EKS-GAA-00453

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00453

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	416.9	3.6E-125	239	488	250

Status

Unreviewed

Ensembl Protein

ENSGACP00000009577

UniProt Accession

G3NW58;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000007232	ENSGACP00000009577	ENSGACT00000009597

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

501

Protein Sequence
(FASTA)

MGCNCSSDYS DGEWMENLDE ICEHCSCPIP PQSCNPYTDQ LTPYPAQHSP PTSPLPDNLV 60

VAIYSYEPTH DGDLGFEKGD TLKIINKDDP EWYLAESLIT GQRGYIPHNF VAMTTVETEP 120

WFFKNISRNE AMRLLLSPGN TLGSFLIRES ETTQGSYSLS IRDLDHDTGE GVKHYRIRNM 180

DNGGFYITAK ISFSSLKELV QHHSREADGL CTKLMKPCQS RAPQKPWWQD EWEIPRESLK 240

LEQKLGAGQF GEVWMGIYNN DRRVAIKNLK MGTMSVEAFL AEANMMKNLQ HPCLVRLFAV 300

VTQEPIYIVT EYMENGSLVD YLKTAEGGTL PMNTLIDMAA QVAEGMAFIE MKNYIHRDLR 360

AANILVSSEL VCKIADFGLA RLIEDNEYTA REGAKFPIKW TAPEAINYGT FSIKSDVWSF 420

GILLTEIVTY GRIPYPGMSN PEVIQNLERG YRMPKPENCS DGLYGVMGLC WKENPDDRPT 480

FEYLKSVLED FFTATERQYQ E 501

Nucleotide Sequence
(FASTA)

ATGGGATGTA ACTGCAGTTC GGACTACTCA GACGGGGAGT GGATGGAGAA CCTGGATGAA 60

ATCTGTGAGC ACTGCAGCTG TCCCATACCT CCCCAGTCAT GCAATCCATA CACAGACCAG 120

CTGACTCCAT ACCCAGCACA GCATTCACCT CCTACATCTC CTTTACCAGA CAACCTTGTG 180

GTGGCCATAT ACAGTTATGA ACCCACCCAT GATGGTGACC TGGGCTTTGA GAAGGGAGAC 240

ACGCTCAAGA TCATCAACAA GGATGATCCA GAGTGGTATT TGGCGGAGTC CCTCATCACG 300

GGCCAGCGAG GCTACATCCC GCATAACTTT GTGGCAATGA CCACAGTGGA GACCGAACCG 360

TGGTTCTTTA AGAACATTTC TAGAAACGAA GCCATGAGGC TCCTCTTGTC TCCTGGGAAC 420

ACGCTGGGCT CCTTCTTGAT TCGAGAGAGT GAGACGACCC AAGGTTCATA TTCCCTTTCG 480

ATCAGGGACT TAGACCACGA CACCGGGGAA GGAGTAAAGC ACTACAGAAT CCGCAACATG 540

GACAATGGTG GCTTCTACAT CACAGCCAAG ATCTCCTTTA GCTCGCTGAA GGAGCTCGTC 600

CAGCATCACT CACGCGAGGC AGACGGGTTG TGCACAAAGC TGATGAAGCC GTGTCAGTCG 660

AGGGCACCGC AAAAGCCCTG GTGGCAGGAC GAGTGGGAGA TTCCCCGAGA GTCCCTGAAG 720

CTGGAGCAAA AGCTCGGAGC GGGACAGTTT GGGGAAGTCT GGATGGGTAT CTACAACAAC 780

GACAGGCGGG TGGCTATTAA GAACCTGAAG ATGGGAACAA TGTCAGTGGA AGCCTTCCTG 840

GCAGAGGCCA ACATGATGAA GAACCTGCAG CATCCGTGCC TCGTACGCCT CTTCGCCGTC 900

GTTACCCAGG AGCCAATCTA TATTGTCACG GAGTACATGG AAAATGGAAG CCTGGTGGAT 960

TACCTCAAAA CAGCAGAGGG AGGCACTTTA CCCATGAACA CTCTGATTGA CATGGCGGCG 1020

CAGGTGGCCG AGGGCATGGC TTTTATAGAG ATGAAAAACT ACATTCATCG AGACCTGAGA 1080

GCAGCCAATA TTCTGGTGTC CAGTGAACTC GTCTGCAAGA TTGCCGACTT TGGACTGGCG 1140

AGGCTGATCG AGGACAACGA ATACACAGCA AGAGAGGGTG CAAAGTTCCC CATCAAATGG 1200

ACAGCCCCAG AGGCTATCAA CTATGGCACC TTTTCCATAA AATCAGATGT GTGGTCATTC 1260

GGCATCCTCC TGACAGAAAT AGTGACATAT GGACGCATAC CGTACCCTGG TATGTCCAAC 1320

CCGGAGGTCA TCCAGAACCT CGAGAGGGGC TACAGAATGC CGAAGCCGGA GAACTGTTCA 1380

GATGGACTCT ATGGCGTCAT GGGCCTGTGC TGGAAGGAGA ACCCGGACGA CAGGCCCACC 1440

TTTGAGTACC TGAAGAGCGT TCTGGAAGAT TTCTTCACTG CCACAGAGAG GCAGTACCAG 1500

GAATAG 1506

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl++klG+GqfGevw+g +++  +va+k lk gt+s eafl+ea+++k+l+h+ lv+l+

Q: 239   LKLEQKLGAGQFGEVWMGIYNNDRRVAIKNLKMGTMSVEAFLAEANMMKNLQHPCLVRLF  298

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+m++Gsl+d+lk+ eg +l++++l+d+aaqvaeGma++e kn+ihr

Q: 299   AVVTQ-EPIYIVTEYMENGSLVDYLKTAEGGTLPMNTLIDMAAQVAEGMAFIEMKNYIHR  357

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+ +lv+k+adfGlarlied+eyta+egak+PikWtaPeai++g+f+iksdv

Q: 358   DLRAANILVSSELVCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFSIKSDV  417

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G++PypGm+n ev++++ergyr+p+pe+c + ly ++  cwk++p++

Q: 418   WSFGILLTEIVTYGRIPYPGMSNPEVIQNLERGYRMPKPENCSDGLYGVMGLCWKENPDD  477

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+l++vl

Q: 478   RPTFEYLKSVL  488

         *******9876

Domain Sequence
(FASTA)

LKLEQKLGAG QFGEVWMGIY NNDRRVAIKN LKMGTMSVEA FLAEANMMKN LQHPCLVRLF 60

AVVTQEPIYI VTEYMENGSL VDYLKTAEGG TLPMNTLIDM AAQVAEGMAF IEMKNYIHRD 120

LRAANILVSS ELVCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFSIKSDVW 180

SFGILLTEIV TYGRIPYPGM SNPEVIQNLE RGYRMPKPEN CSDGLYGVMG LCWKENPDDR 240

PTFEYLKSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013