EKS-GAA-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	300.3	1.5E-89	1889	2142	254

Status

Unreviewed

Ensembl Protein

ENSGACP00000012659

UniProt Accession

G3P4Y6;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009572	ENSGACP00000012659	ENSGACT00000012683

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

2549

Protein Sequence
(FASTA)

MVTGEELEER LKKLLVRLKI PQEDRQLCTL IQILQDLLFL AHTDNAAELF EDKDVHGPLA 60

VVLSSYIGSR GVQQVGWSLL CRLIEICPHT LDQLTRPLQA AKDWEVLGVH QQILKALRHH 120

CADCRVTVVG LRALALLLRS DLIPLLLLEE EEEDVFSLVL EAMKTFPATE EVQLQGCGAL 180

QVLLERAFPV SDDHLVEFVE NQDHVAVLVA LQRFPDNPEL LLQAMRVMLP LARPGSNVEM 240

LMSGGARFYS VVITAMDTFP EGEELQETAC CLLRRFTSES YYNILVMNGV QRVALRACRT 300

FPDNARLQAA ALSCLADLSE SKVVAQQGLE EGEQEENRGR EEVEDLSLGW MEACCTALEL 360

HPAEADVQEA ASWAIHNLSL HGAAVNHSEG DQRTPVHRQL MVAMLLHSSS PSVFHAATSA 420

IATLLAHNGE MRSLLLSSGL HVNLVEMMKR HTTSAKVSIN ACRLLNLLFQ GRTASLDELN 480

MAMSQILSTM KVHNFQPEVQ LEALQASLVF LCPDRSLREH SLSVADPDMA DVSLKVLKTQ 540

CVVEGAHTVY LEVLNRFISS AIIQKSGLKV LSALADCSGA VDLLCQQGAI DTVLHTLQMF 600

PQEREIHYWG FTLLTHLVSK KKLSRMIVPV LASVVVASLL QFSDDPEMLL KCFQVALRML 660

DACSGAAAEL QREDFDRLIF QQLRVERPDQ SNYALHKSVC LALSKMWCDA QLHYGMLEKA 720

CEDGDAALAE CLIELGADVN GKTKAESLIY QVCERGGPQE LVELLLARGA QEQHLRRALA 780

VSVKRGEGPT VIQLLGRLGL DLHNGALCLG GFRLGRLDAA WLSPLLEERG RARSLRHNKS 840

KGVSLARYIQ SLRRSKSVNG PPRSPGEPYL TSGYISDESD DCSLEDSLFY KEDMESDGKK 900

EVKGGSFTMK RGRRRHASAE VGELLRHVSS SRDTGSHTEY CNTGQAENDH TDLAQRRYEF 960

LCSSRDTRCR LIQPTSLFPL FNQAPVKEAE RIVLLDLSGN ELASLSCLMD DGLVQQQLGH 1020

LLRLDLSHNG LLDFPPALCQ SLRSLTRLDL QGNQLRSLPA ELLTLLSLST LNVSRNCVGP 1080

LLTFDPAVSC PSLRQLNLSH NQITAFPRDL GRAAARLEEL SMEGNSLTEL VAPLCLPEIR 1140

LLDVSKNGVE NISPDFLSGC PKLETLSASA NRICSLSHLP TKIITLKLAD NRFADVPQAI 1200

LELPNLRSVD MRTNRIAALP GPGLWASGNL RELMFSHNAI KVLDLSGPIH KWTGLEKLHL 1260

SDNELTQIPQ RIGLLEGITS LDVSRNANLR SFPDEMGKLS RLWDLPLDGL RLQLDLKLIG 1320

GKTKDIVRFF QQRLKKAVPY YRMKLIVVGN PGSGKTALIQ QLMKLKRSRV NSKMAAAGID 1380

VRDWSVRERD KKRMVLNVWD FSGGEEFSGS HPHFLTSRAL YLVVYDLSRG ASEVDALKPW 1440

LFNIKAVAPL SPVILVGTHT DVSDELQLQA CVTKIREELL RHQGFPAIRD YHMVSACEDS 1500

DAIAKLRKAI AREVTGFKIQ GQPVMGQLVP DSYVELERRV LQERGKVPPE FPVLRHRELL 1560

QLIQESQLQL EEAELPHAVH FLSEAAEGVL LHFDDPALQL QELYFIDPQW LCNIISQKLI 1620

LKNCAPWEHP KGVVQRSVVE KSLSETQCFP KSHLTQFFKL LEKFQIALPF GEDQLLVPGS 1680

LSKHRPVIEL PHCENSEVIV RLYEMPYFPM DYWSRQISRL LEVSSYLLCG RGKAVRPNRI 1740

YWRRGVYLSW SPEAYCLVEA NSGEESPSCF VRITVPSSRK GRVLLGQVVD HIDSLLEEWF 1800

PGLLNTDVHG SGEPLLKKWA LYSFEDGQEW SRILLEDLFS CFDNDCLLVN PEDPRCTLPI 1860

SQIAPDLVLS DQPAGTMLDS EELHMDMSKE NRLGDGGFGT VYRSIYKNEE VAVKIFNKHA 1920

SELYIHRLLR QELAVLGRLR HPSLVGLLAA GSSPQVLVME LALSGSLDAL FERERGGLNR 1980

KLQHRIALQV SDGLRYLHSA MIIYRDLKPH NVLLFNLKTD SELIAKITDY GIAQYCCSMG 2040

VRSSEGTPGF RAPEVARGNA IYNQQADVFS FGLLLYDLLT CGQRISDGMK FPSEFDEVAV 2100

QGKLPDPVKH YGCSPWPGFQ ALMKDCLRDS PQGRPTSAQV FDRLNSGQML CLMRELVVPR 2160

VINAECLAVS ADPLNSHRAW VGGGSSARRL GSITAVHLDG SGVTTQEVES SPVLCLVTVQ 2220

IPSEACDWLV AGTQSGSLVV ISTRDPSAWH RLQSATDAVT SLYFHVHRIF SQRKNYLLVG 2280

TADGILTVYE DSVLKQENGQ PVKSLTMGNI NTPLVCLGQS SHPLDGRSVW AGCGTKILAF 2340

TADYEVGRSI DTRPNLVLQQ QRPLGGEACV SRLVVDKYVY LSKAGTTSVE VWDKRGERMV 2400

DRVDCAQIIR HDSAVRSRRA SEAELAGEAA PSWAQVKALL VQSAAALWVG TRGGHLLLLE 2460

LSKHQVLQVI GPCCDSTRCM ASALIGLDTL NWKNVVLVLG RKVPQDADQF DKESVLMVWN 2520

SSLPMEVKDL NKHCEKREQI AARMREQLH 2549

Nucleotide Sequence
(FASTA)

ATGGTTACCG GAGAGGAGCT GGAGGAGAGG TTGAAGAAGC TCCTGGTGAG GCTGAAGATC 60

CCGCAGGAGG ACCGACAGCT CTGCACGCTG ATCCAGATCC TCCAGGATCT GCTTTTCCTC 120

GCGCACACCG ACAACGCTGC CGAGCTGTTT GAGGACAAAG ACGTCCACGG CCCCCTCGCG 180

GTGGTGCTGT CGTCCTACAT CGGCAGCAGA GGAGTCCAGC AGGTGGGCTG GTCGTTGCTT 240

TGTCGGCTGA TTGAAATATG CCCCCACACG CTGGACCAGC TGACCAGGCC CCTGCAGGCA 300

GCCAAGGACT GGGAGGTACT GGGAGTGCAC CAGCAGATCT TGAAGGCGCT GCGTCATCAC 360

TGCGCAGACT GCCGAGTCAC CGTGGTGGGA CTCCGAGCTC TGGCCCTGCT GCTCCGGTCA 420

GACCTGATTC CTCTGCTGTT GCTGGAGGAG GAGGAGGAGG ATGTGTTCAG CCTGGTGCTG 480

GAGGCCATGA AGACTTTTCC TGCCACGGAG GAGGTGCAGC TCCAGGGCTG TGGAGCCCTG 540

CAGGTCCTGT TGGAGAGAGC GTTCCCAGTC AGTGATGACC ACCTGGTGGA GTTCGTGGAG 600

AACCAGGATC ACGTCGCGGT GCTGGTGGCC CTGCAGAGGT TCCCCGACAA CCCCGAGCTG 660

CTGCTGCAGG CCATGAGGGT GATGCTGCCG CTGGCCCGTC CTGGCAGCAA CGTGGAGATG 720

TTGATGTCGG GAGGAGCTCG GTTCTACAGC GTGGTCATCA CCGCCATGGA CACCTTCCCT 780

GAGGGGGAGG AGCTACAGGA GACGGCCTGC TGTCTGCTCC GGAGGTTTAC GTCAGAGAGC 840

TACTACAACA TCCTGGTGAT GAACGGCGTG CAGAGGGTCG CGCTGAGAGC CTGCCGGACA 900

TTCCCGGACA ATGCCAGGCT GCAGGCCGCC GCCCTCTCCT GTCTGGCCGA CCTGAGTGAG 960

AGCAAAGTGG TGGCCCAGCA GGGTCTTGAG GAGGGCGAGC AGGAGGAGAA CCGGGGCCGG 1020

GAGGAGGTGG AGGACCTGAG CCTGGGCTGG ATGGAGGCCT GCTGCACGGC GCTGGAGCTC 1080

CACCCCGCCG AGGCGGACGT TCAGGAAGCC GCGAGCTGGG CCATCCACAA CCTGTCGCTG 1140

CACGGAGCCG CAGTGAACCA CTCGGAGGGG GACCAGAGGA CTCCTGTCCA CAGACAGCTG 1200

ATGGTGGCCA TGCTACTCCA CTCCTCCTCT CCCAGTGTGT TTCACGCCGC GACCAGTGCC 1260

ATCGCCACAC TCCTCGCACA CAACGGTGAG ATGCGTTCCC TGCTACTCTC CAGCGGCCTC 1320

CACGTCAACC TGGTGGAGAT GATGAAGAGA CACACCACCT CAGCCAAAGT GTCCATCAAT 1380

GCTTGCAGGC TGCTCAACCT GCTCTTTCAG GGAAGGACCG CTAGTCTGGA TGAGTTGAAC 1440

ATGGCCATGA GTCAGATCCT CAGCACCATG AAAGTCCACA ACTTCCAGCC GGAGGTTCAG 1500

CTGGAGGCTC TGCAGGCCAG CCTGGTCTTC CTCTGCCCAG ACAGGAGTCT GAGGGAGCAC 1560

AGCCTCTCGG TGGCGGACCC CGACATGGCC GACGTCTCGC TGAAGGTGCT AAAGACCCAA 1620

TGTGTGGTGG AGGGAGCTCA CACGGTCTAC CTGGAGGTTC TCAACAGGTT CATCAGCAGC 1680

GCCATCATTC AGAAGTCCGG TCTGAAGGTT CTGTCCGCTC TGGCCGACTG CTCCGGCGCT 1740

GTGGACCTGC TCTGCCAGCA GGGCGCCATC GACACGGTGC TGCACACGCT GCAGATGTTC 1800

CCGCAGGAAC GAGAGATCCA CTACTGGGGC TTCACGCTGC TCACCCACCT CGTGTCCAAG 1860

AAGAAGCTGT CGAGGATGAT CGTTCCCGTG CTGGCCTCCG TCGTGGTCGC CTCCCTCCTC 1920

CAGTTCAGCG ACGACCCAGA GATGCTCCTG AAGTGTTTTC AGGTGGCTCT GAGAATGCTG 1980

GACGCCTGCT CAGGAGCAGC CGCTGAGCTG CAGAGGGAAG ACTTCGACCG ACTTATCTTC 2040

CAGCAGCTCA GAGTGGAGAG ACCTGACCAG AGCAACTACG CTCTGCATAA GTCGGTGTGC 2100

CTGGCCCTTT CGAAGATGTG GTGCGACGCG CAGCTGCACT ACGGCATGCT GGAGAAGGCC 2160

TGCGAGGACG GGGACGCCGC GCTGGCCGAG TGTCTGATCG AGCTGGGCGC CGACGTCAAC 2220

GGGAAGACCA AAGCAGAGTC GCTCATCTAC CAGGTGTGCG AGCGCGGCGG CCCCCAGGAA 2280

CTGGTGGAGC TCCTTCTCGC CCGAGGTGCC CAGGAGCAGC ACCTCCGCAG GGCTCTGGCT 2340

GTGAGCGTGA AGCGCGGCGA GGGACCCACG GTCATCCAGC TGCTGGGCCG CCTGGGCCTG 2400

GACCTCCACA ACGGTGCCCT CTGCCTGGGG GGCTTCAGGC TGGGCCGCCT AGACGCCGCC 2460

TGGCTCAGCC CGCTGCTGGA GGAACGGGGC CGGGCCCGCA GTCTCCGTCA CAACAAGAGT 2520

AAAGGCGTGA GTCTGGCGAG GTATATTCAG TCGCTGCGGA GGTCCAAGAG CGTCAACGGT 2580

CCCCCCCGAT CTCCGGGCGA GCCCTATCTG ACTTCCGGCT ACATTTCCGA CGAGAGCGAC 2640

GACTGCAGCT TGGAGGACAG TTTGTTCTAC AAAGAGGACA TGGAGAGCGA TGGTAAGAAG 2700

GAGGTGAAGG GGGGGTCCTT CACCATGAAG CGGGGACGGC GCAGACACGC CAGTGCTGAG 2760

GTAGGAGAAC TTCTCCGTCA TGTGTCGAGT AGTCGGGACA CTGGATCTCA TACTGAATAC 2820

TGTAATACCG GTCAGGCTGA GAATGATCAC ACTGATCTCG CTCAGAGGAG ATATGAGTTT 2880

CTCTGTAGCT CCCGTGATAC ACGCTGCCGC TTGATTCAAC CCACTTCCCT TTTTCCTTTA 2940

TTCAACCAAG CTCCGGTCAA AGAGGCCGAG AGGATCGTCC TGCTGGACCT GTCTGGGAAC 3000

GAGCTGGCCT CTCTGTCCTG TCTGATGGAC GACGGCTTGG TCCAGCAGCA GCTGGGGCAT 3060

CTTCTCCGCC TGGACCTGAG CCACAACGGT CTGCTGGATT TCCCCCCCGC TCTCTGCCAG 3120

AGCTTGAGGA GTCTGACCCG ACTGGACCTG CAGGGCAACC AGCTGCGGTC GCTGCCGGCG 3180

GAGCTGCTGA CCCTGCTCTC ACTGAGCACG CTCAACGTCT CTCGCAACTG CGTGGGTCCC 3240

CTGCTGACCT TTGACCCCGC CGTCAGCTGC CCGTCGCTGC GGCAGCTCAA CCTGTCCCAC 3300

AACCAAATCA CAGCGTTCCC TCGGGATCTG GGCCGTGCCG CGGCTCGACT GGAGGAGCTG 3360

TCCATGGAAG GGAACAGTTT GACCGAGCTC GTCGCGCCTC TGTGTCTGCC GGAGATCAGG 3420

CTGCTCGACG TGAGCAAGAA CGGCGTGGAG AACATTTCTC CTGACTTCCT GAGCGGCTGC 3480

CCCAAGCTGG AGACGCTCAG CGCCTCCGCG AACAGAATCT GTTCTCTGTC ACATCTCCCC 3540

ACGAAGATCA TAACGCTGAA ACTGGCCGAC AACCGCTTCG CAGATGTTCC CCAGGCCATA 3600

CTTGAACTTC CCAACTTGCG CTCGGTGGAC ATGAGAACCA ACCGCATCGC TGCTCTGCCC 3660

GGCCCGGGAC TCTGGGCGTC CGGCAACCTC CGCGAGCTGA TGTTCAGCCA CAACGCCATC 3720

AAAGTTCTGG ATCTGAGCGG GCCGATCCAC AAGTGGACCG GGCTGGAGAA GCTCCACCTG 3780

AGCGACAACG AGCTCACTCA GATCCCCCAG CGGATCGGCC TGCTGGAAGG AATCACCTCG 3840

CTGGACGTGA GCCGTAACGC TAACCTGCGC TCCTTCCCCG ATGAGATGGG GAAGCTGAGC 3900

AGACTGTGGG ACCTCCCGCT GGACGGCCTA CGACTCCAGC TGGACCTCAA GCTCATCGGC 3960

GGCAAGACCA AAGACATCGT CAGGTTCTTC CAGCAGCGAC TGAAGAAGGC GGTGCCGTAC 4020

TACCGCATGA AGCTCATCGT GGTGGGGAAC CCCGGCAGCG GGAAGACCGC CCTGATCCAG 4080

CAGCTGATGA AGCTGAAGCG CTCCCGGGTC AACTCCAAGA TGGCCGCCGC GGGCATCGAC 4140

GTCCGCGACT GGAGCGTCAG GGAGCGGGAC AAGAAGAGGA TGGTGCTGAA CGTCTGGGAC 4200

TTCTCAGGGG GGGAGGAGTT CAGCGGCTCT CACCCTCACT TCCTGACGTC CAGGGCTCTG 4260

TACCTCGTGG TGTACGATCT GAGCAGAGGA GCCAGCGAGG TGGACGCCCT GAAGCCCTGG 4320

CTCTTCAACA TCAAAGCTGT CGCCCCTCTG TCCCCGGTCA TCCTGGTGGG AACCCACACG 4380

GACGTGAGCG ACGAGCTGCA GCTTCAGGCC TGCGTGACCA AGATCAGGGA GGAGCTGCTG 4440

AGGCACCAGG GCTTCCCCGC CATCAGGGAC TACCACATGG TCTCTGCCTG CGAGGACTCG 4500

GACGCCATCG CCAAGCTGCG CAAGGCCATC GCCAGGGAGG TCACCGGCTT CAAGATCCAG 4560

GGCCAGCCCG TTATGGGCCA GCTGGTTCCT GACAGCTACG TGGAGCTGGA GCGCCGGGTT 4620

CTGCAGGAGA GGGGCAAGGT TCCCCCGGAG TTCCCCGTCC TCAGGCACCG GGAGCTGCTG 4680

CAGCTCATCC AGGAAAGTCA GCTGCAGCTG GAGGAGGCGG AGCTTCCCCA CGCCGTCCAC 4740

TTCCTGAGTG AAGCCGCTGA AGGGGTTTTA TTGCACTTTG ATGATCCTGC ACTCCAGCTC 4800

CAGGAGCTGT ACTTCATCGA CCCACAGTGG CTGTGCAACA TCATCTCCCA GAAACTCATT 4860

CTAAAGAACT GCGCACCCTG GGAGCATCCT AAAGGAGTTG TCCAGCGCTC AGTGGTGGAA 4920

AAGTCTCTGT CTGAGACCCA ATGTTTCCCC AAGAGCCACC TGACGCAGTT CTTCAAGCTG 4980

CTGGAGAAGT TTCAGATCGC GCTGCCCTTC GGCGAGGACC AGCTGCTGGT GCCCGGCAGT 5040

TTGTCCAAAC ACAGACCGGT GATCGAGCTG CCTCACTGCG AGAACTCCGA GGTGATCGTG 5100

CGTCTGTACG AGATGCCCTA TTTTCCCATG GACTACTGGT CCCGCCAGAT CAGCCGCCTG 5160

CTGGAGGTCT CTTCTTACCT GCTCTGTGGA AGAGGAAAAG CGGTGCGACC CAACCGGATC 5220

TACTGGAGGA GGGGCGTGTA CCTGAGCTGG TCCCCGGAGG CCTACTGTCT GGTGGAGGCC 5280

AATTCAGGGG AGGAGAGCCC GTCCTGCTTC GTCAGGATCA CTGTGCCCTC GTCGCGCAAA 5340

GGCCGGGTGC TGCTGGGTCA GGTGGTGGAT CACATCGACT CCCTGCTGGA GGAGTGGTTT 5400

CCCGGCCTGC TGAACACCGA CGTACACGGC AGCGGCGAGC CTCTGCTGAA GAAGTGGGCG 5460

CTCTACAGCT TCGAGGACGG GCAAGAGTGG AGCAGGATTC TGCTGGAGGA CCTTTTCAGC 5520

TGTTTTGATA ACGATTGTCT GCTGGTGAAC CCGGAGGACC CCCGCTGCAC CCTTCCCATC 5580

TCTCAGATCG CTCCCGACTT GGTGCTGAGT GACCAGCCTG CAGGAACAAT GCTGGACAGC 5640

GAGGAGCTTC ACATGGACAT GTCCAAAGAG AACCGACTGG GGGACGGCGG CTTCGGGACG 5700

GTCTATCGAA GCATCTACAA AAATGAAGAA GTGGCCGTAA AAATCTTCAA CAAGCACGCG 5760

TCTGAGCTCT ACATCCACAG ACTCCTCCGA CAGGAGCTGG CGGTGCTGGG GCGCCTCCGT 5820

CACCCCAGCC TGGTCGGCCT GCTGGCGGCC GGCTCGTCTC CTCAGGTGCT GGTGATGGAG 5880

CTGGCTCTCA GCGGCTCGCT GGACGCCCTG TTTGAGCGCG AGCGCGGTGG CCTCAACAGG 5940

AAGCTGCAGC ACAGAATCGC CCTGCAGGTG TCCGACGGAC TCAGGTACCT TCACTCGGCC 6000

ATGATCATCT ACCGGGATCT GAAGCCCCAC AACGTCCTCC TCTTCAACCT GAAGACCGAC 6060

TCAGAGCTCA TCGCCAAGAT CACGGACTAC GGCATCGCCC AGTACTGCTG CAGCATGGGA 6120

GTGCGGAGCT CGGAGGGCAC GCCGGGTTTC CGAGCGCCGG AGGTCGCCCG CGGCAACGCC 6180

ATCTACAACC AGCAGGCCGA CGTGTTCTCC TTCGGCCTGC TGCTCTACGA CCTGCTGACC 6240

TGTGGCCAGC GAATCTCCGA CGGCATGAAG TTCCCCAGCG AGTTCGACGA GGTGGCGGTG 6300

CAGGGTAAAC TTCCAGACCC AGTGAAACAC TACGGCTGCT CCCCTTGGCC CGGCTTCCAG 6360

GCGCTGATGA AGGACTGTTT GAGGGACAGC CCTCAGGGTC GACCCACCTC TGCTCAGGTG 6420

TTCGACAGGC TGAACTCAGG GCAGATGTTG TGCCTCATGA GGGAGCTGGT GGTTCCCCGG 6480

GTGATCAATG CAGAGTGCCT GGCGGTAAGC GCCGACCCCC TGAACAGCCA CCGCGCCTGG 6540

GTGGGTGGAG GCAGCAGCGC CCGGAGGCTG GGCTCCATCA CGGCTGTCCA CCTGGACGGC 6600

AGCGGCGTCA CCACGCAGGA AGTAGAGAGC AGCCCCGTCT TGTGTCTTGT GACCGTCCAA 6660

ATCCCCAGCG AAGCGTGCGA TTGGCTGGTA GCCGGCACGC AGTCCGGCTC CCTGGTGGTC 6720

ATCAGCACTC GGGACCCGTC GGCTTGGCAC CGCCTGCAGA GCGCCACGGA CGCCGTCACC 6780

TCGCTGTACT TCCACGTGCA CCGTATTTTC AGTCAGAGGA AGAATTACTT GCTTGTCGGG 6840

ACGGCCGACG GAATTCTCAC CGTTTACGAG GACTCTGTTC TCAAGCAAGA GAACGGGCAG 6900

CCGGTGAAAT CGCTCACCAT GGGAAACATC AACACGCCCC TCGTGTGCCT GGGCCAGTCG 6960

TCTCACCCGC TGGACGGCAG GTCCGTGTGG GCCGGCTGCG GCACCAAGAT CCTCGCCTTC 7020

ACCGCCGACT ACGAGGTGGG CAGGAGCATC GACACCAGAC CCAACCTCGT CCTGCAGCAG 7080

CAGCGGCCGC TGGGGGGAGA GGCGTGCGTG TCTCGACTGG TCGTGGATAA ATACGTCTAC 7140

CTGAGCAAAG CCGGCACCAC GAGTGTCGAG GTTTGGGATA AGAGGGGCGA GAGGATGGTG 7200

GACCGCGTCG ACTGCGCTCA GATCATCAGA CACGACTCCG CCGTCAGGAG CAGGAGGGCC 7260

AGTGAGGCGG AGCTGGCCGG CGAGGCGGCC CCCTCCTGGG CCCAGGTGAA GGCCCTGCTG 7320

GTGCAGAGCG CTGCAGCTCT GTGGGTGGGA ACCAGAGGGG GCCACCTGCT GCTGCTGGAA 7380

CTCTCCAAGC ACCAGGTGCT GCAGGTCATC GGCCCCTGCT GCGACTCCAC CCGCTGCATG 7440

GCCTCCGCGC TCATAGGGCT AGATACACTA AACTGGAAGA ACGTGGTGCT GGTTTTGGGC 7500

AGAAAGGTCC CACAAGACGC CGATCAGTTT GACAAGGAGT CAGTCCTGAT GGTGTGGAAC 7560

AGCTCTCTGC CCATGGAGGT CAAAGACTTG AACAAACACT GTGAGAAAAG AGAGCAGATA 7620

GCAGCCAGAA TGAGGGAGCA GCTGCATTAG 7650

Domain Profile

S: 3     kgsllGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlal  62

         k++ lG+G+fG+vyr+ +k eevavk+f+      k+ s  +    +  lrqel+vL +l

Q: 1889  KENRLGDGGFGTVYRSIYKNEEVAVKIFN------KHASELY---IHRLLRQELAVLGRL  1939

         66789************************......6655444...45569**********

S: 63    khPsivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargley  122

         +hPs+v+L++++  P +lv+eLa  gsLd+l+++++     l r+l+++ialqv++gl+y

Q: 1940  RHPSLVGLLAAGSSPQVLVMELALSGSLDALFERERGG---LNRKLQHRIALQVSDGLRY  1996

         ********************************999988...*******************

S: 123   LhkkkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeiv  182

         Lh+++iiyrdLk++nvL+++l++ +++++k++dyGi+++++ +G++++eGt+GfraPe++

Q: 1997  LHSAMIIYRDLKPHNVLLFNLKTDSELIAKITDYGIAQYCCSMGVRSSEGTPGFRAPEVA  2056

         ************************************************************

S: 183   rgevvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlpt  240

         rg+ +y++++dvfsfGllly+ll  g+r+ +g +++ +++++ ++Gk+P++vk++++ p+

Q: 2057  RGNAIYNQQADVFSFGLLLYDLLtCGQRISDGMKFPSEFDEVaVQGKLPDPVKHYGCSPW  2116

         ***********************779****************9*****************

S: 241   plld.LlveCwkekPekrPtasqvvs  265

         p  + L+++C+++ P+ rPt++qv++

Q: 2117  PGFQaLMKDCLRDSPQGRPTSAQVFD  2142

         96544*******************97

Domain Sequence
(FASTA)

KENRLGDGGF GTVYRSIYKN EEVAVKIFNK HASELYIHRL LRQELAVLGR LRHPSLVGLL 60

AAGSSPQVLV MELALSGSLD ALFERERGGL NRKLQHRIAL QVSDGLRYLH SAMIIYRDLK 120

PHNVLLFNLK TDSELIAKIT DYGIAQYCCS MGVRSSEGTP GFRAPEVARG NAIYNQQADV 180

FSFGLLLYDL LTCGQRISDG MKFPSEFDEV AVQGKLPDPV KHYGCSPWPG FQALMKDCLR 240

DSPQGRPTSA QVFD 254

Keyword

Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00369

; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013