EKS-GAA-00022
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00022
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR519.42.2E-15610061274269
StatusUnreviewed
Ensembl ProteinENSGACP00000013853
UniProt AccessionG3P8C9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR (2 of 2)
Gene Synonyms/Alias INSR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000010475ENSGACP00000013853ENSGACT00000013878
OrganismGasterosteus aculeatus
Functional Description
Protein Length1366
Protein Sequence
(FASTA)
MRRWTLRLRA QIVCFIVGTC IVFQCGLIHG EICQSKDIRN NVTNLQSVEN CTIIEGHLKI 60
LLMFKTKTED FRGLSYPRLQ VVTDYVLLFR VYGLEALTDL FPNLAVIRGN NLFFNYALVI 120
YEMLQLKEVG LHSLMNITRG AVRIEKNPDL CYLATLDWSK VLDSVEDNFI VDNKNDRECG 180
DVCPGTAQGQ TTCPQNTING HFRSRCWSQN HCQRMCLDNC RHSACNHKGQ CCHDQCLGGC 240
SEPGNASSCV ACRNLQHGNN CMEKCPPGYY VFRGWRCVSF SFCQQELHNQ CKDSKKLNQD 300
RELGCHEYVI HNGACIPECP SGYTTINSTT LTCSPCAGLC PKLCAGNKTI DSVTSAQALR 360
GCTVLHGNMI IKIRGGNNIA AELEASLGQL EEITGHLTVR RAYALVSLSF LRKLRVIRGE 420
HLEGDVFAFY ALDNQNLHEL WDWSKHNLTI HHGRMFFHYN SKLCMSEIRK MENVTGTKER 480
NQKNDIAVRT NGDQASCVTK LLKFTLIKTS SNMIMLKWEP FWPSDFRDLL GFMVLYKETL 540
YRNVTEFDGQ DACGSNSWAI ADVDPPQRST EGKKADDPGY LIRPLKPWTL YAIMVKTQLS 600
TSDEQQVNGA KSKIIYVRTD ASKPSVPLDP ISSSNSSSQI ILKWKPPTNP NGNITHYRVI 660
CRKQSEDSDL YKFDYCLQGM KLPSRTPTPT VRMNRSGTTQ TSPPGRCCAC PKTDYQLKKE 720
QEEIEYRKTF ENYLHNEVFE SRPSRRRRSV GVANATLPSF FLPAAPGLAF GSTTVPPEDE 780
EGSKVELKVS SKESTVISNL HHFTSYKIEI IACNKVKDVE QCSLASLVSA RTMPEEKADD 840
IPGTVTHEIV AAEPPYVLIK WDSPRSPNGL IILYEVYYRK VEDTEDLTAC VSRPAYLKSG 900
GTKLSLMHPG NYSVRVRATS LAGNGSFTET TYFYMPNSDP GLIWIVMGPV ICFILLLFIG 960
GGVFVILKKR QTEGPTGPLI ASSNPEYIST NDVYIPDEWE VPRDKITVLR ELGQGSFGMV 1020
YEGIAKDIIK GDPDTQVAVK TVNESASLRE RIEFLNEASV MKAFNCHHVV RLLGVVSKGQ 1080
PTLVVMELMT HGDLKSYLRG LRPDSENNPT GRSPPTLKEM IQMAAEISDG MAYLNAKKFV 1140
HRDLAARNCM VAEDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMAPE SLKDGVFTAH 1200
SDCWSFGVVL WEITTLAEQP YQGLSNEQVL KFVMDGGYLD RPDNCPERMH SLMQMCWQYN 1260
PKMRPLFQEI IEMLREDLHP SFHDFSFFYS EENKVPETEE YDLDLDNMES IPLDPSSYSQ 1320
REESLGRDSG PSAARRGNYE EHVPYTHMNG GKKNGRILSL PRSSPS 1366
Nucleotide Sequence
(FASTA)
ATGAGACGCT GGACGCTGAG GCTGAGAGCA CAAATTGTGT GTTTTATCGT CGGCACCTGC 60
ATTGTGTTCC AGTGTGGACT AATACACGGA GAAATCTGCC AGAGTAAGGA CATCCGGAAC 120
AATGTGACCA ACCTCCAGTC GGTGGAGAAC TGCACCATCA TCGAGGGCCA CCTGAAGATT 180
CTGCTCATGT TTAAGACCAA GACTGAGGAC TTCCGGGGCC TCAGCTACCC GAGGCTGCAA 240
GTGGTGACCG ACTACGTGCT GCTGTTCAGG GTCTACGGCC TGGAGGCCCT CACCGACCTC 300
TTCCCCAACC TGGCGGTGAT CCGCGGAAAC AACCTCTTCT TCAACTACGC TCTTGTGATT 360
TACGAGATGC TGCAGCTGAA GGAGGTGGGC CTCCACAGCC TCATGAATAT CACCCGGGGC 420
GCTGTGAGGA TTGAGAAGAA CCCAGACCTG TGCTACCTGG CCACCCTGGA CTGGTCCAAG 480
GTCCTGGACT CAGTGGAGGA CAACTTCATC GTGGATAATA AGAATGACAG AGAGTGTGGA 540
GATGTGTGTC CCGGCACGGC TCAAGGTCAG ACCACCTGCC CACAGAACAC CATCAACGGA 600
CACTTCAGGA GCCGGTGCTG GTCGCAGAAC CACTGCCAGA GAATGTGCCT GGACAACTGT 660
AGGCATAGTG CGTGTAACCA CAAGGGCCAG TGCTGCCATG ACCAGTGCCT CGGCGGCTGT 720
TCTGAGCCAG GTAATGCAAG TAGCTGTGTG GCCTGCAGGA ACCTCCAGCA CGGGAATAAC 780
TGCATGGAAA AGTGTCCTCC TGGATACTAC GTCTTCAGGG GCTGGCGCTG TGTCAGCTTT 840
TCCTTCTGCC AGCAGGAGCT CCACAACCAG TGTAAGGATT CTAAGAAGTT GAACCAGGAC 900
CGAGAGTTGG GCTGCCACGA ATATGTCATC CACAATGGAG CCTGTATTCC AGAGTGTCCG 960
TCAGGATACA CCACTATCAA CTCCACTACG TTGACCTGTT CGCCATGTGC AGGTCTCTGT 1020
CCTAAACTGT GTGCGGGAAA CAAGACGATT GACTCTGTAA CTTCGGCCCA GGCTTTGAGA 1080
GGATGCACCG TTCTCCACGG CAACATGATC ATCAAGATCC GAGGAGGGAA TAATATTGCA 1140
GCTGAATTGG AGGCTAGTTT GGGCCAGCTC GAGGAAATCA CAGGACACCT GACTGTTCGC 1200
AGAGCCTACG CCCTGGTCTC CCTGTCCTTC CTCCGCAAAC TGCGTGTTAT CAGGGGCGAG 1260
CATCTTGAGG GAGATGTCTT CGCCTTCTAC GCGCTGGACA ACCAGAACCT GCATGAGCTG 1320
TGGGATTGGT CCAAGCACAA CCTGACCATC CATCATGGTC GTATGTTCTT CCACTACAAC 1380
TCCAAGCTTT GCATGTCTGA GATCAGAAAG ATGGAGAATG TGACGGGAAC CAAGGAGCGC 1440
AACCAAAAGA ACGACATCGC TGTACGCACC AACGGGGACC AAGCCTCCTG TGTGACCAAG 1500
CTGCTGAAAT TCACCTTGAT CAAGACCTCA TCAAATATGA TTATGCTGAA GTGGGAGCCC 1560
TTTTGGCCTT CAGACTTCAG AGACTTGCTG GGATTTATGG TTCTCTACAA AGAGACGCTG 1620
TACAGGAACG TGACGGAGTT TGATGGACAG GACGCATGCG GCTCCAACAG CTGGGCGATT 1680
GCCGACGTTG ATCCTCCGCA ACGTTCCACG GAGGGCAAGA AGGCGGATGA TCCAGGGTAC 1740
CTTATCCGAC CATTGAAGCC CTGGACCTTG TACGCCATCA TGGTCAAAAC CCAACTATCT 1800
ACGTCTGACG AGCAGCAGGT CAACGGAGCC AAGAGCAAGA TCATCTACGT CCGCACCGAT 1860
GCATCCAAAC CCTCGGTGCC TCTGGACCCC ATTTCCTCCT CCAACTCGTC CTCTCAGATC 1920
ATCCTGAAGT GGAAGCCCCC CACCAATCCC AACGGCAACA TCACCCACTA CCGCGTCATC 1980
TGTCGTAAGC AGTCTGAGGA CAGTGACCTC TACAAGTTTG ACTACTGCCT CCAAGGGATG 2040
AAGCTGCCGT CTCGTACCCC GACCCCCACA GTGAGGATGA ACAGAAGTGG AACCACACAG 2100
ACGAGCCCAC CTGGCCGGTG CTGCGCCTGC CCCAAGACTG ACTACCAGCT TAAGAAGGAG 2160
CAGGAGGAGA TAGAGTATCG CAAGACCTTC GAGAATTACC TCCACAATGA AGTGTTCGAG 2220
AGCAGGCCAT CTCGACGCCG GCGCTCAGTT GGAGTTGCCA ACGCCACCCT GCCCTCATTC 2280
TTCCTCCCTG CAGCCCCCGG CCTGGCTTTC GGATCCACGA CGGTCCCCCC TGAAGACGAG 2340
GAAGGATCCA AGGTGGAACT AAAGGTGTCC TCAAAAGAGT CAACAGTCAT CTCCAACCTG 2400
CACCACTTTA CCAGTTATAA GATAGAGATC ATAGCCTGCA ACAAAGTAAA AGACGTCGAA 2460
CAATGCAGCT TGGCTTCTTT GGTCAGTGCT CGGACTATGC CAGAGGAGAA GGCAGACGAC 2520
ATCCCGGGCA CTGTGACCCA TGAGATCGTG GCGGCCGAGC CTCCCTACGT GCTCATCAAA 2580
TGGGACTCCC CTCGCTCCCC TAACGGCCTC ATCATCCTGT ATGAGGTGTA CTACAGGAAG 2640
GTCGAAGACA CAGAGGATCT CACAGCTTGT GTGTCACGGC CGGCCTACCT CAAGTCAGGT 2700
GGCACAAAGC TTTCGCTTAT GCATCCTGGG AACTACAGTG TGAGGGTCCG CGCCACCTCC 2760
TTGGCGGGAA ATGGCTCTTT TACAGAAACC ACTTACTTCT ACATGCCCAA TTCGGATCCA 2820
GGTTTAATTT GGATTGTGAT GGGTCCAGTC ATCTGCTTCA TCCTGCTGCT GTTCATAGGA 2880
GGTGGAGTCT TTGTCATCCT CAAAAAGAGG CAAACCGAAG GCCCGACCGG ACCTCTTATC 2940
GCCTCCTCGA ACCCAGAGTA CATCAGCACC AATGATGTGT ACATCCCTGA TGAGTGGGAA 3000
GTTCCCCGGG ACAAGATCAC GGTGCTCAGA GAGCTCGGTC AAGGCTCCTT CGGCATGGTG 3060
TACGAGGGAA TCGCCAAGGA CATCATCAAA GGAGACCCGG ACACACAAGT CGCCGTCAAG 3120
ACGGTGAACG AGTCGGCCAG CCTGCGCGAG AGGATCGAGT TCCTGAACGA AGCCTCCGTC 3180
ATGAAGGCTT TCAACTGTCA CCACGTGGTG CGTTTGTTAG GCGTGGTGTC CAAAGGTCAG 3240
CCGACCCTGG TGGTGATGGA GCTGATGACC CACGGTGACC TAAAGAGCTA CCTGCGTGGT 3300
CTCAGGCCGG ACTCTGAGAA CAACCCCACA GGCCGTTCAC CACCTACGCT GAAGGAGATG 3360
ATCCAAATGG CAGCAGAAAT TTCGGATGGC ATGGCCTACC TCAACGCCAA GAAGTTTGTC 3420
CACAGGGACC TGGCAGCCCG AAACTGCATG GTGGCAGAAG ACTTTACCGT CAAGATTGGA 3480
GACTTTGGTA TGACCCGAGA CATCTATGAG ACTGACTACT ACCGTAAAGG AGGTAAGGGC 3540
CTGCTTCCTG TCCGGTGGAT GGCGCCAGAG TCTCTGAAGG ACGGCGTCTT CACAGCCCAC 3600
TCGGACTGCT GGTCATTTGG CGTCGTGCTG TGGGAGATCA CTACGCTAGC AGAGCAGCCT 3660
TACCAGGGTT TATCCAACGA ACAGGTTCTC AAGTTCGTCA TGGATGGAGG ATACCTGGAC 3720
CGGCCGGATA ACTGCCCGGA GAGGATGCAC AGCCTAATGC AGATGTGTTG GCAGTACAAC 3780
CCCAAGATGC GGCCGTTGTT CCAAGAGATC ATCGAGATGT TGCGCGAGGA CCTGCACCCG 3840
TCTTTCCACG ATTTCTCCTT CTTCTACAGC GAGGAGAACA AAGTCCCAGA GACAGAGGAG 3900
TATGACCTGG ACTTGGACAA CATGGAGAGC ATCCCACTGG ACCCGTCTTC GTACTCCCAG 3960
AGAGAGGAGA GCTTAGGCAG GGACAGCGGG CCCTCGGCGG CCCGCAGGGG GAACTATGAG 4020
GAGCACGTCC CCTACACACA CATGAACGGT GGCAAGAAAA ACGGACGAAT CTTATCGTTG 4080
CCCAGGTCCA GCCCTTCCTA A 4101
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i++lrelGqGsfGmvyeG+akd++kg+ +t+va+ktvne+as reriefl+easvmk+f+
Q: 1006  ITVLRELGQGSFGMVYEGIAKDIIKGDPDTQVAVKTVNESASLRERIEFLNEASVMKAFN  1065
         7899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeenea.alappaldkliqmaa  119
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylr lrp++en++ +++pp+l+++iqmaa
Q: 1066  CHHVVRLLGVVSKGQPTLVVMELMTHGDLKSYLRGLRPDSENNPtGRSPPTLKEMIQMAA  1125
         *****************************************8862578************
S: 120   eiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvr  179
         ei+dGmayl+akkfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvr
Q: 1126  EISDGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR  1185
         ************************************************************
S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239
         wm+peslkdGvft++sd wsfGvvlwei+tlaeqpyqGlsneqvlkfv+dgg+l++p+nc
Q: 1186  WMAPESLKDGVFTAHSDCWSFGVVLWEITTLAEQPYQGLSNEQVLKFVMDGGYLDRPDNC  1245
         ************************************************************
S: 240   pelltelmrlcwqynpklrpsfleivell  268
         pe+++ lm++cwqynpk+rp f ei+e+l
Q: 1246  PERMHSLMQMCWQYNPKMRPLFQEIIEML  1274
         **************************975
Domain Sequence
(FASTA)
ITVLRELGQG SFGMVYEGIA KDIIKGDPDT QVAVKTVNES ASLRERIEFL NEASVMKAFN 60
CHHVVRLLGV VSKGQPTLVV MELMTHGDLK SYLRGLRPDS ENNPTGRSPP TLKEMIQMAA 120
EISDGMAYLN AKKFVHRDLA ARNCMVAEDF TVKIGDFGMT RDIYETDYYR KGGKGLLPVR 180
WMAPESLKDG VFTAHSDCWS FGVVLWEITT LAEQPYQGLS NEQVLKFVMD GGYLDRPDNC 240
PERMHSLMQM CWQYNPKMRP LFQEIIEML 269
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Oryzias latipes"; ?>Petromyzon marinus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-ORN-00024
EKS-ORL-00023
EKS-PEM-00008
EKS-TAR-00027
EKS-TEN-00025
EKS-XIM-00024
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013