EKS-GAA-00078

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00078

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	382.8	1.3E-114	166	447	282

Status

Unreviewed

Ensembl Protein

ENSGACP00000014494

UniProt Accession

G3PA70;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000010953	ENSGACP00000014494	ENSGACT00000014520

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

496

Protein Sequence
(FASTA)

TTMNKMKNFK RRFSLSVPRT ETIEENEFTE QINQLNIRHT EGLTPDRLGP PSHDASPLSP 60

EPMTPEAQSP SQPDLHDKAE HKRFSVELRK SGCLPSTSKG KIHYVPLSNQ MGVTKRMSLP 120

MDIRLPPEFL KKLQLESENP PLCKPISRMS RRASLSDIGF GKLETYVKLG KLGEGTYATV 180

FKGRSKLTEN LVALKEIRLE HEEGAPCTAI REVSLLKNLK HANIVTLHDI IHTDRCLTLV 240

FEYLDSDLKQ YLDNCGNLMS MHNVKIFMFQ LLRGLSYCHK RKILHRDLKP QNLLINDKGE 300

LKLADFGLAR AKSVPTKTYS NEVVTLWYRP PDVLLGSTEY STPIDMWGMG CILYEMATGR 360

PMFPGATVKE ELHLVFRLLG TPTEDTWPGI SSNEEFRSYL FPQYRPQALI NHVPRLDTEG 420

IDLLSALLLY DTRRRITSED ALRHSYFLSL GNNIHNLADT ASVFSLRELQ LQKDPGHRSS 480

VFQPLGRGKN RRQSIF 496

Nucleotide Sequence
(FASTA)

ACAACCATGA ACAAGATGAA GAACTTCAAG AGGCGTTTCT CCCTTTCTGT TCCCCGGACT 60

GAGACCATTG AGGAGAACGA GTTCACAGAG CAGATAAACC AGCTCAACAT CCGCCACACT 120

GAGGGCCTGA CACCGGATAG GCTTGGTCCT CCATCTCATG ATGCCAGTCC ATTGAGTCCC 180

GAGCCAATGA CGCCGGAAGC CCAGTCACCT TCACAGCCAG ACCTCCACGA CAAGGCCGAG 240

CACAAGCGTT TCTCCGTAGA GCTTAGAAAG TCTGGATGTC TTCCATCAAC AAGCAAAGGA 300

AAGATACATT ATGTTCCCCT TTCTAATCAA ATGGGCGTCA CTAAGCGCAT GTCTCTGCCC 360

ATGGACATCC GCCTGCCTCC GGAGTTCCTC AAGAAGCTGC AGCTGGAGAG TGAGAACCCA 420

CCGCTCTGCA AACCCATCAG CCGCATGTCT CGGCGTGCTT CCCTGTCCGA CATCGGCTTT 480

GGGAAACTGG AGACGTACGT GAAGCTCGGC AAACTGGGCG AGGGGACGTA TGCCACAGTG 540

TTCAAAGGGC GAAGCAAGCT AACAGAAAAC CTGGTGGCGT TGAAGGAGAT CCGGCTGGAG 600

CACGAGGAGG GAGCACCTTG CACTGCTATC AGAGAAGTAT CCCTACTGAA GAACCTGAAA 660

CACGCCAACA TCGTCACTCT GCACGACATC ATCCACACGG ACCGCTGCCT CACTCTGGTG 720

TTCGAGTATC TTGACAGTGA CCTGAAACAG TACTTGGACA ACTGTGGGAA TCTCATGAGC 780

ATGCATAACG TCAAGATTTT TATGTTCCAA CTCCTGCGTG GTCTGTCCTA CTGTCATAAG 840

AGAAAAATCC TCCACAGAGA CTTAAAGCCT CAGAACCTGC TTATCAACGA CAAGGGAGAG 900

CTGAAACTAG CCGACTTTGG ACTTGCGAGG GCCAAGTCCG TCCCTACCAA GACCTACTCC 960

AATGAGGTGG TAACTCTATG GTATCGACCC CCTGATGTGT TGCTGGGCTC TACAGAATAC 1020

TCCACACCAA TCGACATGTG GGGTATGGGC TGTATCCTGT ACGAGATGGC AACCGGTCGT 1080

CCCATGTTTC CTGGTGCCAC AGTGAAGGAG GAGCTACACT TAGTTTTCAG GCTTCTCGGT 1140

ACTCCAACAG AAGATACCTG GCCAGGGATT AGTAGTAATG AGGAATTTAG GTCTTATCTC 1200

TTTCCTCAAT ACAGACCTCA AGCTCTCATC AACCATGTGC CAAGATTGGA CACGGAGGGG 1260

ATCGACCTGC TATCTGCTCT ACTGCTGTAT GACACCAGAA GGAGAATCAC CTCGGAAGAC 1320

GCTCTACGCC ACTCTTACTT CCTGAGTCTG GGGAATAATA TACACAATTT GGCAGATACT 1380

GCTTCAGTGT TTTCCCTCAG AGAGCTCCAG CTCCAGAAGG ACCCAGGCCA CCGCAGCTCA 1440

GTGTTTCAGC CTCTAGGTCG AGGAAAGAAC CGAAGGCAAA GCATCTTC 1488

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 166   YVKLGKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  224

         78999*******************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ +++ l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+gl+y+H++k

Q: 225   VTLHDIIH-TDRCLTLVFEYLDSDLKQYLDNCGN-LMSMHNVKIFMFQLLRGLSYCHKRK  282

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 283   ILHRDLKPQNLLINDKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  342

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W++gcil e++t +p+f+g + +++l+ +f+llgtp+e++wp++s+ +e++ + fp

Q: 343   PIDMWGMGCILYEMATGRPMFPGATVKEELHLVFRLLGTPTEDTWPGISSNEEFRsYLFP  402

         *******************************************************899**

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++ l ++v++l+++++dll+ ll +d ++Ri++++al+h+yf

Q: 403   QYRPQALINHVPRLDTEGIDLLSALLLYDTRRRITSEDALRHSYF  447

         ********************************************9

Domain Sequence
(FASTA)

YVKLGKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDIIHTDR CLTLVFEYLD SDLKQYLDNC GNLMSMHNVK IFMFQLLRGL SYCHKRKILH 120

RDLKPQNLLI NDKGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGMGCILYE MATGRPMFPG ATVKEELHLV FRLLGTPTED TWPGISSNEE FRSYLFPQYR 240

PQALINHVPR LDTEGIDLLS ALLLYDTRRR ITSEDALRHS YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013