EKS-GAA-00195

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00195

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	500.6	1.1E-150	373	632	260

Status

Unreviewed

Ensembl Protein

ENSGACP00000012095

UniProt Accession

G3P3C2;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009151	ENSGACP00000012095	ENSGACT00000012119

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

684

Protein Sequence
(FASTA)

MGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDELIQ RLQTELDKYR SVIKPATQVV 60

KQNDLHEQQR TKRQAISAEP TAFDIQDLSH VTLPFYPKSP QSKDLIKEAI LDNDFMKNLE 120

LSQIQEIVDC MYPVEYGKDS CIIKEGDVGS LVYVMEDGKV EVTKESLKLC TMGPGKVFGE 180

LAILYNCTRT ATVKTLTNVK LWAIDRQCFQ TIMMRTGLIK HTEYMEFLKS VPTFHGLQED 240

ILSKLADVLE ETHYGDGEYI IRQGARGDTF FIISKGKVNV TREDLPNIEP VYLRSLGKGD 300

WFGEKALQGE DIRTANVIAA EAVTCLVIDR DSFKHLIGGL EEVSSKGHED ADAKAKYEAE 360

NAFFFNLNLA DFNIIDTLGV GGFGRVELVQ LKSDENKTFA MKILKKRHIV DTRQQEHIRS 420

EKLIMQEAHS DFIVRLYRTF KDSKYLYMLM EACLGGELWT ILRDRGSFED STTRFYTACV 480

VEAFAYLHSK GIIYRDLKPE NLILDHRGYA KLVDFGFAKK IGFGKKTWTF CGTPEYVAPE 540

IILNKGHDIS ADYWSLGILM FELLTGSPPF SGPDPMKTYN IILRGIDMIE FPKKITKNAG 600

NLIKKLCSRD NPSERLGNLK NGVKDIQKHK WFEGFNWEGL KKGTLTPPIV PNVTSAVDTS 660

NFDSFPEDNE DPPPDDNSGW DVDF 684

Nucleotide Sequence
(FASTA)

ATGGGCACCT TGCGTGACCT CCAGTACGCG CTCCAGGAGA AGATCGAGGA GCTGCGGCAG 60

AGGGACGCGC TCATCGACGA GCTGGAACTG GAGCTCGACC AGAAAGACGA GCTCATACAG 120

AGACTGCAGA CCGAGCTGGA CAAATACCGC TCCGTTATCA AACCGGCAAC CCAGGTCGTC 180

AAGCAGAACG ATCTGCACGA GCAGCAGAGG ACGAAGAGGC AGGCGATTTC GGCCGAACCC 240

ACAGCCTTCG ACATCCAGGA TCTTAGCCAT GTCACCCTAC CTTTCTACCC CAAAAGCCCA 300

CAGTCCAAAG ACCTGATCAA GGAGGCCATC TTGGACAACG ACTTCATGAA GAACCTGGAG 360

CTGTCGCAGA TTCAAGAGAT CGTGGACTGC ATGTACCCTG TGGAGTATGG AAAGGACAGC 420

TGCATCATTA AGGAAGGCGA TGTGGGCTCG CTGGTCTACG TCATGGAAGA CGGGAAGGTG 480

GAGGTGACGA AGGAGAGTCT GAAGCTCTGC ACCATGGGGC CGGGAAAGGT GTTTGGGGAG 540

CTCGCTATCC TCTACAACTG CACCAGGACC GCCACTGTCA AGACTCTAAC AAATGTCAAG 600

CTGTGGGCCA TCGACCGACA GTGCTTTCAG ACGATCATGA TGAGGACGGG TCTCATCAAG 660

CACACGGAGT ACATGGAGTT TCTGAAAAGC GTTCCCACAT TCCACGGCCT GCAGGAAGAT 720

ATTCTGAGCA AGCTCGCCGA TGTCCTTGAG GAAACGCATT ATGGAGATGG AGAGTACATC 780

ATCAGGCAGG GGGCCAGGGG AGACACCTTC TTCATCATCA GCAAGGGAAA GGTTAATGTG 840

ACCAGGGAAG ACTTGCCCAA TATAGAGCCT GTCTACCTGC GAAGCCTCGG GAAAGGAGAC 900

TGGTTCGGAG AGAAAGCTCT ACAAGGGGAG GACATAAGGA CAGCCAACGT CATTGCAGCA 960

GAGGCAGTCA CCTGTCTGGT CATCGACAGA GATTCATTCA AGCACCTGAT TGGAGGTTTG 1020

GAGGAGGTTT CCAGTAAAGG CCACGAGGAT GCTGATGCCA AAGCCAAATA CGAAGCGGAG 1080

AATGCATTTT TCTTCAACCT CAACCTCGCC GACTTCAACA TCATCGACAC TCTGGGAGTC 1140

GGCGGATTTG GCCGCGTTGA GCTGGTTCAG CTCAAGAGCG ACGAGAACAA AACCTTCGCA 1200

ATGAAGATCC TGAAGAAGCG GCACATTGTC GACACGAGGC AGCAGGAGCA CATTCGTTCA 1260

GAGAAACTCA TCATGCAGGA GGCCCACTCT GACTTCATCG TTAGACTCTA CAGAACATTC 1320

AAGGACAGCA AGTACCTCTA CATGTTGATG GAGGCGTGTT TAGGAGGAGA GCTGTGGACC 1380

ATTCTTCGTG ACCGGGGTTC ATTTGAGGAC TCAACCACCA GGTTTTACAC GGCGTGTGTG 1440

GTGGAGGCCT TTGCCTACCT GCATTCCAAA GGAATCATCT ACAGAGACCT CAAACCAGAG 1500

AACCTTATTT TGGACCACAG AGGATATGCC AAACTGGTCG ACTTTGGCTT CGCCAAGAAG 1560

ATCGGATTCG GAAAGAAAAC GTGGACCTTC TGCGGAACGC CGGAGTATGT AGCACCAGAG 1620

ATCATTCTGA ACAAGGGCCA TGACATCTCA GCCGACTACT GGTCTCTGGG AATCCTCATG 1680

TTTGAGCTCT TAACTGGCAG CCCTCCATTC TCTGGCCCGG ATCCCATGAA AACCTACAAC 1740

ATCATCTTGA GAGGAATCGA CATGATAGAA TTTCCAAAGA AAATTACCAA AAATGCTGGC 1800

AACCTAATTA AAAAGCTATG CAGCAGGGAT AATCCTTCTG AACGACTGGG AAACTTGAAA 1860

AATGGTGTCA AAGACATTCA AAAGCACAAA TGGTTTGAGG GCTTTAACTG GGAGGGCTTG 1920

AAGAAGGGGA CATTGACCCC TCCTATCGTC CCTAATGTGA CATCAGCCGT AGACACAAGT 1980

AACTTTGACA GCTTCCCAGA GGACAACGAG GACCCGCCTC CTGACGACAA CTCCGGCTGG 2040

GACGTTGATT TTTGA 2055

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ksde+k+fa+kilkk+hivdt+qqeh++sek i++ea+sdf

Q: 373   NIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDF  432

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 433   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  492

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 493   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  552

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklc.rdnp  240

         yw+lgil++elltg+ppfsg+dp+ktyn+il+gid++e+p+kitk+a +likklc rdnp

Q: 553   YWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAGNLIKKLCsRDNP  612

         *******************************************************889**

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+g+kdi+khkwf

Q: 613   SERLGNLKNGVKDIQKHKWF  632

         *******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SDENKTFAMK ILKKRHIVDT RQQEHIRSEK LIMQEAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMFE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKITKNAGNL IKKLCSRDNP 240

SERLGNLKNG VKDIQKHKWF 260

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013