EKS-GAA-00392

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00392

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	343.8	8.4E-103	264	515	252

Status

Unreviewed

Ensembl Protein

ENSGACP00000014655

UniProt Accession

G3PAN1;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2 (2 of 2)

Gene Synonyms/Alias

PAK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000011069	ENSGACP00000014655	ENSGACT00000014681

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

539

Protein Sequence
(FASTA)

MCDNGDPEDK PPAPPVRMSS TIFSTSGKDS LSANHSSKPL PSVPEERKPR KKIISIFSGA 60

EKGGRKKDRD KERPEISPPS DFEHTIHVGF DAVTGEFTPS QTPSGARRKT QLQARPLANA 120

NMPKFEPKKK PQAVLDVLKF YDSTGNGRQK YLSFSSSEKD AFSPGPQSPV KKGSELSSPN 180

IKDIDDDDDD EEAPPPIVAP RPEHTKSVYT RSVIEPLPAP SACPDGDSAS KAADRQKKKG 240

KMTDEEIMDR LRTIVSIGDP KKKYTRYEKI GQGASGTVFT AIDVATGQEV AIKQINLQKQ 300

PKKELIINEI LVMKELKNPN IVNFLDSFLM GEELFVVMEY LAGGSLTDVV TETCMDEAQI 360

AAVCRECLQA LEFLHANQVI HRDIKSDNVL LGMDGSVKLT DFGFCAQITP EQSKRSTMVG 420

TPYWMAPEVV TRKAYGPKVD IWSLGIMAIE MVEGEPPYLN ENPLRALYLI ATNGTPELQN 480

PEKLSPVFRD FLTRCLEMDV EKRGGGKELL QHPFLKLAKP LSSLTPLILA AKEAMKGNR 539

Nucleotide Sequence
(FASTA)

ATGTGTGACA ACGGAGACCC CGAGGACAAA CCCCCCGCCC CCCCGGTGAG GATGAGCAGC 60

ACCATCTTCA GCACGAGCGG CAAAGACTCC CTCTCGGCCA ACCACAGCTC CAAGCCGCTG 120

CCCTCCGTGC CCGAGGAGAG GAAGCCCCGC AAGAAGATCA TCTCCATCTT CTCCGGGGCG 180

GAAAAAGGGG GGAGAAAGAA AGATCGAGAC AAAGAGCGAC CAGAGATCTC ACCGCCTTCA 240

GACTTTGAGC ACACCATACA TGTTGGCTTC GATGCCGTCA CGGGGGAGTT CACTCCTTCC 300

CAAACCCCCT CGGGGGCCCG AAGGAAGACC CAGCTCCAAG CGCGGCCACT CGCCAACGCA 360

AACATGCCCA AATTCGAGCC GAAGAAAAAG CCGCAGGCCG TCCTCGACGT GCTGAAGTTC 420

TACGACTCCA CCGGCAACGG CCGCCAGAAG TACCTCAGCT TCTCTTCTTC TGAAAAAGAC 480

GCCTTCTCTC CAGGACCTCA GTCTCCCGTC AAAAAGGGCA GCGAGCTGTC TTCTCCGAAC 540

ATCAAAGACA TCGACGATGA CGACGACGAT GAAGAAGCTC CGCCTCCAAT CGTGGCGCCG 600

AGGCCGGAGC ACACGAAGAG CGTGTACACT CGCTCCGTCA TCGAGCCCCT CCCCGCGCCG 660

AGCGCGTGTC CGGACGGAGA CTCCGCCTCC AAGGCCGCCG ACCGGCAGAA GAAGAAGGGC 720

AAGATGACGG ACGAGGAGAT CATGGACAGA CTGAGAACGA TCGTCAGCAT CGGAGACCCC 780

AAGAAGAAGT ACACCAGATA CGAAAAGATC GGTCAGGGGG CGTCGGGAAC CGTCTTCACG 840

GCCATCGACG TGGCCACGGG ACAAGAGGTG GCCATTAAAC AGATCAACCT GCAGAAGCAG 900

CCCAAGAAGG AGCTGATCAT CAACGAGATT CTGGTGATGA AGGAGCTGAA GAACCCGAAC 960

ATCGTCAACT TCTTGGACAG TTTCCTGATG GGGGAGGAGC TGTTCGTGGT CATGGAGTAT 1020

CTGGCTGGAG GGTCGCTGAC TGACGTGGTG ACAGAGACCT GCATGGACGA GGCTCAGATA 1080

GCAGCTGTCT GCAGAGAGTG TTTACAAGCT CTGGAGTTCC TGCACGCCAA CCAGGTCATC 1140

CACAGAGACA TCAAAAGTGA CAACGTCTTG CTGGGGATGG ACGGCTCCGT CAAGCTGACC 1200

GACTTCGGCT TCTGCGCTCA GATCACCCCG GAGCAGAGCA AGCGCAGCAC CATGGTGGGG 1260

ACGCCGTACT GGATGGCCCC CGAGGTGGTG ACCCGGAAGG CCTACGGGCC CAAGGTGGAC 1320

ATCTGGTCCC TGGGCATCAT GGCCATCGAG ATGGTGGAGG GAGAACCTCC GTACCTGAAC 1380

GAGAACCCGC TGAGGGCTTT GTACCTGATC GCCACCAACG GCACCCCAGA GCTCCAGAAC 1440

CCGGAGAAGC TGTCTCCGGT CTTCAGAGAC TTCCTCACGC GCTGCCTGGA GATGGATGTG 1500

GAGAAGAGAG GCGGCGGCAA AGAGCTGCTG CAGCATCCGT TCCTGAAGCT GGCGAAGCCG 1560

CTCTCCAGCC TCACGCCTCT CATCCTGGCG GCCAAGGAGG CCATGAAGGG CAACCGTTAG 1620

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a ++ tg+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 264   YTRYEKIGQGASGTVFTAIDVATGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  323

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+sfl+ eel++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++vi

Q: 324   FLDSFLMGEELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVI  380

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 381   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  438

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 439   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFRDFLTRCLEM  498

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR   +ell+h+Fl

Q: 499   DVEKRGGGKELLQHPFL  515

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTAID VATGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSFLMGEE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPVFRDFLT RCLEMDVEKR 240

GGGKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013