EKS-GAA-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAA-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph461.01.1E-138609865257
StatusUnreviewed
Ensembl ProteinENSGACP00000016204
UniProt AccessionG3PF30;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2 (2 of 2)
Gene Synonyms/Alias EPHA2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGACG00000012225ENSGACP00000016204ENSGACT00000016236
OrganismGasterosteus aculeatus
Functional Description
Protein Length971
Protein Sequence
(FASTA)
ATCFSMGGGL ELTQPADLQS KEQVLLDMRA SGSELGWLTL PYENGWEIVQ TVVNGSLFYT 60
YSVCSIDSTE QDNWLRTTFI QRRPGATRVS VELRFIVRDC NTFDGASVAC KETFNLFISE 120
ADADVGTNFR KGQFRKVATI APDEVTRGRV LKVNTETRAV GPLSSKGFYL AFQDMGACVA 180
LLSVRVYYKT CPSTVQSLAA FPETVADALR EVEGACVENS IGRATPRIYC TAEGEWVVPV 240
VQCQCLAGYE AAGDSCQVCK PGYFKASASS ELCQVCPDNS KPSAAGATEC QCEEDFFRSP 300
SDSPTSPCSA PPSAPRDLTS TSLSAQGRLQ LSWSPPLVTG GRSDLTYSVA CEHCDEASCV 360
PCGENIRFEP GATDLQDSTV VVGDLDSHLN YTFIVEAHNG VSQFGTDRPI ASITTALDYT 420
DPPKVTLIHL DDRSPTSLSL SWTLSRRPPA HINHRYELMY RRKDGDGERD VTTYTVLILE 480
KSSVQINDLT PDTTYMFRVQ ALSPEGNPGT YSVEHDFLTS PLAESQIQNN STMVMGAVAG 540
VALILLVVVA VLLLRRRRMN SRGRGGAEDP YFSSDQLKPL KTYVDPHMYE DPNIAIQKFV 600
TEIDATAISK QKVIGVGEFG EVFWGVMKTP KRGEVAVAIK TLKPGYSEKQ RQDFLSEASI 660
MGQFSHPNII RLEGVVTKFK HAMIVTEYME NGALDTYLKD RDGEIPSYQL AGMLRGIAAG 720
MKYLSDMNYV HRDLAARNVL VNSLLECKVS DFGLSRVLED DAEGTYTTRG GKIPIRWTSP 780
EAIAYRKFTS ASDVWSFGIV MWEVMAFGER PYWDMSNHEV MKAINEAFRL PAPMDCPSAV 840
YQLMLQCWQH DRSKRPRFTD IVNILDKLLR SPESLKTIAD FDPRVSIRLP SSSGCDGTVF 900
RSVPEWLESI KMNQYKESFA RAGITTMEQV LALRHEDIRN IGVRLPGHMK RIAYSILGLK 960
DETSSLSVFA V 971
Nucleotide Sequence
(FASTA)
GCCACCTGTT TCTCAATGGG CGGCGGGCTC GAGCTCACTC AGCCGGCAGA CCTCCAGTCG 60
AAAGAACAAG TGTTGCTGGA TATGAGAGCT TCAGGATCAG AGTTGGGCTG GTTGACGTTG 120
CCATATGAGA ACGGATGGGA GATAGTCCAG ACGGTGGTGA ACGGCTCCCT CTTCTACACC 180
TACAGCGTTT GTAGCATCGA CTCCACCGAG CAGGACAACT GGTTACGCAC AACGTTCATC 240
CAGCGCCGCC CGGGGGCCAC GCGGGTCTCT GTGGAGCTCC GGTTTATTGT GCGCGACTGC 300
AACACTTTTG ATGGCGCTTC CGTCGCCTGC AAAGAAACCT TCAACCTTTT CATCTCGGAG 360
GCCGACGCCG ACGTAGGGAC CAACTTCCGC AAAGGCCAGT TCCGCAAGGT CGCCACCATC 420
GCTCCCGACG AGGTCACGCG GGGCCGCGTG CTGAAGGTCA ACACGGAGAC GAGGGCGGTG 480
GGGCCGCTGT CTTCAAAGGG TTTCTACCTG GCGTTCCAGG ACATGGGGGC TTGCGTGGCT 540
CTGCTGTCGG TGCGGGTGTA CTACAAAACG TGCCCGTCCA CCGTGCAGAG CCTGGCGGCC 600
TTCCCGGAGA CTGTGGCGGA TGCCCTGCGG GAGGTGGAGG GAGCCTGTGT GGAGAACTCC 660
ATCGGTCGGG CCACCCCACG CATCTACTGC ACCGCTGAGG GGGAATGGGT GGTTCCTGTG 720
GTCCAGTGCC AGTGTCTCGC TGGCTACGAA GCCGCTGGGG ACTCGTGCCA AGTGTGCAAA 780
CCAGGCTACT TCAAGGCTTC TGCATCAAGC GAGTTATGTC AGGTTTGCCC TGATAACAGC 840
AAGCCGTCCG CAGCCGGTGC CACTGAATGT CAATGCGAGG AAGATTTCTT CCGGTCCCCT 900
TCGGACTCCC CTACGTCACC GTGCTCTGCT CCACCCAGTG CCCCACGTGA CCTGACCTCC 960
ACCTCCCTGT CGGCACAGGG CCGGCTGCAA CTATCCTGGA GCCCGCCGCT GGTGACCGGG 1020
GGCCGCAGCG ACCTCACCTA CAGCGTGGCG TGCGAGCACT GCGACGAGGC CTCATGTGTC 1080
CCCTGCGGCG AGAACATCCG CTTCGAGCCG GGCGCCACGG ACCTGCAGGA CAGCACGGTC 1140
GTCGTTGGCG ACCTGGATTC TCATCTGAAC TACACGTTCA TCGTTGAGGC TCACAACGGC 1200
GTGTCCCAGT TCGGCACGGA CAGGCCCATT GCCAGCATCA CCACCGCTCT GGACTACACA 1260
GATCCCCCAA AGGTGACGTT AATCCATCTG GATGATCGCA GCCCCACAAG CCTGTCTCTG 1320
TCCTGGACTC TGTCTCGCAG GCCTCCAGCC CACATCAATC ACCGCTATGA GCTTATGTAC 1380
CGCAGAAAGG ACGGTGATGG CGAGCGGGAC GTGACCACCT ACACAGTCCT GATTCTGGAG 1440
AAAAGTTCCG TCCAGATTAA CGACCTCACC CCAGACACTA CTTACATGTT CAGGGTCCAG 1500
GCCCTGAGTC CTGAAGGAAA CCCCGGCACA TACAGCGTGG AGCACGATTT CCTTACCTCA 1560
CCATTAGCTG AGTCACAGAT CCAGAACAAC TCCACCATGG TGATGGGAGC TGTAGCCGGA 1620
GTAGCGCTTA TTCTGCTTGT TGTGGTGGCC GTCTTGCTGC TGCGTAGACG GAGAATGAAC 1680
TCTCGCGGCA GGGGAGGCGC GGAAGATCCC TACTTCTCAT CAGATCAGCT CAAGCCTCTG 1740
AAGACTTATG TTGATCCACA CATGTACGAG GACCCTAACA TCGCCATCCA GAAGTTTGTC 1800
ACAGAAATCG ACGCCACCGC CATTAGCAAA CAAAAAGTCA TTGGTGTTGG AGAGTTTGGG 1860
GAAGTCTTTT GGGGCGTGAT GAAGACTCCC AAGCGAGGGG AGGTGGCCGT GGCGATCAAG 1920
ACCCTGAAGC CAGGGTACTC TGAGAAACAG AGGCAGGACT TCTTGAGCGA GGCCAGTATC 1980
ATGGGGCAGT TCTCACACCC GAATATCATC CGCCTGGAGG GAGTTGTCAC CAAATTCAAG 2040
CACGCCATGA TAGTGACAGA GTACATGGAG AACGGAGCTC TTGACACCTA CCTGAAGGAT 2100
CGCGATGGAG AGATCCCGTC GTATCAGCTG GCGGGGATGC TGCGTGGAAT AGCTGCCGGC 2160
ATGAAGTACC TCTCTGACAT GAACTACGTC CACCGCGACC TGGCAGCAAG GAATGTTTTG 2220
GTTAACAGCC TCCTGGAGTG CAAAGTTTCT GATTTTGGGC TGTCGCGTGT GCTGGAGGAC 2280
GACGCTGAGG GCACCTACAC AACAAGAGGA GGTAAAATCC CCATTCGCTG GACGTCCCCT 2340
GAGGCCATCG CATACAGGAA GTTCACTTCA GCCAGCGACG TGTGGAGCTT TGGCATCGTC 2400
ATGTGGGAAG TGATGGCGTT TGGAGAGCGG CCCTACTGGG ACATGAGCAA CCACGAGGTC 2460
ATGAAGGCTA TCAACGAAGC CTTCAGGCTT CCGGCTCCGA TGGACTGCCC ATCCGCCGTC 2520
TACCAGCTCA TGCTCCAGTG CTGGCAGCAC GACCGCTCCA AACGACCTCG ATTCACAGAC 2580
ATTGTCAACA TTTTGGACAA ATTGCTTCGC AGCCCAGAGT CTCTAAAAAC CATCGCTGAC 2640
TTTGACCCGC GTGTCTCCAT CCGCCTGCCC AGCAGCAGCG GCTGTGATGG CACCGTGTTC 2700
AGGTCGGTGC CCGAGTGGCT GGAGTCCATC AAAATGAACC AGTACAAGGA AAGCTTCGCT 2760
CGCGCCGGGA TCACCACCAT GGAGCAGGTG CTCGCCTTGA GGCATGAAGA CATCAGGAAC 2820
ATCGGTGTGC GGCTGCCCGG TCACATGAAA AGGATCGCAT ACAGCATCCT GGGCCTGAAA 2880
GACGAGACCA GCTCCCTCAG CGTGTTCGCA GTGTAA 2916
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         + +kviG GefGev+ G +k+p + e+avaiktlk g++ekqr+dflseasi+Gqf+hpn
Q: 609   SKQKVIGVGEFGEVFWGVMKTPKRGEVAVAIKTLKPGYSEKQRQDFLSEASIMGQFSHPN  668
         5689********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         iirleGvvtk k  mivteymengald++l+ +dg++ + ql gmlrGia+gmkylsdm+
Q: 669   IIRLEGVVTKFKHAMIVTEYMENGALDTYLKDRDGEIPSYQLAGMLRGIAAGMKYLSDMN  728
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarn+lvns l ckvsdfGlsrvledd+e +ytt+ggkipirwt+peaiayrkf
Q: 729   YVHRDLAARNVLVNSLLECKVSDFGLSRVLEDDAEGTYTTRGGKIPIRWTSPEAIAYRKF  788
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvws+Giv+wev+++Gerpywdmsn++v+kai+e +rlp+pmdcp+a+yqlml+cw
Q: 789   TSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSAVYQLMLQCW  848
         ************************************************************
S: 242   qkdraerpkfeqivsil  258
         q+dr++rp+f++iv+il
Q: 849   QHDRSKRPRFTDIVNIL  865
         **************985
Domain Sequence
(FASTA)
SKQKVIGVGE FGEVFWGVMK TPKRGEVAVA IKTLKPGYSE KQRQDFLSEA SIMGQFSHPN 60
IIRLEGVVTK FKHAMIVTEY MENGALDTYL KDRDGEIPSY QLAGMLRGIA AGMKYLSDMN 120
YVHRDLAARN VLVNSLLECK VSDFGLSRVL EDDAEGTYTT RGGKIPIRWT SPEAIAYRKF 180
TSASDVWSFG IVMWEVMAFG ERPYWDMSNH EVMKAINEAF RLPAPMDCPS AVYQLMLQCW 240
QHDRSKRPRF TDIVNIL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Cavia porcellus"; ?>Gadus morhua"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAP-00007
EKS-GAM-00004
EKS-ICT-00009
EKS-LOA-00010
EKS-ORN-00019
EKS-TAR-00016
EKS-TEN-00016
EKS-XIM-00017
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013