EKS-GAA-00180

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00180

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	505.8	4.6E-152	652	957	306

Status

Unreviewed

Ensembl Protein

ENSGACP00000009538

UniProt Accession

G3NW08;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000007187	ENSGACP00000009532	ENSGACT00000009552
ENSGACG00000007187	ENSGACP00000009538	ENSGACT00000009558
ENSGACG00000007187	ENSGACP00000009527	ENSGACT00000009547

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1042

Protein Sequence
(FASTA)

MRPKTFPTSN YSGNSQHMLQ EIRNSLRNLS KPSDPPKVDV GGAGKMVSED PRQQGRSVNG 60

KNHHHKALQE IRKSLEPFAN ETSTSGPEVN QHMSGFEEEA VAAYLDTLCA SQTRHVTPSR 120

NMGAVIDYMG KVSYHDAAWE QMVVANPNTT VLKAAGSSHI QQAVLRRPSW KGSKESLVPR 180

HGPLMMDGMM YRSDSPGPPP AFPQGHPGNN QRVNPPLPPQ VRSVTPPPNR GAMPTAPSWD 240

SNPSTKRYSG NMDYLLPRSS PVPQGARADG YQSSAPQNQR GISPVPVGHQ PIIMQSSGPD 300

YMAGGSRQPP PPYPLNQSSR HSPTDQQMQS GGPASSPSYL NGGNIPQSMM VPSRNSHNLE 360

MYNIGPPQSW SQAPLNPNQP QSSSGNQDLS PSWQHNMPVR SNSFNNHQLN SRPAHPSGSQ 420

PSATTVTAIM QAPILQPVKS MRVQKPELHT AVAPTHPPWM QHPPPSPAAP AYQEPPAPAP 480

QIPVVAEAPS YQGPPPPYPK HLLQQQAAPG PPAYDPGANK LSPGREEAAE EESVDAPRDK 540

AVESVAATEK ENKQITTSPV PVRRNKKDEE PRGESGRVAL YSPQAFKFFM EQHVENILKN 600

HQMRIRRRKQ LESEMQRVGL SSEAQEQMRM MLCQKESNYI RLKRAKMDKS MFKRIKTLGI 660

GAFGEVCLAR KEDTGALYAM KTLRKKDVLL RNQVAHVKAE RDILAEADNE WVVRLYYSFQ 720

DRDNLYFVME YIPGGDMMSL LIRLGIFKEE LAQFYIAELT CAVESVHKMG FIHRDIKPDN 780

ILIDRDGHIK LTDFGLCTGF RWTHDSKYYQ SGDHVRQDSM DFSKEWEDAT NCRCTDRLKP 840

LERRKARQHQ RCLAHSLVGT PNYIAPEVLL RTGYTQLCDW WSVGVILYEM VVGQPPFLAT 900

TPLETQMKVI NWKNMLHIPP PAKLSPEASD LIANLCRSPE ERLGKDGVDE IKAHPFFKDT 960

DFSSDLRQQA APYVPTIAHS TDTSNFDPVD PEKLRSGDGD GNLNDTLNGW FRNGKHPEHA 1020

FYEFTFRRFF DDNGHPYSCP KP 1042

Nucleotide Sequence
(FASTA)

ATGAGACCCA AGACGTTTCC CACCAGCAAC TACAGCGGCA ACAGCCAACA CATGCTGCAG 60

GAAATAAGGA ATAGTCTGCG CAACTTGTCC AAACCCTCGG ACCCACCTAA AGTGGACGTC 120

GGAGGTGCTG GGAAAATGGT TTCTGAGGAC CCAAGGCAAC AAGGGCGCTC CGTCAACGGT 180

AAAAACCATC ACCACAAGGC CTTGCAAGAG ATCCGCAAAT CCCTGGAGCC TTTTGCCAAC 240

GAGACCAGTA CCTCGGGCCC CGAGGTGAAC CAACACATGT CTGGGTTTGA AGAGGAGGCC 300

GTTGCAGCAT ATTTAGACAC GCTGTGTGCA AGTCAGACAC GACATGTCAC GCCAAGTCGC 360

AATATGGGGG CAGTTATAGA CTACATGGGT AAGGTGAGCT ACCACGACGC AGCGTGGGAA 420

CAGATGGTTG TTGCCAACCC CAACACTACA GTTCTGAAAG CCGCAGGCTC TTCTCATATC 480

CAGCAGGCTG TGCTGAGGAG GCCGAGCTGG AAAGGTTCGA AGGAGTCGCT GGTGCCTCGA 540

CACGGTCCTC TCATGATGGA TGGAATGATG TACCGCTCAG ACAGCCCCGG ACCTCCGCCC 600

GCCTTCCCAC AGGGTCACCC TGGCAACAAC CAGAGAGTCA ATCCTCCGCT GCCGCCGCAG 660

GTGCGCAGTG TCACGCCTCC ACCAAACCGC GGTGCCATGC CTACGGCGCC ATCCTGGGAC 720

AGCAACCCGT CAACCAAGCG CTACTCTGGC AACATGGATT ACCTTTTACC GCGCAGCTCT 780

CCGGTACCCC AGGGGGCCCG GGCTGATGGG TACCAGTCGT CAGCCCCTCA GAATCAACGG 840

GGGATCAGCC CAGTGCCTGT GGGCCACCAG CCCATCATAA TGCAAAGCTC TGGGCCCGAT 900

TACATGGCGG GGGGCAGTAG ACAGCCTCCT CCGCCTTACC CACTCAACCA GAGCAGCCGG 960

CACAGTCCCA CTGACCAGCA GATGCAGTCC GGAGGACCTG CATCCTCCCC CTCGTACCTC 1020

AATGGTGGGA ACATCCCTCA GTCCATGATG GTTCCCAGCC GGAACAGTCA CAACCTGGAA 1080

ATGTATAACA TAGGTCCTCC TCAGTCCTGG TCCCAGGCGC CTCTGAACCC CAACCAGCCC 1140

CAGTCTTCCT CCGGGAACCA GGATCTGTCC CCATCGTGGC AGCACAACAT GCCGGTGCGC 1200

TCAAATTCCT TCAACAACCA CCAGCTGAAC AGCAGACCGG CCCACCCGTC GGGCTCCCAG 1260

CCTTCTGCCA CCACAGTCAC GGCCATCATG CAGGCCCCCA TCCTGCAGCC GGTCAAAAGC 1320

ATGCGTGTCC AGAAGCCCGA GTTGCACACC GCCGTCGCTC CCACGCACCC TCCGTGGATG 1380

CAGCATCCTC CGCCATCTCC CGCCGCGCCC GCTTACCAAG AGCCCCCAGC CCCGGCACCC 1440

CAGATCCCTG TCGTTGCAGA AGCCCCCAGT TACCAGGGCC CCCCTCCGCC CTATCCCAAG 1500

CATCTCCTCC AACAGCAGGC TGCGCCGGGA CCCCCGGCCT ACGATCCCGG GGCCAATAAG 1560

CTCAGCCCGG GCCGAGAGGA AGCGGCCGAG GAGGAGAGCG TCGACGCCCC CCGGGACAAG 1620

GCGGTGGAGA GCGTCGCCGC AACGGAGAAA GAGAATAAGC AAATCACCAC GTCGCCCGTT 1680

CCCGTCCGCC GCAACAAGAA AGACGAAGAG CCGAGAGGGG AGTCCGGGAG AGTCGCACTC 1740

TACTCCCCCC AGGCCTTCAA GTTCTTCATG GAGCAACACG TGGAGAATAT CCTGAAGAAC 1800

CATCAGATGA GGATTCGGAG GAGGAAGCAG CTGGAAAGTG AAATGCAAAG GGTTGGATTG 1860

TCTTCAGAAG CTCAAGAGCA GATGCGCATG ATGCTCTGCC AGAAGGAGTC TAACTACATC 1920

CGGCTAAAGC GAGCCAAGAT GGATAAATCC ATGTTTAAAA GAATCAAGAC GCTGGGCATC 1980

GGAGCCTTCG GCGAGGTATG CTTGGCCAGA AAGGAGGACA CGGGAGCGCT GTACGCCATG 2040

AAGACGCTCC GCAAGAAGGA CGTGCTGCTG AGGAACCAGG TGGCCCACGT CAAGGCGGAG 2100

AGGGACATCC TGGCCGAGGC GGACAACGAG TGGGTGGTGC GTCTCTACTA CTCGTTCCAG 2160

GACCGGGACA ACCTGTACTT TGTCATGGAG TACATTCCCG GAGGGGACAT GATGAGCCTC 2220

CTCATCCGGC TCGGCATCTT CAAAGAAGAG CTGGCTCAGT TCTACATCGC CGAGCTCACG 2280

TGCGCGGTGG AAAGCGTCCA CAAGATGGGC TTCATCCACC GAGACATCAA GCCCGACAAC 2340

ATCCTCATAG ACCGAGATGG ACACATCAAG CTGACGGACT TCGGCCTCTG CACCGGCTTC 2400

CGCTGGACGC ACGACTCAAA GTATTACCAG AGTGGGGACC ACGTGAGGCA GGACAGCATG 2460

GACTTCAGTA AGGAATGGGA AGACGCCACC AACTGCCGCT GCACGGACCG CCTGAAGCCT 2520

CTGGAGAGGA GGAAGGCCCG GCAGCACCAG CGCTGCCTGG CCCACTCGCT GGTCGGCACG 2580

CCAAACTACA TAGCGCCAGA GGTGCTGCTC CGGACGGGAT ACACGCAGCT GTGTGATTGG 2640

TGGAGCGTCG GCGTCATCTT GTATGAAATG GTGGTGGGAC AGCCTCCCTT CTTGGCGACC 2700

ACGCCCCTGG AGACGCAGAT GAAGGTGATA AACTGGAAGA ACATGCTGCA CATTCCGCCG 2760

CCGGCCAAGC TCAGCCCCGA GGCGTCCGAC CTCATCGCCA ACCTGTGCCG CAGCCCCGAG 2820

GAGCGCCTCG GCAAAGACGG CGTCGACGAG ATCAAGGCCC ACCCGTTCTT CAAGGACACC 2880

GACTTCTCCA GCGACCTGCG GCAGCAGGCG GCGCCGTACG TGCCCACCAT CGCCCACTCC 2940

ACGGACACCT CCAACTTTGA CCCCGTGGAC CCGGAGAAGC TGCGCAGCGG CGACGGCGAC 3000

GGCAACCTCA ACGACACGCT CAACGGCTGG TTCCGCAACG GCAAGCACCC CGAGCACGCC 3060

TTCTACGAGT TCACCTTCCG CCGCTTCTTC GACGACAACG GCCACCCCTA CAGCTGCCCC 3120

AAGCCC 3126

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f+ +k++g+GafGev+l+rk+dt+++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 652   FKRIKTLGIGAFGEVCLARKEDTGALYAMKTLRKKDVLLRNQVAHVKAERDILAEADNEW  711

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqd++nly+vmey+PGGd+m+lli+ +i+keela+fyiael++avesvhk+Gf

Q: 712   VVRLYYSFQDRDNLYFVMEYIPGGDMMSLLIRLGIFKEELAQFYIAELTCAVESVHKMGF  771

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ +++++d++++s+

Q: 772   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSKewedatn  831

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerrk+++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvilyem+

Q: 832   crctdRLKPLERRKARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILYEMV  891

         ****99******************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla tp et++kvinwk++l++p+ ++ls+ea+dli +l+ ++e+rlgk+Gvdei

Q: 892   VGQPPFLATTPLETQMKVINWKNMLHIPPPAKLSPEASDLIANLCRSPEERLGKDGVDEI  951

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 952   KAHPFF  957

         *****9

Domain Sequence
(FASTA)

FKRIKTLGIG AFGEVCLARK EDTGALYAMK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD RDNLYFVMEY IPGGDMMSLL IRLGIFKEEL AQFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHVRQDSMD FSKEWEDATN 180

CRCTDRLKPL ERRKARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILYEMV 240

VGQPPFLATT PLETQMKVIN WKNMLHIPPP AKLSPEASDL IANLCRSPEE RLGKDGVDEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013