EKS-GAA-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	412.1	1.1E-123	711	967	257

Status

Unreviewed

Ensembl Protein

ENSGACP00000012087

UniProt Accession

G3P3B4;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3 (2 of 2)

Gene Synonyms/Alias

ERBB3 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009144	ENSGACP00000012087	ENSGACT00000012111

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1341

Protein Sequence
(FASTA)

MIKWGVILLS LTLSRCLQIA SCQTHEVVCP GTQNGLSSTG SQEIQYNLIK DRYDGCEIIM 60

GNLEITQIES CRDFSFLKAI REVTGYVLIA MNHFQEIPLG QLRVIRGNSL YERRFALSVF 120

FNYPKDGSNG LRQLGLANLT EILEGGVQII NNKYLNYGPW VFWRDIIRDN GALIDIQHNG 180

EKGPCHKSCG DYCWGPNVDQ CQILTKTVCA PQCNGRCFGT SPRDCCHIEC AAGCKGPLDV 240

DCFACRHFND SEACVPQCPQ TLIYNKQTFQ METNPNAKYQ YGSICVSQCP THFVVDGSSC 300

VSACPPDKME VERDGQKQCE FCSGLCPKVC EGTGAEHRQT VDSSNIDSFI NCTKIQGSLH 360

FLVTGILGDD FKNIPALDAK KLEVFHTVRE ITDILNIQSW PEELNDLSVF SSLTTIQGRS 420

PDNKRRFSLM VMRIHTLTSL GLRSLREISD GSVYISQNAN LCYHHTVNWL QLFRGRRVRV 480

NNFNNNRPLA ECVAQGHVCD PLCSDSGCWG PGPDQCLSCR NYSREGTCVG SCHFYTGAPR 540

EFAGPDGECV ACHPECKHQT GTSSCTALGA DKCLACANLQ DGPFCMSSCP TGVNDGQTGL 600

IFKYPNRQGH CEPCHHNCTQ GCSGPGLNDC LEATRLAVSS GQITGIALGL PAGLVLCLVL 660

FFLGVLYHRG LAIRRKRAMR RYLESGESFE PLGPGEKGTK VHARILRPAD LKKIKSLGFG 720

VFGTVHKGVW TPEGETVKIP VSIKTIQDSS GRQTFTEITD HMLSMGSLDH PYIVRLLGIC 780

PGLSLQLVTQ LSSQGSLLEH IRHHKNSMDP QRLLNWCVQI AKGMYYLEEH RMVHRNLAAR 840

NILLKNDYQV QISDYGVADL LYPDDKKYIY TDTKTPLKWM ALESILFRRY THQSDVWSYG 900

VTVWEMMSFG AEPYASVQPQ EVPSLLEKGE RLSQPHICTI DVYMVMVKCW MIDENIRPTF 960

KELASDFTRM ARDPPRYLVI KLEGGEAASV ELHRRESERG LLQADLEDQH EEGLEDGLTT 1020

PPLQHSPSWS LSRSRINSYR VMKYRLLLDS GTSHIGPIGY LPMNPSPVDS IRQLWLQRSR 1080

LSSVRTLPEK SEFSRSGREA ERHEEGSRTG SLHRARFGSE RETCVSIGRH RKLSSASSPS 1140

SYKVWAAEEE EEVDHYGYVL AGPNLTPQRV CSISHSGQRN SRLKNNLSIV VIYPSQEYEI 1200

MSKESGAPLM RASDDQGGAA QGIGRYEYMD IRRSNSTEGE SPALERCGRQ TSSKSAAKTA 1260

DQIVVLLKKE LEEEGEKYHK TNKLPALQEY EEMTRFGVVP SGWEQADYQN LPLKGEAVNT 1320

SFDNPDYWHS RLFLKPDAVS T 1341

Nucleotide Sequence
(FASTA)

ATGATCAAGT GGGGAGTCAT ATTACTGAGT TTGACATTAT CACGGTGCCT ACAAATAGCA 60

TCATGCCAAA CCCATGAAGT GGTGTGTCCC GGGACGCAGA ATGGACTGAG CTCCACGGGT 120

TCTCAGGAGA TTCAGTACAA CCTGATCAAG GACCGGTACG ATGGCTGTGA GATCATCATG 180

GGAAACCTGG AGATCACTCA GATCGAGAGT TGCCGCGACT TCTCCTTCCT CAAGGCGATC 240

CGTGAGGTGA CCGGCTATGT CCTCATTGCC ATGAACCACT TTCAGGAGAT TCCTTTGGGG 300

CAACTACGGG TCATCAGAGG AAACAGCCTT TACGAGAGAC GCTTCGCTCT CTCTGTCTTC 360

TTCAACTACC CCAAGGATGG CTCCAACGGC CTGCGCCAGC TGGGCCTCGC AAACCTGACA 420

GAGATTCTCG AGGGAGGAGT ACAGATTATC AACAACAAGT ACCTTAATTA TGGCCCCTGG 480

GTCTTCTGGC GAGACATCAT CAGGGACAAT GGTGCTCTCA TTGACATCCA GCACAATGGA 540

GAGAAAGGGC CTTGCCATAA ATCCTGTGGA GATTACTGCT GGGGCCCAAA CGTGGACCAA 600

TGTCAGATCT TGACTAAGAC GGTGTGCGCT CCGCAGTGTA ATGGTCGCTG TTTTGGGACG 660

AGCCCCAGGG ACTGCTGCCA CATAGAATGT GCAGCGGGAT GTAAAGGCCC TCTGGACGTG 720

GATTGTTTTG CATGTCGTCA TTTCAACGAC TCTGAAGCCT GCGTGCCTCA GTGTCCACAG 780

ACTTTGATCT ATAACAAGCA GACATTTCAA ATGGAGACCA ACCCTAATGC CAAATATCAG 840

TACGGATCAA TCTGTGTCTC CCAGTGTCCC ACCCATTTCG TGGTGGACGG TAGCTCCTGT 900

GTGAGCGCTT GTCCACCAGA CAAGATGGAG GTGGAGAGAG ACGGCCAGAA GCAGTGTGAG 960

TTCTGCAGCG GACTCTGCCC AAAAGTGTGT GAAGGCACCG GCGCCGAGCA TCGACAAACG 1020

GTGGACTCCA GCAACATAGA CAGCTTCATC AACTGCACCA AGATCCAGGG CAGCCTTCAC 1080

TTCCTGGTCA CAGGGATTCT CGGAGATGAC TTTAAGAACA TCCCGGCGTT GGATGCCAAA 1140

AAGCTGGAGG TTTTTCACAC CGTCAGAGAA ATAACAGATA TCCTAAACAT CCAGTCGTGG 1200

CCCGAAGAAC TGAATGATCT GTCAGTTTTT TCGAGTCTCA CAACCATTCA AGGGAGGTCT 1260

CCTGACAACA AAAGGCGATT TTCTCTGATG GTGATGCGCA TCCACACTCT TACCTCACTG 1320

GGCTTGCGCT CTCTCCGGGA GATCAGTGAT GGCAGTGTGT ACATCAGTCA GAATGCCAAC 1380

CTCTGTTACC ACCACACGGT GAACTGGCTG CAGCTGTTCA GAGGCCGCAG AGTTCGAGTC 1440

AACAACTTCA ACAACAACAG GCCGCTGGCC GAGTGCGTTG CACAGGGCCA TGTGTGTGAC 1500

CCGCTGTGTT CGGACTCAGG ATGCTGGGGC CCGGGACCCG ACCAGTGTCT CTCCTGCAGG 1560

AACTACAGCC GAGAGGGCAC ATGTGTTGGA AGCTGTCATT TCTACACTGG AGCTCCCAGG 1620

GAATTTGCAG GACCTGATGG TGAGTGCGTT GCCTGTCATC CAGAGTGCAA GCATCAGACT 1680

GGGACGTCCA GCTGTACTGC ACTGGGTGCA GACAAGTGTC TGGCATGCGC CAACCTTCAA 1740

GATGGTCCCT TCTGTATGTC CTCTTGTCCC ACTGGGGTAA ACGATGGACA GACAGGACTG 1800

ATTTTCAAAT ACCCCAACAG GCAAGGTCAC TGTGAACCAT GTCACCATAA CTGCACCCAA 1860

GGATGTTCAG GCCCAGGACT AAATGATTGT TTGGAGGCAA CTAGACTGGC AGTAAGCAGT 1920

GGTCAGATCA CAGGCATAGC CTTGGGTTTG CCGGCTGGCT TGGTGTTATG CCTGGTGTTG 1980

TTCTTCCTGG GCGTGCTTTA CCACAGAGGA TTGGCTATCC GCCGCAAGAG AGCCATGAGG 2040

AGGTACCTGG AGAGCGGAGA GAGCTTTGAG CCACTTGGTC CCGGAGAGAA AGGCACCAAG 2100

GTTCATGCCC GCATCCTCAG GCCTGCAGAC CTGAAGAAAA TAAAATCCCT TGGCTTTGGG 2160

GTTTTTGGTA CAGTGCACAA GGGTGTTTGG ACTCCGGAGG GAGAGACCGT GAAGATCCCT 2220

GTGTCCATTA AAACCATTCA AGATAGCTCG GGCCGACAGA CCTTCACCGA GATCACCGAT 2280

CATATGCTGT CCATGGGCAG CTTGGACCAT CCCTACATTG TTCGGCTGCT GGGCATTTGT 2340

CCAGGTCTCA GTCTGCAACT GGTGACCCAG CTCAGTTCTC AGGGCTCTCT ACTGGAGCAC 2400

ATCAGGCATC ACAAGAACAG CATGGACCCC CAGCGCCTGC TCAACTGGTG TGTGCAGATT 2460

GCTAAAGGTA TGTACTACCT GGAGGAGCAC CGCATGGTCC ACAGGAACCT GGCCGCTCGC 2520

AACATCCTGC TTAAGAACGA CTACCAGGTC CAGATTTCTG ACTACGGTGT AGCAGACCTC 2580

CTCTATCCCG ACGACAAGAA ATACATCTAC ACTGACACCA AGACTCCGTT AAAATGGATG 2640

GCCCTGGAGA GCATCTTGTT TCGAAGATAC ACTCATCAAA GTGACGTTTG GAGTTATGGG 2700

GTGACAGTGT GGGAGATGAT GTCATTCGGG GCGGAGCCTT ATGCATCCGT GCAGCCTCAG 2760

GAGGTGCCGA GTCTGCTGGA GAAGGGCGAA CGCCTGTCAC AGCCCCACAT CTGTACCATA 2820

GACGTCTACA TGGTCATGGT TAAGTGCTGG ATGATCGATG AAAATATAAG GCCGACCTTC 2880

AAGGAGCTGG CCAGCGACTT TACTCGCATG GCAAGAGACC CGCCCAGATA TCTTGTCATC 2940

AAGTTGGAAG GAGGAGAAGC TGCCTCAGTG GAGCTCCATC GGAGGGAATC AGAGCGAGGG 3000

CTTCTGCAAG CGGATTTGGA AGACCAACAC GAGGAAGGCC TGGAGGATGG TTTGACAACT 3060

CCTCCTCTCC AACACTCCCC ATCTTGGAGT CTGTCTCGGT CGCGGATTAA TTCGTACAGG 3120

GTAATGAAAT ATAGACTCTT GTTGGACAGT GGTACCTCTC ATATTGGACC TATTGGATAT 3180

CTGCCAATGA ACCCCAGCCC CGTGGACAGC ATCCGCCAGC TGTGGCTTCA GAGGTCTCGA 3240

CTGAGCTCGG TGCGCACGCT GCCCGAGAAG TCGGAGTTCA GCCGCAGTGG CAGAGAGGCG 3300

GAGCGGCATG AGGAGGGTTC ACGGACCGGG AGTCTTCACA GGGCCAGGTT TGGCTCCGAG 3360

AGGGAAACTT GTGTGTCCAT TGGCCGGCAC AGGAAGCTCT CATCAGCATC AAGTCCATCC 3420

TCGTATAAAG TGTGGGCTGC CGAGGAAGAA GAGGAGGTGG ACCACTATGG CTACGTCCTG 3480

GCTGGGCCAA ATCTTACTCC ACAGAGAGTC TGCAGCATCT CTCATTCCGG ACAAAGAAAC 3540

TCAAGACTCA AGAATAATCT GTCTATTGTG GTTATATACC CCTCCCAGGA GTATGAAATC 3600

ATGAGCAAAG AGTCTGGTGC TCCCCTGATG AGAGCTTCGG ATGACCAAGG AGGGGCAGCT 3660

CAAGGGATAG GCAGGTATGA ATACATGGAT ATCAGACGAT CAAACTCTAC GGAGGGAGAG 3720

TCTCCGGCCC TGGAGAGGTG TGGGCGGCAA ACATCTTCAA AGAGTGCAGC AAAGACAGCG 3780

GACCAAATAG TGGTTTTGTT GAAGAAAGAG CTTGAGGAGG AAGGGGAGAA ATACCACAAG 3840

ACAAACAAAC TACCTGCACT TCAGGAGTAT GAGGAGATGA CCAGATTTGG AGTGGTTCCC 3900

AGTGGGTGGG AGCAGGCGGA CTACCAGAAC CTCCCACTGA AGGGGGAAGC TGTCAACACA 3960

TCATTTGACA ACCCAGACTA CTGGCACAGC AGACTGTTCC TCAAGCCAGA TGCTGTTAGC 4020

ACCTAA 4026

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lkk+k lG G+fGtv+kG+w pege+vkipv+ik +++++g+++++e++d++l ++sldh

Q: 711   LKKIKSLGFGVFGTVHKGVWTPEGETVKIPVSIKTIQDSSGRQTFTEITDHMLSMGSLDH  770

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         +++vrllg+c   +lqlvtql   G+ll+++r+hk+++ +q llnwcvqiakGm+ylee+

Q: 771   PYIVRLLGICPGLSLQLVTQLSSQGSLLEHIRHHKNSMDPQRLLNWCVQIAKGMYYLEEH  830

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         r+vhr+laarn+l+k+  +v+i+d+G+a+ll  d+k++ + ++k+p+kw+alesil+r+y

Q: 831   RMVHRNLAARNILLKNDYQVQISDYGVADLLYPDDKKYIYTDTKTPLKWMALESILFRRY  890

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwe+++fGa+py++++ +e+p+llekGerl+qp+ictidvymv+vkcw

Q: 891   THQSDVWSYGVTVWEMMSFGAEPYASVQPQEVPSLLEKGERLSQPHICTIDVYMVMVKCW  950

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela++f

Q: 951   MIDENIRPTFKELASDF  967

         **************998

Domain Sequence
(FASTA)

LKKIKSLGFG VFGTVHKGVW TPEGETVKIP VSIKTIQDSS GRQTFTEITD HMLSMGSLDH 60

PYIVRLLGIC PGLSLQLVTQ LSSQGSLLEH IRHHKNSMDP QRLLNWCVQI AKGMYYLEEH 120

RMVHRNLAAR NILLKNDYQV QISDYGVADL LYPDDKKYIY TDTKTPLKWM ALESILFRRY 180

THQSDVWSYG VTVWEMMSFG AEPYASVQPQ EVPSLLEKGE RLSQPHICTI DVYMVMVKCW 240

MIDENIRPTF KELASDF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013