EKS-GAA-00395

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00395

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	341.5	4.3E-102	16	273	258

Status

Unreviewed

Ensembl Protein

ENSGACP00000016037

UniProt Accession

G3PEL3;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000012107	ENSGACP00000016037	ENSGACT00000016068

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

MNSSVDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH SNIVAYFGSY LRRDKLWISM EYCGGGSLQD IYHVTGPLSE SQIAYMSRET 120

LQGLYYLHNK GKMHRDIKGA NILLTDNGYV KLADFGVSAQ ITATLAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDIWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKV 240

KWTNNFHHFV KLSLTKNPKK RPTAEKLLQH PFVSQPLSRT LAIELLDKSN NPDHSTFNDF 300

DDDDPEPEVS VPHRIRSTSR STREGKTLSE INFGQVKFDA PLRKETAPHH EPCESEPYLD 360

CVEELYYTAR SNLDLQLEYG HDSPSLLGGN KSLLKSVEEE LHQRGHVAYL ENDPFEGDEN 420

KSSTIMRPKV PPPLPPKPKS LCSSPQPPPP PLQKPDDGRP HSEDDGGSGG GGDGTIKRCP 480

ETASPARPAS SVPPRPPPPK LPTRKWISYR FNVLSNLSDQ YLIFGAEEGI YTLNLNELHE 540

TSMEQLFPRR CTWLYVMNSC LLSISGKASQ LYSHALSGLF EQARQLQKLP VAIPTHKLPD 600

KMIPRKYAVS NKIPDTKGCQ KCCVVRNPYT GHKYLCGAFQ SSVMLLEWVE SMQRFMLIKN 660

IDFPLPCPLE VFEMLVVPEQ TYPLICVAVS KGTELNQVVR FGTVNPNSTS SWFTEANTPQ 720

TCVIHVTQLE RDTILVCLDR CIKIVNLPGR LKSSRKLSAE LTFNFQIEAT VCLQDSVLAF 780

WRHGMQGRSF KTNEITQEIS DSTRIFRLLG SDRVVVLESR PTDNPTAHSN LYILAGHENS 840

Y 841

Nucleotide Sequence
(FASTA)

ATGAACTCCA GCGTGGACCT GTCCCGGAGG AATCCGCAGG AGGACTTCGA GCTGATCCAG 60

CGGATAGGAA GCGGCACATA CGGAGATGTG TACAAGGCTC GTAATGTCAA CACAGGAGAG 120

CTGGCTGCCA TCAAAGTCAT CAAACTGGAG CCGGGTGAGG ACTTTGCTGT GGTGCAGCAG 180

GAGATCATAA TGATGAAGGA CTGCAAACAC TCCAACATCG TGGCCTACTT CGGCAGTTAC 240

CTCCGGAGAG ATAAACTATG GATCAGTATG GAGTACTGTG GAGGAGGTTC TCTGCAGGAC 300

ATCTACCACG TGACCGGGCC GCTGTCGGAG TCTCAGATAG CCTACATGTC CCGGGAGACC 360

CTCCAGGGTT TATACTACCT ACACAACAAA GGCAAAATGC ACAGAGACAT CAAGGGCGCC 420

AACATCCTGC TGACAGACAA CGGCTACGTT AAACTAGCTG ACTTCGGAGT GTCGGCTCAG 480

ATCACAGCCA CTCTGGCCAA GAGGAAGTCC TTCATTGGAA CTCCGTACTG GATGGCTCCA 540

GAGGTGGCAG CAGTAGAGAG GAAAGGAGGT TACAACCAGC TGTGTGACAT CTGGGCCGTG 600

GGAATCACTG CAATAGAGCT GGCCGAGCTG CAGCCCCCCA TGTTTGACCT GCACCCCATG 660

AGGGCTCTCT TCCTGATGAC CAAGAGCAAT TTCCAGCCTC CTAAGTTGAA AGATAAAGTC 720

AAGTGGACAA ACAACTTCCA CCATTTTGTC AAACTGTCGC TCACCAAGAA CCCGAAGAAG 780

AGGCCCACGG CTGAGAAGCT GCTGCAGCAC CCGTTCGTGT CCCAGCCCCT CAGCAGGACG 840

TTGGCCATCG AGCTGCTGGA CAAATCCAAC AACCCCGACC ACAGCACCTT CAACGACTTT 900

GACGACGACG ACCCTGAACC CGAGGTCTCC GTTCCTCATC GGATCCGGTC CACCAGCAGG 960

AGCACCAGGG AGGGGAAGAC GCTGTCGGAG ATCAACTTTG GCCAGGTGAA GTTTGACGCT 1020

CCGCTGAGGA AGGAGACGGC GCCTCACCAC GAACCGTGTG AATCTGAGCC CTATCTGGAC 1080

TGTGTTGAGG AGCTCTACTA TACCGCGAGA TCTAATCTGG ACCTGCAGCT GGAGTACGGA 1140

CACGATTCTC CAAGTCTACT GGGAGGAAAC AAGAGTCTCC TCAAATCGGT GGAGGAGGAG 1200

CTTCACCAGA GGGGCCATGT GGCTTACTTA GAAAATGATC CATTTGAAGG AGACGAGAAC 1260

AAATCGAGCA CCATCATGAG GCCGAAGGTC CCGCCTCCTC TTCCTCCAAA GCCGAAGTCG 1320

CTCTGCTCGT CACCACAACC GCCGCCGCCG CCGCTGCAGA AGCCCGACGA CGGCCGCCCG 1380

CACAGCGAGG ACGACGGCGG CAGTGGCGGC GGGGGGGACG GGACCATTAA GCGCTGCCCG 1440

GAGACGGCGA GCCCCGCCAG GCCCGCCTCC AGCGTGCCGC CGAGGCCGCC GCCCCCCAAG 1500

CTGCCGACCC GGAAGTGGAT CTCCTACAGG TTTAATGTGT TGTCTAATCT TTCAGACCAG 1560

TATCTGATAT TCGGGGCTGA GGAGGGAATC TACACGTTAA ACCTTAACGA GCTCCACGAG 1620

ACCTCGATGG AACAGCTCTT TCCTCGGAGG TGCACCTGGC TCTACGTCAT GAACAGTTGT 1680

CTTCTCTCCA TATCCGGAAA AGCCTCCCAG CTCTACTCTC ACGCGCTGAG CGGCCTGTTC 1740

GAGCAGGCCA GGCAGTTACA GAAGTTACCA GTAGCCATTC CCACTCACAA GCTGCCTGAC 1800

AAGATGATTC CCAGGAAGTA CGCAGTGTCC AATAAGATTC CAGACACTAA AGGCTGCCAA 1860

AAGTGCTGCG TAGTCCGTAA CCCGTACACC GGCCACAAGT ACCTGTGTGG AGCCTTCCAG 1920

TCCAGCGTCA TGCTGCTGGA GTGGGTGGAG TCCATGCAGA GGTTCATGCT CATCAAGAAC 1980

ATCGACTTCC CGCTGCCGTG TCCGCTGGAG GTCTTTGAGA TGCTGGTGGT GCCGGAGCAG 2040

ACCTACCCTC TGATCTGCGT GGCGGTCAGC AAGGGCACCG AGCTCAACCA GGTGGTGCGC 2100

TTCGGCACCG TCAACCCCAA CTCTACCTCC TCCTGGTTCA CGGAAGCAAA CACCCCTCAG 2160

ACCTGCGTGA TCCACGTCAC TCAGCTGGAG AGGGACACCA TCCTGGTCTG CCTCGACCGG 2220

TGCATAAAGA TCGTGAACCT CCCAGGCAGG TTGAAGTCCA GCAGGAAGCT GTCGGCCGAG 2280

CTCACCTTCA ACTTCCAGAT CGAAGCGACG GTTTGTCTCC AGGACAGCGT GCTGGCCTTC 2340

TGGAGGCACG GCATGCAGGG ACGCAGCTTC AAGACCAACG AGATCACTCA GGAGATCTCT 2400

GACAGCACAC GCATCTTCAG ACTACTGGGG TCAGACAGGG TGGTGGTGCT GGAGAGCCGG 2460

CCGACCGACA ACCCCACAGC CCACAGCAAC CTGTACATCC TGGCAGGCCA TGAAAACAGC 2520

TACTGA 2526

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++kh+niv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHSNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw+ mey+ gGsl+d+++  ++ +l+E+qiay+ re+l++L ylH+k+++

Q: 76    YFGSYLRRDKLWISMEYCGGGSLQDIYH--VTGPLSESQIAYMSRETLQGLYYLHNKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGYVKLADFGVSAQITATLAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaielae +pP++dl+p++al++++k++  ppklk+k k++++f++fv+

Q: 194   LCDIWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKVKWTNNFHHFVKLS  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHSNIVA 60

YFGSYLRRDK LWISMEYCGG GSLQDIYHVT GPLSESQIAY MSRETLQGLY YLHNKGKMHR 120

DIKGANILLT DNGYVKLADF GVSAQITATL AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DIWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKVKWTNN FHHFVKLSLT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013