EKS-GAA-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	538.9	2.6E-162	462	738	277

Status

Unreviewed

Ensembl Protein

ENSGACP00000016410

UniProt Accession

G3PFN6;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1 (1 of 2)

Gene Synonyms/Alias

FGFR1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000012410	ENSGACP00000016410	ENSGACT00000016442

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

806

Protein Sequence
(FASTA)

MLMRPNILLC LVLFSQVLRT QSRPANNDEA SVETQVELFT LYLGGSLDLS CSAKDSPHAV 60

NWTKDHEAVV DGEHTRIRGV QLVIEAVELT DSGLYACTTF GNHSNYFNVT AEDDDEEEES 120

SSEEAKLLGS QKLLPMAPEW THPEKMEKKL HAVPASKTVK FRCQASGNPT PSLKWYKNGK 180

EFKRDHRIGG FKVRDHVWTI IMESAVPSDK GNYTCLVENE YGSINHTYQL DVVEERSPHR 240

PILQAGLPAN RTAVVGSDVE FECKVFSDPQ PHIQWLKHEE FNGSRLGPDG LAYVRVLKSA 300

GLNTTDKEME VLQLRNVSFD DAGKYTCLAG NSIGYSYHSA WLAVFEAVPH YPPASDTYLE 360

VVIYCVGFFL IVVMIAIAIL VKNRTSSKKS DFNSPLAVHK LAKSIPLRRQ VTVSVDSSSS 420

IHSGVMLVRP SRLSSSGSPM LSGVSEYELP QDPRWELPRD RLVLGKPLGE GCFGLVVMGE 480

ALGLDKEKQN RVTKVAVKML KSDATEKDLS DLISEMEMMK IIGKHKNIIN LLGACTQDGP 540

LYVIVEYASK GNLREYLRAR RPPGMEYCYN PDQVPVETMS IKDLVSCAYQ VARGMEYLSS 600

KKCIHRDLAA RNVLVTEDNV MKIADFGLAR DIHHIDYYKK TTNGRLPVKW MAPEALFDRI 660

YTNQSDVWSF GVLLWEIFTL GGSPYPGVPV EELFKLLKEG HRMDKPSTCT HELYMMMRDC 720

WHAVPSHRPT FKQLVEDLDR CLAMTSNQEY LELSVPLDQY SPNYPDTRSS TCSSGEDSVF 780

SHDAGAEEPC LPKFPPHSNG AAIKKR 806

Nucleotide Sequence
(FASTA)

ATGCTGATGA GGCCAAATAT ACTTCTGTGT CTGGTTCTAT TCTCCCAAGT CTTAAGGACG 60

CAGAGCCGGC CGGCCAACAA TGACGAAGCC TCGGTGGAAA CCCAGGTGGA GCTGTTCACT 120

CTCTATCTCG GGGGTAGTTT GGACCTGAGC TGCTCCGCCA AAGACTCCCC CCATGCCGTC 180

AACTGGACCA AAGACCACGA GGCCGTGGTG GATGGAGAAC ACACGCGCAT CCGCGGCGTC 240

CAGCTGGTGA TCGAGGCGGT GGAGCTGACG GACTCCGGCC TGTACGCGTG CACCACCTTC 300

GGCAACCACA GCAACTACTT CAACGTCACA GCTGAGGACG ATGATGAAGA GGAAGAGTCG 360

TCATCAGAGG AAGCCAAACT CTTGGGCAGT CAAAAACTGC TGCCTATGGC CCCAGAATGG 420

ACTCATCCAG AGAAAATGGA GAAGAAGCTT CATGCCGTCC CGGCCAGTAA GACGGTGAAG 480

TTCCGATGCC AGGCCAGCGG CAACCCGACG CCGAGCCTGA AATGGTACAA GAATGGCAAG 540

GAGTTCAAGA GGGACCATCG CATTGGAGGC TTCAAGGTCC GTGACCACGT CTGGACCATC 600

ATCATGGAAT CTGCTGTGCC CTCTGACAAA GGAAACTATA CCTGTTTGGT AGAAAACGAG 660

TACGGCAGCA TCAATCACAC CTACCAGCTC GACGTAGTCG AAGAGCGTTC TCCCCATAGA 720

CCGATCCTGC AGGCCGGCCT GCCGGCTAAC CGCACCGCAG TGGTTGGCAG CGACGTGGAG 780

TTTGAGTGCA AGGTGTTCAG CGACCCCCAG CCTCACATCC AGTGGCTGAA GCACGAGGAG 840

TTCAATGGAA GCCGACTTGG TCCTGATGGT TTAGCGTATG TCCGTGTTCT CAAGAGCGCT 900

GGCCTAAACA CCACGGACAA GGAAATGGAA GTCCTCCAAC TGAGAAATGT GTCTTTTGAT 960

GACGCTGGGA AGTACACCTG CTTGGCGGGC AATTCTATCG GGTACTCTTA TCACTCTGCA 1020

TGGTTGGCCG TTTTTGAAGC GGTCCCACAC TATCCTCCAG CCAGCGACAC CTACCTGGAG 1080

GTGGTAATCT ACTGCGTGGG CTTCTTTCTC ATTGTGGTCA TGATTGCCAT CGCAATTCTA 1140

GTGAAGAATC GCACCTCATC AAAGAAGAGC GACTTCAACA GTCCGCTGGC CGTCCACAAG 1200

CTGGCCAAAA GCATCCCGCT GCGCAGACAG GTAACAGTGT CCGTGGACTC GAGCTCCTCC 1260

ATCCACTCCG GGGTGATGCT GGTTCGTCCG TCCCGCCTCT CTTCCAGCGG ATCTCCAATG 1320

CTGTCCGGGG TGTCCGAGTA TGAACTACCC CAGGATCCCC GCTGGGAGCT GCCTCGGGAC 1380

AGACTGGTTC TTGGAAAGCC GCTGGGCGAA GGCTGCTTCG GTCTGGTGGT GATGGGAGAG 1440

GCACTGGGTC TTGACAAAGA AAAACAAAAC CGCGTGACCA AGGTTGCGGT CAAAATGTTG 1500

AAATCTGACG CCACAGAGAA AGACCTGTCA GACCTGATTT CAGAGATGGA GATGATGAAG 1560

ATCATTGGGA AGCACAAGAA CATCATTAAT CTGCTGGGAG CTTGCACACA GGATGGTCCT 1620

CTGTATGTGA TCGTAGAGTA CGCGTCCAAG GGCAACCTGC GTGAGTACTT GCGAGCTCGG 1680

CGCCCACCAG GCATGGAGTA CTGCTACAAC CCGGACCAGG TTCCCGTAGA GACCATGTCC 1740

ATCAAAGATC TGGTGTCCTG TGCCTATCAA GTGGCCCGAG GCATGGAGTA CTTGTCCTCT 1800

AAAAAGTGCA TCCACAGGGA CCTCGCCGCT CGCAATGTTT TGGTAACCGA GGACAACGTG 1860

ATGAAAATAG CAGACTTCGG CCTGGCGAGA GATATCCACC ACATTGATTA CTATAAGAAG 1920

ACCACCAATG GTCGTTTACC TGTCAAGTGG ATGGCTCCCG AGGCTCTGTT TGATCGGATA 1980

TACACCAACC AAAGCGATGT CTGGTCATTC GGGGTTCTGC TTTGGGAGAT CTTCACCCTG 2040

GGGGGCTCTC CATACCCCGG AGTCCCAGTG GAGGAGTTGT TCAAGCTGCT GAAGGAAGGT 2100

CACCGAATGG ACAAGCCTTC AACATGCACT CATGAACTAT ACATGATGAT GAGGGACTGC 2160

TGGCATGCTG TTCCTTCGCA CAGACCCACA TTCAAACAGC TGGTTGAGGA CCTTGACCGC 2220

TGCCTGGCCA TGACATCCAA CCAGGAGTAT TTGGAGCTGT CTGTACCTCT GGACCAATAT 2280

TCCCCCAACT ACCCCGACAC CCGCAGCTCC ACGTGCTCCT CGGGGGAGGA CTCTGTCTTC 2340

TCCCACGATG CCGGAGCAGA GGAGCCCTGC CTGCCAAAGT TCCCTCCCCA CTCCAATGGG 2400

GCAGCCATCA AGAAACGCTG A 2421

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fG vv+ ea+gldk+k+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 462   LVLGKPLGEGCFGLVVMGEALGLDKEKQNRVTKVAVKMLKSDATEKDLSDLISEMEMMKI  521

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+++++ +++ e+++

Q: 522   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPDQVPVETMSI  581

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeyl+skkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 582   KDLVSCAYQVARGMEYLSSKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  641

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 642   TNGRLPVKWMAPEALFDRIYTNQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  701

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 702   RMDKPSTCTHELYMMMRDCWHAVPSHRPTFKQLVEDL  738

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGLVVMGEA LGLDKEKQNR VTKVAVKMLK SDATEKDLSD LISEMEMMKI 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCYNP DQVPVETMSI 120

KDLVSCAYQV ARGMEYLSSK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY TNQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSTCTH ELYMMMRDCW HAVPSHRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013