EKS-GAA-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	519.2	3.2E-156	402	675	274

Status

Unreviewed

Ensembl Protein

ENSGACP00000008845

UniProt Accession

G3NU27;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST1 (2 of 2)

Gene Synonyms/Alias

MAST1 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006669	ENSGACP00000008845	ENSGACT00000008864

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1286

Protein Sequence
(FASTA)

MCKSRKESEP QPPLTLPSLN PNNSRPSFSS LACRPCSPLT RPLISVFLRS CRTSNRKSLI 60

LTTTSPTLPR PHSPLPLPGH LGSSPLDSPR NFSPSNPAHF SFASSRRSLH IDGRRWSLAS 120

LPSSGYGTNT PSSTHIITAS PQERLHQLPF QPTMDELHFL SKHFGSTESI TDDDGGHCSP 180

HMRPRSRSLS PGRSSSCYDN EIVMMNHVYK DRFPKATAQM EGRLAEFIQA FSPENVLPLA 240

DGVLSFIHHQ IAELSRDCLA KSREGLITSV YFFELQENLE KLLQDNQNRP LTAQSAGFTW 300

IWKKWLINVG ARVSTGFQEF NPEEFYHLLE AAEDHAKEGH LMKTDIPRYI ISQLGLTRDL 360

IEDMVTLDSY DSEGPLTPET DDSTEDPQGK MRAMKAPEEA DFQSIKLISN GAYGAVYLVR 420

HLETRQRFAM KKINKQNLIL RNQIQQAFVE RDILTFAENP FVVSMFCSFE TRRHLCMVME 480

YVEGGDCATL LKNIGALPVE MARMYFAETV LALEYLHNYG IVHRDLKPDN LLITAMGHIK 540

LTDFGLSKMG LMSLTTNLYE GHIEKDTREF LDKQVCGTPE YIAPEVILRQ GYGKPVDWWA 600

MGIILYEFLL GCVPFFGDTP EELFGQVITD DIVWPEGDEA LPVDAQHLIS SLLQTNPLVR 660

LGTGGAFEVK QHSFFAAVNW NSLLRQKAEF IPHLESEEDT SYFDTRSERY HHVQSYDEDD 720

TNDDEPVEIH RFSSCSPRFS KVYSSMEHLS QLEHKPPGVT LREHKVPRED RVAKRESLGS 780

LTLRDKSWRT GSPEMKRLSC SESSFTESDY SPPSGARRRF SALMDTHRLA SPLEVDSEQP 840

VPVRQAPVTT RGTSLEGATG AVTSQGDLRT LLKDGGGPTA GGKKRKCRRS GAPRPSRAPR 900

GRHRPGAAEA EGEKRNPRPG TKVIKSASAT ALSVIIPAVE QHVASPLASP MSPHSISSNP 960

SSRDSSPSRD YSPMVNVLHS PITIHRSGKK YGFTLRAIRV YMGDSDVYSL HHMVWHVEDG 1020

GPAQEAGLSA GDLITHVNGE SVHGLVHTEV VELILKSGNK VTVTTTPFEN TSIKVGPARR 1080

SSYKSKMARR SKRIGAKEGP EKKRSSLFRK ITKQSNLLHT SRSLSSLNRS LSSGDSLPGS 1140

PTHGLSARSP TQSYRSTLTE SPLMGTSSQS SSPASSTPNS PAASHHMRPS SLHGLSPKLH 1200

RQYRSARCKS AGNIPLSPLA HTPSPTTSSP PPLSGHTVGS SNTTQTFPAK LHSSPPVSRP 1260

RPKSAEPPRS PLLQRVQSAE KLGAPL 1286

Nucleotide Sequence
(FASTA)

ATGTGCAAAA GCCGAAAGGA GTCAGAGCCA CAACCCCCCC TCACCCTCCC GAGCCTTAAT 60

CCAAACAACT CTCGTCCATC CTTTTCCTCC CTCGCCTGTC GCCCCTGTTC TCCCTTAACT 120

CGGCCTCTCA TCTCCGTCTT CCTCCGCAGT TGCCGAACAA GCAACAGGAA AAGCCTGATC 180

CTGACCACCA CCTCTCCCAC GCTGCCTCGC CCTCACTCGC CTCTCCCCCT CCCCGGGCAC 240

CTCGGAAGCA GCCCCCTGGA CAGCCCGCGA AACTTCTCCC CCAGCAACCC GGCGCACTTC 300

TCCTTCGCCT CCTCCAGAAG GTCGCTGCAT ATAGACGGAC GCCGATGGTC TTTGGCGTCT 360

TTGCCTTCCT CTGGATATGG AACCAACACG CCCAGCTCGA CGCATATTAT TACAGCCTCC 420

CCACAGGAGC GCTTGCACCA GCTGCCCTTC CAGCCCACCA TGGATGAGCT CCACTTCTTA 480

TCCAAGCACT TTGGCAGCAC CGAGAGCATC ACGGATGACG ACGGGGGCCA CTGCTCTCCG 540

CACATGCGCC CGCGCTCCCG CAGTCTCAGC CCGGGGCGCT CCTCCTCCTG TTATGATAAC 600

GAGATAGTCA TGATGAACCA TGTGTACAAA GATCGCTTTC CAAAGGCCAC AGCACAGATG 660

GAGGGGAGGC TGGCCGAGTT CATCCAGGCT TTCTCTCCGG AGAACGTTCT CCCGCTGGCC 720

GACGGAGTCC TCAGCTTCAT TCACCACCAG ATCGCCGAGC TGTCCAGGGA CTGCCTGGCC 780

AAGTCCCGCG AGGGCCTCAT CACCTCCGTC TACTTCTTTG AGCTGCAGGA GAACCTGGAG 840

AAGCTTCTTC AGGATAATCA GAATCGTCCC CTAACCGCTC AAAGCGCTGG CTTCACTTGG 900

ATATGGAAGA AATGGCTGAT TAACGTCGGC GCTCGCGTCT CAACTGGTTT CCAGGAGTTC 960

AATCCCGAGG AGTTCTACCA TCTGCTGGAG GCAGCAGAGG ACCACGCCAA GGAGGGTCAC 1020

TTGATGAAGA CGGACATTCC CCGGTACATC ATCAGCCAGC TGGGACTGAC CAGAGACCTT 1080

ATTGAAGATA TGGTAACTCT CGATAGCTAC GACAGCGAGG GGCCGCTAAC GCCCGAAACC 1140

GATGACTCGA CGGAGGATCC ACAGGGTAAG ATGAGAGCGA TGAAAGCGCC AGAAGAAGCT 1200

GACTTCCAGA GCATCAAGCT GATCAGTAAC GGAGCCTACG GCGCCGTGTA CCTGGTGCGT 1260

CACCTAGAGA CCCGCCAGCG GTTTGCCATG AAGAAGATCA ATAAGCAGAA CCTGATCCTG 1320

AGGAACCAAA TCCAGCAGGC CTTCGTGGAG AGAGACATCC TCACCTTCGC AGAGAATCCC 1380

TTTGTCGTCT CCATGTTCTG TTCCTTCGAA ACCCGCCGGC ACCTGTGCAT GGTCATGGAG 1440

TACGTAGAGG GTGGAGACTG TGCCACCCTG CTGAAGAACA TCGGCGCCCT TCCCGTGGAG 1500

ATGGCGCGCA TGTACTTCGC AGAGACCGTG CTCGCGCTGG AGTACTTGCA CAACTACGGC 1560

ATCGTGCACC GTGACCTCAA GCCCGACAAC CTCCTGATCA CCGCGATGGG CCACATCAAG 1620

CTCACAGACT TTGGCCTTTC TAAGATGGGT CTCATGAGTC TGACCACCAA CTTGTACGAG 1680

GGACACATAG AGAAGGACAC GCGTGAGTTC TTGGATAAAC AGGTGTGCGG AACTCCAGAG 1740

TACATCGCCC CGGAGGTTAT TCTCCGTCAA GGTTACGGGA AGCCGGTGGA CTGGTGGGCT 1800

ATGGGCATCA TCCTGTACGA GTTCCTGCTG GGCTGCGTTC CTTTCTTTGG AGACACCCCG 1860

GAGGAGCTGT TCGGGCAGGT CATTACAGAC GACATAGTGT GGCCAGAAGG GGATGAGGCT 1920

CTCCCTGTCG ACGCCCAGCA CCTCATCTCC TCCCTGCTGC AGACCAATCC ACTGGTTCGA 1980

CTAGGCACAG GCGGTGCTTT CGAAGTGAAG CAGCACTCGT TCTTCGCGGC GGTGAACTGG 2040

AACAGCCTAC TGAGACAGAA GGCTGAGTTC ATTCCTCACC TCGAGTCAGA GGAAGACACC 2100

AGCTACTTTG ACACCCGATC CGAGCGCTAC CACCACGTGC AGTCATACGA CGAGGACGAC 2160

ACCAACGACG ATGAGCCCGT GGAGATCCAT CGCTTTTCAT CCTGCTCCCC TCGCTTCAGC 2220

AAGGTGTACA GCAGCATGGA GCATCTGTCC CAGCTGGAGC ACAAACCCCC CGGCGTGACC 2280

CTGCGGGAGC ACAAGGTGCC CCGGGAGGAT CGAGTGGCCA AGAGAGAAAG CCTGGGCAGC 2340

CTCACATTAA GGGACAAGAG CTGGAGGACT GGATCGCCTG AGATGAAGCG CTTATCCTGC 2400

TCTGAGTCCT CCTTCACCGA GAGCGACTAC AGCCCGCCGT CCGGCGCCCG AAGACGCTTC 2460

TCCGCCCTCA TGGACACGCA CCGCCTGGCC TCCCCTCTGG AGGTCGACTC CGAGCAGCCC 2520

GTCCCCGTCA GGCAGGCTCC GGTGACGACC AGAGGGACGT CCCTAGAAGG AGCCACGGGC 2580

GCCGTCACCT CTCAAGGCGA TCTGAGAACA CTCCTCAAAG ATGGCGGCGG GCCCACGGCC 2640

GGAGGTAAGA AGAGGAAATG CCGGCGTTCT GGGGCTCCCA GACCCTCAAG GGCCCCGCGG 2700

GGCCGCCACC GACCTGGTGC TGCGGAGGCT GAAGGAGAGA AACGTAACCC GCGACCAGGG 2760

ACCAAAGTGA TCAAATCTGC CTCCGCTACG GCTTTGTCTG TCATCATCCC TGCGGTGGAG 2820

CAACATGTCG CCTCCCCGCT GGCGAGCCCG ATGTCGCCCC ACTCCATCTC GTCCAACCCG 2880

TCCTCCCGGG ACTCTTCTCC CAGCAGAGAC TACTCTCCCA TGGTCAACGT CCTGCACTCT 2940

CCCATCACCA TCCACCGCTC GGGGAAGAAG TACGGCTTCA CTCTGCGAGC CATCAGAGTC 3000

TACATGGGAG ACAGTGATGT TTACAGCCTA CATCACATGG TCTGGCATGT GGAGGATGGG 3060

GGTCCCGCCC AGGAAGCTGG TCTTAGCGCT GGTGACCTCA TCACTCATGT AAACGGAGAG 3120

TCCGTCCACG GTCTGGTCCA TACAGAGGTG GTGGAGCTCA TCCTGAAGAG TGGAAACAAG 3180

GTGACAGTTA CAACTACTCC ATTTGAGAAC ACCTCTATAA AAGTCGGCCC GGCCCGGAGG 3240

TCCAGCTATA AATCCAAGAT GGCGCGGCGC AGCAAGCGGA TCGGAGCCAA GGAGGGACCA 3300

GAGAAGAAGA GAAGCTCCCT CTTCAGGAAA ATCACCAAGC AGTCCAACCT GCTCCACACC 3360

AGCCGCAGCC TCTCCTCCTT GAATCGCTCT CTTTCATCCG GGGACAGTCT CCCAGGCTCC 3420

CCCACCCACG GCCTCTCCGC CCGCTCGCCC ACTCAGAGTT ACCGCTCCAC GCTCACCGAG 3480

TCCCCTCTCA TGGGCACCTC CTCCCAGAGC AGCTCCCCAG CTTCCAGTAC CCCCAACTCC 3540

CCCGCAGCCT CCCACCACAT GAGGCCCAGC TCCCTGCACG GCCTGTCTCC CAAGCTCCAC 3600

CGCCAGTACC GCTCTGCGCG CTGCAAATCC GCCGGCAACA TCCCCCTGTC GCCCCTGGCT 3660

CACACCCCCT CGCCGACCAC CTCCTCTCCT CCTCCTCTCT CCGGCCACAC GGTGGGGAGC 3720

TCCAACACCA CGCAGACGTT CCCCGCCAAG CTGCACTCCT CGCCGCCCGT CTCCCGGCCC 3780

CGGCCCAAGA GCGCAGAGCC GCCCAGGTCC CCCTTGCTGC AGCGGGTGCA GTCGGCGGAA 3840

AAGCTGGGCG CTCCGCTC 3858

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         f+ iklis+GayGavylvrh etr+rfa+kki+kq+lil+nq+qq+f+erdil++aenpf

Q: 402   FQSIKLISNGAYGAVYLVRHLETRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF  461

         899*********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkniGal+vemar+y+ae+vlaleylh+yGi

Q: 462   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGI  521

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllit++GhikltdfGlsk+glmslttnlyeg+i+kd+refldkqvcgtPey

Q: 522   VHRDLKPDNLLITAMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDTREFLDKQVCGTPEY  581

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevilrqgygkpvdwwa+giilyefl+g+vpffgdtpeelf+qv++d+ivwPe+deal

Q: 582   IAPEVILRQGYGKPVDWWAMGIILYEFLLGCVPFFGDTPEELFGQVITDDIVWPEGDEAL  641

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++lis+ll++nP  rlgtg+a evkqh+f+

Q: 642   PVDAQHLISSLLQTNPLVRLGTGGAFEVKQHSFF  675

         ********************************97

Domain Sequence
(FASTA)

FQSIKLISNG AYGAVYLVRH LETRQRFAMK KINKQNLILR NQIQQAFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNIGALPVEM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITAMGHIKL TDFGLSKMGL MSLTTNLYEG HIEKDTREFL DKQVCGTPEY 180

IAPEVILRQG YGKPVDWWAM GIILYEFLLG CVPFFGDTPE ELFGQVITDD IVWPEGDEAL 240

PVDAQHLISS LLQTNPLVRL GTGGAFEVKQ HSFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013