EKS-GAA-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	453.0	4.1E-136	356	625	270

Status

Unreviewed

Ensembl Protein

ENSGACP00000011634

UniProt Accession

G3P211;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK1 (1 of 2)

Gene Synonyms/Alias

LIMK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000008799	ENSGACP00000011634	ENSGACT00000011658

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

670

Protein Sequence
(FASTA)

MRLMLLCCTW KDERMGEEEA GGRLPVCAGC KQRIYDEQYL QALSCDWHSV CFRCCECSAS 60

LSHWYYEKDG RLYCKKDYWA KFGELCHGCN DPITTGLIMV AGEQKYHPEC FTCLNCRTFI 120

GDGDTYALVE RSKLYCGHCY YQTVVTPLSL PDTPCPRIPH TVTLVSIPAS VEGSNGRRGR 180

GFSVAIDQPL SPINGYSPEH GPTVRVSQVE PDCISPDVKN SIHVGDRILE INGTPIHNVP 240

LDEIDLLIQE TSRRLQLTIE HDPHSLEGGP SEAGEPVDGP LSPPLSGGLV LPITQPPNPD 300

INNLRSRIIT RSYSIDKSPG SSNAASPISQ RKDINRSESL RVVSNQTHRI FRPSDLIHGE 360

VLGKGCFGQA IKVTHKETGE VMVMKELIRF DDETQRTFLK EVKVMRCLDH PNVLKFIGVL 420

YKDKRLNFIA EYIKGGTLRE IIKKMDSNYP WKRRVSFAKD IAAGMTYLHS MNIIHRDLNS 480

HNCLVRENNT VVVADFGLSR LMVDDKHEET LSQGKLPGLK KHDRRKRYTV VGNPYWMAPE 540

MIHGKSYDER VDIFSFGIML CEIIGRVNAD PDYLPRAMDF GLNVSGFLEH FCPPDCPPAY 600

FPMAAVCCEL DADKRPAFSK LDEWLENLKM HLDMGLPLVS EVEQLHKTFW KNHSGARPEN 660

GLHAHPQQPE 670

Nucleotide Sequence
(FASTA)

ATGAGGTTGA TGCTGCTCTG CTGCACCTGG AAGGACGAAC GCATGGGAGA GGAGGAAGCC 60

GGAGGACGTT TGCCCGTGTG CGCGGGATGC AAACAGAGGA TCTACGATGA GCAGTACCTC 120

CAGGCCCTCA GCTGTGACTG GCACAGCGTC TGCTTCAGGT GCTGCGAGTG CAGCGCTTCG 180

CTGTCCCACT GGTACTACGA AAAAGATGGA CGACTCTACT GCAAGAAGGA CTACTGGGCC 240

AAATTCGGGG AGCTGTGCCA CGGCTGCAAC GACCCGATCA CCACCGGCCT CATCATGGTC 300

GCAGGGGAAC AGAAATATCA CCCAGAGTGC TTCACCTGTC TGAACTGCAG AACATTTATC 360

GGGGATGGCG ACACATACGC TCTGGTGGAG AGATCCAAAC TCTACTGCGG TCACTGTTAC 420

TACCAGACCG TCGTCACGCC GCTGTCCCTG CCGGACACGC CGTGCCCACG GATCCCTCAC 480

ACGGTCACAC TCGTGTCCAT CCCGGCCTCC GTCGAGGGCA GCAACGGACG CAGAGGACGA 540

GGTTTCTCCG TGGCCATCGA CCAGCCGCTC AGCCCGATCA ACGGCTACAG CCCCGAGCAC 600

GGACCCACAG TCAGAGTCTC CCAGGTGGAA CCAGACTGCA TCAGTCCAGA TGTGAAAAAC 660

TCCATCCACG TTGGAGATAG GATCCTTGAA ATCAACGGGA CGCCCATACA CAACGTCCCT 720

CTGGATGAGA TCGACCTGCT CATCCAGGAG ACCAGTCGGC GGCTGCAGCT CACTATCGAG 780

CACGACCCCC ACAGTCTGGA GGGAGGCCCC TCGGAGGCCG GGGAGCCAGT GGACGGCCCC 840

CTGTCCCCCC CGCTGTCGGG GGGCCTCGTC CTGCCCATCA CACAGCCCCC CAACCCCGAC 900

ATCAACAACC TCAGATCCCG CATCATCACA CGGAGCTACA GCATCGATAA GTCTCCGGGC 960

TCCAGCAACG CAGCGTCCCC CATCTCCCAG AGGAAGGACA TCAATCGATC GGAGTCGCTC 1020

CGCGTCGTGT CCAATCAGAC GCATCGCATC TTCCGGCCGT CTGACCTCAT CCACGGAGAG 1080

GTGCTGGGGA AGGGCTGCTT CGGACAGGCC ATCAAGGTGA CCCACAAGGA AACTGGGGAG 1140

GTGATGGTGA TGAAAGAGTT GATCCGCTTC GATGACGAGA CTCAGAGAAC ATTCCTCAAA 1200

GAGGTAAAAG TCATGCGGTG CCTGGATCAC CCCAACGTGC TCAAGTTCAT CGGAGTCCTC 1260

TACAAGGACA AGAGGCTCAA CTTCATCGCA GAGTACATAA AGGGAGGCAC CCTGAGAGAA 1320

ATCATCAAGA AAATGGACAG CAACTATCCC TGGAAACGCC GGGTCAGCTT CGCCAAGGAC 1380

ATAGCTGCTG GGATGACATA TCTGCATTCC ATGAACATAA TCCACCGGGA CCTCAACTCC 1440

CACAACTGTC TAGTCCGGGA GAACAACACG GTGGTGGTGG CAGACTTCGG GCTGTCCCGT 1500

CTCATGGTGG ACGACAAGCA CGAGGAGACG TTGTCGCAGG GTAAGCTGCC CGGCCTCAAG 1560

AAGCACGACC GCAGAAAGCG GTACACGGTG GTGGGAAACC CCTACTGGAT GGCTCCTGAG 1620

ATGATCCACG GGAAGAGCTA CGATGAGAGA GTAGACATCT TCTCCTTTGG TATAATGCTC 1680

TGCGAGATAA TTGGCAGGGT GAACGCGGAC CCGGACTACC TCCCCAGGGC GATGGACTTC 1740

GGACTGAACG TGTCTGGTTT CCTGGAGCAC TTCTGTCCTC CTGATTGTCC CCCCGCCTAC 1800

TTCCCCATGG CTGCTGTGTG CTGTGAGCTC GACGCCGACA AACGACCGGC TTTCTCCAAA 1860

CTTGACGAGT GGCTTGAGAA CCTGAAGATG CACCTGGACA TGGGTTTACC GCTGGTGTCC 1920

GAAGTGGAGC AGCTGCACAA GACCTTCTGG AAGAACCACA GCGGCGCGCG GCCCGAAAAC 1980

GGTCTGCACG CCCACCCCCA ACAGCCGGAG TAA 2013

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkG+f++++kvth+++Gevmv+kelir+d+e+++++lkevk++r+l+hpnvlk

Q: 356   LIHGEVLGKGCFGQAIKVTHKETGEVMVMKELIRFDDETQRTFLKEVKVMRCLDHPNVLK  415

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119

         fiGvl+kdk+l++++eyi+gGtl+e++k+++s +pw++rv++akdia+G++ylhs++iih

Q: 416   FIGVLYKDKRLNFIAEYIKGGTLREIIKKMDSnYPWKRRVSFAKDIAAGMTYLHSMNIIH  475

         *******************************99***************************

S: 120   rdlnsknclvredksvvvadfGlarlvveerkks....eklrslkkkdrkkrltvvGsPy  175

         rdlns+nclvre+++vvvadfGl+rl+v+++++      kl+ lkk+dr+kr+tvvG+Py

Q: 476   RDLNSHNCLVRENNTVVVADFGLSRLMVDDKHEEtlsqGKLPGLKKHDRRKRYTVVGNPY  535

         *****************************9988777779*********************

S: 176   wmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaed  235

         wmaPe+++gksyde+vd+fsfGi+lceii+rv+adPdylPr++dfgl+v+ f e++++ d

Q: 536   WMAPEMIHGKSYDERVDIFSFGIMLCEIIGRVNADPDYLPRAMDFGLNVSGFLEHFCPPD  595

         ************************************************************

S: 236   cPeaflklavvccdldpesrpsfeelekkl  265

         cP+a++++a+vcc+ld+++rp+f++l+++l

Q: 596   CPPAYFPMAAVCCELDADKRPAFSKLDEWL  625

         **************************9997

Domain Sequence
(FASTA)

LIHGEVLGKG CFGQAIKVTH KETGEVMVMK ELIRFDDETQ RTFLKEVKVM RCLDHPNVLK 60

FIGVLYKDKR LNFIAEYIKG GTLREIIKKM DSNYPWKRRV SFAKDIAAGM TYLHSMNIIH 120

RDLNSHNCLV RENNTVVVAD FGLSRLMVDD KHEETLSQGK LPGLKKHDRR KRYTVVGNPY 180

WMAPEMIHGK SYDERVDIFS FGIMLCEIIG RVNADPDYLP RAMDFGLNVS GFLEHFCPPD 240

CPPAYFPMAA VCCELDADKR PAFSKLDEWL 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013