EKS-GAA-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	339.9	2.2E-101	2734	3062	329

Status

Unreviewed

Ensembl Protein

ENSGACP00000009262

UniProt Accession

G3NV93;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM (1 of 2)

Gene Synonyms/Alias

ATM (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000006981	ENSGACP00000009262	ENSGACT00000009282

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

3105

Protein Sequence
(FASTA)

MSLVLSDLLV CCRGLENDKA TERKKEAERF RRLLRSPEVV QELDRTSGPK AKGSKTLTWD 60

TVFRFLQRYV QKETESMQSS KSNVTATTLA TRKKKMAEMC SLMKYFIRYA NKRGPRLKCS 120

EMLKHVMDVL QNSYSCSAYG EDYSSLLVKD ILSVRKYWCD ILPQQWHNLL NLYCEFFNAS 180

SKSINRVLVS RVIRTLVQGC CMQTDGFNDA LFAFFSKALL NARRGLLLNP RFKLAILPTQ 240

EKHLAVLEHL VSALNSFLRS AAMNCRMRVC RLGEELLPPL LYVWADMRPS SALKEEIVDF 300

FNLQICVHHP KGAKTQDTGR AKDWTRWRSL LCNLYDALIR EISHIGSRGK YVTGTRHIAV 360

KDNLTELTAD ICHQLFSDDH DTHIVEVTQA SFRATQLGSP THGSASKRRR IELGWEVLRE 420

HLQPQLNDFD VIPWLQITAV LASKYPSMVP GQELVPLLSA LYQLLAEQRR GERGPYVLRS 480

LRELARCQSC HPDRARVHGA ELARLWGRVW ALAVRGVSSP QTEALSLDLL RSVVHGGLIN 540

MDREFWKLFC GSACKPSQGA ALCLAEALLN CPPPKSIISR SARDYGGVTE GSAAHDLKET 600

LIAWLLMSDQ SEELEESSRP HPIICRDFPY NLIATLLVSL TLKDTRTGLK PFDFLFLFLS 660

AFSQEKTTPK AKDNLEEIER LYLQFSFNTL ASPTAVAGES AAAARTDGRF AAVLFLRNKL 720

EQSLLCVADN LLNCYSPDSH STPPECLVRC FTLLTGVLAG HVSAGFLTEE EACRSPLYTK 780

AKALAQDFSG FVSSVRVKMT EEGTMSTLRS VITLCTQSAS RKNKDSVGPV SSRLFMMILP 840

ASLLCELADI CKLLLSDVSK RVSFVDEDDH MDDDLDVTRT QQGDDIDLFD EGETSNGDGS 900

HRAKGDNSEA SCAKSLLADE HLAQQDVALL AVLELLCACG SVRLVPGLLF KPQEVRRRLL 960

LLLEQMDFSK ALHLNMYLVL LKKLPAEDSL SPEEFDSLLR PLADLCSLHR QDQEVCTAVL 1020

LGLLPSIASL RNTHHTSEEM KHVQGSLLQV VSAFCFLGQT GKGMTAVRAA LVRCLVALLE 1080

ADPCCSWAVL SIRGAESAED RPVSVILPSH LADAHHQVRM LVAMSVERLF LETRAELPDR 1140

RNMLPLKQQQ AAFESIYLKA QEGMKPPRSS SAEDQQDESF NRKATLLKTL SVVLRCSPVC 1200

EKQALFALFQ SYKENNIEEH LIKKMLGSVS RALGYRSVKT FVSSHLYYLV AEWLAQRQSD 1260

DRYTLGSFPY TLLDHDTVKD FYHSSYQVLI PHLVFLDDFE QVKSIGRYLD KDWKVLLADC 1320

FPKIMVNILP YFALSGQDVH VAQRKDKAHK VYDLLKDDNC LGKPQIDTLI RSNLADIVVE 1380

LLMTLYEGSG ADGNGGDLKR FTGELDPIPN PPYFSSNVIK ATLEYLSKCN SANHKTLVAI 1440

LSKTPISIQR ILLAVCERAA ETTNSYERHR ILLMYHLFVN LLLVEVKDGL GGAWAFVLRD 1500

IIYTLVHHLN SRRAQCDEVS TRSLSLCCDL LTSVCRAALE FCDGALDGHL QVIVGTLTAQ 1560

AKSRPAVSGQ VNSLLRFLVI ENQEKLKEAI SRLEPFPDLP EFRELRSVQR RLKCNTVIFT 1620

LRQEIDHFLS VTSCDSLPLT RLEGLKELTR QLHDNKHQIR ELLKECHAEP SDSVLVRLVL 1680

GLLQLCKLAA NHPEGADILE AAGSCLGELG PVDLSTIALL HGRDPLYKKD ASRFNSTESH 1740

CLYVVLNCMN DALTQQRIEV RQAAALCVKR ILATRSGVDF WEQHKDSRDP LLAYLNPFRK 1800

AKEKAAVLTA EASLQAKEKL VSQQLWIPRA GGHKAWLKAL CTALLDSEGV RSEALLLSRP 1860

LCLVRADCCQ RLLPLIIHSI LLEDSNGLWR ETLSSRIRDF FSFCCRSAQA ASRSATPLSS 1920

DSESEAASPG LYDKNSLRTM LAVIDYLRHQ QRPLEAGSSS FGTVSDSNFW LELNYLEVAK 1980

AAQSCSAHFT ALLYTEIYVD KIKADLEETT RKINFEENSQ NFTISSLTEK SMEDTNISLQ 2040

ELLIEVYRSI GEPDSLYGCG GETTTSPLTR IRTYEHEAMW GKALTSYNLH TTLPEVTRQV 2100

GIVEGLQNIG LSNILTTYMR GLESEGVEWG AELRELRFQA AWRNTQWDCE LSERSEKSKP 2160

GFHESVFSSL HALRDKEFSV FDETLKQARY DFNKKGADVA ELCRGSLEAV SSLYPSLRNL 2220

QSIRELESAK QLFAKPFSDV TLREVCREWR QHSELLADSD FALVEPILAL RTVAHQTLLA 2280

RGGDPDHIQY VSSVLSDHLM ELCRLARNAG NTQLAEQAVF QMKQNGGGGS WASSPVLSWQ 2340

LEEAQVFWAK GEQGLALGLL RQMVHRLEEK VSPKRPVDMN SALVPVYTES LRLCGSWLAE 2400

TCLENPGVIL KNYLERAVEV IEEASGVRDS RLQSQRTEAF LSLARFSDAQ YQSIGKYMNS 2460

SEFENKQALL ERAKEEVDLM RKREVTSNRY TTKVMRELAL DQKSLSDRQT DRQRFLLKAV 2520

ENYIRCLEGG EHDTWVFRLA SLWLENAGVK VVNDMMKVRV ERIPSYKFLP LMYQLAARMG 2580

TKMATGVTED TGFHDVLRKL ICRASREHPH HTLFIILALV NANKDENFGK SRLSKSAPRQ 2640

GSPLDLERSN VALRIIGELR KERGEMIRGV EKLCDAYIAL AYMDASKHKA EKKPIPIPAD 2700

QPITQIKNLH EVAIPTMEIK VDQSCCYDDL VTIRSFVPQY HLVGGVNLPK IIDCVGSDGT 2760

TRRQLVKGQD DLRQDAVMQQ VFSMCSMLLQ RNADTRKRKL NIRRYKVVPF SQRSGVLEWC 2820

SGTVPIGEFL VDTNKGAHKR FRPKDLTNLA CRKRMMECQS FDEKLRGFGE VCKNFRPVFR 2880

YFCMERFLDP AVWMEKRLAY TRSVATSSIV GYIVGLGDRH INNILVDEQT AELVHIDLGV 2940

AFEQGKILPT PETVPFRLSR DIVDGMGITG VEGVFRRCCE KTLEVMRSSQ EALLTIVEVL 3000

LYDPLFDWTM NPLKAFYLQH DEQQELNATL GSTMGGVDMD SHRKPSDSQS FNKVAERVLL 3060

RLQEKLKGVE EGTVLTVGGQ VNLLIQQAMD PKNLSRLFPG WQAWV 3105

Nucleotide Sequence
(FASTA)

ATGAGTCTGG TTCTCAGTGA TCTGCTGGTC TGCTGCAGGG GGCTGGAGAA TGACAAGGCC 60

ACAGAGAGAA AGAAAGAAGC TGAACGCTTC AGGAGACTCC TTCGCAGTCC AGAAGTGGTT 120

CAGGAGTTGG ATCGCACCTC CGGACCTAAA GCGAAAGGCT CTAAAACCCT GACATGGGAT 180

ACCGTTTTCA GATTTTTGCA GCGTTACGTC CAGAAGGAGA CGGAAAGCAT GCAATCGAGC 240

AAATCCAACG TCACTGCGAC CACGCTCGCC ACACGGAAGA AGAAGATGGC TGAAATGTGC 300

AGCTTGATGA AATACTTCAT TCGATACGCA AACAAACGCG GACCCCGCCT CAAGTGCAGC 360

GAGATGCTGA AACACGTGAT GGACGTCTTG CAGAATTCAT ACAGCTGTTC CGCCTATGGA 420

GAAGATTATA GCAGCCTCTT GGTAAAGGAC ATCCTCTCCG TCCGCAAGTA CTGGTGTGAC 480

ATCCTTCCGC AGCAGTGGCA CAATCTTTTG AACTTGTACT GCGAATTTTT TAACGCTTCG 540

TCCAAGTCCA TCAACCGCGT TCTGGTGAGC CGAGTGATCC GCACGCTGGT GCAGGGCTGC 600

TGCATGCAGA CGGACGGATT CAACGACGCC CTGTTCGCCT TCTTCTCTAA AGCCCTTCTG 660

AACGCCAGGC GAGGGCTTTT ATTGAATCCG CGTTTCAAAT TGGCCATTTT GCCTACGCAG 720

GAGAAGCACC TGGCTGTTTT GGAGCACCTG GTCTCGGCGC TCAACAGCTT CTTGAGATCC 780

GCGGCCATGA ACTGTCGCAT GAGGGTGTGT CGCCTCGGCG AGGAGCTCCT GCCTCCACTG 840

CTGTATGTCT GGGCAGATAT GAGGCCCAGC TCGGCTCTCA AAGAGGAGAT TGTGGACTTC 900

TTTAACCTGC AGATTTGTGT CCACCACCCG AAAGGAGCCA AGACACAAGA CACCGGTAGA 960

GCAAAAGACT GGACCAGGTG GCGGAGTCTG CTGTGCAACC TGTATGACGC CTTGATCAGG 1020

GAAATCAGCC ATATAGGCAG CAGGGGGAAG TACGTCACTG GGACACGACA CATAGCTGTC 1080

AAAGACAATC TCACTGAGCT CACGGCTGAC ATCTGTCATC AGCTGTTCAG CGACGACCAT 1140

GACACCCATA TCGTGGAGGT GACCCAGGCC TCCTTCAGAG CCACTCAGCT GGGGAGTCCC 1200

ACCCACGGCT CGGCCAGCAA GCGCCGGCGC ATCGAACTGG GCTGGGAGGT CCTGCGGGAG 1260

CATCTGCAGC CTCAGCTGAA TGACTTTGAT GTCATACCAT GGCTACAGAT CACCGCAGTG 1320

CTCGCCTCCA AGTACCCGTC CATGGTACCC GGCCAGGAGC TGGTCCCGCT GCTGTCGGCG 1380

CTGTACCAGC TCCTGGCCGA GCAGCGGAGG GGGGAGAGGG GGCCGTACGT GCTGCGAAGT 1440

CTGAGGGAGC TGGCCCGGTG CCAGTCCTGC CACCCGGACA GGGCCCGTGT CCACGGCGCC 1500

GAGCTGGCCC GGCTGTGGGG TCGGGTGTGG GCGCTGGCGG TGCGGGGGGT CAGCTCGCCT 1560

CAGACCGAGG CGCTCAGCCT GGACCTGCTG AGGTCTGTTG TCCACGGAGG ACTCATCAAT 1620

ATGGACCGAG AGTTCTGGAA GCTCTTCTGC GGATCAGCAT GTAAACCGTC CCAGGGCGCT 1680

GCTCTCTGCC TGGCCGAGGC CCTGCTGAAC TGTCCTCCCC CTAAAAGTAT CATCTCACGC 1740

TCGGCGAGGG ACTACGGGGG GGTCACGGAG GGTTCTGCAG CACACGACCT GAAGGAGACC 1800

CTAATAGCCT GGCTGCTGAT GAGCGATCAG AGCGAAGAGC TGGAGGAAAG CTCCAGACCT 1860

CACCCCATCA TCTGCAGAGA CTTCCCTTAC AACCTAATAG CGACCCTCTT GGTGTCCCTG 1920

ACCTTGAAAG ACACGAGAAC GGGCCTGAAG CCTTTCGACT TTTTATTTTT ATTTTTAAGT 1980

GCCTTCTCTC AAGAAAAAAC AACACCCAAA GCCAAAGACA ACCTGGAGGA GATTGAGAGG 2040

CTCTACTTGC AGTTCAGCTT CAACACGCTG GCCTCTCCCA CGGCCGTCGC CGGCGAGTCA 2100

GCGGCAGCGG CTCGGACTGA CGGGCGATTC GCTGCCGTCC TCTTCCTCAG GAACAAGTTG 2160

GAGCAGTCGC TGCTTTGCGT GGCCGACAAC CTGCTCAACT GCTACTCTCC CGATTCTCAC 2220

TCCACGCCGC CAGAGTGTCT GGTGCGCTGT TTCACGCTGC TAACCGGGGT GTTGGCGGGT 2280

CACGTATCCG CTGGGTTTCT GACGGAGGAG GAGGCCTGCC GCTCGCCACT CTACACTAAA 2340

GCCAAGGCGC TGGCCCAAGA CTTCAGCGGC TTTGTCTCTA GCGTGAGAGT GAAGATGACT 2400

GAGGAAGGAA CCATGAGCAC ACTGAGATCT GTCATCACGC TCTGCACACA GTCGGCCAGC 2460

AGGAAAAACA AGGACAGCGT TGGTCCCGTC TCCTCCCGTC TGTTCATGAT GATTCTGCCG 2520

GCCAGTCTCC TCTGCGAGCT GGCTGACATC TGCAAACTGT TGTTAAGCGA CGTTTCCAAG 2580

AGGGTCAGCT TCGTGGACGA AGACGACCAT ATGGACGATG ACCTGGACGT GACCAGAACT 2640

CAACAAGGAG ACGACATTGA CCTGTTCGAC GAGGGCGAGA CCAGCAACGG CGATGGGAGT 2700

CACAGAGCGA AGGGCGACAA CAGTGAGGCT TCCTGTGCAA AAAGTCTGCT TGCAGACGAA 2760

CATCTGGCCC AGCAGGACGT GGCTCTCCTC GCCGTCCTGG AGCTCCTGTG CGCGTGCGGC 2820

TCCGTGCGGC TCGTCCCCGG CCTGCTCTTC AAACCACAGG AGGTGCGGCG CAGGCTGCTG 2880

CTGCTGCTGG AGCAGATGGA CTTCAGCAAA GCCCTGCACC TGAACATGTA TCTCGTCCTG 2940

TTGAAGAAGC TTCCCGCCGA GGACTCGCTC TCGCCGGAGG AATTTGATTC CCTGCTCCGT 3000

CCTTTGGCGG ACCTGTGTTC TTTGCACCGT CAGGACCAAG AGGTCTGTAC AGCTGTTCTG 3060

CTCGGTTTGT TGCCCTCCAT CGCCAGCCTT AGGAACACCC ACCACACTTC GGAGGAGATG 3120

AAACATGTTC AGGGATCTCT GCTACAAGTG GTGTCTGCAT TCTGTTTCCT GGGTCAAACG 3180

GGGAAAGGCA TGACTGCTGT GCGAGCCGCC TTGGTGAGAT GTCTGGTGGC TTTGCTGGAG 3240

GCTGACCCTT GTTGTAGTTG GGCAGTCTTA AGCATCAGAG GGGCCGAGAG TGCGGAAGAT 3300

CGGCCCGTGT CCGTCATCCT TCCTTCTCAC CTCGCAGACG CCCACCACCA AGTCCGCATG 3360

CTGGTAGCCA TGTCGGTGGA GAGGTTGTTT CTGGAGACGA GAGCGGAGCT TCCAGACAGG 3420

AGGAACATGC TGCCGCTTAA ACAACAGCAG GCGGCTTTCG AGAGCATTTA CCTGAAGGCT 3480

CAGGAAGGAA TGAAGCCTCC CAGAAGCAGC TCAGCCGAAG ACCAGCAGGA CGAGTCGTTC 3540

AACCGCAAAG CCACGCTGTT GAAGACCTTG TCTGTTGTGC TGCGTTGTAG CCCGGTCTGC 3600

GAAAAACAGG CTCTGTTTGC CCTCTTCCAG TCCTACAAAG AGAACAACAT AGAGGAACAT 3660

CTCATCAAAA AGATGCTGGG CAGCGTTTCC AGAGCGCTGG GCTACCGGAG TGTGAAGACA 3720

TTCGTCAGTT CCCACCTGTA CTACCTGGTA GCCGAGTGGC TGGCGCAGAG ACAGTCCGAC 3780

GACCGCTACA CTCTCGGATC TTTCCCGTAC ACCCTCCTGG ACCACGACAC GGTCAAAGAC 3840

TTCTATCACT CTTCCTACCA GGTGTTAATC CCCCACCTGG TCTTCCTGGA TGACTTTGAG 3900

CAGGTGAAGT CTATCGGCAG GTATCTCGAC AAGGACTGGA AAGTGTTGCT GGCCGACTGT 3960

TTCCCAAAGA TCATGGTCAA CATCCTGCCG TACTTTGCCT TGTCGGGCCA GGATGTGCAT 4020

GTCGCGCAGC GGAAAGACAA GGCCCACAAA GTGTACGACC TGCTCAAAGA CGACAACTGT 4080

CTGGGCAAAC CGCAAATTGA CACGCTGATC CGCAGCAACC TGGCGGACAT AGTGGTCGAA 4140

CTGCTGATGA CTCTGTACGA AGGAAGTGGA GCCGACGGGA ACGGAGGAGA CCTGAAGCGC 4200

TTCACAGGGG AACTGGACCC CATACCGAAC CCGCCATACT TCAGCTCTAA TGTCATTAAA 4260

GCCACGCTGG AATACCTCAG CAAGTGCAAC AGTGCAAACC ACAAGACTTT GGTAGCCATT 4320

CTGTCAAAAA CTCCAATTTC CATCCAGAGG ATTCTGCTGG CGGTGTGTGA AAGGGCAGCG 4380

GAGACGACCA ACAGCTATGA ACGTCATCGC ATCCTGCTCA TGTATCACCT GTTCGTCAAC 4440

CTGCTGCTCG TGGAGGTGAA GGACGGCCTC GGAGGAGCCT GGGCCTTCGT CCTCAGGGAC 4500

ATCATCTACA CACTCGTTCA CCATCTGAAC AGCAGACGAG CTCAATGCGA TGAGGTTTCT 4560

ACCCGGAGCC TCTCTCTGTG CTGCGACCTG TTGACCTCCG TGTGCCGGGC AGCGCTGGAG 4620

TTCTGTGACG GCGCTCTGGA CGGCCACCTG CAGGTCATCG TCGGGACTCT AACCGCTCAG 4680

GCCAAGAGCC GGCCCGCCGT CTCAGGGCAG GTGAACAGTC TGTTAAGGTT TCTCGTGATA 4740

GAAAATCAAG AGAAGTTAAA AGAAGCCATC AGCCGCCTGG AGCCTTTTCC TGACCTCCCT 4800

GAATTCCGAG AGCTGCGCTC TGTACAGCGC AGGCTCAAAT GTAACACTGT GATCTTCACT 4860

CTGAGACAGG AGATTGACCA CTTCCTGTCA GTGACGTCCT GTGACTCCTT ACCTCTGACC 4920

AGACTGGAGG GGCTGAAGGA GCTGACCAGG CAGCTGCATG ACAACAAGCA CCAGATCCGG 4980

GAGCTGCTGA AAGAGTGCCA TGCCGAACCC TCCGACAGCG TGCTGGTGAG GCTGGTTCTC 5040

GGTCTGCTGC AGCTCTGTAA GCTGGCAGCC AACCACCCGG AAGGAGCCGA CATTCTTGAG 5100

GCAGCGGGCA GCTGTCTGGG GGAACTGGGT CCCGTGGACC TCTCCACCAT CGCCCTTCTT 5160

CACGGCCGAG ACCCCCTGTA TAAAAAGGAC GCGTCCCGCT TCAACTCCAC AGAGTCCCAT 5220

TGCCTCTACG TCGTCCTGAA CTGCATGAAC GACGCACTCA CTCAACAGCG TATCGAGGTG 5280

AGGCAGGCGG CCGCTCTGTG CGTGAAGCGC ATCCTCGCCA CTCGGTCCGG AGTCGATTTC 5340

TGGGAGCAAC ACAAAGACAG CAGAGACCCC CTGCTGGCCT ACCTCAACCC CTTTAGAAAG 5400

GCCAAGGAGA AGGCGGCAGT TCTGACCGCT GAGGCGAGTC TGCAGGCCAA GGAGAAGCTG 5460

GTGAGTCAGC AGCTTTGGAT TCCCCGGGCA GGCGGCCACA AGGCCTGGCT GAAGGCCCTG 5520

TGCACCGCCC TGCTCGACAG CGAAGGGGTC CGGAGTGAAG CGCTGCTGCT GTCCCGACCG 5580

CTGTGCCTGG TGCGCGCGGA CTGCTGCCAG AGGCTGCTGC CGCTCATCAT CCACTCCATC 5640

CTCCTGGAAG ACAGTAACGG CTTGTGGAGG GAGACGCTCT CCTCCCGCAT CCGGGACTTC 5700

TTCAGCTTTT GTTGCAGAAG CGCTCAGGCC GCCAGTCGCT CCGCCACGCC GCTCAGCTCT 5760

GACTCCGAGT CAGAAGCTGC CAGTCCTGGC CTGTACGACA AGAACTCTCT GCGCACGATG 5820

CTCGCCGTTA TCGACTATCT GAGGCACCAA CAGAGACCTC TGGAAGCTGG AAGCTCCTCC 5880

TTTGGCACGG TGAGTGACTC AAACTTCTGG CTGGAGCTGA ACTACCTGGA GGTGGCCAAA 5940

GCGGCGCAGT CCTGCTCGGC ACATTTCACC GCTCTGCTGT ACACCGAGAT CTATGTGGAT 6000

AAGATCAAAG CCGACCTGGA GGAGACAACA CGTAAGATCA ATTTTGAAGA GAACAGCCAG 6060

AACTTCACCA TCTCCAGCCT CACTGAGAAG AGCATGGAAG ACACCAATAT CAGTCTGCAG 6120

GAGCTGCTGA TTGAGGTGTA TCGCAGCATC GGAGAGCCTG ATAGTCTGTA CGGCTGCGGC 6180

GGAGAGACCA CTACAAGTCC GCTGACAAGG ATTCGAACCT ACGAGCACGA GGCCATGTGG 6240

GGGAAGGCGC TGACCTCATA CAACCTCCAC ACTACTCTGC CCGAGGTCAC TCGTCAAGTG 6300

GGAATTGTGG AGGGCCTGCA GAACATTGGT CTGAGCAACA TCCTCACCAC CTACATGAGG 6360

GGTCTGGAGA GTGAAGGGGT GGAGTGGGGG GCCGAGCTGA GAGAGCTCCG CTTCCAGGCC 6420

GCATGGAGGA ACACGCAGTG GGACTGTGAG CTGTCAGAGA GGAGTGAGAA ATCCAAACCC 6480

GGCTTCCACG AGTCAGTGTT TAGTTCCCTG CATGCGCTGA GGGACAAAGA GTTCTCCGTA 6540

TTCGACGAAA CTCTGAAACA GGCCAGGTAT GATTTTAATA AGAAGGGTGC AGATGTGGCG 6600

GAGCTGTGCA GAGGAAGCCT GGAGGCCGTG TCTTCTCTGT ACCCGTCTCT CAGGAACCTG 6660

CAGAGCATCA GGGAGCTGGA GAGTGCCAAA CAGCTCTTTG CTAAGCCCTT CTCCGATGTG 6720

ACTCTGAGGG AGGTTTGCAG AGAGTGGCGA CAGCACTCCG AGCTGCTCGC CGACAGCGAC 6780

TTCGCTCTGG TGGAGCCCAT CCTGGCCCTC CGCACCGTGG CCCACCAGAC CCTGCTAGCC 6840

AGGGGGGGAG ACCCCGACCA CATCCAGTAC GTCAGCTCTG TGCTCAGTGA CCACCTCATG 6900

GAGCTCTGCC GGCTGGCTCG AAATGCTGGG AATACACAGC TCGCAGAGCA GGCCGTCTTC 6960

CAGATGAAGC AGAATGGTGG TGGAGGGTCC TGGGCGTCAT CCCCTGTGTT GTCATGGCAG 7020

CTGGAAGAGG CCCAGGTGTT CTGGGCAAAA GGGGAGCAGG GGCTGGCCCT GGGGCTGCTG 7080

AGACAGATGG TACACCGGCT CGAGGAGAAG GTCAGCCCTA AACGCCCCGT GGACATGAAT 7140

TCCGCCCTGG TCCCGGTTTA CACAGAGAGC CTGCGGCTGT GTGGCAGCTG GCTGGCTGAG 7200

ACCTGCCTGG AAAATCCCGG AGTAATACTG AAGAACTACC TGGAGAGGGC GGTGGAGGTG 7260

ATCGAGGAGG CATCAGGAGT TCGGGACTCC AGGCTGCAGA GTCAGCGGAC GGAGGCCTTC 7320

TTGTCTCTGG CGCGCTTCTC CGACGCTCAG TACCAGAGCA TCGGCAAATA CATGAACTCC 7380

TCCGAGTTTG AGAACAAGCA GGCGCTGCTG GAGAGGGCCA AAGAAGAAGT GGACCTGATG 7440

AGGAAGCGTG AAGTGACTTC CAACAGGTAC ACAACGAAGG TGATGAGAGA GCTGGCGCTG 7500

GACCAGAAGT CCCTCTCCGA CCGGCAGACC GACAGACAGC GCTTCCTCCT CAAAGCTGTG 7560

GAGAATTACA TCCGGTGTCT GGAGGGAGGG GAGCACGACA CCTGGGTGTT TCGCCTGGCT 7620

TCGCTGTGGC TGGAGAACGC CGGCGTCAAG GTCGTCAACG ACATGATGAA GGTCCGGGTG 7680

GAGCGGATCC CTTCCTACAA GTTTCTGCCT CTCATGTATC AGCTGGCCGC TCGCATGGGA 7740

ACCAAGATGG CAACTGGCGT TACCGAGGAT ACCGGGTTCC ATGATGTCCT CCGCAAACTG 7800

ATCTGCAGAG CGTCTCGGGA GCACCCTCAT CACACGCTCT TCATCATCCT CGCCCTGGTG 7860

AACGCCAACA AGGACGAGAA CTTTGGCAAG AGCCGACTGT CTAAGAGCGC TCCGCGGCAG 7920

GGTTCGCCGC TTGACCTCGA GCGCTCCAAT GTGGCCCTGA GGATCATCGG CGAGCTCCGG 7980

AAAGAGAGAG GCGAGATGAT CCGAGGGGTC GAGAAGCTGT GCGACGCCTA CATCGCTCTG 8040

GCTTATATGG ACGCCAGCAA GCACAAGGCG GAGAAGAAGC CTATTCCCAT CCCTGCTGAT 8100

CAGCCCATCA CCCAAATCAA AAACCTGCAT GAGGTTGCCA TCCCAACAAT GGAGATCAAG 8160

GTGGATCAGT CTTGTTGCTA TGACGACCTG GTGACCATCA GGTCCTTCGT GCCACAGTAC 8220

CACCTGGTTG GAGGAGTCAA CCTGCCCAAA ATCATCGACT GCGTCGGCTC TGACGGGACG 8280

ACCAGGAGAC AACTGGTCAA GGGTCAGGAC GACCTGCGGC AGGACGCTGT GATGCAGCAG 8340

GTCTTCAGCA TGTGCTCCAT GCTGCTGCAG CGCAACGCCG ACACCCGCAA GAGGAAGCTC 8400

AACATCCGAC GCTACAAGGT GGTGCCGTTC TCGCAGCGTA GCGGCGTGTT GGAGTGGTGT 8460

TCGGGCACGG TGCCTATTGG AGAGTTTCTA GTGGACACCA ACAAAGGAGC CCACAAACGC 8520

TTCAGACCCA AGGACCTGAC CAACTTGGCC TGCCGCAAAA GGATGATGGA GTGCCAGTCG 8580

TTCGATGAGA AGCTCCGGGG CTTCGGCGAG GTGTGCAAGA ACTTCCGGCC GGTCTTCAGG 8640

TATTTCTGCA TGGAGCGATT CCTGGACCCC GCGGTGTGGA TGGAGAAGCG TCTGGCTTAC 8700

ACCCGCAGCG TGGCCACCTC TTCTATAGTT GGCTACATCG TCGGCCTGGG GGACAGACAC 8760

ATCAATAACA TTCTGGTTGA TGAGCAGACT GCTGAGCTGG TGCACATCGA CTTGGGTGTG 8820

GCCTTTGAGC AGGGGAAGAT CCTCCCCACC CCCGAGACTG TCCCCTTCAG ACTGTCTAGA 8880

GACATTGTGG ACGGGATGGG CATCACTGGA GTGGAGGGGG TTTTCAGGAG ATGTTGTGAG 8940

AAGACATTGG AGGTGATGAG GAGCTCTCAA GAAGCTCTGC TGACTATTGT CGAGGTGCTG 9000

CTGTATGACC CTTTGTTCGA CTGGACCATG AACCCGCTGA AGGCCTTCTA CCTGCAGCAC 9060

GACGAGCAGC AGGAGCTCAA CGCTACGCTG GGCTCCACCA TGGGGGGCGT TGACATGGAC 9120

AGCCACCGTA AACCCAGCGA CAGTCAAAGC TTCAACAAAG TGGCGGAGCG GGTGCTGCTG 9180

AGGCTGCAGG AGAAGCTGAA GGGGGTGGAG GAGGGAACGG TGCTCACCGT GGGGGGGCAG 9240

GTCAACCTGC TCATCCAACA AGCCATGGAC CCCAAAAACC TCAGCAGACT CTTCCCGGGC 9300

TGGCAGGCCT GGGTG 9315

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

          +f ++ +++   + pk +   Gsdg ++++Lvkg++Dlrqd++++q+fs++  lL++++

Q: 2734  RSFVPQYHLVGGVNLPKIIDCVGSDGTTRRQLVKGQDDLRQDAVMQQVFSMCSMLLQRNA  2793

         567777777888888999******************************************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

          t++rkL+ir+ykVvp s+rsg++ew+ +tv+++e+l   v+ ++++++   + r+kdl

Q: 2794  DTRKRKLNIRRYKVVPFSQRSGVLEWCSGTVPIGEFL---VDTNKGAHK---RFRPKDLT  2847

         *************************************...566777887...89******

S: 122   tvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrslA  179

         +  +rk +++ ++    l  f ev++n+ p  +++++++e f++p++w e+r aytrs+A

Q: 2848  NLACRKRMMECQSFDekLRGFGEVCKNFRP--VFRYFCMERFLDPAVWMEKRLAYTRSVA  2905

         *********99987777*************..9***************************

S: 180   vislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivn  239

         ++s+vgyi+gLgdrh +n+l+d++t+e+vhid+gvafe++k+ l++pe+vPFRL r+iv+

Q: 2906  TSSIVGYIVGLGDRHINNILVDEQTAELVHIDLGVAFEQGKI-LPTPETVPFRLSRDIVD  2964

         ******************************************.*****************

S: 240   algvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk........kkktsk  291

         ++g+tgveGvfr++ce++l+v+r+s+e llti+ev+lydpl+dw++        ++ +++

Q: 2965  GMGITGVEGVFRRCCEKTLEVMRSSQEALLTIVEVLLYDPLFDWTMnplkafylQHDEQQ  3024

         **********************************************99988844333333

S: 292   eteeelaekakaealkikkllskvekaenavatrdllll  330

         e + +l ++    +++++++ s  ++++n+va+r+ll+l

Q: 3025  ELNATLGSTMGGVDMDSHRKPS-DSQSFNKVAERVLLRL  3062

         3334444444445555555543.3567777777776665

Domain Sequence
(FASTA)

RSFVPQYHLV GGVNLPKIID CVGSDGTTRR QLVKGQDDLR QDAVMQQVFS MCSMLLQRNA 60

DTRKRKLNIR RYKVVPFSQR SGVLEWCSGT VPIGEFLVDT NKGAHKRFRP KDLTNLACRK 120

RMMECQSFDE KLRGFGEVCK NFRPVFRYFC MERFLDPAVW MEKRLAYTRS VATSSIVGYI 180

VGLGDRHINN ILVDEQTAEL VHIDLGVAFE QGKILPTPET VPFRLSRDIV DGMGITGVEG 240

VFRRCCEKTL EVMRSSQEAL LTIVEVLLYD PLFDWTMNPL KAFYLQHDEQ QELNATLGST 300

MGGVDMDSHR KPSDSQSFNK VAERVLLRL 329

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013