EKS-GAA-00287

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00287

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	393.7	4.9E-118	86	369	284

Status

Unreviewed

Ensembl Protein

ENSGACP00000010202

UniProt Accession

G3NXY2;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK2

Gene Synonyms/Alias

MKNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000007681	ENSGACP00000010202	ENSGACT00000010224

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MVQNKMTEVT GFHRSFKVQN PFESDDFTKN GSHLLDSSFN FDSSPRHDMP SSQPIDIPDA 60

KKRNKKKKRC RATDSFSGRF EDVYRLHEEL LGEGAYARVQ TCFNLITNKE YAVKIIEKRP 120

GHSRNRVFRE VEMLYQCQGH SNILELVEFF EEEDKFYLVF EKLRGGSILA HIHKRRYFSE 180

QEASVVVQDI ASALDFLHNK GMAHRDLKPE NILCKSADKI SPVKICDFDL GSGIKLNSDS 240

SPISTPELLT PCGSAEYMAP EVVEAFSEEA TIYDKRCDLW SLGVILYIML SGYPPFVGRC 300

GGDCGWELGE PCHTCQNTLF ESIQEGKYEF PEKDWAHISS SAKDLISKLL VRDAKNRLSA 360

RQVLHHPWVQ GGACDTLPTS ILHQRSSKAR DLTFFADKAM AVNRQLAEQD GIDDQQHQEV 420

PFVVTATGSS MRLSLLSNSR LARRRQQPSQ QPSQLKTGPV SAAELRQLLA PLVIVGDCA 479

Nucleotide Sequence
(FASTA)

ATGGTGCAAA ACAAGATGAC CGAAGTCACT GGATTCCATC GCTCCTTCAA GGTCCAAAAT 60

CCCTTTGAAT CTGATGACTT CACCAAAAAT GGATCCCATC TTCTGGATTC GTCATTTAAT 120

TTTGATTCCT CCCCAAGACA TGACATGCCC TCCAGCCAGC CTATTGACAT CCCCGATGCC 180

AAGAAGAGAA ACAAGAAGAA AAAGCGTTGC AGGGCAACGG ACAGTTTCTC TGGACGATTC 240

GAGGATGTCT ACAGGCTGCA TGAAGAGCTA CTAGGAGAAG GTGCTTATGC CAGAGTGCAA 300

ACATGCTTCA ACCTCATCAC CAACAAAGAG TATGCTGTGA AGATCATTGA GAAGCGACCG 360

GGTCACAGCC GAAACCGTGT CTTCCGTGAG GTTGAGATGC TCTATCAGTG CCAGGGCCAC 420

AGTAACATCC TGGAGCTGGT GGAGTTCTTC GAAGAGGAAG ACAAATTCTA CCTGGTGTTT 480

GAAAAGCTTA GAGGAGGGTC TATCTTGGCG CATATCCACA AGAGACGGTA CTTCAGTGAG 540

CAGGAAGCTA GTGTTGTTGT GCAGGACATC GCCAGTGCTC TAGATTTCCT GCATAACAAG 600

GGAATGGCAC ACAGAGACCT GAAACCTGAG AACATTCTCT GCAAGAGTGC AGACAAGATT 660

TCCCCAGTCA AGATCTGTGA CTTCGACCTT GGCAGTGGGA TCAAGCTGAA CAGCGACAGC 720

TCGCCAATCT CCACCCCTGA GCTCCTCACC CCCTGTGGCT CAGCAGAGTA CATGGCACCC 780

GAGGTGGTTG AGGCGTTCAG TGAGGAGGCC ACAATTTACG ACAAGCGCTG CGACCTGTGG 840

AGCCTTGGGG TCATCCTCTA CATCATGCTG AGTGGCTACC CTCCCTTTGT AGGCCGCTGT 900

GGAGGTGACT GTGGCTGGGA ATTAGGGGAG CCATGCCACA CCTGCCAGAA CACACTCTTT 960

GAGAGTATCC AGGAAGGAAA ATATGAGTTT CCAGAGAAAG ACTGGGCTCA CATCTCCTCA 1020

AGTGCCAAAG ACCTAATCTC CAAACTCCTG GTTAGAGATG CCAAAAACCG CCTGAGTGCC 1080

CGCCAGGTGC TGCACCACCC CTGGGTCCAG GGGGGTGCGT GTGACACTTT ACCAACATCC 1140

ATTCTGCATC AAAGATCCAG CAAAGCCAGG GATCTTACAT TCTTTGCTGA CAAGGCCATG 1200

GCCGTAAACC GGCAGCTGGC TGAACAAGAT GGCATAGACG ACCAGCAGCA CCAGGAAGTC 1260

CCGTTCGTCG TTACCGCTAC TGGCTCCTCC ATGCGCCTCT CCCTTCTTTC CAACTCCAGG 1320

CTGGCCCGGC GCAGGCAGCA ACCCAGCCAG CAACCCAGCC AGCTCAAGAC GGGGCCCGTC 1380

TCTGCCGCAG AGCTTCGTCA ACTCTTGGCC CCTCTCGTTA TTGTGGGAGA TTGTGCCTGA 1440

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         l+ee+lGeG++++v++c++  t+++ya+ki+     ++r++v+reve+++q++gh+ni+e

Q: 86    LHEELLGEGAYARVQTCFNLITNKEYAVKIIekrpgHSRNRVFREVEMLYQCQGHSNILE  145

         6789********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         l+++fe    +e++++lv+ekl+GG++l++i++r++f+e+eas vv+diasal+flh+k+

Q: 146   LVEFFE----EEDKFYLVFEKLRGGSILAHIHKRRYFSEQEASVVVQDIASALDFLHNKG  201

         ******....9*************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaket..eee.......eelktpcltaeyvaP  167

         +ahrDlkpen+L++s +k +pvk+cDf+l++++  + +       +el tpc++aey+aP

Q: 202   MAHRDLKPENILCKSADKISPVKICDFDLGSGIklN-SdsspistPELLTPCGSAEYMAP  260

         ********************************9543.25899999***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+ea++eea++ydk+CDlWslGvilyi+l+GypPf++++g           ++++++l+

Q: 261   EVVEAFSEEATIYDKRCDLWSLGVILYIMLSGYPPFVGRCGgdcgwelgepcHTCQNTLF  320

         ****************************************88******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iqegkyefPe++W+++s++akdli+klL+rd+k+rl++++vl+hpwv

Q: 321   ESIQEGKYEFPEKDWAHISSSAKDLISKLLVRDAKNRLSARQVLHHPWV  369

         ************************************************8

Domain Sequence
(FASTA)

LHEELLGEGA YARVQTCFNL ITNKEYAVKI IEKRPGHSRN RVFREVEMLY QCQGHSNILE 60

LVEFFEEEDK FYLVFEKLRG GSILAHIHKR RYFSEQEASV VVQDIASALD FLHNKGMAHR 120

DLKPENILCK SADKISPVKI CDFDLGSGIK LNSDSSPIST PELLTPCGSA EYMAPEVVEA 180

FSEEATIYDK RCDLWSLGVI LYIMLSGYPP FVGRCGGDCG WELGEPCHTC QNTLFESIQE 240

GKYEFPEKDW AHISSSAKDL ISKLLVRDAK NRLSARQVLH HPWV 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013