EKS-GAA-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	328.0	5.5E-98	171	419	249

Status

Unreviewed

Ensembl Protein

ENSGACP00000016292

UniProt Accession

G3PFB8;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000012327	ENSGACP00000016292	ENSGACT00000016325

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

KKKSRIQISA PSNFEHRVHT DFDEQEQKFV GLPRQWQSLI EDTAKRPKPF IDATVITTVE 60

PVRHQDSSPQ NGPSGGSSQG SSSSKPPVSH PHPHHASHPS LAPESSQHPH TQQPSVPAPR 120

PPAPSGPPVP GAPPQGRSPQ REPQRVSHEQ FRAALQMVVE PGDPRTYLDH YIKIGEGSTG 180

IVCIATVKTT GKLVAVKKMD LRKQQRRELL FNEVVIMRDY HHENVVEMYN SYLVGDELWV 240

VMEFLEGGAL TDIVTHTRMN EEQIAAVCLS VLKALSVLHT QGVIHRDIKS DSILLTHDGR 300

VKLSDFGFCA QVSKEVQRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP 360

PYFNEPPLKA MKMIRDNLPP KLKNLHKVSP LLKGFLDRML VRDPSQRASA NELLKHPFLT 420

KAGPPSCIVP LMRQNRMR 438

Nucleotide Sequence
(FASTA)

AAGAAGAAGT CTCGCATCCA GATTTCCGCT CCATCCAACT TTGAGCATCG CGTGCACACA 60

GACTTTGACG AGCAGGAGCA GAAGTTTGTT GGGCTGCCGC GGCAATGGCA GTCTCTCATC 120

GAAGACACGG CCAAAAGGCC CAAACCCTTC ATCGACGCAA CCGTCATCAC TACTGTAGAG 180

CCGGTCCGAC ACCAGGACTC GTCCCCCCAA AACGGCCCCT CCGGCGGCTC CTCCCAAGGC 240

TCCTCCAGCT CCAAGCCCCC CGTAAGCCAC CCGCACCCTC ATCACGCTTC CCACCCAAGC 300

CTGGCCCCCG AGTCCAGCCA GCACCCTCAC ACCCAGCAGC CCAGCGTTCC GGCCCCGCGG 360

CCCCCTGCGC CCTCTGGGCC CCCGGTGCCG GGCGCTCCGC CCCAGGGCCG CTCTCCGCAG 420

AGGGAACCGC AGAGGGTTTC CCACGAGCAG TTCAGAGCGG CACTGCAGAT GGTGGTGGAG 480

CCCGGCGATC CGCGAACCTA CCTGGACCAC TACATTAAGA TCGGGGAGGG ATCAACGGGG 540

ATCGTGTGCA TCGCCACAGT GAAGACCACC GGGAAGCTGG TGGCCGTGAA GAAGATGGAC 600

TTGAGGAAGC AGCAGCGCAG AGAACTGCTC TTCAATGAGG TGGTGATCAT GCGGGACTAT 660

CACCATGAGA ACGTGGTGGA GATGTACAAC AGCTACCTGG TGGGAGACGA GCTCTGGGTG 720

GTCATGGAGT TCCTGGAGGG CGGAGCGCTC ACCGACATCG TGACACACAC CAGGATGAAT 780

GAGGAGCAGA TCGCCGCGGT GTGTTTGTCT GTCCTGAAGG CTCTGTCCGT CCTCCACACA 840

CAGGGTGTGA TCCACAGAGA CATCAAGAGC GACTCCATCC TCCTCACCCA CGATGGCCGA 900

GTGAAGCTGT CAGACTTTGG CTTCTGCGCA CAGGTGTCTA AGGAAGTGCA AAGAAGGAAG 960

TCTCTGGTGG GGACACCTTA CTGGATGGCA CCAGAGCTTA TATCCAGGCT GCCCTATGGA 1020

CCAGAGGTGG ACATCTGGTC TCTGGGCATC ATGGTCATAG AGATGGTGGA CGGGGAGCCG 1080

CCGTACTTCA ACGAGCCGCC GCTCAAAGCC ATGAAGATGA TCCGAGACAA CCTTCCCCCC 1140

AAACTCAAGA ACCTGCACAA GGTCTCCCCT CTGCTGAAAG GCTTTCTGGA CAGAATGTTG 1200

GTGCGAGATC CATCTCAGAG GGCCTCTGCC AACGAGCTCC TCAAACACCC CTTCCTGACG 1260

AAGGCGGGGC CGCCGTCCTG CATCGTCCCT CTGATGAGGC AGAACCGGAT GAGA 1314

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v++a+ k+tg+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++

Q: 171   YIKIGEGSTGIVCIATVKTTGKLVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVEMYN  230

         568*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ lH+++viHrd

Q: 231   SYLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIAAVCLSVLKALSVLHTQGVIHRD  287

         *************************...9*******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt++g+VkLsdfg++aq++k++++rk++vgtpywmAPE+i+  +  Y  ++Di

Q: 288   IKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELIS--RLPYGPEVDI  345

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++++plka+ +i +n ppklk+ +k+s+ +k f++++l ++p+

Q: 346   WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRMLVRDPS  405

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R+sa+ellkh+Fl

Q: 406   QRASANELLKHPFL  419

         *************7

Domain Sequence
(FASTA)

YIKIGEGSTG IVCIATVKTT GKLVAVKKMD LRKQQRRELL FNEVVIMRDY HHENVVEMYN 60

SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLS VLKALSVLHT QGVIHRDIKS 120

DSILLTHDGR VKLSDFGFCA QVSKEVQRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI 180

MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP KLKNLHKVSP LLKGFLDRML VRDPSQRASA 240

NELLKHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013