EKS-GAA-00518

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00518

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	358.6	2.4E-107	273	541	269

Status

Unreviewed

Ensembl Protein

ENSGACP00000012896

UniProt Accession

G3P5M3;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009764	ENSGACP00000012896	ENSGACT00000012920

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

619

Protein Sequence
(FASTA)

MSSFSRHRHG SPSPRVPPIR QKLQFTCSDG EDEPIEDVNN STGGESGFTE MDSPMPVRRV 60

AEDKRLEGDS SPLNRSGGDD DVELWDEESF GSPTHLRSPR SVIFANCSPS PRKASRLYGG 120

SPERSYVQDD GEGSSSPIPD CPDTPPHKTF RKLRLFDTPH TPKSLLSRAR ASGPGSSSRR 180

VALFKNAEAS GKSITDTGRR QQTPHVNFNP FTPDSLLIQS ATQQRNRKRA HWNDSCGEDM 240

EASDGEGEDE VLPPSKRITM MESNMMSRYA SEFLELEKIG CGEFGAVFKC VKRLDGCIYA 300

IKRSKKPLAG SVDEQNALRE VYAHAVLGQH PHVVRYYSAW AEDDHMLIQN EYCNGGTLSD 360

AISENYRRLS YLSELELKDL LLQVTRGLKY IHSTSLVHMD IKPSNIFISR KSVSSCDECD 420

DDEGVTTSVV YKIGDLGHVT RVNNPQVEEG DSRYLANEIL QEDYSKLTKA DIFALALTVV 480

NASGAEPLPT NGDKWHEIRE GKLPAIPQVL SPEFLSLLKL MIHPDPSRRP STSELIKHPV 540

LLTAARMSAD QLRVELNAEK FKNALLQKEL KKAQQARAAA EEKVLSTDRV LTRSTVQSNP 600

RSSRLIGKKM NRSVSLTIY 619

Nucleotide Sequence
(FASTA)

ATGTCGAGCT TCAGTCGCCA TCGGCACGGA TCTCCGTCTC CTAGAGTTCC ACCGATTCGG 60

CAGAAACTGC AGTTCACGTG CAGCGACGGG GAGGACGAGC CCATCGAGGA CGTCAACAAC 120

AGCACGGGCG GAGAGTCCGG CTTCACGGAG ATGGACTCCC CGATGCCGGT GCGACGGGTC 180

GCCGAAGACA AGCGGCTGGA GGGCGACAGT AGCCCGCTGA ACCGGTCCGG CGGAGACGAC 240

GACGTGGAGC TGTGGGACGA GGAGAGTTTC GGGTCTCCGA CTCACCTGCG ATCGCCGAGA 300

AGCGTTATCT TCGCCAACTG CTCGCCGTCG CCGCGCAAGG CTTCCCGGTT GTACGGAGGG 360

TCACCGGAGC GGTCCTACGT GCAGGACGAC GGGGAAGGAT CCAGCTCCCC GATCCCGGAC 420

TGCCCCGACA CACCGCCGCA CAAAACGTTC AGAAAACTCA GACTTTTTGA CACACCGCAC 480

ACACCAAAGA GCTTGCTGTC CAGAGCCAGG GCCTCCGGCC CGGGATCCTC CAGCAGGAGA 540

GTTGCCCTGT TCAAGAATGC GGAGGCTTCG GGGAAGTCGA TCACAGACAC GGGCAGGAGA 600

CAGCAGACCC CCCATGTCAA CTTTAACCCC TTCACACCCG ACTCCCTCCT CATCCAGTCC 660

GCTACACAGC AGAGGAACAG GAAGCGAGCA CACTGGAATG ACTCTTGTGG AGAAGACATG 720

GAGGCAAGTG ACGGCGAAGG AGAGGATGAA GTCTTACCTC CATCGAAGAG GATCACCATG 780

ATGGAGAGCA ACATGATGTC CAGGTACGCC TCGGAGTTCC TCGAGCTGGA GAAGATCGGC 840

TGCGGAGAGT TTGGTGCTGT GTTCAAGTGT GTGAAAAGAC TCGATGGCTG CATCTACGCC 900

ATCAAGAGGT CGAAGAAACC TCTGGCCGGC TCCGTAGACG AACAGAACGC CCTGCGGGAG 960

GTGTACGCCC ATGCCGTGCT GGGCCAGCAT CCCCACGTGG TGCGCTACTA CTCCGCCTGG 1020

GCCGAGGACG ACCACATGCT CATCCAGAAC GAGTACTGCA ACGGCGGCAC GCTCTCTGAC 1080

GCCATCTCCG AGAATTACAG GCGGCTCAGT TACCTGAGCG AGCTGGAGCT GAAGGACCTG 1140

CTGCTGCAAG TCACACGGGG CCTCAAGTAC ATCCACTCCA CATCTCTGGT GCACATGGAC 1200

ATCAAGCCCA GTAACATCTT CATTTCACGA AAATCTGTAT CAAGCTGTGA TGAATGTGAT 1260

GATGACGAAG GAGTGACCAC CAGCGTGGTC TACAAAATAG GGGATCTGGG TCATGTGACA 1320

CGAGTGAACA ATCCACAAGT GGAGGAAGGT GACAGCAGAT ACTTGGCCAA TGAAATTTTA 1380

CAAGAGGACT ACAGTAAGTT GACGAAGGCG GACATCTTTG CCCTGGCCCT GACTGTTGTC 1440

AACGCCTCGG GGGCGGAGCC TCTTCCCACC AACGGAGACA AATGGCACGA GATCCGAGAG 1500

GGAAAACTGC CCGCCATCCC CCAAGTGCTT TCTCCAGAGT TTCTAAGTCT TCTCAAGCTG 1560

ATGATCCATC CTGATCCAAG TAGACGGCCG TCAACGTCCG AACTCATCAA ACACCCGGTG 1620

CTCCTCACGG CTGCCCGGAT GAGCGCCGAT CAGCTCAGAG TGGAGCTCAA TGCGGAGAAG 1680

TTCAAGAACG CACTGCTCCA GAAGGAGCTG AAGAAGGCCC AGCAGGCTCG AGCTGCCGCA 1740

GAGGAGAAGG TTTTGTCCAC CGACCGGGTC CTGACCCGCT CCACGGTGCA GTCCAATCCC 1800

AGATCCTCCA GACTCATCGG CAAGAAGATG AACCGGTCGG TCAGCCTCAC CATCTAC 1857

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+ekiG Gefg vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 273   FLELEKIGCGEFGAVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPH  332

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+gg L++a++e+++  ++l+e elk++ll++++gl+y+H

Q: 333   VVRYYSAWAEDDHMLIQNEYCNGGTLSDAISENYRRLSYLSELELKDLLLQVTRGLKYIH  392

         ************************************************************

S: 121   ssslvHlDikpenifi.................tkevtlklgDlGlvtelnsedkskveE  163

         s+slvH+Dikp+nifi                 t++v++k+gDlG+vt++   ++++veE

Q: 393   STSLVHMDIKPSNIFIsrksvsscdecdddegvTTSVVYKIGDLGHVTRV---NNPQVEE  449

         **************************************************...9******

S: 164   GDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdeilk  222

         GDsryla+Eilqe+yskl kaDiF+l+lt+++++++++lP+nG++Wh++R+gklp  i +

Q: 450   GDSRYLANEILQEDYSKLtKADIFALALTVVNASGAEPLPTNGDKWHEIREGKLP-AIPQ  508

         *******************************************************.****

S: 223   elsedlrellklmlepdperRptaeellkhevl  255

         +ls ++ +llklm++pdp+rRp+++el+kh+vl

Q: 509   VLSPEFLSLLKLMIHPDPSRRPSTSELIKHPVL  541

         ******************************986

Domain Sequence
(FASTA)

FLELEKIGCG EFGAVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHPH 60

VVRYYSAWAE DDHMLIQNEY CNGGTLSDAI SENYRRLSYL SELELKDLLL QVTRGLKYIH 120

STSLVHMDIK PSNIFISRKS VSSCDECDDD EGVTTSVVYK IGDLGHVTRV NNPQVEEGDS 180

RYLANEILQE DYSKLTKADI FALALTVVNA SGAEPLPTNG DKWHEIREGK LPAIPQVLSP 240

EFLSLLKLMI HPDPSRRPST SELIKHPVL 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013