EKS-GAA-00375
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00375
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk503.22.1E-151564833270
StatusUnreviewed
Ensembl ProteinENSGACP00000011618
UniProt AccessionG3P1Z5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLTK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000008800ENSGACP00000011618ENSGACT00000011641
OrganismGasterosteus aculeatus
Functional Description
Protein Length1173
Protein Sequence
(FASTA)
ADWEVLQNVI GQVDEPFQVI LRYTSCLRTG EGTLALDSLE FIDCESDHQF LGLEAACGES 60
FHCENSGVCI DQSQVCNFHT DCPLGEDEGF ICEVSLMTWL FNSCGASGPL GPTQAQCDST 120
YRNQNVSVTV GKEDPLKGVQ MWRVPATNRY LISAYGAAGG KGAKNHNKRN HGVFISGTFP 180
LEKGDILYIL VGHQGEDACP GRNPHTQRIC LGESSVIEDK LRGESGVEWA GGGGGGGGAT 240
YIFKMEGDDL VPLLVAAGGG GNAYLEDPES SLEKLELEQY ENSTMAPSTN GQTGAAGGGG 300
GWKDSQSSHL KAGKSLAEGA EGGSSCSLAL SKLSWSTFGG FGGGGGACTA GGGGGGYRGG 360
DAALKDEITS DGQNGISFIH PMGEIFLQPL AAMESHGDCE IKVHLNCSHC ETRSCKREKN 420
TQLILCLCED DNKVLASDNV TCVSALANPS KSKPKRLLNS SSFLLPPPRA DPDGLQGKMS 480
TSFILAVVVS TVASGVALIG TAVILMWYRR KNNLDAVNGH LWSPEYKLSK LRSSTIMTDY 540
NPNYCFAGKA ACLNELKEVP RKNITLLRAL GHGAFGEVYE GQVLGMSGDN SPLQVAIKTL 600
PEICSEQDEM DFLMEALIMS KFSHDNIVRC IGVSLNILPR FILLELMTGG DMKSFLRQNR 660
PRAGQTSSLT MRELLQMARD IAFGCRYLEE NHFIHRDIAA RNCLLTCPGP DRVAKIGDFG 720
MARDIYRASY YRKGGRAMLP VKWMPPEAFM EGVFTCKTDT WSFGVLLWEI LSLGFMPYPC 780
KTNQEVLEFV TSGGRMDPPK SCPGPVYRIM TQCWQHCPEH RPNFSTILER IDYCSQDPDV 840
INTPLPVEYA PAADDKGGPT ILPSDLASLT PLLVSHPVSQ AFPSQLGVSS LGLGPTPLPP 900
QPTKPRVLLQ RTQPVHQEVT SCREALQPCW AEPVPAPGLP AGGHWLHPEP SGHQPCSRNS 960
SSSGSQRLKN KTKNLWNPTY GSWVLESFRG KKTLAHTQSM PLSSSATTAP NTQAPHTCNA 1020
NCEHNEAECN SAHPPPPGLC TSSTSSPSGP TKTPPSTSSH KTPTSGPVRA GTDLAKLQSF 1080
PCGNVNYAYD EQSYEAESAP VKNSSFAPVA SAGSGPGTGV WPHAASSCVP KLLLKRHASY 1140
GHEDVRRHAK AEKPARDRDS GFSLSEDLSV NPV 1173
Nucleotide Sequence
(FASTA)
GCTGACTGGG AGGTTCTGCA GAATGTGATT GGTCAAGTGG ACGAGCCCTT CCAGGTGATC 60
CTGCGCTACA CTTCCTGTTT GAGGACAGGT GAAGGCACCT TGGCCCTGGA CTCTCTGGAG 120
TTCATAGACT GTGAATCGGA TCACCAGTTC CTCGGACTGG AGGCGGCTTG TGGGGAATCT 180
TTCCACTGTG AGAATTCCGG AGTCTGCATC GACCAGAGCC AAGTGTGCAA CTTTCACACC 240
GACTGTCCTT TAGGGGAGGA CGAGGGCTTC ATCTGTGAGG TTTCTTTGAT GACGTGGTTG 300
TTCAACTCAT GTGGTGCCAG TGGTCCCCTC GGCCCGACCC AGGCCCAGTG TGACAGCACC 360
TACAGGAACC AAAATGTCAG CGTTACTGTG GGGAAGGAAG ATCCCTTGAA AGGAGTCCAA 420
ATGTGGAGGG TCCCTGCTAC AAACCGATAC CTGATCTCCG CTTACGGGGC CGCAGGAGGG 480
AAAGGAGCCA AAAACCACAA CAAGCGCAAC CACGGGGTCT TCATATCTGG CACATTTCCT 540
CTGGAGAAAG GAGATATTCT GTACATCTTG GTGGGCCACC AGGGAGAGGA CGCGTGCCCC 600
GGGAGAAACC CCCACACGCA GAGGATCTGC CTGGGAGAGT CGTCAGTGAT TGAAGACAAA 660
CTGAGGGGGG AGAGCGGTGT GGAGTGGGCC GGAGGAGGAG GCGGAGGAGG CGGAGCCACC 720
TACATCTTTA AGATGGAGGG AGATGACCTG GTTCCCTTGC TGGTTGCGGC TGGTGGAGGA 780
GGAAACGCCT ACCTGGAGGA CCCAGAGTCC AGTCTGGAGA AGTTAGAACT GGAACAGTAT 840
GAAAACAGCA CCATGGCTCC CAGCACCAAT GGCCAGACCG GGGCTGCAGG TGGAGGTGGA 900
GGCTGGAAAG ACAGTCAAAG TTCCCACCTG AAAGCGGGGA AGTCTCTGGC GGAGGGGGCC 960
GAGGGGGGGT CCTCGTGTTC CCTCGCCCTG TCCAAGCTCA GCTGGTCGAC CTTTGGGGGA 1020
TTTGGGGGTG GAGGTGGGGC CTGCACGGCT GGAGGCGGTG GAGGAGGTTA CAGAGGAGGT 1080
GACGCCGCAC TGAAGGACGA GATCACATCC GACGGTCAGA ACGGAATCTC ATTCATTCAT 1140
CCGATGGGAG AGATTTTCCT TCAGCCTCTG GCAGCCATGG AGAGTCATGG CGATTGTGAG 1200
ATCAAGGTGC ATCTGAACTG CAGCCACTGT GAAACACGCA GCTGCAAACG AGAAAAGAAT 1260
ACCCAGCTCA TCCTCTGCCT CTGCGAAGAT GACAACAAAG TCCTGGCCAG CGACAACGTC 1320
ACGTGCGTCA GCGCCCTGGC AAATCCGTCA AAATCCAAAC CAAAGCGGCT TTTGAATTCT 1380
TCTTCTTTTC TCCTCCCTCC TCCGCGAGCA GATCCCGATG GCCTGCAGGG CAAGATGTCC 1440
ACCTCTTTCA TCCTGGCAGT CGTGGTCTCC ACCGTTGCGA GCGGCGTGGC GCTGATCGGC 1500
ACCGCCGTCA TTCTGATGTG GTACCGCAGG AAGAACAACC TTGATGCAGT GAATGGTCAT 1560
CTGTGGAGTC CAGAGTACAA GCTGAGCAAG CTCCGCTCCT CCACCATCAT GACGGACTAC 1620
AACCCCAACT ACTGCTTTGC AGGGAAGGCC GCCTGCCTCA ACGAACTGAA GGAAGTGCCA 1680
CGCAAGAACA TAACGCTCCT CAGGGCTCTT GGCCATGGTG CATTCGGTGA AGTCTACGAA 1740
GGACAGGTTC TGGGCATGAG CGGCGATAAC AGCCCGCTGC AGGTGGCCAT AAAGACTCTT 1800
CCAGAAATCT GCTCCGAACA GGATGAAATG GATTTCCTGA TGGAGGCCCT GATTATGAGC 1860
AAGTTCAGCC ATGACAACAT AGTGCGGTGC ATCGGCGTCA GCCTCAACAT CCTGCCTCGT 1920
TTCATCCTGC TGGAGCTCAT GACGGGAGGA GACATGAAGA GCTTTCTGAG ACAGAACAGG 1980
CCACGGGCGG GCCAGACCTC TTCTCTCACC ATGCGGGAGC TGCTGCAGAT GGCCAGGGAC 2040
ATCGCCTTCG GCTGTCGCTA CCTGGAGGAG AACCACTTTA TACACAGAGA CATTGCTGCT 2100
AGAAATTGCC TGCTTACCTG CCCTGGACCA GACAGAGTGG CCAAAATTGG CGATTTTGGT 2160
ATGGCACGAG ACATTTACAG AGCCAGCTAT TACAGGAAAG GTGGCCGCGC CATGCTGCCG 2220
GTCAAATGGA TGCCACCGGA GGCCTTCATG GAGGGAGTCT TCACATGCAA GACGGATACA 2280
TGGTCTTTTG GGGTGTTGCT GTGGGAAATC CTCTCGCTGG GATTCATGCC GTATCCTTGT 2340
AAAACCAACC AAGAGGTGCT GGAGTTTGTC ACCAGCGGAG GCAGAATGGA TCCTCCCAAG 2400
AGCTGTCCCG GGCCTGTCTA TCGGATCATG ACCCAGTGTT GGCAACACTG TCCCGAGCAC 2460
CGGCCCAACT TCTCTACCAT CCTGGAGAGA ATTGACTACT GCTCTCAGGA CCCGGATGTG 2520
ATCAACACAC CTCTGCCCGT TGAATACGCC CCCGCTGCAG ACGACAAAGG AGGCCCAACA 2580
ATCCTCCCCT CTGACCTCGC CAGCCTCACT CCCCTCTTGG TGTCCCATCC TGTGTCCCAG 2640
GCTTTCCCCT CCCAGCTGGG TGTCTCCTCT CTGGGCCTCG GCCCAACACC GCTTCCCCCA 2700
CAGCCTACCA AACCGCGTGT GCTCCTCCAG AGGACCCAAC CCGTCCACCA AGAAGTGACA 2760
TCGTGCCGCG AGGCTTTGCA GCCGTGCTGG GCGGAGCCCG TGCCGGCCCC CGGTTTGCCG 2820
GCGGGAGGCC ACTGGCTCCA CCCGGAGCCT TCCGGGCACC AGCCGTGCTC CAGAAACAGC 2880
TCCTCTTCGG GGAGCCAGAG GCTGAAGAAC AAGACAAAGA ACCTGTGGAA CCCCACATAC 2940
GGCTCCTGGG TTTTGGAAAG CTTCCGGGGG AAGAAAACGC TGGCTCACAC TCAGTCCATG 3000
CCGCTCTCGA GCTCCGCCAC CACCGCCCCC AACACACAGG CCCCTCACAC CTGCAACGCA 3060
AACTGTGAAC ACAACGAGGC TGAGTGCAAC AGCGCCCACC CGCCGCCGCC CGGCCTCTGC 3120
ACTTCCTCTA CCTCGTCCCC GTCCGGCCCG ACTAAAACGC CCCCGAGCAC GTCCTCCCAT 3180
AAGACCCCGA CAAGTGGGCC CGTCAGAGCC GGTACGGACC TGGCTAAGCT CCAGAGTTTC 3240
CCCTGTGGCA ACGTCAACTA CGCCTACGAC GAGCAGAGCT ACGAGGCCGA AAGCGCGCCC 3300
GTCAAAAACA GCAGCTTTGC CCCCGTGGCC TCCGCGGGGA GCGGCCCTGG GACTGGCGTT 3360
TGGCCTCACG CCGCCTCCTC TTGTGTGCCC AAGCTGCTGC TGAAGCGCCA CGCCAGCTAC 3420
GGGCACGAGG ACGTGAGGCG ACACGCCAAG GCCGAGAAAC CCGCGCGGGA CCGAGACTCC 3480
GGCTTTTCTC TGTCCGAAGA CCTCAGCGTT AACCCCGTCT GA 3522
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i+l+ralG+GafGevyeg+v g++gd+s+l+va+ktlpe +seqde+dfl+eali+skf+
Q: 564   ITLLRALGHGAFGEVYEGQVLGMSGDNSPLQVAIKTLPEICSEQDEMDFLMEALIMSKFS  623
         799*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr+iGvsl+ lpr+illel++GGd+ksflr++rp+  q ssl+m++ll++a+d+a 
Q: 624   HDNIVRCIGVSLNILPRFILLELMTGGDMKSFLRQNRPRAGQTSSLTMRELLQMARDIAF  683
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkggra+lpvkw
Q: 684   GCRYLEENHFIHRDIAARNCLLTCPGPDRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  743
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeaf+eG+ft+ktd+wsfGvllwe++slG++pyp k+nqevle+v++Ggr+d+pk +p
Q: 744   MPPEAFMEGVFTCKTDTWSFGVLLWEILSLGFMPYPCKTNQEVLEFVTSGGRMDPPKSCP  803
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h pe+rp+f +iler+++
Q: 804   GPVYRIMTQCWQHCPEHRPNFSTILERIDY  833
         ***************************986
Domain Sequence
(FASTA)
ITLLRALGHG AFGEVYEGQV LGMSGDNSPL QVAIKTLPEI CSEQDEMDFL MEALIMSKFS 60
HDNIVRCIGV SLNILPRFIL LELMTGGDMK SFLRQNRPRA GQTSSLTMRE LLQMARDIAF 120
GCRYLEENHF IHRDIAARNC LLTCPGPDRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFMEGV FTCKTDTWSF GVLLWEILSL GFMPYPCKTN QEVLEFVTSG GRMDPPKSCP 240
GPVYRIMTQC WQHCPEHRPN FSTILERIDY 270
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00293
EKS-DAR-00653
EKS-DRM-00153
EKS-GAG-00254
EKS-LAC-00314
EKS-MAE-00034
EKS-MEG-00249
EKS-NOL-00277
EKS-ORN-00393
EKS-ORL-00363
EKS-PAT-00291
EKS-PES-00269
EKS-PEM-00167
EKS-PTV-00067
EKS-TAG-00317
EKS-TAR-00396
EKS-XET-00374
EKS-XIM-00391
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR011009; Kinase-like_dom.
IPR023415; LDLR_class-A_CS.
IPR002172; LDrepeatLR_classA_rpt.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00057; Ldl_recept_a; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS01209; LDLRA_1; 1.
PS50068; LDLRA_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013