EKS-GAA-00099

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00099

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	445.9	8.0E-134	84	367	284

Status

Unreviewed

Ensembl Protein

ENSGACP00000012455

UniProt Accession

G3P4D2;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3A (1 of 2)

Gene Synonyms/Alias

GSK3A (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009447	ENSGACP00000012455	ENSGACT00000012479

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

440

Protein Sequence
(FASTA)

MSGSGRPRTS SFAEPPGAPG SAAAGAGSSV AGGSSTGKTG ASQASGSSST SFGNLKLPRD 60

SGKVTTVVAT PGQGPDRPQE VSYTDIKVIG NGSFGVVYQA RLIDSQEMVA IKKVLQDKRF 120

KNRELQIMRK LDHCNIVRLR YFFYSSGEKK DEVYLNLVLD FVPETVYRVA RHFNKAKTTI 180

PIIYVKVYMY QLFRSLAYIH SQGVCHRDIK PQNLLVDPET AILKLCDFGS AKQLVRGEPN 240

VSYICSRYYR APELIFGATD YTSNIDIWSA GCVLAELLLG QPIFPGDSGV DQLVEIIKVL 300

GTPTREQIRE MNPNYTEFKF PQIKAHPWTK VFKPRTPPEA IALCSRLLEY TPVTRLSPLE 360

ACAHAFFDEL RQPNTRLPSG RDLPLLFNFS PVELSIQPQL NSTLIPPHAR AQTSPASHDG 420

SVSDSTAQPS SAPGSLNNST 440

Nucleotide Sequence
(FASTA)

ATGAGCGGCA GCGGGCGGCC CAGGACCAGC TCATTCGCTG AGCCTCCCGG AGCTCCCGGA 60

TCCGCTGCAG CCGGTGCCGG ATCATCAGTA GCCGGTGGAA GCTCGACAGG AAAAACTGGG 120

GCTTCACAAG CCAGTGGAAG CAGCTCGACG AGCTTTGGGA ATTTGAAACT TCCCAGAGAC 180

AGTGGCAAGG TGACAACGGT GGTAGCCACA CCCGGCCAAG GTCCCGACCG CCCCCAGGAA 240

GTGTCCTATA CAGACATAAA GGTTATAGGA AATGGCTCCT TTGGGGTGGT CTACCAGGCT 300

CGCCTCATCG ACAGCCAGGA GATGGTGGCA ATTAAGAAAG TTCTCCAAGA CAAGAGGTTT 360

AAGAATAGAG AGCTGCAAAT TATGAGGAAA TTGGACCACT GCAACATCGT GAGGCTACGC 420

TACTTCTTCT ACTCCAGTGG AGAGAAGAAA GATGAGGTGT ATTTGAATCT GGTGCTGGAC 480

TTCGTACCCG AGACGGTGTA CAGGGTGGCT CGGCATTTCA ACAAGGCCAA GACCACCATC 540

CCCATCATCT ATGTTAAGGT GTACATGTAT CAGCTGTTCC GCAGTCTGGC TTATATCCAT 600

TCCCAGGGCG TGTGTCACAG AGACATCAAG CCCCAAAACC TCCTGGTGGA CCCAGAGACG 660

GCCATCCTCA AACTCTGTGA CTTCGGCAGT GCGAAGCAGT TAGTTCGGGG GGAGCCAAAT 720

GTGTCCTATA TCTGCTCGCG GTACTATCGC GCCCCGGAGC TCATCTTTGG TGCCACCGAC 780

TACACATCCA ACATCGACAT CTGGTCGGCC GGCTGCGTGC TGGCCGAGCT GCTGCTGGGC 840

CAGCCCATCT TCCCTGGGGA CAGCGGAGTG GACCAGCTCG TAGAAATCAT CAAGGTTCTG 900

GGGACACCAA CAAGGGAGCA GATCAGAGAG ATGAACCCGA ACTACACAGA GTTCAAATTC 960

CCTCAGATCA AAGCGCACCC TTGGACAAAG GTGTTCAAGC CTCGCACCCC ACCGGAGGCC 1020

ATCGCCCTCT GCTCTCGACT GCTGGAATAC ACGCCGGTGA CCAGGCTGTC TCCCCTGGAG 1080

GCGTGTGCGC ACGCCTTCTT CGACGAGCTG CGTCAGCCCA ACACTCGCCT GCCGAGCGGA 1140

CGAGATCTGC CGCTCCTTTT CAACTTCAGT CCCGTCGAGC TGTCTATCCA GCCCCAGTTG 1200

AACTCCACAC TCATTCCTCC TCACGCTCGT GCACAGACAT CGCCTGCCTC ACACGATGGC 1260

AGTGTGTCAG ACAGTACCGC CCAGCCCAGC TCAGCACCCG GATCCCTCAA CAACAGCACC 1320

TGA 1323

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l++++e+ vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf

Q: 84    TDIKVIGNGSFGVVYQARLIDSQEM-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  142

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd+vylnlvl+++Pet+++v+r+++++k+++++++vk+y+yQlfr+lay+hs+

Q: 143   FYSSGEKKDEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQ  202

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd+et++lKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 203   GVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  262

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iD+WsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 263   SNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  322

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k ++++ea++l++++l+y+p +Rls+le++ah ff

Q: 323   IKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFF  367

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLI DSQEMVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60

YSSGEKKDEV YLNLVLDFVP ETVYRVARHF NKAKTTIPII YVKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPETAIL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180

NIDIWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK PRTPPEAIAL CSRLLEYTPV TRLSPLEACA HAFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013