EKS-GAA-00526

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00526

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	437.0	2.3E-131	150	402	253

Status

Unreviewed

Ensembl Protein

ENSGACP00000008428

UniProt Accession

G3NSV6;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKA

Gene Synonyms/Alias

AURKA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006354	ENSGACP00000008428	ENSGACT00000008447
ENSGACG00000006354	ENSGACP00000008417	ENSGACT00000008436
ENSGACG00000006354	ENSGACP00000008424	ENSGACT00000008443

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

420

Protein Sequence
(FASTA)

HRAVCNYHPF FLKIRFESNC DGPKRIPVSH QSQAAVVTPT PHQRVLGVSN GPRRIQRPAS 60

HQKPASQVSA VVKSTHPTDQ NVNPAAQAGH RAPQPKRVSQ QIQPKTNVNP EPAKAPSEPA 120

NPDKPQSRRN TKSVTARFCS RSRRWSLENF DIGRPLGKGK FGNVYLAREQ QSKFILALKV 180

LFKKQLEKAG VEHQLRREVE IQSHLRHPNI LRLYGYFHDL SRVYLILEFA PKGELYSELQ 240

RCGCFPEARS ATYIMELADA LNYCHSKKVI HRDIKPENLL LGANGELKIA DFGWSVHTPS 300

SRRSTLCGTL DYLPPEMIEG KTHDEKVDLW SLGVLCYEFL VGKPPFETKS HEETYRKISR 360

VEYTYPTQAN ISAGAKDLVA RLLKHNPMQR LPIQGVLAHP WVVESATKKP TTLTSDELSQ 420

Nucleotide Sequence
(FASTA)

CACCGGGCCG TTTGTAATTA TCATCCTTTT TTTCTAAAAA TAAGATTTGA GTCCAACTGT 60

GACGGGCCGA AGCGGATCCC GGTGTCCCAT CAGTCGCAGG CTGCTGTGGT CACACCGACT 120

CCTCACCAGC GGGTTCTAGG CGTGTCAAAC GGGCCCCGGC GCATTCAGCG GCCCGCGTCG 180

CACCAAAAAC CGGCGTCTCA GGTCTCTGCG GTGGTCAAGT CCACGCACCC CACTGATCAG 240

AACGTGAACC CCGCCGCTCA GGCCGGACAC CGTGCGCCAC AGCCCAAACG CGTTTCTCAA 300

CAGATCCAAC CAAAGACAAA TGTGAACCCG GAGCCGGCCA AGGCGCCGTC GGAACCGGCA 360

AACCCAGACA AGCCACAGAG TAGGCGCAAT ACAAAGTCAG TAACTGCACG TTTCTGCTCG 420

CGCAGCAGGC GGTGGAGCCT GGAGAATTTC GACATTGGCC GTCCCTTAGG AAAGGGTAAA 480

TTTGGAAATG TCTACCTGGC CAGAGAGCAA CAAAGTAAGT TCATCTTGGC CCTGAAGGTG 540

CTGTTCAAGA AGCAGCTGGA GAAGGCCGGG GTGGAGCACC AGCTGAGGAG AGAGGTGGAG 600

ATCCAGTCTC ACCTCAGGCA CCCAAATATC CTGCGTCTCT ACGGTTACTT CCATGACTTG 660

TCACGTGTCT ATCTCATCCT GGAGTTTGCA CCCAAGGGTG AGCTGTACAG TGAGCTGCAG 720

CGCTGTGGAT GTTTTCCGGA GGCCAGAAGT GCCACATACA TAATGGAACT GGCCGACGCA 780

CTCAACTATT GCCACTCCAA GAAGGTGATC CACAGGGACA TAAAACCAGA GAACCTGTTA 840

CTGGGGGCCA ACGGAGAGCT CAAGATTGCA GACTTTGGCT GGTCCGTCCA CACTCCCTCC 900

TCCAGGAGAT CCACACTCTG CGGCACGCTG GACTATTTGC CTCCAGAGAT GATTGAGGGA 960

AAAACTCACG ATGAGAAGGT GGATCTGTGG AGTCTTGGCG TCCTTTGCTA CGAGTTCCTG 1020

GTGGGAAAGC CACCCTTTGA AACGAAGAGT CACGAGGAGA CCTACCGCAA GATATCAAGG 1080

GTGGAGTACA CTTACCCCAC ACAAGCCAAT ATCAGTGCTG GAGCCAAAGA CTTGGTTGCG 1140

AGGCTGCTGA AGCACAACCC GATGCAAAGA CTGCCCATCC AGGGAGTCCT GGCTCACCCC 1200

TGGGTGGTTG AGAGCGCCAC CAAGAAACCC ACAACTCTAA CCAGCGACGA GCTCAGCCAG 1260

TGA 1263

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         f+iGr+lGkGkfGnvylare++skfi+alkvlfk+qlek+gve+qlrre+eiqshl+hpn

Q: 150   FDIGRPLGKGKFGNVYLAREQQSKFILALKVLFKKQLEKAGVEHQLRREVEIQSHLRHPN  209

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrlygyfhd +rvylile+ap+Gely elq+   + e r+a+yi eladal+y+h+kkv

Q: 210   ILRLYGYFHDLSRVYLILEFAPKGELYSELQRCGCFPEARSATYIMELADALNYCHSKKV  269

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg +gelk+adfGwsvh+pss+r tlcGtldylppem+eg+++dekvdl

Q: 270   IHRDIKPENLLLGANGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDL  329

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklps..svskgakdliskllkkepke  238

         w+lGvlcye+lvGkppfe++s++ety++i++v++++p+  ++s+gakdl+++llk++p +

Q: 330   WSLGVLCYEFLVGKPPFETKSHEETYRKISRVEYTYPTqaNISAGAKDLVARLLKHNPMQ  389

         *************************************733699*****************

S: 239   rltladvlahpwi  251

         rl+++ vlahpw+

Q: 390   RLPIQGVLAHPWV  402

         ************8

Domain Sequence
(FASTA)

FDIGRPLGKG KFGNVYLARE QQSKFILALK VLFKKQLEKA GVEHQLRREV EIQSHLRHPN 60

ILRLYGYFHD LSRVYLILEF APKGELYSEL QRCGCFPEAR SATYIMELAD ALNYCHSKKV 120

IHRDIKPENL LLGANGELKI ADFGWSVHTP SSRRSTLCGT LDYLPPEMIE GKTHDEKVDL 180

WSLGVLCYEF LVGKPPFETK SHEETYRKIS RVEYTYPTQA NISAGAKDLV ARLLKHNPMQ 240

RLPIQGVLAH PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013