EKS-GAA-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	359.8	1.1E-107	25	289	265

Status

Unreviewed

Ensembl Protein

ENSGACP00000014523

UniProt Accession

G3PA99;

Protein Name

Protein Synonyms/Alias

Gene Name

TNIK (2 of 2)

Gene Synonyms/Alias

TNIK (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000010967	ENSGACP00000014523	ENSGACT00000014549

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1335

Protein Sequence
(FASTA)

MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60

DEEEEIKAEI NMLKKYSHHR NIATYYGAFI KKNPPGIDDQ LWLVMEFCGA GSVTDLIKNT 120

KGNSLKEEWT AYICREILRG LTHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPEATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKSHSQRPST EQLLKHPFIR ELPNERQIRI 300

QLKDHIDRTK KKRGERDETE YEYSGSEEED EEREMGEPSS IINVPGESTL RRDFLRLQLA 360

NKERSENEEH KRLLLAERQK RIEEQKEQRR RLEEQQQRER ELRKQHEREQ RRRYEEMEQL 420

RREEERRHSE REQEYIRRQL EEEQRQLEIL QQQLLQEQAL LMEYKRKQIE EQRQAERLQR 480

QLQQERAYLV SLQQQQQQEG RQAEKKPLYH YKDINNPSDK PAWAKEVEER SKLNRQSSPA 540

MQHKVANRIS DPSLPPRSES FSSVGMQPAR TPPTHRSIEP EMAHLIPVKT HSASMSGSQS 600

LQDQTGSALS EGLSVGSPRP EMPRQNSDPT SDTPGPPQRT AGRDERERDR DKDRDRTAWL 660

REEDLPPKVP QRTTSISPAL VRKNSPNGGV GLGPRTASHL IRASNPDLRR SELSLDAMLQ 720

RTSSNSSSSS SPSSQGGSAE RRGTKTCTDS HKSQVKSDES PPGPNQEAKS KQEEGRESAR 780

PSRPASYKKA IDEDLSALAK ELRELRVEEG SRPPVKVTDY SSSSEGSESS DEDGETVGHD 840

GTVAVSDIPR IMPAAKSSGE TYGGLTEDSL GDAYNSSKDG TLVMREEAEE RRRGSHSESN 900

GFGNHSNHGN LPDLVQQSNS PSATPASALQ ELGNMAEFGL GGSKSSFTPF VDPRVYQTSP 960

SENDDETSPE DFGIPAMFSS ELLRQEQARL NEARKISVVN VNPTNIRPHS DTPEIRKYKK 1020

RFNSEILCAA LWGVNLLVGT ENGLMLLDRS GQGKVYNLIT RRRFLQMDVL EGLNVLVTIS 1080

GKKNKLRVYY LSWLRNRILH NDPEVEKKQG WITVGELEGC VHYKVVKYER IKFLVIALKN 1140

SVEIYAWAPK PYHKFMAFSF TELQHRPQLV DLTVEEGQRL KVIYGSSVGF HVIDVDSGNP 1200

YDIYIPSHIQ SQVTPHAIVV LPKTDGMEML LCYEDEGVYV NTYGRITKDV VLQWGEMPTS 1260

VAYIHSNQIM GWGEKAIEIR SVETGHLDGV FMHKRAQRLK FLCERNDKVF FASVRSGGSS 1320

QVFFMTLNRS SMMNW 1335

Nucleotide Sequence
(FASTA)

ATGGCCAGCG ACTCTCCGGC TCGGAGTCTG GACGAAATCG ACCTGTCCGC TCTGAGGGAT 60

CCTGCTGGAA TCTTTGAGCT GGTTGAGCTG GTGGGAAATG GCACCTATGG GCAGGTGTAC 120

AAGGGGCGCC ATGTTAAGAC AGGCCAACTG GCAGCCATCA AGGTCATGGA TGTCACCGGG 180

GATGAGGAAG AGGAGATTAA AGCAGAAATT AACATGCTGA AGAAATACAG TCACCATCGG 240

AACATCGCCA CCTACTATGG AGCGTTCATC AAGAAGAACC CCCCGGGCAT AGATGACCAG 300

CTATGGCTCG TCATGGAATT CTGTGGAGCC GGCTCGGTGA CCGACTTGAT CAAGAACACA 360

AAGGGAAACT CTCTGAAAGA GGAGTGGACT GCTTACATCT GCCGGGAGAT TCTCAGGGGT 420

CTGACTCATC TCCATCAGCA CAAGGTCATC CACAGAGACA TCAAGGGACA GAACGTCCTG 480

CTGACTGAGA ACGCAGAGGT CAAACTAGTG GACTTTGGCG TGTCAGCCCA GTTGGACAGA 540

ACCGTGGGGA GGAGGAACAC GTTCATCGGG ACGCCGTACT GGATGGCGCC GGAGGTCATC 600

GCCTGCGACG AGAACCCCGA GGCCACGTAT GACTTCAAGA GCGATTTATG GTCCCTGGGA 660

ATCACAGCAA TAGAGATGGC TGAAGGAGCA CCACCGCTGT GCGATATGCA CCCGATGAGA 720

GCCCTCTTCC TCATCCCGCG CAATCCCGCC CCCAGACTCA AGTCAAAGAA GTGGTCCAAG 780

AAGTTCCAGT CGTTCATAGA GAGCTGTCTG GTCAAGAGCC ACAGCCAGCG ACCCAGCACC 840

GAGCAGCTCC TCAAACACCC GTTCATCAGA GAGCTGCCCA ACGAGAGGCA GATCCGCATC 900

CAGCTGAAGG ACCACATCGA CCGCACCAAG AAGAAGAGAG GAGAGAGGGA TGAGACAGAG 960

TACGAGTACA GCGGCAGCGA AGAGGAGGAT GAAGAAAGGG AAATGGGTGA ACCAAGCTCC 1020

ATCATCAACG TCCCCGGAGA GTCGACCCTG AGGCGGGACT TCCTGCGCCT GCAGCTGGCC 1080

AATAAGGAGC GATCGGAAAA TGAGGAGCAC AAGCGCCTGC TGTTGGCTGA GAGACAGAAA 1140

CGCATCGAGG AACAGAAGGA GCAGAGAAGG CGGCTGGAGG AGCAGCAGCA GCGAGAGCGA 1200

GAGCTCAGGA AGCAGCATGA GAGGGAACAG AGGAGGCGCT ATGAGGAAAT GGAGCAGCTC 1260

CGTAGAGAGG AGGAGAGGAG GCATTCGGAG AGAGAACAGG AGTATATTCG TAGACAGCTG 1320

GAAGAGGAAC AGAGGCAGTT AGAGATTCTC CAGCAGCAGC TACTACAAGA ACAGGCGTTA 1380

CTGATGGAGT ACAAACGTAA GCAGATAGAG GAGCAGCGGC AGGCAGAGCG GCTGCAGAGG 1440

CAACTCCAGC AGGAGAGAGC CTACCTCGTG TCTCTACAGC AGCAGCAGCA GCAGGAGGGA 1500

AGGCAGGCAG AGAAGAAACC GCTTTACCAC TACAAAGACA TCAACAATCC TAGTGACAAA 1560

CCTGCCTGGG CTAAAGAAGT GGAGGAGCGA TCTAAGCTGA ACAGACAGAG CTCCCCAGCA 1620

ATGCAGCACA AAGTGGCCAA CCGTATCTCC GACCCCTCCC TCCCTCCCCG CTCCGAGTCC 1680

TTCAGCAGTG TGGGCATGCA GCCCGCCCGC ACCCCACCCA CCCACCGCTC CATCGAACCA 1740

GAGATGGCCC ACCTTATTCC AGTGAAGACC CACTCCGCCT CTATGTCCGG CTCGCAGTCT 1800

CTGCAGGACC AGACGGGCTC GGCTCTGAGT GAGGGGCTCA GCGTGGGCTC CCCCAGGCCC 1860

GAGATGCCCC GGCAGAACTC AGACCCCACT TCTGACACCC CCGGGCCGCC GCAGCGCACC 1920

GCGGGCAGAG ATGAGCGTGA ACGGGATAGA GACAAGGATC GGGACAGGAC CGCCTGGCTG 1980

AGAGAGGAGG ACCTCCCACC CAAGGTCCCT CAGAGAACCA CTTCCATCTC CCCAGCCCTG 2040

GTCAGGAAGA ACTCCCCTAA TGGAGGAGTG GGCCTGGGAC CTCGCACAGC TTCTCACCTC 2100

ATACGGGCCA GTAACCCAGA CCTGCGGCGC TCCGAGCTCT CGCTGGACGC CATGCTGCAA 2160

AGAACTTCGT CCAACTCATC ATCCTCGTCC TCCCCTTCGT CTCAGGGAGG CTCAGCCGAG 2220

AGGAGAGGTA CGAAGACCTG CACCGACAGC CACAAAAGTC AAGTCAAATC GGATGAATCC 2280

CCTCCAGGAC CCAATCAGGA GGCAAAGTCC AAACAGGAGG AGGGCCGTGA ATCCGCCAGA 2340

CCCAGCAGAC CTGCAAGCTA TAAGAAAGCC ATAGATGAGG ACCTAAGTGC ATTGGCTAAG 2400

GAACTGAGAG AATTGAGGGT GGAGGAGGGC AGCAGACCCC CAGTCAAGGT GACAGACTAC 2460

TCGTCCTCGA GTGAAGGTTC AGAGAGCAGC GATGAGGACG GGGAGACAGT GGGACACGAT 2520

GGGACCGTTG CTGTTAGCGA CATCCCCCGC ATCATGCCAG CAGCGAAAAG CAGCGGTGAG 2580

ACGTATGGAG GGCTGACAGA GGACTCTCTG GGAGATGCCT ATAATAGCTC CAAGGATGGC 2640

ACTCTAGTGA TGAGAGAGGA GGCAGAGGAG AGGAGGAGAG GGAGCCACAG CGAGAGTAAT 2700

GGGTTCGGGA ATCACAGTAA CCACGGTAAC CTCCCTGACC TGGTGCAGCA GAGCAACTCT 2760

CCCTCAGCAA CACCCGCCTC AGCTTTGCAG GAACTGGGCA ACATGGCTGA GTTCGGTCTG 2820

GGTGGGTCCA AATCATCCTT CACCCCATTC GTTGATCCCC GTGTCTATCA AACCTCCCCG 2880

AGTGAAAACG ATGACGAAAC GTCCCCCGAA GACTTTGGTA TCCCAGCCAT GTTCTCCAGC 2940

GAGCTGCTGA GGCAGGAGCA GGCCAGACTA AACGAAGCCC GAAAGATCTC GGTGGTCAAC 3000

GTCAACCCCA CTAACATCCG ACCCCACAGC GACACGCCGG AGATCCGCAA ATACAAGAAA 3060

CGCTTCAACT CGGAGATCCT GTGTGCTGCA CTCTGGGGCG TGAACCTGCT GGTGGGGACA 3120

GAGAACGGTC TCATGCTACT AGACCGAAGT GGACAGGGAA AAGTCTATAA CCTGATCACC 3180

AGGCGGCGCT TCCTGCAGAT GGACGTGCTG GAGGGGCTCA ATGTGCTGGT CACCATATCT 3240

GGGAAAAAGA ATAAGTTGCG TGTCTACTAC TTGTCCTGGC TGAGGAACAG AATATTACAC 3300

AACGACCCAG AAGTCGAGAA GAAGCAGGGC TGGATTACAG TTGGGGAGCT GGAGGGCTGT 3360

GTGCATTATA AAGTTGTCAA ATACGAGAGG ATTAAGTTCC TTGTGATTGC GCTAAAGAAC 3420

TCTGTGGAAA TCTATGCCTG GGCTCCTAAA CCCTACCACA AGTTCATGGC CTTCTCCTTC 3480

ACCGAGCTGC AGCACCGTCC CCAGCTGGTT GACCTGACGG TGGAGGAAGG TCAGAGGTTA 3540

AAGGTCATCT ACGGCTCCAG CGTGGGCTTC CATGTCATTG ACGTGGACTC GGGCAACCCT 3600

TACGACATCT ACATCCCCTC GCATATCCAG AGCCAGGTGA CGCCCCATGC CATCGTGGTG 3660

CTCCCTAAAA CTGATGGAAT GGAGATGCTG CTGTGTTACG AGGACGAGGG CGTCTACGTC 3720

AACACCTACG GGCGGATCAC CAAGGACGTG GTGCTACAGT GGGGAGAGAT GCCTACCTCC 3780

GTTGCCTACA TCCACTCAAA TCAAATCATG GGCTGGGGGG AGAAAGCCAT AGAGATCCGC 3840

TCTGTAGAGA CCGGTCATCT GGATGGAGTC TTTATGCACA AGAGAGCCCA GAGACTCAAA 3900

TTCCTTTGTG AGCGCAACGA CAAGGTATTC TTTGCTTCGG TGCGCTCAGG AGGAAGCAGC 3960

CAGGTGTTCT TCATGACCCT CAACAGAAGC TCTATGATGA ACTGGTGA 4008

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee++ ei++lkk++h +ni

Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKAEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+ ayi+re+l++L++

Q: 84    TYYGAFIKknppgiDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWTAYICREILRGLTH  143

         ************************************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            e +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f

Q: 204   enpEATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262

         99999*********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++f+e+cl k+ ++Rps+++llkh+F+

Q: 263   QSFIESCLVKSHSQRPSTEQLLKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKAEINMLK KYSHHRNIAT 60

YYGAFIKKNP PGIDDQLWLV MEFCGAGSVT DLIKNTKGNS LKEEWTAYIC REILRGLTHL 120

HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPEATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240

FIESCLVKSH SQRPSTEQLL KHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013