EKS-GAA-00084

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00084

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	351.6	3.9E-105	10	297	288

Status

Unreviewed

Ensembl Protein

ENSGACP00000008387

UniProt Accession

G3NSR9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK6

Gene Synonyms/Alias

CDK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006323	ENSGACP00000008387	ENSGACT00000008406

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

325

Protein Sequence
(FASTA)

MDKESTGTQY EPVAEIGEGA YGKVYKARDL KNGGRFVALK RVRVQTEEEG MPLSTIREVA 60

VLRQLEAFDH PNVVRLFDVC TVSRTDRETK LTLVFEHVDQ DLTTYLEKAP DPGVPPETIK 120

HMMYQLLQGL DFLHSHRVVH RDLKPQNILV TSGGQIKLAD FGLARIYSFQ MALTSVVVTL 180

WYRAPEVLLQ SSYATPVDLW SVGCIFAEMF RRRPLFRGNS DVDQLGKIFD VVGVPSVEDW 240

PQEVALPQTA FTSRHPKPIE DLVPDMDEQG RALLMQFLAF NSSRRISAFV ALSHPYFQSV 300

DSLSRSVYAA QPIPSNKPTM EERTA 325

Nucleotide Sequence
(FASTA)

ATGGACAAGG AAAGCACGGG TACTCAGTAT GAACCCGTGG CCGAGATCGG AGAAGGCGCG 60

TACGGGAAGG TGTACAAGGC GAGAGACCTG AAGAACGGAG GGCGCTTCGT AGCCCTGAAG 120

AGGGTTCGCG TGCAGACGGA GGAAGAGGGG ATGCCTCTCT CCACCATCCG GGAGGTGGCG 180

GTACTGAGGC AGCTCGAGGC GTTCGACCAC CCCAATGTTG TGAGGTTGTT TGACGTGTGT 240

ACGGTCTCGC GGACGGACAG AGAAACCAAG CTCACCCTGG TCTTTGAGCA CGTGGATCAG 300

GACCTGACCA CCTACCTGGA GAAGGCCCCC GATCCCGGAG TACCGCCCGA GACCATTAAG 360

CATATGATGT ACCAGCTGCT CCAGGGGCTG GACTTCCTGC ACTCGCACCG AGTGGTTCAC 420

CGTGACCTGA AGCCCCAGAA CATCCTGGTG ACCAGCGGAG GACAGATCAA GCTGGCCGAC 480

TTTGGTCTCG CCCGCATCTA CAGCTTCCAG ATGGCGCTCA CCTCCGTGGT GGTGACCCTG 540

TGGTACAGAG CCCCAGAGGT GCTGCTCCAG TCCAGTTACG CCACACCGGT GGACCTGTGG 600

AGCGTCGGCT GCATCTTCGC CGAGATGTTC AGGAGAAGAC CGCTTTTTCG AGGAAACTCA 660

GATGTTGATC AGCTGGGGAA AATTTTTGAC GTTGTCGGGG TACCTTCGGT GGAGGACTGG 720

CCCCAGGAAG TGGCTCTGCC ACAGACTGCT TTCACATCCC GGCACCCGAA GCCCATAGAG 780

GACTTGGTCC CAGACATGGA CGAGCAAGGA CGGGCCCTCT TAATGCAATT CCTCGCCTTC 840

AATTCCTCCA GGAGGATATC TGCCTTCGTT GCGCTCAGCC ACCCCTACTT TCAAAGTGTG 900

GACAGCCTCA GTAGGAGTGT GTACGCGGCG CAGCCGATCC CGAGCAACAA GCCCACTATG 960

GAGGAGAGGA CTGCCTGA 978

Domain Profile

S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56

         ye +++igeG+ygkvyka+d k+ g++vAlK++r+++e+eg+p +++rE+++l++l   +

Q: 10    YEPVAEIGEGAYGKVYKARDlKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLeafD  69

         88899***************888999*****************************98889

S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112

         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k +  ++++e++k++++qll+g

Q: 70    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKHMMYQLLQG  129

         ************99855569****************************************

S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172

         l++lHs++++HRDlKpqN+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe+L

Q: 130   LDFLHSHRVVHRDLKPQNILVTSGGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  188

         *****************************************99.****************

S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232

         l++ +Y t vD+Wsvgci+ae+++r+plf+g+s++dql +if+++g ps ++wp+   lp

Q: 189   LQS-SYATPVDLWSVGCIFAEMFRRRPLFRGNSDVDQLGKIFDVVGVPSVEDWPQEVALP  247

         *88.5*******************************************************

S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +    f+++++k +++ v++++e+++ ll ++la++ ++Risa  al+h+yf

Q: 248   QTA--FTSRHPKPIEDLVPDMDEQGRALLMQFLAFNSSRRISAFVALSHPYF  297

         *76..99999*****************************************9

Domain Sequence
(FASTA)

YEPVAEIGEG AYGKVYKARD LKNGGRFVAL KRVRVQTEEE GMPLSTIREV AVLRQLEAFD 60

HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLEKA PDPGVPPETI KHMMYQLLQG 120

LDFLHSHRVV HRDLKPQNIL VTSGGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180

QSSYATPVDL WSVGCIFAEM FRRRPLFRGN SDVDQLGKIF DVVGVPSVED WPQEVALPQT 240

AFTSRHPKPI EDLVPDMDEQ GRALLMQFLA FNSSRRISAF VALSHPYF 288

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013