EKS-GAA-00370
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00370
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR479.53.2E-144691948258
StatusUnreviewed
Ensembl ProteinENSGACP00000009484
UniProt AccessionG3NVW5;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000007160ENSGACP00000009484ENSGACT00000009504
OrganismGasterosteus aculeatus
Functional Description
Protein Length1258
Protein Sequence
(FASTA)
CLGTDMKLTL PSSLNHYEDP EAALHPAAKV VHGHLEITHL HGDLDLSFLQ GIVEVQGYVL 60
VAHVSVSLLP LDNLRIIRGS QLYNSSYALA VLDNTLGGRG LRTLRLRSLT EILLGAVFIW 120
GNPQLCFPDP QNIVWRDTLD EKNDHAGKHR LQPRANNCPN CSPVCKTGCW GETGEDCQHL 180
TRINCASGCQ RCKGPNAHDC CHMQCAAGCT GPKDLDCLAC RHFNDSGVCK ENCPPPTIYD 240
PVTYQIKINP NRKFNFGATC VKTCPYNYLA MEVACTLNCP KANQEVVVKN PDGNEMQKCE 300
KCEGDCPKVC YGLGSDNQGA IDNQGIAMVT SANVEQFNKC KKIFGSLAFL PQSFASDPAS 360
NTSGLTFEHL RSFKNLEEIT DYLYIEAWPE EWSNLSVFEN LKVIRGRMLY KGVFSLAVQN 420
LHIRSLGLRS LRSVSGGLVL LHNNSQLCYT SSLPWDSLLH PTEGPHRIVS HNQDAQLCEE 480
EGRVCHPLCK GGCWGPGPSQ CVSCSAFQRG IECVKQCDIN QGSVREYTDG SLCVACHAEC 540
QPVNGSASCH GPRADQCTEC RHYQDGEFCV ERCPSGVKED QQTVWKYSNA TGHCLPCNTT 600
CTLSCTLMDE RGCPVDTRTG PGTTIAAAVG GVVLVFILLA LLVFYLRRQK ILREKEAMRR 660
ILQEHELVEP LTPSGASPNQ AQMRILKETE LKKLRVLGAG AFGTVYKGVW APDGENVKIP 720
VAIKVLRENT SPKANKEILD EAYVMAGVAS PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY 780
VRENKDRIGS QFLLNWCVQI AKGMSYLEDV RLVHRDLAAR NVLVKNPNHV KITDFGLARL 840
LDIDETEYHA DGGKVPIKWM ALESILHRKF THQSDVWSYG VTVWELMTFG AKPYDMIPAR 900
EIPDVLEEGE RLPQPLICTI DVYMIMVKCW MIDPDSRPRF TDLVSDFSVM ARDPPRYVVI 960
QNDEQMSMSN PVDSQFFRML LEEEGNNMRE LLDAEEYLVP QTNPFSRTQV DGAPPNGPSR 1020
HQSHRSRDQG LDGESSAPGG PRSMYSSLST LGRSQYATLP LGVCSPSGEW IPQYRTLDRS 1080
PSAGGQSDSV FLDGPPDDAS LPPASPGRCC RDPAYSNGSQ GDLETDRPSG FPPPHLLHHS 1140
LPRRSRGQVH SHALPEYVNQ EIRDPRSGVA ERPSTLPRKG SRADRRPPNG LCSGHSVEIP 1200
RALTSPAFDN PYYLDLVAKA NAAVERDGRG PRHVNGFVTP TAENPEYLGL AETWSGYT 1258
Nucleotide Sequence
(FASTA)
TGCCTGGGCA CAGACATGAA ACTGACCCTG CCCTCCAGCC TGAACCACTA CGAAGACCCT 60
GAAGCTGCTC TACACCCGGC TGCAAAGGTC GTCCACGGCC ACCTGGAGAT CACGCACCTT 120
CATGGAGACC TCGACCTCTC CTTCCTACAG GGGATCGTGG AGGTCCAGGG CTACGTGCTC 180
GTGGCTCATG TGTCCGTGAG CCTGTTGCCT TTGGACAACC TTCGGATCAT AAGAGGCAGC 240
CAGCTGTACA ACTCCAGCTA CGCCCTGGCC GTGCTGGATA ACACTCTGGG CGGACGGGGG 300
CTCAGGACGC TGCGGCTTCG TAGCCTCACC GAGATCCTGT TGGGTGCCGT GTTTATTTGG 360
GGCAACCCCC AGCTGTGCTT CCCAGACCCC CAGAACATTG TTTGGAGGGA TACTTTGGAC 420
GAGAAGAACG ACCACGCCGG GAAGCACCGA CTGCAGCCTC GGGCCAATAA CTGTCCAAAT 480
TGTTCCCCCG TATGTAAGAC GGGCTGCTGG GGAGAAACTG GGGAGGACTG CCAGCACTTG 540
ACCCGTATTA ATTGTGCGTC CGGCTGTCAG CGCTGTAAAG GCCCCAATGC TCATGACTGC 600
TGTCACATGC AGTGTGCTGC TGGGTGCACC GGACCCAAAG ACCTGGACTG CCTGGCCTGC 660
CGCCACTTCA ACGACAGCGG CGTGTGTAAG GAGAACTGCC CGCCGCCAAC GATCTACGAC 720
CCCGTCACCT ATCAGATCAA AATCAACCCC AACAGGAAGT TCAACTTTGG AGCCACCTGC 780
GTCAAGACGT GTCCCTATAA CTATCTGGCC ATGGAGGTGG CTTGTACTTT GAATTGTCCC 840
AAAGCCAACC AGGAAGTTGT CGTCAAGAAC CCCGATGGAA ACGAGATGCA GAAATGTGAA 900
AAGTGTGAAG GAGACTGTCC CAAAGTGTGC TACGGTCTGG GTTCGGACAA CCAGGGGGCC 960
ATTGACAACC AAGGCATCGC CATGGTAACG TCGGCTAATG TGGAGCAGTT CAACAAGTGT 1020
AAGAAGATTT TCGGTAGTCT GGCCTTCCTC CCCCAGAGCT TTGCAAGTGA CCCTGCGAGC 1080
AACACATCAG GTCTGACCTT CGAGCACCTG CGCAGCTTCA AGAACCTGGA GGAGATAACG 1140
GATTATTTGT ACATCGAAGC CTGGCCAGAG GAGTGGAGTA ACCTCAGTGT GTTTGAGAAC 1200
CTGAAGGTGA TCCGAGGCAG GATGCTCTAC AAGGGCGTGT TTTCACTGGC CGTCCAGAAT 1260
CTTCACATCC GGTCTCTGGG GTTGCGTTCA CTGCGCAGCG TCAGCGGAGG TTTGGTCCTG 1320
TTGCACAACA ACTCCCAGCT GTGCTACACC AGCTCCCTGC CCTGGGACAG CCTGCTGCAT 1380
CCCACCGAGG GGCCTCACCG CATCGTCAGC CACAACCAGG ACGCCCAACT CTGTGAGGAA 1440
GAGGGGCGTG TTTGTCACCC GCTGTGCAAG GGGGGCTGCT GGGGGCCGGG GCCCAGCCAG 1500
TGTGTGTCCT GCAGTGCTTT CCAACGTGGC ATTGAGTGCG TGAAGCAGTG TGACATCAAC 1560
CAGGGGTCTG TCCGTGAATA CACAGACGGA TCTTTGTGCG TCGCCTGTCA CGCGGAGTGT 1620
CAACCGGTCA ATGGCTCCGC CTCCTGTCAC GGCCCGCGGG CGGATCAATG CACCGAGTGT 1680
CGACACTACC AGGACGGCGA GTTTTGCGTG GAGCGCTGTC CCAGCGGCGT GAAGGAGGAT 1740
CAGCAGACCG TGTGGAAGTA CAGCAACGCC ACGGGACACT GTCTGCCCTG CAACACCACC 1800
TGCACGCTGT CCTGCACCCT GATGGACGAG AGAGGCTGCC CCGTCGACAC CAGGACAGGA 1860
CCGGGCACAA CAATCGCGGC CGCAGTGGGT GGAGTGGTGC TGGTCTTCAT CCTGCTCGCC 1920
CTGCTGGTCT TCTACCTGAG GCGACAGAAG ATCCTCAGGG AGAAGGAGGC CATGAGGAGG 1980
ATCCTGCAGG AACACGAGCT CGTGGAGCCT CTGACACCCA GCGGCGCGTC ACCCAATCAG 2040
GCTCAGATGC GCATCCTGAA GGAGACAGAG TTAAAAAAAC TCCGGGTTCT GGGTGCAGGC 2100
GCCTTCGGTA CCGTTTACAA GGGAGTGTGG GCTCCTGATG GGGAGAACGT GAAAATACCG 2160
GTGGCCATTA AGGTGTTACG AGAGAACACC TCGCCAAAGG CCAATAAAGA GATCCTCGAT 2220
GAGGCCTACG TGATGGCCGG CGTGGCCAGC CCCTACGTGT GCCGTCTGCT GGGGATCTGT 2280
CTGACCTCCA CGGTGCAGCT GGTCACGCAG CTGATGCCGT ACGGCTGCCT CCTGGACTAC 2340
GTCAGGGAGA ACAAGGACCG CATCGGCTCC CAGTTCCTCC TCAACTGGTG TGTCCAGATC 2400
GCCAAGGGGA TGAGTTATCT GGAGGACGTC CGGCTGGTCC ACAGGGATTT GGCCGCCCGC 2460
AACGTTCTGG TGAAGAACCC GAACCACGTG AAGATCACCG ACTTCGGTCT GGCCCGTCTG 2520
CTCGATATCG ACGAGACCGA ATACCACGCC GACGGAGGGA AGGTTCCGAT AAAGTGGATG 2580
GCGCTCGAGT CTATTCTGCA CAGGAAGTTT ACTCATCAGA GCGACGTCTG GAGCTACGGC 2640
GTGACGGTCT GGGAGCTGAT GACGTTTGGG GCTAAACCCT ACGACATGAT CCCCGCCAGA 2700
GAAATCCCAG ACGTCTTGGA GGAAGGAGAA CGGCTCCCCC AGCCCCTCAT CTGCACCATC 2760
GACGTCTACA TGATCATGGT CAAATGTTGG ATGATCGACC CCGACAGCAG GCCGCGGTTC 2820
ACAGACCTCG TCAGCGATTT CAGTGTAATG GCGAGAGATC CGCCTCGCTA CGTCGTCATC 2880
CAGAACGACG AGCAGATGAG CATGTCCAAC CCGGTGGACA GCCAGTTCTT CCGGATGCTT 2940
CTGGAGGAGG AAGGGAACAA TATGAGGGAG CTGCTGGATG CTGAGGAGTA CCTGGTGCCT 3000
CAGACGAACC CCTTCTCCAG GACTCAGGTG GACGGGGCTC CGCCCAACGG GCCCTCCAGA 3060
CACCAGTCGC ACCGGAGCAG AGATCAGGGT CTAGACGGCG AGTCCTCGGC CCCCGGCGGC 3120
CCCCGCAGCA TGTACTCCTC CCTGAGCACC CTCGGGCGCA GCCAGTACGC CACCTTACCT 3180
CTAGGGGTCT GCAGCCCCAG CGGCGAGTGG ATTCCCCAGT ACCGGACTCT GGACCGCAGC 3240
CCCTCGGCGG GGGGGCAGTC GGACTCGGTC TTCCTGGACG GGCCGCCGGA CGACGCCTCG 3300
CTGCCCCCGG CCAGCCCCGG GCGCTGCTGC CGAGACCCCG CCTACTCCAA CGGCAGCCAG 3360
GGCGACCTGG AGACGGACAG GCCGAGCGGC TTCCCCCCCC CGCACCTCCT TCACCACTCG 3420
CTGCCCCGGC GGAGTCGCGG GCAGGTTCAC AGTCACGCCT TGCCAGAGTA CGTCAACCAG 3480
GAGATTCGGG ACCCGAGGTC GGGGGTCGCC GAGCGGCCCA GCACGCTGCC CCGTAAGGGC 3540
TCCCGGGCCG ACCGGCGGCC CCCCAACGGC CTCTGCTCCG GCCACAGCGT GGAGATCCCG 3600
AGGGCCCTCA CCTCGCCAGC CTTTGACAAC CCGTACTACC TGGACCTTGT GGCCAAAGCC 3660
AACGCCGCAG TGGAGAGAGA CGGGAGAGGG CCCAGGCACG TGAATGGGTT CGTGACCCCC 3720
ACTGCGGAGA ATCCGGAGTA CCTGGGACTA GCGGAAACCT GGAGCGGATA TACTTGA 3777
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkkl+vlG+GafGtvykG+w p+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 691   LKKLRVLGAGAFGTVYKGVWAPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVAS  750
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq llnwcvqiakGmsyle+ 
Q: 751   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQFLLNWCVQIAKGMSYLEDV  810
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+rk+
Q: 811   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRKF  870
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpyd ipa+eipd+le+Gerl+qp ictidvym++vkcw
Q: 871   THQSDVWSYGVTVWELMTFGAKPYDMIPAREIPDVLEEGERLPQPLICTIDVYMIMVKCW  930
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srp+f +l+++fs
Q: 931   MIDPDSRPRFTDLVSDFS  948
         **************9996
Domain Sequence
(FASTA)
LKKLRVLGAG AFGTVYKGVW APDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVAS 60
PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIGS QFLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKNPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILHRKF 180
THQSDVWSYG VTVWELMTFG AKPYDMIPAR EIPDVLEEGE RLPQPLICTI DVYMIMVKCW 240
MIDPDSRPRF TDLVSDFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GOG-00296
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 2.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013