EKS-GAA-00461
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00461
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK341.05.7E-10293349257
StatusUnreviewed
Ensembl ProteinENSGACP00000012901
UniProt AccessionG3P5N2;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K10
Gene Synonyms/Alias MAP3K10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000009773ENSGACP00000012905ENSGACT00000012929
ENSGACG00000009773ENSGACP00000012901ENSGACT00000012925
OrganismGasterosteus aculeatus
Functional Description
Protein Length949
Protein Sequence
(FASTA)
NPYWTAVFDY EATADEELTL RRGDLLEVLS KDSKVSGDEG WWTGKIQDKV GIFPCNYVTR 60
GDATNYRKLT VGGLVPGGVG DCPLEIDFSE LLLDEVIGAG GFGKVYKGVW RREEVAVKAA 120
RQDPDEDISA TAESVRQEAR LFWMLRHTNI ISLHGVCLQE PNLCLVMEYA RGGALNRALA 180
GKKVPPRVLV NWAVQVATGM DYLHNQAFVP IIHRDLKSSN ILILEPVERE DLGGRTLKIT 240
DFGLAREWHQ TTKMSAAGTY AWMAPEVIKV SLFSKSSDVW SFGVLLWELL TGEVPYREID 300
ALAVAYGVAM NKLTLPIPST CPEPFAQLLG ECWSPNPRSR PSFTNILKRL QAIEQSAMFQ 360
MPLESFHSLQ EDWRLEIQQM FDELRAKEKE LRSWEEALAR AAEEQREQEE QLKRREQELA 420
EREIDIVERE LNIIIHQMYQ EKPSVKKRKG HFKKSRLLKL GRDGNCISLP SVGFEHKITV 480
QASPSVDKRK TQGSESTTPP ASPGVIPRLR AIRLTPSDGS KTWGRSAVCK KEELSTSKKK 540
GRTWGPSSTI QKERVGGEEK LKSLGEGCKV WSSSAPNLGK SPKHAPMTAG FSSLNEMEEC 600
PEFEESPGSL QPSETSSNGA AEDSGSLWGN LGPNPVPNVG NASNQDSLRR CSQRKKSDML 660
LMGCASLLAS VALGQDLLQL GKLQEQRKKK EGLFQRTGRF RRSTSPPSRN LSLSLSRHHD 720
STLPCLDPSP SVTLLSLSSL SDCNSTKSLL PSDPDDYPLT PVTGLKTPAA PPAPALNPLL 780
DLRAESFKKE PNQSLTPTHV SAAMALNRGH RRTPSEGAIR PRAQTMGHHR TPSDGSMPMP 840
RTQDTLDIPR LPDPSIIFPV PHRRKGPLIS PLERPKTLEF APRPRPTPAK MRADPRKLGS 900
ISRTLSSSPG SSCDSPLGSG DSGAGTARPN LMDMDVEGQS SDQTVPLCG 949
Nucleotide Sequence
(FASTA)
AACCCCTACT GGACGGCAGT GTTCGACTAC GAGGCCACGG CAGACGAGGA GTTAACCCTG 60
CGGCGCGGGG ATCTCCTTGA GGTTCTCTCC AAAGACTCTA AAGTCTCTGG GGACGAGGGT 120
TGGTGGACGG GCAAGATCCA GGACAAGGTG GGGATCTTCC CATGTAACTA CGTCACCAGG 180
GGGGATGCCA CCAACTACCG GAAGCTGACC GTAGGAGGGC TGGTTCCGGG CGGGGTCGGC 240
GATTGCCCGT TGGAAATAGA CTTCTCCGAA CTGCTCCTGG ATGAGGTGAT TGGAGCCGGT 300
GGGTTCGGGA AGGTGTACAA AGGAGTGTGG CGGAGAGAGG AAGTAGCAGT AAAGGCCGCC 360
AGGCAAGACC CCGATGAGGA TATTAGCGCC ACAGCAGAGA GCGTGCGCCA GGAGGCCAGG 420
CTCTTCTGGA TGCTCCGGCA CACCAACATA ATCTCTCTGC ATGGAGTCTG CCTGCAAGAA 480
CCCAACCTGT GCCTGGTAAT GGAGTACGCC AGAGGGGGGG CTCTGAACCG AGCGCTCGCT 540
GGCAAGAAGG TGCCCCCGAG GGTTCTGGTG AACTGGGCGG TCCAGGTGGC CACGGGGATG 600
GACTACCTGC ACAACCAGGC CTTCGTACCT ATCATCCACA GAGACCTCAA GTCCAGCAAT 660
ATCCTCATCC TGGAGCCGGT GGAGCGGGAG GACCTGGGAG GCAGAACGCT GAAGATCACG 720
GACTTCGGTC TGGCCAGAGA GTGGCACCAG ACCACCAAGA TGAGCGCGGC GGGGACTTAC 780
GCCTGGATGG CCCCCGAGGT CATCAAGGTC TCGCTCTTCT CCAAGAGCAG CGACGTGTGG 840
AGCTTCGGGG TGCTGCTGTG GGAGCTGCTG ACCGGCGAGG TTCCCTACCG GGAGATAGAC 900
GCGCTGGCGG TCGCTTACGG TGTCGCCATG AACAAGCTCA CGCTTCCCAT CCCGTCCACG 960
TGCCCCGAGC CTTTCGCTCA GCTGCTGGGA GAGTGCTGGA GCCCAAACCC CCGCAGCCGG 1020
CCCTCCTTCA CCAACATCCT GAAACGACTG CAGGCCATCG AGCAGTCGGC CATGTTTCAG 1080
ATGCCTCTGG AGTCTTTTCA CTCCTTACAG GAAGACTGGA GGCTTGAGAT CCAGCAGATG 1140
TTTGACGAGC TCAGGGCCAA AGAGAAGGAG CTGAGGTCCT GGGAGGAGGC GTTGGCTCGA 1200
GCGGCTGAGG AGCAGAGGGA GCAGGAGGAG CAGCTTAAGA GGAGGGAGCA GGAGCTGGCA 1260
GAGAGGGAGA TTGACATCGT GGAGCGAGAG CTGAACATCA TCATCCATCA GATGTACCAG 1320
GAGAAACCCA GCGTGAAGAA GCGAAAAGGA CACTTCAAGA AGAGCAGATT ACTGAAACTG 1380
GGCAGAGACG GCAACTGCAT CAGTCTGCCC TCTGTAGGGT TTGAGCATAA AATCACAGTT 1440
CAGGCGTCTC CCAGTGTGGA CAAGAGGAAG ACTCAGGGCA GCGAGAGCAC CACCCCGCCT 1500
GCCAGCCCGG GGGTCATCCC CCGACTCAGG GCCATAAGAC TGACGCCCAG CGACGGCAGT 1560
AAGACGTGGG GACGCAGTGC TGTGTGCAAG AAGGAGGAGC TGTCCACCAG CAAGAAGAAA 1620
GGACGCACCT GGGGGCCGAG CTCGACCATC CAGAAGGAGA GGGTCGGCGG GGAGGAAAAA 1680
TTGAAGTCGT TGGGTGAAGG ATGCAAAGTC TGGTCGTCCA GTGCACCAAA TCTGGGAAAG 1740
TCCCCTAAAC ACGCACCCAT GACTGCCGGC TTCTCCAGCC TCAATGAGAT GGAGGAGTGC 1800
CCCGAGTTTG AGGAGTCACC CGGGTCCCTG CAGCCCTCAG AGACCAGCAG CAACGGGGCC 1860
GCCGAGGACT CTGGGTCCCT GTGGGGCAAC CTGGGGCCAA ACCCGGTGCC TAATGTTGGC 1920
AATGCGAGCA ACCAGGACTC GCTGCGTCGC TGCAGCCAGA GGAAGAAGAG CGATATGCTT 1980
CTGATGGGTT GTGCCTCTCT GCTCGCGTCG GTCGCCCTCG GACAAGACCT GCTGCAGCTG 2040
GGAAAACTCC AGGAGCAGCG TAAGAAGAAG GAAGGTCTCT TCCAGCGGAC AGGACGTTTC 2100
CGTCGCAGCA CCTCTCCACC CAGCCGAAAC CTCTCCCTCT CCCTCTCCAG ACATCACGAC 2160
TCTACGCTCC CCTGTCTGGA CCCGTCTCCC TCTGTGACCC TCCTCTCTTT GTCCTCGCTG 2220
TCTGATTGCA ACTCCACCAA GTCCCTCCTT CCCTCCGACC CGGACGACTA CCCCCTGACC 2280
CCCGTGACGG GGCTCAAAAC GCCGGCGGCG CCCCCGGCTC CCGCCCTCAA CCCGCTCTTG 2340
GACCTGCGGG CGGAGAGCTT TAAGAAGGAG CCCAACCAGT CGCTTACGCC CACGCACGTG 2400
TCTGCAGCCA TGGCCCTGAA CAGAGGACAC AGACGGACCC CTTCGGAGGG GGCGATACGA 2460
CCCCGGGCTC AAACTATGGG TCACCACAGG ACGCCGTCGG ATGGGAGCAT GCCCATGCCA 2520
CGTACACAGG ACACCCTGGA CATCCCCCGC CTGCCCGACC CCTCCATCAT CTTCCCGGTC 2580
CCCCACAGGC GTAAAGGCCC CCTCATCAGC CCTCTCGAGA GACCCAAGAC GCTGGAGTTT 2640
GCCCCCCGGC CTCGGCCCAC TCCGGCCAAG ATGAGAGCCG ACCCCCGGAA GCTGGGCTCC 2700
ATCTCCCGGA CCCTCAGCTC GTCGCCGGGC AGCAGCTGTG ACAGCCCCCT CGGCTCAGGG 2760
GACAGCGGCG CCGGCACCGC GCGACCAAAC CTTATGGACA TGGACGTGGA GGGCCAGAGT 2820
TCGGACCAGA CCGTCCCCCT GTGTGGA 2847
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         l+e+ig+g fgkvyk+ wr +evavK++r++  e  ++++e++++ea+l+++l+h nii 
Q: 93    LDEVIGAGGFGKVYKGVWRREEVAVKAARQDPDEdiSATAESVRQEARLFWMLRHTNIIS  152
         689****************************99989999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l+Gvcl+epnl+lvmey++gg+L+++l++   ++++++vlv+wa+q+A Gm+YLh++a +
Q: 153   LHGVCLQEPNLCLVMEYARGGALNRALAG---KKVPPRVLVNWAVQVATGMDYLHNQAFV  209
         *****************************...99**************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         +iihrdLks+n+L+       +   +tlki+dFG are++++tkmsaagt+awmaPEv+k
Q: 210   PIIHRDLKSSNILIlepvereDLGGRTLKITDFGLAREWHQTTKMSAAGTYAWMAPEVIK  269
         ******************9988899***********************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
          + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L+
Q: 270   VSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFAQLL  329
         ************************************************************
S: 234   kecwnedpekRpsfseivks  253
          ecw+ +p++Rpsf++i+k 
Q: 330   GECWSPNPRSRPSFTNILKR  349
         *****************987
Domain Sequence
(FASTA)
LDEVIGAGGF GKVYKGVWRR EEVAVKAARQ DPDEDISATA ESVRQEARLF WMLRHTNIIS 60
LHGVCLQEPN LCLVMEYARG GALNRALAGK KVPPRVLVNW AVQVATGMDY LHNQAFVPII 120
HRDLKSSNIL ILEPVEREDL GGRTLKITDF GLAREWHQTT KMSAAGTYAW MAPEVIKVSL 180
FSKSSDVWSF GVLLWELLTG EVPYREIDAL AVAYGVAMNK LTLPIPSTCP EPFAQLLGEC 240
WSPNPRSRPS FTNILKR 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-CAJ-00382
EKS-CAP-00410
EKS-DAR-00758
EKS-DRM-00176
EKS-FEC-00366
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LAC-00393
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-ORN-00485
EKS-ORC-00355
EKS-ORL-00447
EKS-OTG-00380
EKS-PAT-00359
EKS-POA-00368
EKS-RAN-00393
EKS-SUS-00331
EKS-TAR-00480
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
EKS-XIM-00474
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013