EPS-GAA-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAA-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	270.0	3.3E-80	23	298	276

Status

Unreviewed

Ensembl Protein

ENSGACP00000014204

UniProt Accession

G3P9D0;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B (2 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000010723	ENSGACP00000014204	ENSGACT00000014229

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MGAFLDKPRT EKHNLHAEGN GVRYGLSSMQ GWRVEMEDAH TAVLGLPAPG MTDWSFFAVY 60

DGHAGSRVAN YCSKHLLEHI IGASLVQADD SNSDSPTPAP PTVEAVKVGI RTGFLKIDEH 120

MRSFSDLRNG MDRSGSTAVG ILLSPEHFFF INCGDSRAVL YRNSHVCFST LDHKPCNPRE 180

RERIQNAGGS VMIQRVNGSL AVSRALGDFD YKCVDGKGPT EQLVSPEPEV FEVVRAPEHD 240

QFVVLACDGI WDVMSNEELC EFVKSRLEVS DDLEKVCNEV VDTCLHKGSR DNMSVVLVCL 300

PNGPKVSEEA VRKDAELNKY LESRVEEMLS RAGEDGFPDL VAVMRNLSTD IGMPSLPPGG 360

GLASKRSVIE AVYNRLNPYR EEDGGARLLD DIW 393

Nucleotide Sequence
(FASTA)

ATGGGTGCGT TCCTGGACAA GCCCAGGACC GAGAAGCACA ACCTGCACGC CGAGGGCAAC 60

GGCGTGCGCT ACGGCCTGAG CTCCATGCAG GGCTGGCGGG TGGAGATGGA GGACGCTCAC 120

ACGGCGGTGC TGGGACTCCC GGCGCCCGGT ATGACCGACT GGTCCTTCTT CGCCGTGTAC 180

GACGGCCACG CCGGCTCCAG GGTCGCCAAC TACTGCTCCA AGCATCTCCT GGAGCACATA 240

ATCGGTGCTA GCTTGGTGCA GGCCGACGAC TCCAACAGTG ACTCTCCGAC GCCGGCGCCT 300

CCCACCGTGG AGGCGGTGAA GGTCGGGATC CGGACGGGCT TCCTGAAGAT CGACGAGCAC 360

ATGCGCAGCT TCTCCGACCT CCGCAACGGC ATGGACCGCA GCGGCTCCAC GGCGGTGGGC 420

ATCCTCCTGT CGCCCGAACA CTTCTTCTTC ATCAACTGCG GCGACTCTCG GGCCGTCCTG 480

TACCGCAACT CGCACGTGTG CTTCTCCACG CTCGACCACA AGCCCTGCAA CCCGCGCGAG 540

CGAGAGCGCA TCCAGAACGC CGGCGGCTCC GTGATGATCC AACGGGTCAA CGGGTCGCTG 600

GCCGTGTCCA GGGCCTTGGG GGACTTTGAT TACAAGTGCG TGGACGGCAA GGGCCCCACG 660

GAGCAGCTGG TTAGCCCGGA GCCGGAAGTG TTCGAGGTGG TCCGGGCGCC CGAGCACGAT 720

CAGTTTGTGG TCCTGGCGTG CGATGGCATC TGGGACGTCA TGTCCAACGA GGAGCTGTGC 780

GAGTTCGTGA AGTCACGGCT GGAGGTGTCC GACGACCTGG AGAAGGTCTG CAACGAAGTG 840

GTGGACACCT GCCTGCACAA GGGGAGTCGG GATAACATGA GTGTTGTGTT AGTGTGTTTG 900

CCCAACGGCC CCAAAGTGTC GGAGGAAGCT GTGAGGAAAG ACGCTGAGCT CAACAAATAC 960

CTGGAGTCTC GAGTTGAAGA GATGCTGTCT CGGGCCGGCG AGGACGGCTT TCCCGACCTG 1020

GTAGCAGTGA TGAGGAACCT GTCCACCGAC ATCGGCATGC CCTCGTTGCC CCCAGGGGGG 1080

GGCCTGGCCA GCAAACGCAG TGTTATTGAA GCAGTATACA ACCGCCTGAA CCCATACAGA 1140

GAGGAAGATG GGGGGGCGCG GCTCTTGGAT GACATTTGG 1179

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ ++   +  ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVLGLPAP--GMTDWSFFAVYDGHAGSRVANYCSKHLLEHI  80

         79****************997666664..4445*************************99

S: 62    aeele............sseseerkvkkalakaFlstdeelkvleeksldidksGstavv  109

                             ++ + vk  ++++Fl++de+++ +++ ++ +d+sGstav

Q: 81    IGASLvqaddsnsdsptPAPPTVEAVKVGIRTGFLKIDEHMRSFSDLRNGMDRSGSTAVG  140

         98866678888877776455666777799*******************************

S: 110   alikdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvl  169

         +l+++++++++n+GdSravL rn +++  + dHkp +++E+eRi++aggsv+ +   Rv+

Q: 141   ILLSPEHFFFINCGDSRAVLYRNSHVCFSTLDHKPCNPRERERIQNAGGSVMIQ---RVN  197

         ******************************************************...***

S: 170   GvLavsRalGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsne  219

         G+LavsRalGd+++k         ++v+pePev+++ + +e++ f++La+DG+wdv+sne

Q: 198   GSLAVSRALGDFDYKcvdgkgpteQLVSPEPEVFEVVRAPEHDqFVVLACDGIWDVMSNE  257

         ***************************************99999****************

S: 220   eavslvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         e++++v+++le +++++++++++v+++l++gs+dn+s+++v

Q: 258   ELCEFVKSRLEVSDDLEKVCNEVVDTCLHKGSRDNMSVVLV  298

         ************************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VLGLPAPGMT DWSFFAVYDG HAGSRVANYC SKHLLEHIIG 60

ASLVQADDSN SDSPTPAPPT VEAVKVGIRT GFLKIDEHMR SFSDLRNGMD RSGSTAVGIL 120

LSPEHFFFIN CGDSRAVLYR NSHVCFSTLD HKPCNPRERE RIQNAGGSVM IQRVNGSLAV 180

SRALGDFDYK CVDGKGPTEQ LVSPEPEVFE VVRAPEHDQF VVLACDGIWD VMSNEELCEF 240

VKSRLEVSDD LEKVCNEVVD TCLHKGSRDN MSVVLV 276

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013