EKS-GAA-00172

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00172

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	407.1	3.0E-122	216	459	244

Status

Unreviewed

Ensembl Protein

ENSGACP00000014158

UniProt Accession

G3P984;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000010666	ENSGACP00000014158	ENSGACT00000014183

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

463

Protein Sequence
(FASTA)

MKYEPRFPKY KHHDLTVTSR SPRQKMNWAA GTQCVAKGDQ KKQKPGELAY QKGDILTIVE 60

ASTKKGFYKA RLNTTGEEGL INSSNMRTRE ALRVDPSLSL MPWFHGKISG PEAVNKLQPA 120

EDGLYLVRES IRHPGDYVLC VSVSGDVVHY RVIYQDKQLT IDNTQYFYNL IDMIEFYSKN 180

KGSIATTLLK PKQKQGTKSA ELELSKSGWL LDITKLKLGE NIGEGEFGAV YEGVYMDQRV 240

AVKTIKCDVT AQAFLQETTV MTKLQHKNLV RLLGVILHKG LHIVTELMTK GNLVNFLRTR 300

GRSVINSVQL LRFALDVCEG MEYLEAKRLV HRDLAARNVL VSDDSLAKIS DFGLTKVDPK 360

VSDNAKLPVK WTAPEALKKE KFSTKSDVWS YGVLLWEIFS YGRQPYPKMS LKEVKERVEG 420

GYRMEAPDDC PSVVYSLMKM CWEQEPRRRP AFHKLREKLE REI 463

Nucleotide Sequence
(FASTA)

ATGAAATATG AACCACGTTT CCCGAAATAT AAACACCACG ATTTAACTGT GACGTCACGT 60

TCTCCTCGAC AGAAGATGAA CTGGGCCGCC GGCACACAGT GTGTGGCCAA GGGGGACCAA 120

AAGAAACAAA AACCCGGAGA ACTGGCTTAC CAGAAAGGAG ACATCCTCAC TATTGTTGAG 180

GCCAGCACGA AGAAGGGCTT TTACAAAGCC AGACTCAACA CCACGGGCGA GGAAGGACTC 240

ATAAACTCCA GCAATATGCG CACAAGGGAG GCTCTGCGCG TTGACCCCAG CCTCAGCCTC 300

ATGCCTTGGT TCCACGGGAA GATCTCTGGT CCGGAGGCCG TGAACAAGCT GCAGCCGGCC 360

GAGGACGGAC TGTATCTGGT TCGAGAGTCC ATCCGCCATC CCGGCGACTA CGTCCTGTGT 420

GTCAGCGTTT CAGGAGATGT TGTCCACTAC CGGGTGATTT ACCAGGACAA GCAGCTGACC 480

ATCGATAACA CGCAGTATTT CTACAACCTC ATCGACATGA TAGAGTTCTA CTCAAAGAAC 540

AAAGGCTCCA TTGCTACGAC ACTTCTGAAA CCCAAACAAA AACAAGGAAC CAAGTCAGCT 600

GAGTTGGAGC TCTCCAAAAG TGGATGGCTG CTGGACATTA CAAAGCTCAA ACTGGGGGAG 660

AACATAGGAG AGGGGGAGTT TGGTGCTGTT TATGAAGGAG TCTACATGGA CCAGAGGGTG 720

GCAGTAAAGA CCATTAAATG TGATGTCACA GCTCAGGCCT TCCTGCAGGA GACCACAGTC 780

ATGACGAAGC TCCAGCATAA AAACCTGGTG CGATTGTTGG GGGTCATTCT TCACAAAGGG 840

CTTCATATTG TCACAGAACT CATGACTAAG GGGAACCTTG TCAACTTTCT CAGGACAAGA 900

GGACGCTCGG TGATAAACTC AGTTCAGCTG CTCCGCTTTG CTCTAGACGT GTGTGAGGGG 960

ATGGAGTACC TGGAGGCCAA GAGGTTGGTC CACAGAGATC TGGCAGCTCG TAACGTGTTG 1020

GTCTCTGACG ACAGCCTGGC CAAGATCAGC GACTTCGGTC TGACCAAAGT GGACCCAAAG 1080

GTGTCCGACA ACGCCAAACT GCCGGTGAAA TGGACGGCCC CCGAAGCTCT GAAGAAAGAG 1140

AAATTCTCCA CAAAATCGGA TGTTTGGAGC TACGGCGTTC TGCTGTGGGA GATCTTCTCT 1200

TACGGTCGTC AACCTTATCC TAAGATGTCC CTGAAGGAGG TGAAGGAGAG GGTGGAGGGG 1260

GGCTATCGCA TGGAGGCTCC AGACGACTGC CCCTCCGTTG TTTACTCGCT GATGAAGATG 1320

TGCTGGGAGC AGGAGCCACG CAGGAGACCC GCTTTTCACA AACTGAGAGA GAAACTTGAG 1380

CGAGAGATT 1389

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lklge+ig+gefg+v  g y +++vavk+ik+d+taqafl+e++vmtkl+h+nlv+llgv

Q: 216   LKLGENIGEGEFGAVYEGVYMDQRVAVKTIKCDVTAQAFLQETTVMTKLQHKNLVRLLGV  275

         689*********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gl++vte ++kg+lv++lr+rgr+++++ qll+faldv+egmeyle+k+lvhrdl

Q: 276   ILHK-GLHIVTELMTKGNLVNFLRTRGRSVINSVQLLRFALDVCEGMEYLEAKRLVHRDL  334

         **98.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarnvlvs+d +ak+sdfgl+k + k +d +klpvkwtapealk++kfstksdvws+g+l

Q: 335   AARNVLVSDDSLAKISDFGLTKVDPKVSDNAKLPVKWTAPEALKKEKFSTKSDVWSYGVL  394

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lweifs+gr pyp+++lk+v ++ve gy+meap+ cp+ vy+lmk +we e+ +rp+f+k

Q: 395   LWEIFSYGRQPYPKMSLKEVKERVEGGYRMEAPDDCPSVVYSLMKMCWEQEPRRRPAFHK  454

         ************************************************************

S: 241   lkekl  245

         l+ekl

Q: 455   LREKL  459

         ***97

Domain Sequence
(FASTA)

LKLGENIGEG EFGAVYEGVY MDQRVAVKTI KCDVTAQAFL QETTVMTKLQ HKNLVRLLGV 60

ILHKGLHIVT ELMTKGNLVN FLRTRGRSVI NSVQLLRFAL DVCEGMEYLE AKRLVHRDLA 120

ARNVLVSDDS LAKISDFGLT KVDPKVSDNA KLPVKWTAPE ALKKEKFSTK SDVWSYGVLL 180

WEIFSYGRQP YPKMSLKEVK ERVEGGYRME APDDCPSVVY SLMKMCWEQE PRRRPAFHKL 240

REKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013