATGAAAATG TGTATGAAGC CAAAGAAGGA 1200

AGTAAATTCC CTGTGAAGTG GACCGCGCCG GAGGCCATCA ACGACCATAA GTTCACCATA 1260

AAATCAGACG TCTGGTCCTT TGGGATCCTG CTGTACGAGA TCATGACGTT TGGACAGATG 1320

CCTTACCCAG CCATGTCAAA TTACCAAGTC GTCCATCAGG TCCCCCAGGG CTACAGGATG 1380

CCAAATCCCC CCAACTGTCC CAAAGTCATG TATGACATCA TGGCGGACTG CTGGAAGGAG 1440

AAGGAAAATG ATCGGCCCAC ATTCGAGACC CTGCAGTGGA AGCTGGAGGA CTTGATCTTT 1500

GACCAGGACG TGACCTCCTA CGACGATGCC AGCCGCTATT AG 1542

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +kl+kklG+GqfGev++g+w+++++vavktlk+gt++ e+fl+eaq++k+lrh+kl++ly

Q: 242   IKLLKKLGAGQFGEVFEGRWNETTSVAVKTLKPGTMDAEDFLREAQLMKRLRHPKLIQLY  301

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ eePiyi+telm++Gsll++l++++g +l +++++++aaqva+Gma+le +n+ihr

Q: 302   AVCTMEEPIYIITELMNNGSLLEYLNKDKGVTLGISQQIEMAAQVAAGMAFLELQNYIHR  361

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar++    ++ y+akeg+k+P+kWtaPeai+ +kftik

Q: 362   DLAARNVLVGENNVCKVADFGLARVFMkenENVYEAKEGSKFPVKWTAPEAINDHKFTIK  421

         ************************764456889***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t G++Pyp m+n +v++qv +gyr+p+p +cp+ +y++++ cwk++

Q: 422   SDVWSFGILLYEIMTFGQMPYPAMSNYQVVHQVPQGYRMPNPPNCPKVMYDIMADCWKEK  481

         ************************************************************

S: 238   peerPtfetlqevl  251

          ++rPtfetlq++l

Q: 482   ENDRPTFETLQWKL  495

         ***********986

Domain Sequence
(FASTA)

IKLLKKLGAG QFGEVFEGRW NETTSVAVKT LKPGTMDAED FLREAQLMKR LRHPKLIQLY 60

AVCTMEEPIY IITELMNNGS LLEYLNKDKG VTLGISQQIE MAAQVAAGMA FLELQNYIHR 120

DLAARNVLVG ENNVCKVADF GLARVFMKEN ENVYEAKEGS KFPVKWTAPE AINDHKFTIK 180

SDVWSFGILL YEIMTFGQMP YPAMSNYQVV HQVPQGYRMP NPPNCPKVMY DIMADCWKEK 240

ENDRPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013