EKS-GAA-00029
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00029
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/Trio334.84.5E-100241496256
StatusUnreviewed
Ensembl ProteinENSGACP00000010871
UniProt AccessionG3NZT8;
Protein Name
Protein Synonyms/Alias
Gene NameTRIO (1 of 2)
Gene Synonyms/Alias TRIO (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000008174ENSGACP00000010861ENSGACT00000010884
ENSGACG00000008174ENSGACP00000010823ENSGACT00000010846
ENSGACG00000008174ENSGACP00000010871ENSGACT00000010894
OrganismGasterosteus aculeatus
Functional Description
Protein Length545
Protein Sequence
(FASTA)
MLVTQDYMAV KEDEISVSQG EVVQILASNQ QNMFLVFRAA TEQGPAAEGW IPGFVLGHTS 60
AIAADCPEGS MKKPSSWHTS LRIRKKSEKK EKEAKKDGKL ENGYRKSREG LANKVSVKLL 120
NPNYIYDVPP EFLVPLSDVT CDNGDGVTLR CKVCGRPRAA VTWKGPDQSN LTSNGHFSIA 180
YSDTGEATLR ISGAASEDDG VYTCVATNEL GSVTSSASLR VLAVSTCGIR VSWKDNFESH 240
YTEVVELGRG RFSVVKRCDQ QGVKRLVAVK QVNKKLMRRD RVTQELNLLQ RLQHPNIVSL 300
IDTYETPSSY ALVLEMADQG RLLDYIVSWG NLTEEKVACY LKDILEALHY LHNCRIVHLD 360
VKPENLLVAN DSSGQPTVKL TDFGDAVQLS SLPYVHPLLG SPEFASPELV LGEPVSLTSD 420
LWSLGVVTYV LLSGASPFLD ESAEETCLNI CRLDFSFPRD YFQGVGQAAR DFICLLLRTD 480
PGRRPPAGLC LQEAWLQAGP ADGPARAEGC LDTSRLVSFI DRRKHQTDAR AIGGVRSFIQ 540
GRPSA 545
Nucleotide Sequence
(FASTA)
ATGTTGGTGA CCCAGGACTA CATGGCCGTG AAGGAGGATG AGATCAGCGT CAGCCAGGGC 60
GAGGTGGTCC AGATCTTGGC CAGCAACCAG CAGAACATGT TCCTGGTGTT CAGGGCGGCC 120
ACGGAGCAGG GCCCCGCCGC CGAGGGCTGG ATCCCCGGGT TCGTGCTGGG ACACACCTCG 180
GCCATCGCCG CCGACTGCCC CGAGGGCTCC ATGAAGAAGC CGTCGTCCTG GCACACGTCC 240
CTGCGCATCC GCAAAAAGTC CGAGAAGAAG GAGAAGGAGG CGAAGAAAGA CGGCAAGCTG 300
GAAAACGGTT ACAGGAAGTC CCGAGAAGGC CTGGCCAATA AGGTTTCTGT AAAGCTTCTA 360
AATCCAAACT ACATCTATGA TGTTCCACCA GAGTTCCTTG TACCTCTGAG CGATGTCACG 420
TGTGACAACG GAGACGGCGT CACCCTCAGG TGCAAAGTCT GCGGTCGGCC CCGGGCCGCC 480
GTCACCTGGA AGGGCCCCGA CCAGAGCAAC CTCACCAGCA ACGGACACTT CAGCATCGCC 540
TACAGTGATA CCGGAGAGGC GACGCTGCGG ATAAGCGGCG CGGCTTCGGA GGACGATGGC 600
GTTTACACCT GCGTCGCCAC CAACGAGCTG GGCAGCGTGA CGTCATCGGC GAGCCTCCGG 660
GTGCTGGCCG TGTCCACTTG TGGGATCAGA GTCAGCTGGA AGGACAACTT CGAGTCCCAC 720
TACACCGAGG TGGTCGAACT GGGCAGGGGC CGTTTCTCCG TGGTGAAGCG ATGTGACCAG 780
CAGGGCGTCA AGCGTCTGGT GGCGGTCAAA CAGGTGAACA AGAAGCTGAT GAGGCGGGAC 840
CGGGTGACTC AGGAACTCAA CCTGCTGCAG AGGCTCCAAC ACCCCAACAT AGTGAGCCTG 900
ATCGACACGT ACGAAACCCC CAGCAGCTAC GCCCTCGTCC TGGAGATGGC CGACCAAGGT 960
CGTCTGCTGG ACTACATCGT CAGCTGGGGG AATCTGACGG AGGAGAAAGT GGCCTGTTAC 1020
CTGAAGGACA TTTTAGAAGC TTTACATTAT CTGCATAACT GCAGGATAGT GCATTTGGAC 1080
GTAAAACCTG AGAACCTGCT GGTCGCCAAC GACTCCAGCG GCCAGCCGAC GGTCAAACTC 1140
ACGGACTTCG GCGACGCCGT CCAGCTCAGC AGCCTCCCTT ACGTCCACCC TCTGCTGGGC 1200
AGCCCCGAGT TCGCCTCGCC CGAGTTGGTC CTCGGGGAGC CCGTCTCGCT GACCTCCGAC 1260
CTGTGGAGCC TGGGCGTGGT GACCTACGTG CTGCTGAGCG GCGCCTCCCC CTTCCTCGAC 1320
GAGAGCGCCG AGGAGACCTG CCTGAACATC TGCCGGCTGG ACTTCAGCTT CCCCAGGGAC 1380
TACTTCCAGG GCGTCGGCCA AGCGGCCCGC GATTTCATCT GCCTGCTCCT GAGGACCGAC 1440
CCGGGCCGGA GGCCCCCGGC CGGGCTGTGC CTCCAGGAGG CGTGGCTGCA GGCCGGCCCG 1500
GCCGACGGCC CGGCCAGAGC CGAGGGCTGC CTGGACACCT CTCGCCTGGT CTCCTTCATA 1560
GACAGGAGGA AGCACCAGAC GGACGCCCGG GCCATCGGAG GCGTCCGGAG CTTCATCCAG 1620
GGTCGCCCTT CAGCC 1635
Domain Profile
S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60
         y+++ e+gRGrFsvvk++++++ kr va+k v+kk +++++v++E+++L+rLqHp++vsl
Q: 241   YTEVVELGRGRFSVVKRCDQQGVKRLVAVKQVNKKLMRRDRVTQELNLLQRLQHPNIVSL  300
         89999*******************************************************
S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120
          d+yetp s+ l+lE++++++LLd+++++++l+E++v+ yl+++leal+YLHn+r++HLD
Q: 301   IDTYETPSSYALVLEMADQGRLLDYIVSWGNLTEEKVACYLKDILEALHYLHNCRIVHLD  360
         ************************************************************
S: 121   ikpenllv..laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatD  178
         +kpenllv   +  +++vk+ D+g+A++l++  + + llg+pEf++PE++ gepvs ++D
Q: 361   VKPENLLVanDSSGQPTVKLTDFGDAVQLSSLPYVHPLLGSPEFASPELVLGEPVSLTSD  420
         ********877899**********************************************
S: 179   iWavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqed  238
         +W++Gv++yvlLsg sPfldes++et+lni+++++sf++++f+g+ ++A++F++ +L +d
Q: 421   LWSLGVVTYVLLSGASPFLDESAEETCLNICRLDFSFPRDYFQGVGQAARDFICLLLRTD  480
         ************************************************************
S: 239   prkRPsaaecLqhpWl  254
         p +RP a  cLq+ Wl
Q: 481   PGRRPPAGLCLQEAWL  496
         ***************8
Domain Sequence
(FASTA)
YTEVVELGRG RFSVVKRCDQ QGVKRLVAVK QVNKKLMRRD RVTQELNLLQ RLQHPNIVSL 60
IDTYETPSSY ALVLEMADQG RLLDYIVSWG NLTEEKVACY LKDILEALHY LHNCRIVHLD 120
VKPENLLVAN DSSGQPTVKL TDFGDAVQLS SLPYVHPLLG SPEFASPELV LGEPVSLTSD 180
LWSLGVVTYV LLSGASPFLD ESAEETCLNI CRLDFSFPRD YFQGVGQAAR DFICLLLRTD 240
PGRRPPAGLC LQEAWL 256
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00018
EKS-ANC-00016
EKS-HOS-00021
EKS-ICT-00019
EKS-LOA-00019
EKS-MAM-00020
EKS-TEN-00032
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity
GO:0035023; P:regulation of Rho protein signal transduction
KEGG
InterPros
IPR001251; CRAL-TRIO_dom.
IPR000219; DH-domain.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR018159; Spectrin/alpha-actinin.
IPR002017; Spectrin_repeat.
Pfam
PF07679; I-set; 1.
PF00069; Pkinase; 1.
PF00621; RhoGEF; 2.
PF00018; SH3_1; 1.
PF00435; Spectrin; 3.
SMARTs
SM00408; IGc2; 1.
SM00233; PH; 2.
SM00325; RhoGEF; 2.
SM00220; S_TKc; 1.
SM00516; SEC14; 1.
SM00326; SH3; 2.
SM00150; SPEC; 7.
Prosites
PS50191; CRAL_TRIO; 1.
PS50010; DH_2; 2.
PS50835; IG_LIKE; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013