EKS-GAA-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	374.4	3.9E-112	48	332	285

Status

Unreviewed

Ensembl Protein

ENSGACP00000015720

UniProt Accession

G3PDP6;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000011869	ENSGACP00000015720	ENSGACT00000015751

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

LLATGFFCVA TDIEKSQPVN IPDAAKRKKK KRTRATDSSM GTFNDLYKLT DEVLGQGAYA 60

KVQGCISLQN GQEYAVKIIE KSAGHSRSRV FREVETLYQC QGNNNILELI HFFEDSCCFY 120

LVFEKLRGGT ILTHIQNRKY FDELEASKVV RDIAQALDFL HTKGIAHRDL KLENILCEYT 180

DRVSPVKICD FDLGSGVKLS SACTPITTPE LTTPCGSAEY MAPEVVEVFT DEASFYDKRC 240

DLWSLGVILY ILLSGSPPFT GRCGTDCGWD RGETCRTCQT HLFESIQQGK YEFPDKDWDH 300

ITEGAKDLIS KLLVRDATLR LSAARVLKHP WVQGNAPERG LPTPHVLQRN SSTKDLSQFA 360

ADAIAFNRQL SQHDEQREDV GAVVCPVRLS PPSNSRLARR RAQTNALRSS DFAPASDDLT 420

A 421

Nucleotide Sequence
(FASTA)

TTGCTCGCAA CTGGATTCTT TTGTGTTGCC ACAGATATCG AGAAAAGCCA GCCAGTGAAC 60

ATCCCCGATG CAGCGAAAAG AAAAAAGAAG AAGAGAACCA GAGCGACGGA CAGCTCCATG 120

GGCACTTTTA ATGATCTGTA CAAGCTGACG GATGAGGTGC TCGGTCAAGG GGCCTACGCT 180

AAAGTTCAAG GGTGCATAAG TTTGCAGAAC GGACAGGAGT ATGCTGTGAA GATTATAGAA 240

AAGAGTGCGG GGCACAGCCG GAGCAGAGTC TTTCGAGAAG TGGAAACTCT CTACCAGTGT 300

CAAGGAAACA ACAACATTTT GGAATTGATC CATTTCTTTG AAGACAGCTG CTGCTTTTAT 360

TTGGTGTTTG AAAAGCTGCG TGGTGGCACC ATTCTCACAC ACATCCAGAA CCGGAAGTAC 420

TTTGACGAGC TGGAGGCCAG TAAGGTGGTC AGGGACATCG CCCAAGCGCT TGACTTCCTG 480

CACACTAAAG GCATTGCCCA TCGAGACCTC AAGCTGGAGA ACATCCTCTG TGAATACACT 540

GATCGGGTGT CCCCAGTGAA GATCTGCGAC TTTGACTTGG GGAGTGGAGT GAAGCTCAGC 600

AGTGCCTGTA CGCCCATAAC GACCCCGGAG CTCACCACGC CGTGTGGCTC AGCAGAGTAT 660

ATGGCTCCAG AAGTAGTCGA GGTGTTCACT GACGAGGCCT CTTTCTACGA CAAACGCTGT 720

GACCTTTGGA GTCTCGGGGT CATCCTCTAC ATCCTACTGA GCGGAAGCCC CCCGTTCACA 780

GGCCGCTGTG GCACCGACTG TGGCTGGGAC CGCGGAGAAA CCTGCAGGAC CTGCCAGACT 840

CACCTGTTCG AGAGCATCCA GCAGGGCAAG TACGAATTCC CAGACAAGGA CTGGGATCAC 900

ATCACCGAGG GGGCCAAGGA TCTCATCTCC AAGCTGCTGG TTCGGGACGC AACCCTTCGC 960

CTCAGTGCTG CTCGGGTCCT CAAGCACCCT TGGGTGCAAG GGAACGCCCC AGAGAGAGGT 1020

CTTCCCACTC CTCATGTTCT ACAGAGGAAC AGCAGCACCA AAGACCTGAG CCAGTTCGCA 1080

GCCGACGCCA TCGCCTTCAA CCGGCAGCTG TCTCAGCACG ACGAGCAGCG GGAGGACGTG 1140

GGGGCCGTCG TTTGCCCCGT GAGGCTTTCC CCTCCTTCCA ACTCCAGACT GGCCCGCCGG 1200

CGGGCGCAGA CCAACGCGCT GCGCAGCAGT GACTTCGCCC CCGCGTCCGA CGACCTCACG 1260

GCCTGA 1266

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+evlG+G+++kv+ c++ ++g++ya+ki+     ++r++v+reve+++q++g++ni+

Q: 48    KLTDEVLGQGAYAKVQGCISLQNGQEYAVKIIeksagHSRSRVFREVETLYQCQGNNNIL  107

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli +fe    d+ +++lv+ekl+GG +l++iq+rk+f e eas+vv+dia+al+flh+k

Q: 108   ELIHFFE----DSCCFYLVFEKLRGGTILTHIQNRKYFDELEASKVVRDIAQALDFLHTK  163

         *******....99***********************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaP  167

         +iahrDlk en+L+e +++++pvk+cDf+l+++++ +        +el+tpc++aey+aP

Q: 164   GIAHRDLKLENILCEYTDRVSPVKICDFDLGSGVKLSsactpittPELTTPCGSAEYMAP  223

         ********************************9954456888888***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+e++++ea++ydk+CDlWslGvilyill+G pPf++++g           r+++ +l+

Q: 224   EVVEVFTDEASFYDKRCDLWSLGVILYILLSGSPPFTGRCGtdcgwdrgetcRTCQTHLF  283

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iq+gkyefP+++W++++e akdli+klL+rd++ rl+++ vl+hpwv

Q: 284   ESIQQGKYEFPDKDWDHITEGAKDLISKLLVRDATLRLSAARVLKHPWV  332

         ************************************************8

Domain Sequence
(FASTA)

KLTDEVLGQG AYAKVQGCIS LQNGQEYAVK IIEKSAGHSR SRVFREVETL YQCQGNNNIL 60

ELIHFFEDSC CFYLVFEKLR GGTILTHIQN RKYFDELEAS KVVRDIAQAL DFLHTKGIAH 120

RDLKLENILC EYTDRVSPVK ICDFDLGSGV KLSSACTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDEASFYD KRCDLWSLGV ILYILLSGSP PFTGRCGTDC GWDRGETCRT CQTHLFESIQ 240

QGKYEFPDKD WDHITEGAKD LISKLLVRDA TLRLSAARVL KHPWV 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013