EKS-GAA-00367
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00367
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR493.51.6E-148636892257
StatusUnreviewed
Ensembl ProteinENSGACP00000008624
UniProt AccessionG3NTE9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (1 of 2)
Gene Synonyms/Alias ERBB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000006497ENSGACP00000008624ENSGACT00000008643
ENSGACG00000006497ENSGACP00000008617ENSGACT00000008636
OrganismGasterosteus aculeatus
Functional Description
Protein Length955
Protein Sequence
(FASTA)
VCAGTENKLS TLSDLEQQYR TLRKYYENCE VVMGNLEITS IDRSRDLTFL RSIREVTGYV 60
LVALNQFDYL PLENLRIIRG NKLYEDRYSL AIFLNYRRDG NSGLRQLGLK NLTGQKCNRS 120
CNGRCWGPKG DQCQSLTKTV CAEQCDGRCF GPYVSDCCHR ECAGGCYGPK DTDCFACTNF 180
NDSGACVTQC PQPFVYNPTT FQLEHNPRAK YTYGAFCVKK CPHNFVVDHS SCVRACPSNK 240
MEVEEKRVKM CIPCTDICPK ACDGIGTASL QAAQTVDSRN IDKFVNCTKI NGNLVFLITG 300
IKGDVYHNIE ALDPEKLNVF RTVREITGFL NIQSWPDNMT DLSVFSNLAT IGGRALYSGI 360
SLLVLKQQSI SSLQLRSLRE ISAGNVHIAE NSQLCYYDTV NWTRLFRAPN QKVLVRNNQS 420
PRKCSKERMV CDPLCSDTGC WGPGPDQCLS CRYFSRGRTC VDTCNLYEGD IREYANGSVC 480
VECDAQCEQA DDDSLTCNGP GPERCVRCVH FKDGPNCVEK CPDGLQGANS FIFKYAESNN 540
ECHPCHANCT QGCIGPRLQD CIGWMDRTPL IAAGVIGGLF LVVIMALSVA VSVRRKNIKK 600
KRALRRFLET ELVEPLTPSG TAPNQAQLRI LKETELKRVK ILGSGAFGTV YKGIWIPEGE 660
SVKIPVAVKI LNEATGPKAN VEFMDEALIM ASVEHPHLVR LLGVCLSPTI QLVTQLMPHG 720
CLLDYVLEHK DNIGSQLLLN WCVQIAKGMM YLEERRLVHR DLAARNVLVK SPNHVKITDF 780
GLARLLDVNE KEYNADGGKM PIKWMALECI HYRKFTHQSD VWSYGVTIWE VMTFGGKPYD 840
GISTRDIPDL LEKGERLPQP PICTIDVYMV MVKCWMIDAD SRPKFKELAA EFTRMARDPQ 900
RYLVIQGDDR MKLPSPDDSK FFQSLLDEEE LEDLMDAEEY LVPHSFNIPP LAYTP 955
Nucleotide Sequence
(FASTA)
GTTTGTGCTG GTACCGAAAA CAAGCTGAGC ACCCTATCGG ACCTTGAACA GCAGTACCGC 60
ACCTTGAGGA AATACTACGA GAACTGCGAA GTGGTAATGG GCAACCTTGA GATCACAAGC 120
ATCGACCGCA GCCGGGACCT CACCTTCCTC AGATCTATCC GTGAAGTGAC AGGCTACGTG 180
TTAGTGGCAC TCAACCAGTT CGACTACCTC CCTTTGGAGA ACTTGAGAAT CATCCGAGGA 240
AACAAGCTCT ATGAGGACCG CTACTCCCTC GCAATCTTCC TCAACTACAG ACGCGATGGA 300
AACTCCGGCC TTCGCCAGCT CGGCCTGAAA AACCTCACGG GTCAAAAGTG CAATCGTTCC 360
TGTAACGGCC GTTGCTGGGG GCCGAAAGGT GACCAGTGTC AGAGCTTAAC TAAGACCGTT 420
TGTGCTGAGC AGTGTGACGG CCGTTGCTTC GGCCCCTATG TTAGTGACTG CTGCCATCGT 480
GAGTGTGCAG GTGGCTGCTA TGGACCCAAG GACACAGACT GCTTTGCTTG CACCAACTTC 540
AATGACAGCG GGGCATGTGT GACCCAGTGC CCCCAGCCCT TTGTCTACAA CCCCACCACC 600
TTCCAACTGG AACACAATCC CAGAGCAAAG TACACCTACG GAGCCTTCTG CGTCAAAAAG 660
TGTCCTCATA ACTTTGTGGT GGATCATAGC TCCTGTGTGA GAGCCTGTCC CAGTAACAAG 720
ATGGAGGTGG AGGAGAAACG TGTTAAGATG TGCATTCCTT GTACTGACAT CTGTCCAAAA 780
GCGTGTGACG GCATCGGCAC AGCCAGCCTA CAAGCGGCTC AGACGGTAGA CTCCAGAAAC 840
ATTGACAAGT TTGTCAACTG CACCAAAATC AACGGCAACC TGGTGTTTCT TATCACTGGG 900
ATCAAAGGGG ACGTGTATCA CAACATTGAA GCTTTGGACC CAGAAAAACT CAATGTGTTT 960
CGCACCGTTC GGGAGATTAC AGGCTTCCTG AACATCCAGT CTTGGCCCGA CAACATGACA 1020
GACCTGAGTG TTTTCTCCAA CCTGGCAACT ATTGGGGGAA GAGCGCTATA TAGTGGGATC 1080
TCCCTCCTGG TGTTGAAGCA GCAGAGCATC TCGTCCCTGC AGCTCCGGTC ACTGAGAGAG 1140
ATCAGCGCCG GGAATGTCCA CATTGCAGAG AACAGCCAGC TCTGCTACTA CGACACCGTG 1200
AACTGGACCA GACTGTTCCG GGCTCCAAAC CAGAAGGTTC TCGTCCGCAA CAACCAGAGC 1260
CCACGGAAGT GCTCCAAGGA GCGCATGGTG TGTGACCCGC TGTGTTCCGA CACCGGGTGT 1320
TGGGGTCCAG GCCCCGATCA GTGCCTCTCC TGCAGATACT TCAGCCGTGG ACGGACCTGT 1380
GTGGATACCT GCAATCTTTA TGAAGGGGAT ATTCGAGAAT ATGCCAACGG ATCGGTGTGT 1440
GTGGAGTGTG ATGCGCAGTG TGAGCAAGCT GACGATGACT CTTTGACCTG CAACGGTCCG 1500
GGCCCAGAGC GATGTGTGAG GTGCGTCCAT TTCAAGGATG GTCCCAACTG TGTTGAAAAG 1560
TGTCCCGATG GCCTGCAAGG CGCCAACAGT TTCATCTTCA AGTACGCAGA GTCCAATAAC 1620
GAATGCCATC CCTGCCACGC CAACTGCACA CAGGGGTGCA TTGGACCAAG ACTGCAGGAC 1680
TGCATTGGCT GGATGGACAG AACCCCTCTG ATCGCAGCGG GAGTGATCGG CGGCCTCTTT 1740
CTGGTGGTGA TCATGGCGTT AAGCGTAGCG GTGTCTGTGC GCCGGAAGAA CATCAAGAAG 1800
AAAAGAGCCC TGCGTCGCTT CCTGGAGACT GAGCTGGTGG AACCTTTAAC ACCAAGTGGA 1860
ACTGCACCCA ATCAAGCCCA GCTTCGTATT CTGAAAGAGA CAGAACTCAA AAGGGTCAAG 1920
ATTCTCGGGT CTGGGGCCTT CGGGACTGTT TACAAGGGCA TTTGGATCCC TGAGGGTGAA 1980
TCCGTCAAGA TTCCTGTAGC TGTTAAAATC CTAAATGAGG CCACGGGACC AAAGGCTAAC 2040
GTTGAGTTCA TGGACGAGGC CCTGATCATG GCCAGCGTGG AGCACCCTCA CCTGGTCCGC 2100
CTGCTGGGCG TCTGCCTGAG TCCCACCATC CAGCTGGTCA CGCAGCTGAT GCCTCACGGG 2160
TGCCTGCTCG ACTACGTCCT CGAGCACAAG GACAACATCG GATCCCAGCT GTTGCTCAAC 2220
TGGTGTGTCC AGATTGCTAA GGGGATGATG TATCTGGAGG AGCGGCGGCT GGTCCACAGG 2280
GACCTGGCAG CCCGAAATGT CCTGGTCAAA TCTCCCAACC ACGTCAAGAT CACTGACTTT 2340
GGCCTCGCTC GGCTGCTGGA TGTCAATGAG AAAGAGTATA ATGCTGATGG AGGAAAGATG 2400
CCAATCAAAT GGATGGCACT GGAGTGTATC CATTACAGGA AGTTTACTCA TCAGAGTGAC 2460
GTTTGGAGTT ACGGGGTCAC CATCTGGGAG GTGATGACCT TTGGTGGGAA GCCGTACGAT 2520
GGGATTTCCA CCAGAGATAT CCCGGACCTG CTCGAGAAAG GGGAACGCCT CCCTCAGCCT 2580
CCCATTTGCA CCATTGACGT CTACATGGTC ATGGTCAAAT GCTGGATGAT TGATGCAGAT 2640
AGTCGGCCCA AGTTCAAGGA GCTGGCTGCA GAGTTCACTC GGATGGCTCG AGATCCCCAA 2700
AGATACTTAG TCATCCAGGG TGACGACCGC ATGAAGTTGC CCAGCCCCGA CGACAGCAAG 2760
TTCTTCCAGA GCCTCCTGGA TGAGGAGGAG CTGGAGGACC TAATGGATGC TGAAGAGTAC 2820
CTGGTGCCCC ACTCCTTCAA CATTCCACCA CTGGCATACA CTCCG 2865
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++k+lGsGafGtvykGiwipege+vkipva+k+l+e+tg+kan e++deal++as++h
Q: 636   LKRVKILGSGAFGTVYKGIWIPEGESVKIPVAVKILNEATGPKANVEFMDEALIMASVEH  695
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv ehkd++Gsq llnwcvqiakGm+ylee+
Q: 696   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVLEHKDNIGSQLLLNWCVQIAKGMMYLEER  755
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ +eke++a+ggk+pikw+ale+i++rk+
Q: 756   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDVNEKEYNADGGKMPIKWMALECIHYRKF  815
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+we++tfG kpydgi++++ipdllekGerl+qppictidvymv+vkcw
Q: 816   THQSDVWSYGVTIWEVMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKCW  875
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srpkfkela+ef
Q: 876   MIDADSRPKFKELAAEF  892
         ***************99
Domain Sequence
(FASTA)
LKRVKILGSG AFGTVYKGIW IPEGESVKIP VAVKILNEAT GPKANVEFMD EALIMASVEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VLEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDVNEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWEVMTFG GKPYDGISTR DIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Danio rerio"; ?>Latimeria chalumnae"; ?>Oryzias latipes"; ?>Petromyzon marinus"; ?>Sus scrofa"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00255
EKS-DAR-00650
EKS-LAC-00313
EKS-ORL-00357
EKS-PEM-00164
EKS-SUS-00266
EKS-XIM-00377
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013