EKS-GAA-00144

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00144

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	433.4	3.9E-130	1021	1281	261

Status

Unreviewed

Ensembl Protein

ENSGACP00000015921

UniProt Accession

G3PE85;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R (1 of 2)

Gene Synonyms/Alias

MST1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000012007	ENSGACP00000015909	ENSGACT00000015940
ENSGACG00000012007	ENSGACP00000015921	ENSGACT00000015952

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1324

Protein Sequence
(FASTA)

LAPSPVNFSV VYTMPFFQAR GTIQNLVNNS LYQEVYIASQ NVIEAVNRSL EKVWELRTGP 60

VGSPECHICD LCDIDKDPNI LEETNNQVLL LDTLFMSLYS CGSSQYGVCY FHQLNPNGES 120

PSLSKCLFRK DSNSAAYCPD CLASPLGTKV TMVEEGQTVY FFVATTVNDS VTQRYARKSI 180

SVRRPLATED GFYKDVRGLT VLPGLRGTYQ IEYVYSFFTQ EFVYFLSVQR ESPYQDSSPF 240

QTRLGRLPRN EWEMKRYREV ILECRFEPKR RKRNVASEPY KDVVYNVVQA AHFGKAGKEL 300

AEELGAEEED DILYGVFAVT DDNGVTEHDS ALCAFPIDNV NKAIGRFLDR ACMKISSRGC 360

GATHDVFFLN ILLSHEQGEM ISNRDHPTMM SKPYYRVDLF NRQMTDVLLT SLLVTTIENK 420

TVAHIGTSTG RLLQLVLTRS SPLIFANYSL VENQRVSSIA AVYSAEYLLF VVGDKMIQVP 480

QKGPGCQHFL TCAMCLTAPK FMGCGWCSGV CSWESECHSR WRNESCQPGI TGFFPRTAPP 540

DGQTELTVCG WEFQSPLKPA ITSRSHQVRL GQTPCTVLPV KSNNTHLVCK IRSGSIELSK 600

PVNITVEVHE GKVEGRYSID GKAEMPGFTF VIPNITEIQP NYGPRVGGTL ITITGPHLDA 660

GRTRKVTLND MPCPIKRVTE PKGNVSSIIC LSQAISEVRD VPLSVFIDKS PVLTTKVFYY 720

KDNPMITAVL PDCSFDRGSK IVIGGENLDS VYRTVIRFKP NESHLKPVTR ECIGKSLPTR 780

MECISPAFPR DETEEGQLSF DMDGALGLWN KEFSYHPYGE PIPFETDGNV LKLYPGSCMT 840

IIMTVAGVNC DAKVLDNEIT CRIPKNMTIP GEGLRVKISI NGQVHDVGTV VRVSNHYMVG 900

IVLGILAALV AGAVLAFVVM KHLRKKKKAS MVESRLTHSP SRSGTNNMEL LPVGDYRRVS 960

LSPPTPLVGS VVFPSRSYAA ANIDPALTPL MPSEKISISS FRPELLEEVK DVLIPAEMLI 1020

VKHQRIIGKG HFGTVYHGYF KDPSNREIHC AVKSLNRITD VEEVEQFLKE GIIMKGFHHI 1080

NVLSLLGILL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT VKDLIGFGLQ VTKGMEYLAQ 1140

KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSV QDHRKAKLPV KWMAIESLQT 1200

QKFTSKSDVW SFGVLMWEML TRGASPYPEV DPYDITHYLL KGRRLPQPQY CPDPLYIIIL 1260

QCWDPDPELR PSFATLVLAV STILSSLEGE HYISLNVTYV NLDQPRPYPA LTESADEKDS 1320

TDVE 1324

Nucleotide Sequence
(FASTA)

CTTGCCCCCA GCCCAGTCAA CTTCTCTGTG GTTTACACAA TGCCCTTCTT TCAGGCCCGT 60

GGCACCATCC AGAACTTAGT CAATAACTCA CTCTACCAGG AGGTGTACAT TGCCTCTCAG 120

AATGTGATCG AAGCTGTCAA CAGAAGCTTG GAGAAGGTGT GGGAGCTCCG CACTGGGCCG 180

GTGGGAAGCC CAGAGTGTCA CATATGCGAC TTGTGCGACA TTGACAAGGA TCCTAACATC 240

CTGGAGGAGA CAAACAATCA GGTCTTGCTG TTGGATACTC TCTTTATGTC TTTATACTCT 300

TGTGGAAGTT CTCAGTATGG TGTATGCTAT TTCCACCAAC TAAACCCAAA TGGAGAGTCG 360

CCTTCCCTTT CCAAGTGTTT GTTCAGAAAG GATTCTAATT CCGCTGCCTA CTGTCCAGAT 420

TGTTTGGCCA GCCCTCTTGG CACCAAAGTC ACAATGGTCG AAGAGGGTCA GACTGTCTAC 480

TTCTTTGTTG CCACCACTGT CAATGACAGC GTTACCCAGC GGTACGCAAG GAAGTCCATA 540

TCAGTGCGTC GACCACTGGC CACAGAAGAT GGCTTCTACA AGGACGTGCG TGGCCTGACT 600

GTCCTTCCTG GATTGCGGGG GACATACCAA ATTGAATACG TCTACAGCTT TTTTACTCAG 660

GAGTTTGTCT ACTTCCTCTC AGTTCAGAGA GAGAGCCCCT ATCAGGACTC CTCTCCGTTT 720

CAGACTCGCT TGGGCCGTCT CCCACGCAAT GAATGGGAGA TGAAAAGGTA CCGCGAGGTG 780

ATCCTGGAGT GTCGGTTCGA ACCAAAGCGC CGGAAGAGGA ACGTAGCCAG CGAGCCCTAT 840

AAGGACGTGG TGTACAACGT GGTCCAGGCA GCCCACTTTG GCAAGGCAGG CAAGGAGCTG 900

GCAGAGGAGT TGGGCGCCGA GGAGGAGGAC GACATCCTCT ATGGGGTTTT TGCGGTCACT 960

GATGACAACG GGGTGACGGA GCACGACTCG GCCCTGTGCG CCTTCCCGAT TGACAACGTG 1020

AACAAAGCCA TCGGCAGGTT TCTTGACAGG GCCTGTATGA AAATCTCATC ACGAGGGTGT 1080

GGAGCAACAC ATGATGTCTT CTTTCTTAAC ATCTTGTTGT CACATGAACA AGGTGAGATG 1140

ATATCCAACA GGGACCATCC TACTATGATG TCAAAGCCCT ACTACAGAGT GGACCTCTTC 1200

AACAGGCAGA TGACAGATGT CCTGCTCACA TCCTTGCTGG TCACAACTAT AGAGAACAAG 1260

ACCGTTGCCC ATATTGGCAC CTCAACCGGA CGCCTGCTGC AGCTTGTATT GACAAGATCC 1320

AGCCCTCTAA TCTTTGCCAA TTACTCTTTG GTAGAGAACC AGAGAGTCTC GTCTATTGCT 1380

GCTGTTTACT CAGCAGAGTA TCTTCTCTTT GTGGTTGGAG ACAAGATGAT TCAGGTGCCC 1440

CAGAAAGGGC CGGGCTGTCA ACACTTCTTG ACTTGTGCCA TGTGCCTGAC GGCACCGAAG 1500

TTCATGGGTT GTGGCTGGTG CTCCGGAGTG TGCTCCTGGG AGAGCGAGTG TCACAGTCGC 1560

TGGAGGAACG AGTCGTGCCA GCCGGGGATC ACTGGGTTCT TTCCACGGAC TGCTCCTCCT 1620

GATGGTCAAA CAGAGCTAAC GGTGTGCGGA TGGGAGTTCC AGTCTCCCTT GAAACCTGCA 1680

ATCACCTCCA GATCCCACCA GGTCCGACTG GGACAGACTC CATGTACGGT GCTTCCAGTC 1740

AAAAGCAACA ACACACACTT GGTATGTAAG ATTCGCTCTG GGTCCATTGA GCTGTCCAAA 1800

CCAGTTAACA TTACAGTGGA GGTGCACGAG GGCAAGGTGG AGGGACGTTA CTCTATTGAC 1860

GGGAAGGCAG AAATGCCAGG ATTCACATTT GTGATTCCCA ACATCACAGA AATCCAGCCC 1920

AACTATGGAC CTCGTGTTGG GGGCACACTC ATCACAATAA CTGGGCCGCA CTTGGATGCT 1980

GGGAGGACCA GAAAAGTTAC TCTCAACGAC ATGCCCTGTC CTATAAAGAG AGTCACAGAG 2040

CCCAAAGGCA ATGTGTCCTC CATCATCTGT CTGTCCCAGG CCATCTCAGA GGTGAGGGAC 2100

GTCCCCCTGA GCGTTTTTAT CGATAAGTCT CCCGTCCTCA CCACAAAGGT GTTTTACTAC 2160

AAAGACAACC CGATGATTAC AGCCGTCCTG CCTGACTGTA GTTTTGACAG GGGGTCGAAG 2220

ATTGTCATTG GGGGGGAGAA CCTGGATTCT GTTTACCGCA CTGTCATCCG CTTTAAACCC 2280

AATGAGAGCC ACTTGAAACC TGTGACAAGG GAGTGCATCG GCAAGTCCTT GCCCACGAGG 2340

ATGGAGTGCA TCTCTCCTGC GTTCCCCAGG GATGAGACAG AAGAAGGACA GCTTTCTTTT 2400

GACATGGACG GAGCGTTGGG ACTATGGAAC AAAGAGTTCT CCTACCACCC CTATGGCGAG 2460

CCCATTCCTT TTGAAACAGA TGGAAACGTG CTGAAGTTGT ACCCCGGCTC CTGTATGACT 2520

ATCATTATGA CAGTGGCGGG TGTCAATTGT GACGCTAAAG TCCTGGATAA TGAGATCACC 2580

TGCAGGATCC CCAAGAACAT GACCATCCCC GGGGAGGGCC TGCGGGTGAA GATCTCCATC 2640

AACGGGCAGG TCCACGACGT TGGTACTGTG GTGAGGGTCA GTAACCACTA CATGGTGGGC 2700

ATTGTTTTGG GGATCCTGGC GGCTCTGGTG GCTGGGGCGG TGCTGGCCTT CGTTGTTATG 2760

AAACACTTGA GAAAGAAGAA GAAAGCCTCC ATGGTAGAGA GCCGTTTGAC CCACAGTCCT 2820

AGCCGCTCCG GGACAAATAA CATGGAGCTC TTGCCTGTTG GGGACTACAG GAGAGTATCA 2880

CTGAGTCCTC CCACCCCACT GGTTGGGTCG GTGGTGTTCC CCAGCCGGAG CTATGCTGCA 2940

GCCAACATAG ATCCTGCCCT CACCCCCCTC ATGCCCTCAG AGAAGATCTC CATCTCCAGT 3000

TTTAGGCCAG AGCTGCTGGA GGAGGTGAAG GATGTTCTCA TCCCCGCTGA GATGCTCATT 3060

GTGAAGCACC AGCGGATCAT AGGGAAGGGT CATTTTGGCA CTGTCTACCA TGGCTACTTC 3120

AAAGACCCCA GCAACAGAGA AATCCACTGC GCGGTCAAGT CTTTGAACAG AATAACAGAT 3180

GTTGAAGAGG TGGAGCAGTT TCTAAAGGAA GGGATCATAA TGAAGGGTTT CCACCACATT 3240

AATGTGCTGT CTCTGCTGGG CATTCTCCTG CCGCAGGAGG GACTCCCTTT AGTGGTACTA 3300

CCGTACATGA AACACGGTGA CCTGCGACAC TTCATACGCT GCGAGAAAAG GAACCCCACC 3360

GTCAAGGATC TGATTGGCTT TGGGCTACAG GTTACCAAGG GGATGGAGTA TTTAGCTCAG 3420

AAGAAGTTTG TGCACAGAGA TCTTGCAGCA CGCAATTGCA TGCTGGACGA GTCATATACA 3480

GTGAAGGTGG CAGACTTTGG CATGGCGAGA GATGTGTTTG ATAAGGAGTA CTACAGTGTT 3540

CAGGACCACA GGAAGGCTAA GCTGCCCGTC AAGTGGATGG CAATCGAAAG TCTGCAGACA 3600

CAGAAATTCA CCTCCAAGTC TGATGTGTGG TCCTTTGGTG TGCTGATGTG GGAGATGTTG 3660

ACCAGGGGAG CGAGCCCCTA CCCAGAGGTG GACCCTTATG ACATAACACA TTACTTACTG 3720

AAGGGCAGGA GGCTTCCCCA GCCTCAGTAC TGCCCTGACC CTTTGTATAT CATTATCCTT 3780

CAGTGCTGGG ACCCTGATCC AGAGTTGAGG CCCAGCTTTG CTACATTGGT GTTGGCCGTC 3840

TCCACCATCC TTTCCAGCCT GGAGGGAGAG CACTATATCA GTTTGAATGT CACCTACGTC 3900

AACCTGGACC AGCCGCGACC GTACCCCGCC CTCACAGAGT CTGCCGACGA AAAAGACTCC 3960

ACAGATGTTG AG 3972

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++++iGkGhfG+vy+g ++d+++++i++avksl+ritd+e+ve+fl+eg++mk+++h

Q: 1021  VKHQRIIGKGHFGTVYHGYFKDPSNREIHCAVKSLNRITDVEEVEQFLKEGIIMKGFHHI  1080

         56789*******************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi l++eglplvvlpymk+Gdl++fir e+rn+tvkdl++f+lqv+kgmeyla+

Q: 1081  NVLSLLGILLPQEGLPLVVLPYMKHGDLRHFIRCEKRNPTVKDLIGFGLQVTKGMEYLAQ  1140

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+lde++tvkvadfG+ardv+dke+y+v+++r+a+lpvkw+a+eslqt

Q: 1141  KKFVHRDLAARNCMLDESYTVKVADFGMARDVFDKEYYSVQDHRKAKLPVKWMAIESLQT  1200

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k ft+ksdvwsfGvl+we+ltrga+py+ev+++d+t+yl +grrl++p+ycpd ly ++

Q: 1201  QK-FTSKSDVWSFGVLMWEMLTRGASPYPEVDPYDITHYLLKGRRLPQPQYCPDPLYIII  1259

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         l+cw ++p+ rp+f+ lv  +s

Q: 1260  LQCWDPDPELRPSFATLVLAVS  1281

         ****************998765

Domain Sequence
(FASTA)

VKHQRIIGKG HFGTVYHGYF KDPSNREIHC AVKSLNRITD VEEVEQFLKE GIIMKGFHHI 60

NVLSLLGILL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT VKDLIGFGLQ VTKGMEYLAQ 120

KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSV QDHRKAKLPV KWMAIESLQT 180

QKFTSKSDVW SFGVLMWEML TRGASPYPEV DPYDITHYLL KGRRLPQPQY CPDPLYIIIL 240

QCWDPDPELR PSFATLVLAV S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013