EKS-GAA-00337

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00337

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.2	9.7E-136	177	464	288

Status

Unreviewed

Ensembl Protein

ENSGACP00000011925

UniProt Accession

G3P2V2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B (1 of 2)

Gene Synonyms/Alias

ACVR1B (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009013	ENSGACP00000011925	ENSGACT00000011949

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

ALHCNCTNCK SGSECETDGA CMASTYYSQG KEQHVRICID RDNLVPPGQP FYCLSAEGLL 60

NTHCCYVDYC NSIEVPVPTK EGDWSGSGSS WGPVELVAVI AGPVFLLCVL LMVGVFLFQY 120

HQRAYSHRQR LEVEDPSCDH LYMAKDKTLQ DLIYDMSTSG SGSGLPLFVQ RTVARTIVLQ 180

EIIGKGRFGE VWRGKWRGGD VAVKIFSSRE ERSWFREAEI YQTIMLRHEN ILGFIAADNK 240

DNGTWTQLWL VSDYHEHGSL FDYLNRYSVT IEGMIKLALS AASGLAHLHM EILGTQGKPG 300

IAHRDLKSKN ILVKKNGMCA IADLGLAVRH ESITDTIDIA PNQRVGTKRY MAPEVLDETI 360

NMKHFDSFKC ADIYALGLVY WEIARRCNAG GIHEEYQLPY YDLVPSDPSI EEMRKLVCEQ 420

KLRPNVPNWW QSYESLRVMG KIMRECWYAN GAARLTALRI KKTLSQLSVE EDVKM 475

Nucleotide Sequence
(FASTA)

GCTCTGCATT GTAACTGCAC AAACTGCAAG TCTGGCTCCG AGTGTGAAAC GGACGGCGCC 60

TGCATGGCCT CCACATACTA CAGCCAGGGC AAGGAGCAAC ACGTGCGCAT CTGCATCGAC 120

CGGGACAACC TGGTCCCTCC GGGACAACCG TTCTACTGCC TGAGCGCCGA AGGCCTGCTC 180

AACACACATT GCTGCTATGT GGATTATTGC AACAGTATTG AAGTCCCGGT CCCGACGAAG 240

GAGGGCGACT GGTCCGGCTC CGGCAGCTCC TGGGGGCCGG TGGAGCTGGT GGCGGTCATC 300

GCCGGGCCGG TGTTCCTCCT CTGTGTGCTG CTGATGGTCG GCGTGTTCCT GTTCCAGTAC 360

CACCAGAGGG CCTACAGCCA CAGGCAGAGG CTGGAGGTGG AGGACCCGTC CTGTGACCAC 420

CTGTACATGG CTAAGGACAA GACCCTGCAG GACCTCATCT ATGACATGTC CACCTCCGGA 480

TCCGGCTCTG GTCTGCCCCT GTTTGTGCAG CGGACTGTGG CAAGGACCAT TGTGCTGCAG 540

GAGATCATAG GAAAGGGTCG TTTTGGGGAG GTGTGGAGGG GGAAATGGCG AGGAGGAGAC 600

GTGGCGGTGA AGATCTTCTC CTCCAGAGAG GAGCGCTCCT GGTTCAGAGA GGCCGAGATC 660

TACCAGACAA TCATGCTGCG CCACGAGAAC ATCCTCGGAT TCATTGCAGC GGACAATAAA 720

GACAACGGTA CATGGACTCA GCTGTGGCTG GTGTCAGACT ATCATGAGCA CGGCTCTCTT 780

TTTGACTATC TTAACCGCTA CTCCGTCACC ATCGAGGGCA TGATCAAACT GGCCCTGTCG 840

GCCGCCAGCG GCCTGGCCCA CCTGCACATG GAGATCCTCG GCACTCAGGG TAAGCCGGGC 900

ATCGCTCACC GGGACCTCAA GTCTAAAAAT ATCCTGGTGA AGAAGAACGG CATGTGTGCC 960

ATCGCTGACC TCGGCCTGGC CGTCCGCCAC GAGTCCATCA CAGACACAAT CGACATAGCG 1020

CCCAACCAAC GCGTGGGCAC CAAGAGGTAT ATGGCTCCAG AAGTCCTGGA CGAAACCATC 1080

AACATGAAAC ACTTTGACTC CTTCAAGTGT GCTGACATTT ACGCGCTGGG CCTTGTGTAC 1140

TGGGAGATAG CTCGCCGCTG CAATGCAGGA GGGATCCACG AGGAGTACCA GCTGCCCTAC 1200

TACGACCTCG TGCCCTCTGA CCCCTCCATA GAGGAGATGA GGAAGTTGGT GTGTGAACAG 1260

AAGCTGAGGC CCAACGTGCC CAACTGGTGG CAGAGCTACG AGTCTCTGCG TGTGATGGGT 1320

AAGATCATGA GGGAGTGCTG GTACGCCAAC GGGGCGGCCC GGCTGACGGC GCTGCGCATC 1380

AAGAAGACCC TGTCTCAGCT CAGCGTGGAG GAGGACGTCA AGATGTGA 1428

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++k+rg +vAvKifs+++e+sw+rE+eiyqt++lrhenil+fia

Q: 177   IVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIA  236

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+ +++e +++lals+asGlahLH+ei gt+

Q: 237   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQ  296

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++e+ ++++d+a n++vGtkRYmaPE

Q: 297   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPE  354

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 355   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNA-GGIHEEYQLPYYDLVPSDPSIEEM  413

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++v+e+klrP++p+ w++ e l+++ k+++ecW+a+++aRltalr+kk+l

Q: 414   RKLVCEQKLRPNVPNWWQSYESLRVMGKIMRECWYANGAARLTALRIKKTL  464

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR EAEIYQTIML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YSVTIEGMIK LALSAASGLA HLHMEILGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHESITDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNAGGIHEEY QLPYYDLVPS DPSIEEMRKL 240

VCEQKLRPNV PNWWQSYESL RVMGKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013