EPS-GAA-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAA-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	276.4	3.7E-82	23	290	268

Status

Unreviewed

Ensembl Protein

ENSGACP00000011134

UniProt Accession

G3P0L1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000008424	ENSGACP00000011134	ENSGACT00000011157

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MGAFLDKPKM EKYNSRGEGN DLRYGLSSMQ GWRVEMEDAH TAVIGLAHGL DPWSFFAVYD 60

GHAGSQVAKY CCEHLLEHIT TNSDFQSALQ EDPSVDSVKN GIRTGFLQID EHMRTISEKK 120

HGVDRSGSTA VGVMIAPSHI YFINCGDSRG LLSRGGAVHF FTQDHKPSNP LEKERIQNAG 180

GSVMIQRVNG SLAVSRALGD FDYKCVHGKG PTEQLVSPEP EVYAIERCEG EDEFIILACD 240

GIWDVMANEE LCDFVRSRLE VTDDLERVSN EIVDTCLYKG SRDNMSVVLI CFPGAPKVSP 300

EAVKREAELD KYLEGRVEEI LKKQGDEGPP DLVHVMRTLA SESIPNLPPG GELASKRSVI 360

EAVYNKLNPY RSDDTDSAST DDMW 384

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTCTGGACAA ACCAAAGATG GAAAAATACA ATTCCCGCGG TGAGGGCAAC 60

GACCTGAGGT ATGGGCTGAG CAGCATGCAG GGTTGGCGAG TGGAGATGGA AGATGCGCAC 120

ACAGCCGTTA TCGGGCTGGC CCACGGTCTC GATCCCTGGT CGTTCTTCGC TGTTTATGAC 180

GGGCATGCTG GCTCTCAGGT GGCCAAGTAC TGCTGTGAGC ACCTGCTGGA GCACATCACC 240

ACCAACTCAG ACTTCCAGAG TGCTTTGCAG GAGGACCCCT CCGTAGATAG CGTGAAGAAT 300

GGGATCCGCA CGGGGTTCCT GCAGATTGAC GAACACATGC GAACCATCTC CGAGAAAAAG 360

CATGGTGTGG ACCGCAGTGG TTCCACGGCA GTGGGAGTGA TGATCGCTCC CAGCCACATC 420

TACTTTATCA ATTGCGGCGA CTCAAGGGGC CTCCTCAGCC GGGGCGGAGC TGTGCACTTC 480

TTCACGCAAG ATCACAAACC CAGCAACCCC CTGGAGAAGG AAAGGATCCA GAACGCAGGC 540

GGCTCAGTCA TGATCCAGCG AGTTAACGGT TCTTTAGCGG TGTCCCGGGC TTTGGGAGAC 600

TTCGACTACA AGTGTGTGCA TGGAAAAGGT CCGACAGAGC AGCTTGTGTC CCCGGAACCC 660

GAAGTGTATG CAATAGAGAG ATGCGAGGGC GAAGATGAAT TCATTATACT AGCCTGTGAT 720

GGCATCTGGG ATGTCATGGC CAATGAGGAA CTGTGTGACT TTGTCAGGTC AAGACTAGAG 780

GTGACCGATG ATCTTGAAAG AGTCAGCAAT GAGATTGTTG ACACCTGCTT GTACAAGGGG 840

AGCCGAGACA ATATGAGTGT TGTTTTAATC TGCTTTCCTG GGGCACCAAA GGTCTCTCCA 900

GAAGCAGTGA AACGGGAGGC TGAGCTGGAC AAATATCTGG AGGGCAGAGT AGAAGAGATT 960

CTTAAAAAGC AGGGGGATGA AGGTCCCCCG GATTTGGTCC ATGTTATGCG GACGTTAGCA 1020

TCTGAGAGCA TCCCTAACCT CCCCCCCGGG GGAGAGCTGG CGAGCAAACG AAGTGTTATT 1080

GAAGCAGTCT ATAACAAGCT CAATCCCTAC CGAAGCGATG ACACAGACTC TGCGTCCACA 1140

GACGACATGT GGTAA 1155

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ +++   +    ++ff+vyDGh+gs+vak+c e+l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVIGLAHGLDP---WSFFAVYDGHAGSQVAKYCCEHLLEHI  79

         69*****************98888887665...***************************

S: 62    aeele.....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsk  116

         +++ +     +++++ + vk+ ++++Fl++de+++ ++ek++  d+sGstav ++i +s+

Q: 80    TTNSDfqsalQEDPSVDSVKNGIRTGFLQIDEHMRTISEKKHGVDRSGSTAVGVMIAPSH  139

         ***999999989999999******************************************

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsR  176

         +y++n+GdSr +L+r+g ++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsR

Q: 140   IYFINCGDSRGLLSRGGAVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSR  196

         ***********************************************...**********

S: 177   alGdlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeavslvr  226

         alGd+++k         ++v+pePev+ +++ + edef+iLa+DG+wdv+ nee++++vr

Q: 197   ALGDFDYKcvhgkgpteQLVSPEPEVYAIERcEGEDEFIILACDGIWDVMANEELCDFVR  256

         *******************************677888***********************

S: 227   dvlekkeaeqeaakkLvklalargskdnvsaivv  260

         ++le +++++ +++++v+++l +gs+dn+s++++

Q: 257   SRLEVTDDLERVSNEIVDTCLYKGSRDNMSVVLI  290

         *****************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLAHGLDP WSFFAVYDGH AGSQVAKYCC EHLLEHITTN 60

SDFQSALQED PSVDSVKNGI RTGFLQIDEH MRTISEKKHG VDRSGSTAVG VMIAPSHIYF 120

INCGDSRGLL SRGGAVHFFT QDHKPSNPLE KERIQNAGGS VMIQRVNGSL AVSRALGDFD 180

YKCVHGKGPT EQLVSPEPEV YAIERCEGED EFIILACDGI WDVMANEELC DFVRSRLEVT 240

DDLERVSNEI VDTCLYKGSR DNMSVVLI 268

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013