EKS-GAA-00085

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00085

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	349.4	1.9E-104	12	295	284

Status

Unreviewed

Ensembl Protein

ENSGACP00000013024

UniProt Accession

G3P5Z1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000009848	ENSGACP00000013024	ENSGACT00000013049
ENSGACG00000009848	ENSGACP00000013028	ENSGACT00000013053
ENSGACG00000009848	ENSGACP00000013014	ENSGACT00000013039

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

343

Protein Sequence
(FASTA)

MALEAKSRNK RYEKLDFLGE GQFATVYKAR DKTNDTIVAI KKIKVGHRTE AKDGINRTAL 60

REIKLLQELH HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDTSLVLT PSNIKAYILM 120

TLQGLEYMHQ HWVLHRDLKP NNLLLDGSGV LKLADFGLAK AFGSPNRVYT HQVVTRWYRS 180

PELLFGARMY GVGVDMWAVG CILAELLLRI PFLAGDSDLD QLTKIFEALG TPTEETWPGM 240

SSLPDYVSFK IFPGTPLEHI FTAAGDDLLE LLQSLFTFNP LTRTTATQAL KMRYFSNRPG 300

PTLGPQLPRP NCSAEALREK ETIGLKRTIE GLETTVMKKK LIF 343

Nucleotide Sequence
(FASTA)

ATGGCGCTCG AAGCAAAATC AAGAAACAAA CGATACGAGA AACTGGATTT CCTCGGAGAG 60

GGTCAGTTCG CCACGGTGTA CAAAGCCAGG GACAAAACCA ATGACACCAT AGTTGCCATT 120

AAAAAGATTA AGGTTGGCCA CAGGACTGAG GCTAAAGATG GTATTAACAG GACTGCTCTC 180

CGAGAGATCA AACTACTGCA GGAGCTGCAT CATCCAAATA TCATCGGGCT CCTCGATGCC 240

TTTGGACACA AATCTAACAT CAGCCTGGTG TTTGATTTCA TGGAAACGGA CCTGGAGGTG 300

ATCATCAAAG ACACCAGCCT AGTTCTGACT CCATCCAACA TCAAAGCCTA CATCCTAATG 360

ACCCTGCAGG GATTGGAGTA TATGCACCAA CACTGGGTCC TGCACAGGGA TCTGAAGCCC 420

AACAATCTGC TGTTAGATGG CAGCGGAGTG TTGAAGTTGG CTGATTTTGG TCTGGCCAAA 480

GCATTTGGCA GCCCCAACAG AGTCTACACA CATCAAGTTG TTACCAGGTG GTACCGCTCC 540

CCTGAGCTCC TGTTTGGTGC CAGGATGTAC GGTGTGGGTG TCGACATGTG GGCGGTGGGA 600

TGCATCTTGG CCGAGTTACT CCTTCGGATA CCATTCCTCG CTGGAGACTC TGATCTTGAC 660

CAGCTGACGA AGATCTTTGA GGCTCTCGGG ACGCCTACAG AAGAGACGTG GCCGGGAATG 720

AGTAGTCTAC CGGATTATGT GTCCTTCAAA ATATTTCCTG GCACACCGCT GGAACATATA 780

TTTACTGCAG CTGGAGACGA CTTGCTAGAG CTGCTGCAGA GCCTGTTCAC CTTTAACCCC 840

TTGACGAGGA CCACAGCGAC ACAAGCTCTG AAGATGCGGT ACTTCAGTAA TCGACCCGGT 900

CCCACTCTTG GCCCACAACT CCCCCGACCC AACTGTTCAG CCGAGGCCCT GAGGGAGAAG 960

GAAACGATCG GGCTCAAGAG GACAATCGAG GGCCTGGAGA CAACTGTTAT GAAGAAGAAG 1020

CTCATCTTCT GA 1032

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+++++vA+Kki++ +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKTNDTIVAIKKIKVGHRTEakdGINRTALREIKLLQELHH  71

         99********************************98765555******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+y+H

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDTSL-VLTPSNIKAYILMTLQGLEYMH  129

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         ++++lHRDlKp+NlL++ +g+lklaDfGla+af+sp++ yt++vvT+wYr+PelL+ga+

Q: 130   QHWVLHRDLKPNNLLLDGSGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRSPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p++ g+s+ dql++if+ lgtp+e++wp++s+lp+y  s

Q: 190   YGVGVDMWAVGCILAELLLRIPFLAGDSDLDQLTKIFEALGTPTEETWPGMSSLPDYV-S  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f+  + + l++ ++++ ++ l+ll++l++++p +R++a++al+ +yf

Q: 249   FKIFPGTPLEHIFTAAGDDLLELLQSLFTFNPLTRTTATQALKMRYF  295

         999999*********99****************************98

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KTNDTIVAIK KIKVGHRTEA KDGINRTALR EIKLLQELHH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDTSLVLTP SNIKAYILMT LQGLEYMHQH 120

WVLHRDLKPN NLLLDGSGVL KLADFGLAKA FGSPNRVYTH QVVTRWYRSP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRIP FLAGDSDLDQ LTKIFEALGT PTEETWPGMS SLPDYVSFKI 240

FPGTPLEHIF TAAGDDLLEL LQSLFTFNPL TRTTATQALK MRYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013