EKS-GAA-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph514.93.7E-155606863258
StatusUnreviewed
Ensembl ProteinENSGACP00000008942
UniProt AccessionG3NUC4;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000006747ENSGACP00000008942ENSGACT00000008962
OrganismGasterosteus aculeatus
Functional Description
Protein Length968
Protein Sequence
(FASTA)
VNLLDSKASQ GELGWISYPS HGWEEISGVD EHYTPIRTFQ VCNVMEYSQN NWLRTNWISR 60
QSAQKIYVEL KFTLRDCNSI PLVLGTCKET FNLLYQETDD DQGSHFREHL FTKIDTIAAD 120
ESFTQMDLGD RILKLNTEVR EVGPMTKKGF YLAFQDVGAC VALVSVRVYF KKCPHTVRNL 180
ASFPDTVPMD SQSLVEVKGS CVNHSKEEEG ARECTCSTEG SWLVQVAHTK CVSVYQENEF 240
AISMCRAGFY KSTLGNTECA KCPPHSFSHH EGSLHCGCEK NYFRADGDPA SMACTRPPSA 300
PRNVISSINE TSVILDWSWP EDAGGRRDVT FTVLCKRCRG GGVANGSSGG NLRCEPCRSN 360
VHFLPRASGL HNTTVTVGDL LAHTNYTFEI EALNGVSSLA PKMRQYAAVT ITTNQAAPSP 420
VAVIRKEKTS RSSVSLSWQQ PERPNGIILD YEIKYYEKEE QETSYTILRA RGCNVTLNGL 480
KPNTAYLLQI RARTAAGYGA SSPSFQFETS PDSAFSISSE SSQVVLIAIS SAVAIILLTV 540
LLYVLIGRIG RFCCHSKSKH PDEKRLHFGN GHLRLPGIRT YVDPHTYEDP SQAVHEFAKE 600
LDASCIAIDK VVGAGEFGEV CSGRLKLPSK KEICVAIKTL KGGFTDKQRR DFLAEASIMG 660
QFDHPNIIRL EGVVTRSKPV MIVTEYMENG SLDSFLRKHD AQFTGIQLVG MLRGIASGMK 720
YLSDMGYVHR DLAARNILVN SNLVCKVSDF GLSRVLEDDP EAAYTTRGGK IPIRWTAPEA 780
IAYRKFTSAS DAWSYGIVLW EVMSYGERPY WEMSNQDVIK AVDEGYRLPP PMDCPATLYQ 840
LMLDCWQKER NNRPKFEQIV SILDKLIRNP GSLKITANTT SRPANLLLDR SSSEVPAMGT 900
LGDWIDGMRT LPCKEAFSGV SYSSCDTLAK TSTEDLKKVG VTIVGPQKKI VSSLKALDSH 960
TKNGPVPV 968
Nucleotide Sequence
(FASTA)
GTCAACCTCT TAGACTCTAA AGCAAGCCAA GGGGAGTTGG GATGGATTTC CTACCCGTCG 60
CATGGGTGGG AGGAGATCAG TGGGGTGGAT GAGCACTACA CTCCCATCCG GACCTTCCAG 120
GTCTGCAACG TGATGGAGTA CAGCCAGAAC AACTGGCTGC GCACCAACTG GATCTCTCGC 180
CAGTCGGCCC AGAAGATATA CGTGGAGCTG AAGTTCACCC TGAGGGACTG CAACTCCATC 240
CCGCTGGTCT TGGGCACCTG CAAAGAGACC TTCAACCTCC TCTACCAGGA GACAGACGAC 300
GACCAGGGGA GTCACTTCAG AGAACACCTG TTCACTAAGA TAGACACCAT CGCCGCTGAC 360
GAAAGCTTCA CCCAAATGGA CCTCGGGGAT CGCATTCTCA AGCTTAACAC CGAGGTGCGC 420
GAGGTGGGTC CCATGACCAA GAAGGGCTTC TACCTGGCGT TCCAGGACGT GGGCGCCTGC 480
GTGGCTTTGG TTTCAGTGAG GGTTTACTTC AAGAAGTGCC CCCACACGGT GAGGAATCTG 540
GCCTCGTTCC CCGACACGGT GCCCATGGAC TCCCAGTCGC TGGTGGAGGT CAAAGGCTCA 600
TGCGTCAATC ACTCCAAAGA GGAGGAGGGC GCCCGCGAAT GTACCTGCAG CACGGAGGGG 660
AGTTGGTTGG TCCAGGTCGC GCATACTAAG TGTGTAAGTG TGTACCAGGA AAATGAATTT 720
GCTATTTCAA TGTGCAGGGC CGGTTTCTAC AAATCTACTC TGGGAAATAC GGAGTGTGCA 780
AAGTGCCCGC CACATAGTTT CTCACACCAT GAGGGGTCGC TGCACTGCGG CTGTGAGAAA 840
AACTACTTCC GTGCCGATGG AGATCCTGCA TCCATGGCCT GTACCCGACC CCCTTCGGCT 900
CCTCGAAACG TGATCTCTTC CATTAACGAG ACCTCCGTCA TCCTGGACTG GAGCTGGCCG 960
GAAGACGCCG GCGGCCGCAG GGACGTCACC TTCACCGTCC TCTGCAAACG CTGCCGCGGG 1020
GGTGGCGTCG CCAACGGCAG TAGCGGCGGC AACCTGCGTT GCGAGCCTTG CCGGAGTAAC 1080
GTTCACTTCC TGCCGAGAGC CTCGGGCCTC CACAACACCA CCGTGACGGT GGGAGACCTG 1140
CTGGCCCACA CTAACTACAC CTTTGAGATC GAAGCGCTGA ACGGCGTGTC GTCGCTGGCG 1200
CCCAAGATGA GGCAGTACGC TGCGGTCACC ATCACCACCA ACCAAGCTGC TCCCTCCCCA 1260
GTAGCAGTGA TCCGAAAGGA AAAGACGTCT CGGAGCAGTG TCTCCCTGTC CTGGCAGCAG 1320
CCAGAAAGAC CCAACGGCAT TATCCTCGAC TATGAGATCA AATACTACGA AAAGGAGGAG 1380
CAGGAGACCA GCTACACAAT CCTCCGTGCT CGGGGCTGTA ATGTGACCCT GAATGGCCTG 1440
AAGCCCAACA CCGCCTACCT GCTGCAGATC AGAGCGCGCA CAGCTGCCGG GTACGGAGCC 1500
AGCAGCCCGA GTTTCCAGTT CGAGACCAGC CCCGACTCAG CGTTCTCCAT CTCCAGTGAG 1560
AGCAGCCAGG TTGTTCTGAT CGCCATTTCC TCCGCCGTGG CCATCATCCT CCTCACCGTG 1620
CTGCTCTACG TCCTGATTGG CAGGATTGGC AGGTTCTGTT GCCACAGCAA ATCCAAACAT 1680
CCTGATGAGA AAAGGCTGCA CTTTGGCAAC GGCCACTTGC GTCTGCCGGG TATCAGGACC 1740
TACGTGGACC CTCACACGTA CGAGGACCCG AGCCAGGCCG TGCACGAGTT TGCGAAGGAG 1800
CTGGACGCCT CCTGCATCGC CATCGACAAA GTGGTTGGAG CAGGTGAGTT TGGCGAGGTG 1860
TGCAGCGGTC GTCTGAAGCT ACCAAGCAAG AAGGAGATCT GTGTGGCCAT CAAGACGCTT 1920
AAAGGAGGAT TCACGGATAA GCAGAGGCGG GACTTCCTGG CCGAGGCGTC AATCATGGGG 1980
CAGTTTGACC ACCCCAACAT CATCAGGCTG GAGGGGGTGG TAACACGCAG TAAACCCGTC 2040
ATGATCGTCA CAGAATACAT GGAGAATGGA TCCCTGGACA GTTTCTTGAG AAAACACGAC 2100
GCCCAGTTCA CCGGCATCCA GCTGGTCGGC ATGCTGCGTG GCATCGCCTC GGGCATGAAG 2160
TACCTGTCCG ACATGGGCTA CGTGCACCGA GACCTGGCGG CTCGGAACAT CCTGGTCAAC 2220
AGCAACCTGG TGTGCAAAGT GTCCGACTTC GGCCTGTCCC GAGTGCTGGA GGACGACCCG 2280
GAGGCCGCCT ACACCACCAG GGGAGGGAAG ATCCCAATCC GCTGGACAGC TCCAGAGGCC 2340
ATCGCCTACA GGAAGTTTAC ATCGGCCAGT GATGCTTGGA GTTACGGCAT CGTGCTCTGG 2400
GAAGTGATGT CATATGGGGA ACGGCCGTAC TGGGAGATGT CCAATCAGGA TGTAATAAAG 2460
GCTGTAGATG AAGGATACCG CCTCCCCCCA CCCATGGACT GCCCAGCTAC ACTTTACCAG 2520
CTGATGTTGG ACTGCTGGCA GAAAGAGAGG AATAACCGGC CTAAATTTGA ACAGATTGTC 2580
AGCATCCTGG ATAAACTGAT TCGCAACCCT GGTAGCCTCA AAATCACGGC CAACACCACA 2640
TCCAGGCCGG CCAACTTGTT GTTGGACAGG AGCAGTTCCG AGGTTCCCGC GATGGGGACG 2700
CTGGGTGACT GGATAGATGG AATGAGGACC CTGCCCTGTA AGGAGGCCTT CTCCGGGGTC 2760
AGCTACAGCT CCTGTGACAC CCTGGCCAAG ACCTCCACTG AGGATCTAAA AAAGGTTGGA 2820
GTGACTATCG TTGGACCGCA GAAAAAGATT GTGAGCAGCC TCAAAGCCCT CGATTCCCAC 2880
ACCAAGAATG GCCCAGTACC TGTATAA 2907
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk+g t+kqrrdfl+easi+Gqfdhp
Q: 606   IAIDKVVGAGEFGEVCSGRLKLPSKKEICVAIKTLKGGFTDKQRRDFLAEASIMGQFDHP  665
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+skpvmivteymeng+ldsflrk+d qft iqlvgmlrGiasgmkylsdm
Q: 666   NIIRLEGVVTRSKPVMIVTEYMENGSLDSFLRKHDAQFTGIQLVGMLRGIASGMKYLSDM  725
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrk
Q: 726   GYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  785
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasd+wsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpa+lyqlmldc
Q: 786   FTSASDAWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPATLYQLMLDC  845
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkfeqivsil
Q: 846   WQKERNNRPKFEQIVSIL  863
         ***************986
Domain Sequence
(FASTA)
IAIDKVVGAG EFGEVCSGRL KLPSKKEICV AIKTLKGGFT DKQRRDFLAE ASIMGQFDHP 60
NIIRLEGVVT RSKPVMIVTE YMENGSLDSF LRKHDAQFTG IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDAWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP ATLYQLMLDC 240
WQKERNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAG-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
EKS-XIM-00020
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013