EKS-GAA-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	448.9	7.4E-135	1094	1353	260

Status

Unreviewed

Ensembl Protein

ENSGACP00000012136

UniProt Accession

G3P3G3;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009190	ENSGACP00000012136	ENSGACT00000012160

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1429

Protein Sequence
(FASTA)

MNLRSLHAAM LLWSLCPGTR AQCDASSQTN KLDLSVSFEL PTFTADFPIQ NMVTLDGIVY 60

VGAVNRIYAL APNLTKLSEY RTGPLLANET CGQKPTGAVS GGGGRMDNRN IALVVENIYD 120

KGLFSCGSAD NGVCRRHVLD DDISPKTVDE QVSCFGDKAR PRKGQPGDSD VVVSPSGSQV 180

LNVESNVIKF FAGNSEIPGS GNVSGNATRP HTLALRKMKT SQNGFTFFSA RSHMDLIPSL 240

RGNYYLRYVY SFHSGPFTYF LTVQRVSWDS QAYHTRIARM CSGDVEIRRY VEMPLECIST 300

DKRRRRSEET MKVFNILQAA HVGKVGHDVE LQKKLLVEEG GDVLFAAFAR GKPNSSEPTP 360

NSAVCAISVS HINKMFKLYM QGCNTVDPYH FTGSDRKSCY NVSSSDDCGP HEGIHEGKEG 420

EYRLQVTQFF QRLVYWHKEL TNTLVTSITV VPVHGRTVAY LGTADGRHIQ VLFSRLASPH 480

VNIRLDSRPV SAAVALLEAD GSDGALLMAT GNKITRVPLI GPGCGQLTTC TSCLLSSRVT 540

ECGWCDGRCS RADRCPPPSV WTQDYCPPVI TKVFPTSGPI RGSTAVTVCG GGFGFDKTES 600

FRPYMVTVEV AGAPCRLPRQ DNIKWTVIQC SPVFSGNFTP SGHTVKVTSG QKVATAEGFT 660

FVDPVIHEIF PTFGPKSGGT MLTIRGAFLD TGSKREVTIG KGACKILSLS STMLTCKTPS 720

HADTAPSKQT VKLTVDSVER LAPAPFTFNP NPIVNSIQPS RSFVSGGCTV SAHGSFLQSG 780

LQPQMVLTTG QDAEVFHVSC VYGENRTSIQ CTTPSLAKLA LQPPVVTKVA FVLDGYYTSQ 840

RDLIYVEDPL FQDPKLTSKD NKSIVELKGH HMDREAMKCQ VLTVSNHSCE SLTLSGNTLE 900

CIVPTELQAD TSKELQVEWR QADSIRHLGK VTLAQEPDYT GLVVGCVCVS LLLLLLGSLL 960

MWRRNKHIDD LSEVWYDGRG HIQHLDRLAN ARSVSPTNEM VSHESVDYRT TLIEDPGGDR 1020

PETCRGAPPI YGGNGELLSP RLRRMGGGLS LGMEGELVSP LLMAPVHIDP SCLHPDLLTE 1080

VQHVVIAREQ LLLHLNQVIG RGHFGCVFHG TLLEADGQKQ HCAVKSLNRI TDLEEVSQFL 1140

KEGIIMKDFS HLNVLSLLGI CLPPSGSPLV VLPYMKHGDL RNFIRDEGHN PTVKDLMGFG 1200

LQVARGMEYL ASKKFVHRDL AARNCMLDES YTVKVADFGL ARDVYDKEYY SVHNKSGVKL 1260

PVKWMALESL QTHKFTPKSD VWSFGVLLWE LMTRGAPPYS DVNSFDITVF LLQGRRLLQP 1320

EFCPDALYTV MIECWHPKPE RRPSFSELVS SISAIFSSFS GEHYVLLNTT YVNIEKMSPY 1380

PSLLTSSASP SASSNASYSS TPSSSDPSTS TSLPTQSPFF GHAKQECCI 1429

Nucleotide Sequence
(FASTA)

ATGAATCTCC GCTCCCTCCA TGCCGCCATG CTGCTGTGGT CCTTGTGCCC CGGCACTCGG 60

GCCCAGTGTG ATGCTTCCTC CCAGACCAAC AAACTCGACC TCTCCGTCTC CTTCGAGCTC 120

CCGACGTTCA CCGCAGACTT TCCGATTCAG AACATGGTGA CGCTGGACGG GATCGTCTAC 180

GTCGGGGCGG TGAACAGAAT CTACGCCCTG GCCCCGAACC TCACAAAGCT GTCTGAGTAC 240

CGCACGGGGC CCCTGCTCGC CAACGAGACC TGCGGCCAGA AACCGACCGG TGCTGTTTCC 300

GGCGGCGGCG GCAGGATGGA CAACCGGAAC ATTGCCTTGG TGGTGGAGAA CATTTACGAT 360

AAGGGTTTGT TCAGCTGCGG CTCGGCGGAC AACGGGGTCT GCCGCCGCCA CGTCCTGGAC 420

GACGACATCA GCCCCAAAAC CGTAGACGAG CAAGTGTCCT GCTTCGGCGA CAAGGCGAGG 480

CCGCGCAAGG GTCAGCCCGG CGACTCGGAC GTGGTCGTCA GCCCTTCGGG CTCCCAGGTG 540

CTCAACGTGG AAAGCAACGT CATCAAGTTT TTCGCGGGGA ACTCAGAGAT ACCGGGCAGC 600

GGAAACGTCT CGGGCAACGC GACGCGTCCC CACACCTTGG CCCTGCGCAA GATGAAGACG 660

AGCCAGAACG GCTTCACCTT CTTCTCCGCG CGCTCGCACA TGGACCTGAT CCCGTCTCTC 720

CGTGGAAACT ACTACCTGCG ATACGTTTAC TCCTTTCACA GTGGACCATT CACCTACTTC 780

CTCACGGTGC AGCGGGTGAG CTGGGACTCG CAGGCCTACC ACACCCGCAT CGCCCGCATG 840

TGCTCCGGGG ACGTGGAGAT CCGCCGCTAC GTGGAGATGC CTCTCGAGTG CATCAGCACC 900

GACAAAAGGC GGCGGCGCTC CGAGGAAACC ATGAAGGTAT TCAACATCCT CCAGGCGGCC 960

CACGTCGGCA AGGTGGGCCA CGACGTCGAG CTCCAGAAGA AGCTGTTAGT GGAGGAAGGC 1020

GGCGACGTGC TGTTCGCCGC CTTCGCCCGG GGAAAGCCGA ACTCCTCGGA GCCCACCCCA 1080

AACTCGGCCG TCTGCGCCAT TTCCGTGAGC CACATCAACA AAATGTTCAA GCTGTACATG 1140

CAGGGGTGCA ACACAGTCGA CCCGTATCAC TTCACGGGGT CGGACAGGAA GTCCTGCTAC 1200

AACGTGAGTT CATCGGACGA CTGCGGCCCG CACGAGGGAA TCCACGAAGG CAAGGAGGGC 1260

GAGTACCGCC TGCAGGTGAC CCAGTTCTTC CAGAGGCTTG TGTACTGGCA CAAAGAGCTG 1320

ACCAACACCT TGGTCACGTC CATCACTGTG GTGCCGGTAC ACGGCCGGAC TGTGGCGTAC 1380

CTGGGCACCG CCGACGGGCG CCACATACAG GTGCTCTTCT CCCGACTTGC CTCTCCGCAT 1440

GTCAACATCC GGCTGGACTC GAGACCCGTC TCCGCTGCCG TGGCGCTGCT GGAGGCCGAC 1500

GGCTCAGACG GCGCCCTGCT GATGGCGACT GGGAACAAGA TCACTCGCGT CCCTCTGATT 1560

GGCCCCGGCT GTGGTCAGCT GACCACCTGC ACTTCCTGTT TGCTGTCATC GCGGGTCACC 1620

GAATGCGGCT GGTGCGACGG ACGCTGCAGC AGAGCCGACC GGTGCCCCCC CCCCTCCGTC 1680

TGGACCCAGG ACTACTGCCC ACCTGTCATC ACCAAGGTGT TCCCGACCTC CGGGCCGATT 1740

CGCGGCTCCA CGGCGGTCAC CGTGTGTGGT GGCGGCTTCG GCTTCGACAA GACGGAGAGC 1800

TTCAGGCCCT ACATGGTGAC GGTGGAGGTG GCCGGAGCTC CCTGCAGGCT GCCCCGACAG 1860

GACAACATCA AGTGGACTGT GATTCAGTGT TCCCCAGTGT TCAGCGGGAA CTTCACCCCG 1920

TCAGGACACA CCGTGAAGGT CACCAGCGGC CAGAAGGTCG CCACAGCGGA GGGCTTCACC 1980

TTCGTGGACC CCGTGATTCA CGAAATCTTC CCGACATTCG GGCCGAAGTC GGGGGGCACC 2040

ATGCTGACCA TCAGGGGGGC CTTCCTGGAC ACGGGGAGCA AGCGGGAGGT GACAATCGGG 2100

AAAGGGGCCT GTAAGATCCT GAGCCTGTCG TCCACCATGC TGACCTGCAA GACGCCTTCC 2160

CACGCCGACA CCGCCCCCTC CAAGCAGACA GTGAAGCTGA CGGTGGACTC GGTGGAGCGC 2220

CTGGCGCCAG CGCCGTTCAC CTTCAACCCA AACCCCATCG TCAACAGCAT CCAGCCCTCG 2280

CGCTCCTTCG TCAGCGGAGG ATGCACGGTG TCAGCTCACG GGTCCTTCCT CCAGTCCGGC 2340

CTCCAGCCCC AGATGGTCCT CACCACGGGT CAGGATGCTG AGGTCTTCCA TGTGAGCTGC 2400

GTGTACGGGG AGAACCGCAC GTCCATCCAG TGCACCACGC CCTCCCTGGC CAAACTGGCT 2460

CTGCAGCCGC CCGTGGTCAC CAAGGTGGCG TTTGTCTTGG ACGGCTACTA CACCAGTCAG 2520

CGGGATCTGA TCTACGTGGA GGACCCCCTC TTCCAGGACC CCAAGCTCAC CTCCAAGGAC 2580

AACAAGAGCA TCGTGGAGCT CAAGGGTCAC CACATGGACA GGGAGGCCAT GAAGTGTCAG 2640

GTCCTCACGG TCTCCAACCA CAGCTGTGAG AGTCTGACTC TGAGTGGGAA CACTCTGGAG 2700

TGCATCGTCC CCACCGAGCT GCAGGCCGAC ACCTCCAAGG AGCTGCAGGT GGAGTGGCGC 2760

CAGGCGGATT CCATCCGGCA CCTGGGAAAG GTGACGCTGG CTCAGGAGCC GGACTACACG 2820

GGCCTGGTGG TGGGCTGCGT GTGCGTCAGC CTGCTGCTGC TGCTGCTGGG CTCGCTGCTC 2880

ATGTGGAGGA GGAACAAACA CATCGACGAT CTGTCCGAGG TGTGGTACGA TGGCCGTGGT 2940

CACATCCAGC ATCTGGACCG GCTGGCCAAC GCGAGGAGCG TCAGCCCCAC CAACGAAATG 3000

GTCTCCCACG AGTCGGTCGA CTATAGAACG ACCCTGATAG AGGATCCGGG TGGCGACCGG 3060

CCTGAGACGT GCCGAGGGGC TCCTCCCATC TACGGGGGCA ACGGGGAGCT GCTGTCCCCC 3120

AGACTGCGGA GAATGGGGGG TGGGCTCAGC CTGGGGATGG AGGGCGAGCT GGTGTCCCCC 3180

CTGCTGATGG CCCCGGTCCA CATTGACCCG TCCTGCCTCC ACCCGGACCT GCTGACCGAG 3240

GTGCAGCACG TGGTCATCGC CAGGGAGCAG CTGCTGCTCC ACCTCAACCA GGTCATCGGC 3300

AGAGGTCACT TCGGTTGTGT TTTCCACGGA ACGCTACTGG AGGCAGACGG GCAGAAGCAG 3360

CACTGTGCCG TCAAGTCCCT GAACCGCATC ACCGATTTGG AAGAAGTATC CCAGTTCCTG 3420

AAGGAGGGGA TCATCATGAA GGACTTCAGC CACCTAAACG TTCTCTCGCT TCTGGGAATC 3480

TGCCTGCCGC CTTCAGGCTC GCCGCTGGTG GTTCTGCCCT ATATGAAGCA CGGCGACCTG 3540

CGCAACTTCA TCCGTGATGA AGGACACAAC CCAACAGTGA AGGACCTAAT GGGCTTCGGG 3600

CTGCAGGTGG CCAGAGGGAT GGAGTATCTA GCCAGCAAGA AGTTTGTCCA CCGAGACCTA 3660

GCAGCCAGGA ACTGCATGCT GGACGAGAGC TATACGGTGA AGGTGGCAGA CTTCGGCCTG 3720

GCGAGAGACG TCTACGATAA AGAATACTAC AGCGTCCACA ACAAGAGCGG AGTCAAGCTG 3780

CCAGTCAAGT GGATGGCTCT GGAGAGTCTG CAGACACACA AGTTCACCCC CAAGTCGGAT 3840

GTGTGGTCGT TTGGCGTGTT GCTGTGGGAA CTGATGACCC GCGGAGCTCC ACCGTATTCG 3900

GATGTGAACT CCTTCGACAT CACCGTGTTC CTGCTGCAGG GGAGGAGGCT GCTGCAGCCC 3960

GAGTTTTGCC CCGACGCACT CTACACCGTG ATGATCGAAT GCTGGCATCC AAAGCCGGAG 4020

CGCCGACCTT CCTTCTCTGA GCTGGTGTCG AGCATCTCCG CCATCTTCTC CAGCTTCAGC 4080

GGGGAGCACT ACGTCCTGCT CAACACCACC TACGTCAACA TTGAGAAGAT GAGCCCTTAC 4140

CCGTCTCTCC TCACCTCCTC CGCCTCGCCC TCCGCCAGCA GCAACGCTTC CTACTCCTCT 4200

ACGCCTTCCT CATCCGACCC CTCCACCTCC ACGTCCCTGC CGACTCAGTC CCCCTTCTTT 4260

GGCCATGCGA AGCAGGAATG CTGCATCTGA 4290

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         + ++viG+GhfG+v++g+l++ +++k+++avksl+ritd+e+v++fl+eg++mk+++h n

Q: 1094  HLNQVIGRGHFGCVFHGTLLEADGQKQHCAVKSLNRITDLEEVSQFLKEGIIMKDFSHLN  1153

         789*********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsllGi+l+++g+plvvlpymk+Gdl++fir+e +n+tvkdl++f+lqva+gmeylask

Q: 1154  VLSLLGICLPPSGSPLVVLPYMKHGDLRNFIRDEGHNPTVKDLMGFGLQVARGMEYLASK  1213

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardv+dke+y+v+++ + +lpvkw+aleslqt+

Q: 1214  KFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKSGVKLPVKWMALESLQTH  1273

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k ft ksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly vm+

Q: 1274  K-FTPKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYTVMI  1332

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsiis  262

         +cw++kp++rp+fs+lvs is

Q: 1333  ECWHPKPERRPSFSELVSSIS  1353

         ******************997

Domain Sequence
(FASTA)

HLNQVIGRGH FGCVFHGTLL EADGQKQHCA VKSLNRITDL EEVSQFLKEG IIMKDFSHLN 60

VLSLLGICLP PSGSPLVVLP YMKHGDLRNF IRDEGHNPTV KDLMGFGLQV ARGMEYLASK 120

KFVHRDLAAR NCMLDESYTV KVADFGLARD VYDKEYYSVH NKSGVKLPVK WMALESLQTH 180

KFTPKSDVWS FGVLLWELMT RGAPPYSDVN SFDITVFLLQ GRRLLQPEFC PDALYTVMIE 240

CWHPKPERRP SFSELVSSIS 260

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013