EKS-GAA-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	356.8	9.5E-107	13	265	253

Status

Unreviewed

Ensembl Protein

ENSGACP00000010854

UniProt Accession

G3NZT1;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000008202	ENSGACP00000010854	ENSGACT00000010877

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

915

Protein Sequence
(FASTA)

MSVSIGEKIE DFKVLTLLGK GSFACVYRAK SVKTGLEVAI KTIDKKAMHK AGMVQRVINE 60

VEIQCRLKHP SILELYNYFE DSNYVYLVLE MCHNGEMSRH LKERKMSFSE DEARHFMHQI 120

LKGMLYLHTH GILHRDLTLS NLLLTSNMNI KIADFGLATQ LKLPNEKHFT MCGTPNYISP 180

EVATHSAHGL ESDVWSLGCM FYAFLMGRPP FDTDTVKHTL SKVVLGEYDM PSHISPEAQD 240

LIHLLLQRDP GHRPSLSAVL DHPFMTQNRL VRTKELGVGE DGSMDSGIAT ISTACTSSTS 300

AGSNSRLQRR TRHVIGSALP NRMMPIPILP RQTNPACYED GDQWQQQHQA ERFHREGRSR 360

GVQGGDSGQP HSRYLRRAHS SECSGSSASG HGPSHAELGR CHSEENLTGL ERTVFPMSST 420

PHPFSQHGKH PSPPAKQSPN SGYLFPSQIA HPPNSQFQDL EGVTNWLNNE GSGQRPTDNS 480

THSSGGGSFH SSRGPLGVHN SWTDKPMSRG VNPHHNLASS CDSYRENLPG AEFQPPRGSE 540

LKLPPGVAKE KKTLRDVVPP LCASRLKPIR QKTKNAVVSV LDTGEVCMEL LKCHGGQERV 600

KEVLRISCDG SMVTIYQPNG GKGFPVLDCP PAPPEDILIC SYEDLPEKYW KKYQYASKFV 660

QLVKSKTPKV TLYTKYAKVM LMENSPNADL EACFYDGAKT HKTSELVRVV EKSGKSYTVK 720

GEAGLSGLSP ESRLHVELSD EGHSMCLSLE AAITAEEQRS TKKVPFFPIT IGRRPANPDT 780

PGSSALPPHP VPPDTSPPKP PQITPSMISY DGSDFTTASV SKKCSPLQQD TGKVVKSIFV 840

PNVGWASQLT SGEVWVQFND GSQLVVQAGV SCITYTSPEG RITRYKENEK LPEHVKEKLH 900

CLSTILGLLA NPTAY 915

Nucleotide Sequence
(FASTA)

ATGAGTGTTT CCATCGGCGA GAAGATCGAG GATTTCAAGG TCCTCACCCT CCTCGGCAAA 60

GGCTCCTTTG CGTGTGTTTA CCGGGCCAAA TCGGTGAAGA CTGGCCTGGA GGTCGCCATC 120

AAAACGATTG ACAAAAAAGC AATGCACAAG GCCGGTATGG TGCAACGTGT GATCAACGAG 180

GTGGAGATTC AGTGCCGGTT GAAACATCCT TCTATACTTG AGCTCTACAA CTACTTTGAA 240

GACAGCAACT ACGTGTACTT GGTGTTGGAG ATGTGCCACA ATGGGGAGAT GAGTCGGCAC 300

CTTAAAGAGC GGAAAATGTC TTTCTCCGAG GATGAAGCAA GACATTTCAT GCATCAAATA 360

TTGAAGGGGA TGCTTTATTT ACACACCCAC GGCATCCTGC ATCGAGATCT GACGCTGTCG 420

AACCTTTTGC TGACGAGCAA CATGAACATT AAGATCGCAG ACTTTGGCCT CGCCACTCAG 480

CTCAAACTCC CAAATGAAAA GCACTTCACC ATGTGTGGGA CGCCCAACTA CATCTCCCCG 540

GAGGTGGCCA CCCACAGCGC CCACGGTCTT GAATCCGATG TCTGGTCCCT GGGCTGCATG 600

TTCTACGCCT TTCTGATGGG CCGCCCCCCG TTTGACACTG ACACGGTCAA ACACACTCTG 660

TCTAAAGTGG TTCTCGGCGA GTACGATATG CCGAGCCACA TTTCTCCAGA GGCTCAGGAT 720

CTGATCCATC TCCTGCTGCA GAGGGACCCC GGCCATCGTC CCAGCCTCTC TGCAGTGCTG 780

GACCACCCGT TCATGACCCA GAACCGGCTG GTTAGGACCA AGGAGCTGGG GGTGGGGGAG 840

GACGGTTCCA TGGACAGCGG CATTGCCACC ATCTCCACGG CCTGCACCTC CTCCACCTCG 900

GCCGGCAGCA ATAGCCGCCT CCAGAGGAGG ACCAGGCACG TGATTGGCTC AGCCCTGCCT 960

AACCGAATGA TGCCTATTCC AATCCTCCCA CGCCAAACCA ACCCCGCCTG CTATGAAGAC 1020

GGCGACCAGT GGCAGCAGCA GCATCAGGCG GAGCGATTTC ACAGAGAGGG GAGGAGCAGG 1080

GGGGTTCAAG GTGGAGACAG CGGGCAGCCT CACTCTCGCT ACCTGAGGAG GGCTCACTCG 1140

TCAGAATGCT CCGGCTCGTC GGCCTCCGGC CACGGGCCGA GTCACGCCGA GCTCGGGAGA 1200

TGTCACTCCG AGGAGAATCT CACTGGTTTG GAAAGAACGG TCTTCCCGAT GTCCTCCACC 1260

CCGCACCCGT TTTCACAGCA CGGAAAGCAC CCGTCCCCCC CCGCCAAGCA GTCCCCAAAC 1320

TCCGGGTATT TGTTTCCCTC ACAGATTGCA CATCCACCAA ACTCGCAATT TCAAGACCTG 1380

GAGGGAGTTA CGAATTGGCT CAACAATGAG GGTTCTGGGC AGAGACCCAC AGACAACAGC 1440

ACTCACAGCA GCGGCGGCGG CAGCTTCCAC AGCAGCAGAG GTCCTTTGGG GGTCCACAAT 1500

TCCTGGACAG ACAAACCCAT GAGCCGAGGT GTAAACCCTC ATCACAACCT GGCCTCCAGC 1560

TGCGACTCGT ACAGGGAGAA TCTACCCGGA GCAGAGTTCC AACCTCCTCG CGGCAGCGAA 1620

TTAAAGCTCC CACCCGGCGT GGCTAAAGAG AAGAAAACGC TGCGAGACGT CGTCCCGCCT 1680

CTGTGCGCGT CCAGATTAAA GCCCATCCGA CAGAAAACCA AAAACGCCGT GGTGAGCGTC 1740

CTGGACACGG GGGAAGTGTG TATGGAGTTG TTAAAATGCC ACGGTGGTCA AGAGAGGGTC 1800

AAAGAAGTCC TTCGGATTTC CTGTGACGGT TCGATGGTGA CAATATACCA GCCCAATGGT 1860

GGGAAGGGGT TTCCTGTCTT GGACTGTCCT CCTGCTCCTC CAGAAGATAT TCTGATCTGT 1920

AGCTACGAGG ACCTTCCAGA AAAATACTGG AAGAAGTACC AATACGCCTC CAAGTTTGTG 1980

CAGCTCGTGA AATCCAAAAC TCCTAAAGTG ACCCTTTACA CCAAATATGC AAAGGTCATG 2040

CTGATGGAGA ACTCTCCCAA TGCAGACCTG GAAGCTTGCT TCTATGACGG CGCGAAGACT 2100

CACAAGACGT CCGAGCTGGT GCGAGTGGTG GAGAAGAGCG GGAAGTCGTA CACCGTGAAG 2160

GGCGAGGCGG GGCTGAGCGG CCTGAGCCCG GAGAGCCGGC TGCACGTGGA GCTGTCCGAT 2220

GAGGGCCACA GCATGTGTTT GTCCCTGGAG GCCGCCATCA CCGCCGAGGA GCAGCGCAGC 2280

ACCAAGAAGG TCCCCTTCTT CCCCATAACG ATTGGCAGGA GACCTGCCAA CCCAGACACT 2340

CCGGGCTCGT CAGCCCTGCC CCCCCACCCG GTGCCTCCTG ATACTTCACC TCCTAAACCT 2400

CCTCAAATCA CTCCTTCGAT GATCTCCTAC GATGGGTCAG ATTTCACCAC GGCCAGTGTG 2460

AGTAAGAAAT GCTCCCCACT GCAACAGGAC ACGGGAAAAG TGGTGAAGTC CATATTCGTG 2520

CCCAATGTCG GATGGGCGTC CCAGCTGACG AGCGGAGAGG TGTGGGTGCA ATTCAACGAC 2580

GGCTCTCAGC TGGTGGTTCA GGCCGGAGTT TCCTGCATCA CCTACACGTC TCCTGAGGGG 2640

AGGATCACCA GGTACAAGGA GAACGAGAAG TTGCCCGAGC ACGTCAAGGA GAAACTGCAC 2700

TGTCTCTCCA CCATCCTGGG ACTGCTGGCC AACCCCACAG CGTAT 2745

Domain Profile

S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61

         ++  llGkG+fa +y++k+++t+ ++a+k+++k++++k+ + ++v +e+ei ++lkh++i

Q: 13    KVLTLLGKGSFACVYRAKSVKTGLEVAIKTIDKKAMHKAGMVQRVINEVEIQCRLKHPSI  72

         67789*******************************************************

S: 62    vklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekri  120

         ++ly++fed+++vylvle+c+++++ + lk+r  +++e e+r++++qi++g++ylh++ i

Q: 73    LELYNYFEDSNYVYLVLEMCHNGEMSRHLKERkMSFSEDEARHFMHQILKGMLYLHTHGI  132

         ***************************99999458*************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdl+l+nl+l++++++ki+dfGlat+l+ ++e++ t+cGtPnyi+Pev+++++h+le+

Q: 133   LHRDLTLSNLLLTSNMNIKIADFGLATQLKLPNEKHFTMCGTPNYISPEVATHSAHGLES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++y++l+G+PPf+t+++k+t++k++  ey +Ps++s+ea++li+ ll+++P +

Q: 193   DVWSLGCMFYAFLMGRPPFDTDTVKHTLSKVVLGEYDMPSHISPEAQDLIHLLLQRDPGH  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++vl+++f+

Q: 253   RPSLSAVLDHPFM  265

         ***********98

Domain Sequence
(FASTA)

KVLTLLGKGS FACVYRAKSV KTGLEVAIKT IDKKAMHKAG MVQRVINEVE IQCRLKHPSI 60

LELYNYFEDS NYVYLVLEMC HNGEMSRHLK ERKMSFSEDE ARHFMHQILK GMLYLHTHGI 120

LHRDLTLSNL LLTSNMNIKI ADFGLATQLK LPNEKHFTMC GTPNYISPEV ATHSAHGLES 180

DVWSLGCMFY AFLMGRPPFD TDTVKHTLSK VVLGEYDMPS HISPEAQDLI HLLLQRDPGH 240

RPSLSAVLDH PFM 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013