EKS-GAA-00404

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00404

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.2	3.2E-96	34	292	259

Status

Unreviewed

Ensembl Protein

ENSGACP00000012362

UniProt Accession

G3P439;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK (2 of 2)

Gene Synonyms/Alias

SLK (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009370	ENSGACP00000012362	ENSGACT00000012386
ENSGACG00000009370	ENSGACP00000012366	ENSGACT00000012390

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1173

Protein Sequence
(FASTA)

MSFFNFRKIF KLGPDKKKKQ YEHVHRDVNP EEIWDIIGEL GDGAFGKVYK AQNKQNKTLA 60

AAKVIDTKTE DELEDYMVEI EILASCDHHH IVKLLDAFYF DGKLWILIEF CAGGAVDAIM 120

LELERPLTEP QIRVVCRQTL EALSYLHENK VIHRDLKAGN ILLSLNGEVK LADFGVSAKN 180

TKTFQRRDSF IGTPYWMAPE VVMCETSKDR PYDFKADIWS LGVTLIELAQ IEPPNHEMNP 240

MRVLLKIAKS EPPTLMHPSR WSPEFNDFLR RALDKNVDNR WGTQQLLQHP FVTSVTDSKP 300

LRELIAEAKA EVTEEIEDSP DTPLERRIAI SLSTQAAPGH KRVPSDASAA SSEDDKVPPT 360

SSALESVTEK TEAESAEDRI SDKLSDEGLG TSEVDKTEEE KLNEVSDASN EDLASGLTEP 420

AKDFISQGPT EPPGPGDSRA EEIPAEPVVA QPDEAGDAVD TQELLPGGQT TVEERKEMQG 480

EKTVAAGTGE SIESHGRPED KLEEPEFVSG EVALAEEESK EPDETPRHEL TDDRIENTAN 540

VTVVNIHPQS TASKVVDTNI NVATDTKLSE DESPAAVLPD KEATEEKPAD GAEQLQPDDP 600

NKGEDDRGEQ APNTPTNAVS DEAKVPSEES HPAVPSRDEE EAPGVDESTS QDATRVPEES 660

ETGPESKTEG GSPAAAQPDL EKDSDSGSSS AADSNSLDLN LSISSFLSKT KEGGSVSMQE 720

SRRQKKTLKK TRKFMVDGVE VSVTTSKIVT DSDTKSEELR FLRRQELREL RLLQKEEQRA 780

QQQLSNKLQQ QREQIFRRFE QETAAKKRQY DQEVENLEKK QKQTIERLEQ DHTSRLRDEA 840

KRIKADQDKE LSKFQNMLKN RKKEAKQEVG QSPKHMRKDL MKRVREDLLL LKNSEEQEFL 900

QKQQQELDGA LKKIIQQHKL EITTIERDCL NHKQQLMRAR EAAMWELEER HLQEKHQQLK 960

QQLKDQYFLQ RHQLLKRHEK EMEQMHRYNQ RMFEEMKNKQ NQERVRLPKI QRSEAKTRMA 1020

MFKKSIRITA TAAVTPEQER ERIKQFASQE DKRQKNERLH QHQKHENQMR DLQLQCDSNI 1080

RELQQLQNEK CHLLIEHETQ KLKELDEEHS QEIKEWREKL RPRKKALEDE FTRKLQEQEV 1140

FFKMSGESEC LNPSTQSRVS KFYPIPNLHN SGL 1173

Nucleotide Sequence
(FASTA)

ATGTCTTTCT TCAATTTTCG CAAGATATTC AAGCTGGGAC CCGACAAGAA GAAGAAGCAG 60

TACGAGCACG TGCACCGCGA CGTCAACCCC GAGGAGATAT GGGACATCAT CGGGGAGCTC 120

GGAGATGGAG CCTTCGGGAA AGTGTACAAG GCTCAGAACA AGCAGAACAA AACCCTCGCT 180

GCCGCCAAGG TGATCGACAC CAAGACGGAG GATGAATTGG AGGACTACAT GGTGGAGATC 240

GAGATCCTCG CCTCCTGCGA CCACCATCAC ATCGTCAAGC TGCTGGATGC CTTCTATTTT 300

GATGGCAAGC TGTGGATTCT GATTGAGTTC TGTGCGGGTG GTGCAGTGGA TGCCATCATG 360

CTGGAGCTCG AGAGGCCCCT GACGGAGCCC CAGATCCGCG TGGTGTGCCG GCAGACTTTG 420

GAGGCCTTGT CTTACCTCCA CGAGAACAAA GTCATCCACA GAGACTTGAA AGCCGGGAAC 480

ATTCTCCTCT CTCTGAATGG AGAAGTGAAA CTGGCTGACT TTGGGGTGTC CGCTAAAAAT 540

ACCAAGACTT TTCAGAGGAG AGATTCTTTC ATCGGCACTC CGTATTGGAT GGCCCCAGAG 600

GTGGTGATGT GCGAAACTTC CAAGGACCGT CCGTACGACT TCAAGGCCGA CATCTGGTCC 660

CTCGGCGTAA CCCTGATCGA GCTGGCGCAG ATCGAGCCGC CCAACCACGA GATGAACCCC 720

ATGAGAGTGC TGCTGAAAAT AGCCAAGTCG GAGCCACCCA CACTCATGCA TCCTTCTCGC 780

TGGTCACCGG AATTTAACGA CTTTCTGCGA AGGGCGCTTG ATAAGAATGT GGACAATAGG 840

TGGGGCACGC AACAGCTTCT ACAGCATCCT TTCGTCACCA GTGTGACGGA CAGCAAACCG 900

CTCAGAGAGC TCATAGCTGA AGCCAAAGCT GAAGTCACAG AGGAGATCGA GGACAGCCCT 960

GATACGCCTT TGGAAAGACG TATTGCTATT TCTCTTTCCA CGCAGGCGGC TCCCGGGCAC 1020

AAGCGAGTGC CATCAGATGC CAGCGCGGCC AGCTCAGAGG ATGACAAAGT CCCGCCGACT 1080

TCCTCCGCCC TGGAATCCGT TACAGAGAAG ACGGAGGCCG AGTCGGCCGA GGACCGGATC 1140

AGCGACAAGC TGTCCGATGA GGGTCTTGGA ACGAGCGAGG TAGACAAGAC GGAGGAGGAG 1200

AAACTCAACG AGGTGTCGGA TGCTAGCAAT GAAGACCTAG CCTCTGGGCT AACAGAACCC 1260

GCCAAGGACT TTATATCGCA AGGTCCTACA GAGCCGCCTG GACCAGGAGA TAGTCGAGCT 1320

GAGGAGATTC CCGCTGAGCC TGTGGTTGCA CAGCCAGATG AAGCTGGAGA TGCAGTGGAC 1380

ACCCAAGAAC TTTTACCAGG TGGTCAAACA ACAGTGGAGG AACGGAAGGA GATGCAAGGA 1440

GAGAAAACGG TCGCTGCTGG TACAGGAGAA TCCATTGAAT CCCATGGCCG ACCCGAAGAC 1500

AAACTAGAAG AACCAGAATT CGTATCAGGG GAGGTGGCTC TGGCAGAAGA AGAAAGCAAG 1560

GAGCCAGATG AGACCCCTCG GCATGAATTG ACAGACGACA GAATAGAAAA CACTGCTAAT 1620

GTCACCGTTG TAAACATACA CCCCCAGAGT ACAGCGTCGA AGGTAGTGGA CACGAACATA 1680

AATGTCGCCA CGGACACAAA GTTGAGCGAG GACGAGTCCC CTGCTGCGGT GCTGCCGGAC 1740

AAAGAGGCCA CAGAGGAAAA GCCCGCGGAC GGGGCAGAGC AGCTTCAACC AGACGATCCG 1800

AATAAGGGGG AGGACGATCG GGGGGAACAG GCCCCAAACA CACCCACAAA TGCAGTCAGC 1860

GACGAAGCCA AAGTCCCCTC GGAGGAGTCT CACCCGGCGG TCCCAAGTAG AGACGAGGAG 1920

GAAGCTCCTG GCGTAGACGA GAGCACCTCC CAAGATGCCA CCCGCGTGCC GGAGGAGAGC 1980

GAAACGGGTC CAGAGAGCAA GACGGAGGGC GGGAGCCCCG CCGCGGCTCA GCCGGATTTA 2040

GAGAAGGACT CCGACTCCGG AAGCAGCTCT GCCGCCGATA GCAACAGCCT TGACCTCAAC 2100

CTGTCCATCT CCAGCTTCCT GTCGAAGACC AAGGAAGGGG GCTCCGTGTC CATGCAGGAG 2160

TCCAGACGTC AGAAGAAGAC CCTGAAGAAG ACGCGCAAGT TCATGGTGGA CGGCGTGGAG 2220

GTCAGCGTGA CGACGTCGAA GATAGTGACG GACAGCGACA CCAAGAGCGA GGAGCTGAGG 2280

TTCCTGAGGC GGCAGGAGCT GAGAGAGCTG CGCCTCCTGC AGAAAGAGGA GCAGAGGGCC 2340

CAGCAGCAGC TGAGCAACAA GCTGCAGCAG CAGAGAGAGC AGATCTTCCG ACGCTTTGAA 2400

CAGGAAACCG CGGCCAAGAA GCGTCAGTAT GACCAAGAAG TGGAGAACCT TGAGAAGAAG 2460

CAGAAGCAGA CCATCGAGCG GCTGGAGCAG GACCACACCA GCCGGCTCCG AGACGAAGCC 2520

AAACGCATCA AGGCGGATCA GGACAAGGAG CTGTCCAAGT TCCAAAACAT GCTGAAGAAC 2580

CGGAAGAAAG AGGCCAAACA GGAAGTTGGA CAGTCCCCCA AACACATGAG AAAAGACCTC 2640

ATGAAACGCG TAAGGGAGGA TCTGTTGCTC CTTAAGAACT CCGAGGAGCA AGAGTTCCTA 2700

CAGAAGCAGC AGCAAGAGCT GGACGGAGCT CTGAAGAAAA TCATCCAGCA GCACAAACTG 2760

GAGATCACCA CCATTGAGAG AGACTGCTTG AATCACAAGC AGCAGCTGAT GAGAGCTCGA 2820

GAGGCGGCCA TGTGGGAGTT AGAGGAGCGC CATCTGCAGG AGAAGCACCA GCAGCTGAAG 2880

CAGCAGCTGA AAGACCAGTA CTTCCTGCAG AGACACCAGC TGCTGAAGAG GCATGAGAAA 2940

GAGATGGAGC AGATGCATCG CTACAACCAG CGAATGTTCG AGGAGATGAA GAACAAACAG 3000

AACCAAGAGA GGGTTCGTCT GCCCAAGATT CAGCGGAGCG AGGCCAAAAC CCGCATGGCC 3060

ATGTTCAAGA AGAGCATCCG CATCACCGCC ACGGCAGCGG TCACGCCCGA GCAGGAGAGG 3120

GAACGGATAA AACAGTTTGC TTCTCAGGAA GACAAGAGGC AGAAGAACGA GAGGCTCCAT 3180

CAACACCAGA AACACGAGAA CCAGATGAGA GATCTGCAGC TGCAGTGTGA CTCGAACATC 3240

CGGGAGCTGC AGCAGCTGCA GAATGAGAAA TGCCACCTTC TGATTGAACA TGAGACTCAG 3300

AAGCTGAAGG AGCTGGATGA GGAGCACAGC CAAGAGATAA AGGAGTGGAG AGAGAAGCTG 3360

AGACCAAGGA AGAAGGCGCT CGAGGACGAG TTCACACGGA AGCTCCAGGA GCAGGAGGTC 3420

TTCTTCAAGA TGAGCGGCGA ATCCGAATGC CTTAACCCCA GCACCCAGAG TCGAGTATCC 3480

AAATTCTACC CCATCCCGAA CCTGCACAAC TCTGGTTTAT AG 3522

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         ++++ e+g+Ga+gkvy+a++k++++l+a k+i+++++++le+++ ei++l +++h++iv+

Q: 34    WDIIGELGDGAFGKVYKAQNKQNKTLAAAKVIDTKTEDELEDYMVEIEILASCDHHHIVK  93

         678999******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f+ + +lw+++e++agG+++ ++  el+++l+E qi++++r++l+aL+ylH++kvi

Q: 94    LLDAFYFDGKLWILIEFCAGGAVDAIML-ELERPLTEPQIRVVCRQTLEALSYLHENKVI  152

         ***************************9.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niLl+ +geVkL+dfgv+a+ +kt ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILLSLNGEVKLADFGVSAKNTKTFQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d kaDiwslG+t+iela+ epP ++++p+++llki+k+epp+l++++++s+ef++f++++

Q: 213   DFKADIWSLGVTLIELAQIEPPNHEMNPMRVLLKIAKSEPPTLMHPSRWSPEFNDFLRRA  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+ +++ll+h+F+

Q: 273   LDKNVDNRWGTQQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WDIIGELGDG AFGKVYKAQN KQNKTLAAAK VIDTKTEDEL EDYMVEIEIL ASCDHHHIVK 60

LLDAFYFDGK LWILIEFCAG GAVDAIMLEL ERPLTEPQIR VVCRQTLEAL SYLHENKVIH 120

RDLKAGNILL SLNGEVKLAD FGVSAKNTKT FQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

FKADIWSLGV TLIELAQIEP PNHEMNPMRV LLKIAKSEPP TLMHPSRWSP EFNDFLRRAL 240

DKNVDNRWGT QQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013