EPS-GAA-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAA-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	187.6	4.7E-55	704	949	246

Status

Unreviewed

Ensembl Protein

ENSGACP00000017208

UniProt Accession

G3PHY2;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1 (1 of 2)

Gene Synonyms/Alias

PHLPP1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013009	ENSGACP00000017208	ENSGACT00000017242

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1234

Protein Sequence
(FASTA)

TLYVQLHGEA VRRLSPDERP LQIQNDFLFK LGFKDPWRVQ EEGLNTEIGS LLRFYAGKPQ 60

SIESSERVQL SGTYNVRKGK LQLPVNRWTR RQVILCGTCL IVSSVKESQT GKMHILPLIG 120

GKVEEVKKHN HCLAFSSAGP QSQTYYVSFD SFTEHLRWHR QAAKVMVSQR INSVDLSCCS 180

LEQLPPNLFY SHDLTHLNLK QNFLPADQRL QQLQRFSRLR SLNLSNNHLG QFPHAICDIP 240

TLTEVNLSCN YLTCVPGSVG AMANLQTFLL DGNGLAELPV ELGSLQRLTY LGLSFNQFHH 300

VPQVLEQLAA MEKLCMAGNR LDTLTLQNFR LLRVKHIDLR LNKISSVVAD EPDLLRHVTQ 360

LDVRDNRLTH LDASVFPRLE VLHCERNRIA SLRAKGSLLK GVYAANNELR QLDISPVPSN 420

LTYMDISRNR MESLPDWLCE AKKLEVLDMS HNLITELPAR LFCSNSLRKL SAGHNQLQKL 480

PERVERPLLE ILDVQHNQLV ELSSNLFLKS DSLRSLNASA NKLEHLPPSS LSEESNSILQ 540

ELYLTNNRLT DKCVPLLTGH THLRVLHMAY NHLQTFPASK MAKLEELEEV DLSGNLLKTV 600

PTTIMNCRRM HTLIAHSNAI EVFPEVMQLM EILQCVDLSC NELSDITLPE NLPPKLQELD 660

LTGNPRLNLD HKTLEQLNNI RCFRIDPPPT FSSNEASGGP AVWSHGYTEA SGVKNKLCVA 720

ALSVSSFCGS REALYGVFDG DRNVEVPYLL QCTMNDVLAE EIHKTKSEED YMIHTFLVMQ 780

RKLGTAGQKL GGSAALCHIR HDPTDPSGCF TLTAANVGKC KAVLCRDGKP LSLSLLHNVG 840

LEEEYRRVRQ HRAIVTEDNK VNGVTDSTRI MGYSFLYPSV IPCPYVQTVT LTPQDEFFIL 900

GSRGLWDAVS PAEAVEAVRN VPDGLAAAKK LCTLAQGYGC TDSLCAVVVQ LSVSEDCCSC 960

CCSEPPQPPP SPGLGPYPPS SSERPSDGSL PVPPSSCSEI SSEISTSEMS SEVGSTASSD 1020

EPPQSSLVLL HEQPQHCCAL HPACLAGSFQ RQLSSATFSS ALSDNGLDSE DEEPIAGVFS 1080

NGSRVEVEAD IHCLKAESAA ASSPPCSPSP QTSQPSSSSQ ERTTPTLPPP PPPPCTPEPL 1140

EEGIDTSPGE AKRRVNGSVA RQEKSHNLIE VAAAAPSKKS GGYFTAPAQP DPDDQFIIPP 1200

ELEEEVKEIM KQHQQKQQKP PATDQPTDYY DTPL 1234

Nucleotide Sequence
(FASTA)

ACGCTGTACG TGCAGCTCCA CGGCGAGGCG GTCCGGAGGC TGAGTCCGGA CGAGAGGCCT 60

CTGCAGATCC AGAACGACTT TCTCTTCAAG CTCGGATTCA AGGACCCGTG GAGGGTCCAA 120

GAGGAGGGCC TCAACACGGA AATCGGCTCC TTGTTGCGCT TCTACGCAGG GAAGCCCCAA 180

AGCATCGAGA GCTCCGAGCG GGTCCAGCTG TCCGGGACGT ACAACGTCCG CAAGGGGAAG 240

CTCCAGCTGC CGGTCAACCG CTGGACCAGG CGGCAGGTCA TTCTGTGCGG CACCTGCCTC 300

ATCGTCTCCT CGGTCAAGGA GAGCCAGACG GGGAAGATGC ACATCCTGCC GCTCATTGGA 360

GGAAAAGTGG AGGAAGTAAA GAAGCACAAC CACTGCTTGG CTTTCAGCTC GGCGGGGCCT 420

CAGAGTCAGA CGTACTACGT CAGCTTCGAC AGCTTCACCG AGCACCTGCG CTGGCACAGG 480

CAGGCCGCCA AGGTAATGGT GTCCCAGAGG ATCAACTCGG TGGATCTGTC CTGCTGCAGT 540

CTGGAGCAGC TTCCGCCCAA CCTCTTCTAC AGCCACGACC TCACCCACCT CAACCTCAAG 600

CAAAACTTCC TGCCTGCAGA CCAGCGGCTG CAGCAGCTGC AGAGATTTTC CCGCCTGCGA 660

AGCCTCAACC TGTCCAACAA CCACCTCGGC CAGTTCCCCC ATGCCATCTG TGACATCCCC 720

ACTCTGACGG AGGTCAACCT CAGCTGTAAT TACTTGACCT GTGTCCCGGG CTCAGTGGGA 780

GCCATGGCCA ATCTGCAGAC GTTCCTGTTG GACGGAAACG GTCTGGCTGA GCTGCCCGTG 840

GAGCTGGGCT CCCTCCAGAG GTTGACTTAC CTGGGCCTCT CCTTCAACCA GTTCCACCAC 900

GTGCCACAGG TGCTGGAGCA GTTAGCCGCC ATGGAGAAGC TGTGCATGGC CGGAAACCGC 960

CTCGACACGC TCACCCTGCA GAATTTCCGA CTGCTCCGTG TCAAACACAT CGATCTGAGG 1020

TTGAATAAGA TCTCCAGCGT GGTGGCGGAC GAGCCGGACC TGCTGAGGCA CGTAACGCAG 1080

CTGGACGTGA GGGACAACAG GCTGACGCAC CTGGACGCCT CCGTCTTCCC CAGACTGGAG 1140

GTGCTTCACT GCGAGAGGAA CCGCATCGCC TCCCTCCGGG CCAAGGGGAG CCTGCTCAAA 1200

GGCGTCTACG CCGCCAACAA CGAGCTCCGG CAGCTGGATA TAAGTCCTGT GCCCTCTAAT 1260

CTCACTTACA TGGACATCTC GAGGAACCGT ATGGAGTCCT TGCCAGACTG GCTGTGCGAG 1320

GCCAAGAAAC TGGAAGTTCT GGACATGAGC CACAACCTCA TCACTGAGCT GCCGGCGCGG 1380

TTGTTTTGCA GCAACAGTCT GAGGAAGCTG AGTGCAGGAC ACAACCAGTT GCAGAAGCTT 1440

CCTGAAAGAG TGGAGCGCCC TCTGCTGGAG ATATTGGACG TACAGCACAA TCAACTGGTG 1500

GAGCTGTCCA GCAACCTGTT CCTCAAATCT GACAGTTTAC GGTCCCTGAA TGCGTCAGCC 1560

AATAAGCTGG AGCACCTGCC GCCATCCAGC CTATCGGAGG AGAGCAACAG CATCCTGCAG 1620

GAACTCTATT TGACCAACAA CCGGCTGACT GATAAGTGCG TTCCGCTGCT AACGGGCCAC 1680

ACGCACCTTC GTGTTCTGCA CATGGCCTAC AACCATCTGC AGACCTTCCC GGCCAGTAAA 1740

ATGGCCAAGC TGGAGGAGCT GGAGGAGGTG GACCTGAGTG GAAACCTGCT GAAGACGGTG 1800

CCCACCACCA TCATGAATTG CCGGCGGATG CACACGCTCA TCGCCCACTC CAACGCCATC 1860

GAGGTCTTCC CCGAGGTCAT GCAGCTGATG GAGATTCTCC AGTGTGTGGA TCTGAGCTGT 1920

AACGAGCTGA GTGACATCAC GCTACCGGAG AATCTGCCGC CCAAGCTCCA GGAGCTGGAC 1980

CTGACTGGAA ACCCCCGTCT CAACCTGGAC CACAAGACCC TGGAGCAGCT CAATAATATC 2040

CGTTGCTTCC GTATTGATCC GCCTCCGACC TTTTCCTCCA ACGAGGCATC TGGTGGGCCC 2100

GCTGTGTGGA GTCACGGGTA CACGGAGGCC TCGGGCGTCA AGAATAAACT GTGTGTTGCA 2160

GCTCTTTCGG TCAGCAGTTT CTGCGGGAGC CGCGAGGCTC TGTACGGCGT GTTCGACGGG 2220

GACCGGAACG TGGAGGTGCC CTACTTGTTG CAGTGCACAA TGAATGACGT GTTGGCGGAG 2280

GAGATCCACA AGACCAAGAG CGAGGAAGAC TACATGATCC ATACTTTCCT CGTCATGCAA 2340

AGAAAACTGG GAACTGCCGG GCAGAAACTG GGTGGCTCGG CTGCTCTGTG CCACATTCGC 2400

CACGACCCCA CCGACCCCAG TGGCTGCTTC ACCCTCACAG CTGCTAATGT GGGAAAGTGC 2460

AAGGCCGTCC TGTGTCGCGA CGGAAAGCCT CTGTCACTGT CGCTGCTTCA CAACGTGGGC 2520

CTCGAGGAGG AGTACCGCAG GGTCAGGCAG CACAGGGCTA TCGTCACCGA GGACAACAAG 2580

GTGAACGGCG TCACCGATTC GACGCGAATC ATGGGCTACT CCTTCCTCTA CCCGTCCGTC 2640

ATCCCTTGTC CCTACGTGCA GACGGTCACT CTCACCCCGC AGGACGAGTT CTTCATTCTG 2700

GGCAGCCGGG GCCTGTGGGA CGCCGTGTCC CCCGCCGAGG CCGTGGAGGC GGTGCGAAAC 2760

GTCCCCGACG GCCTGGCCGC CGCCAAGAAG CTGTGCACGC TGGCGCAGGG CTACGGCTGC 2820

ACCGACAGCC TGTGCGCCGT CGTGGTGCAG CTCAGCGTCA GTGAAGACTG CTGCTCCTGC 2880

TGCTGCTCCG AGCCTCCCCA GCCACCTCCC AGCCCCGGCT TGGGGCCCTA CCCCCCGTCG 2940

TCGTCCGAGC GGCCCTCGGA CGGCTCCCTC CCCGTGCCGC CTTCCTCCTG CAGCGAGATC 3000

AGCAGCGAGA TCAGCACCAG CGAGATGAGC AGCGAGGTGG GCTCCACGGC CTCGTCCGAC 3060

GAGCCGCCGC AGAGCTCCTT GGTGCTGCTG CACGAGCAGC CGCAGCACTG CTGTGCCCTC 3120

CATCCGGCCT GCTTGGCGGG CTCCTTCCAG AGGCAGCTGT CCAGTGCCAC TTTCTCCAGC 3180

GCCCTGTCCG ACAACGGGCT GGACAGCGAG GACGAGGAGC CCATCGCCGG CGTTTTCTCC 3240

AATGGGAGCC GCGTGGAAGT AGAGGCAGAC ATCCACTGCC TCAAAGCAGA GTCCGCCGCC 3300

GCCTCCTCCC CCCCCTGCTC CCCATCACCA CAAACGTCAC AACCCTCGTC TTCCAGCCAG 3360

GAGCGAACCA CGCCGACTCT GCCCCCGCCT CCGCCCCCGC CATGCACCCC GGAGCCCCTA 3420

GAGGAGGGGA TCGACACGAG TCCCGGAGAG GCCAAGAGGA GGGTTAACGG CTCGGTGGCA 3480

CGTCAGGAAA AGAGTCACAA CCTGATCGAG GTGGCGGCTG CCGCCCCCTC CAAGAAGTCC 3540

GGGGGCTACT TCACAGCTCC AGCACAGCCC GACCCGGACG ACCAGTTCAT CATCCCGCCT 3600

GAGCTGGAGG AGGAAGTGAA GGAAATAATG AAGCAGCATC AGCAGAAGCA GCAGAAGCCG 3660

CCGGCGACCG ACCAGCCCAC GGACTACTAC GACACCCCTC TGTGA 3705

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s+++f+ s+e+     ++gv+DG+++ ev + +++++ ++l

Q: 704   SHGYTEASGVKNKLCVAALSVSSFCGSREA-----LYGVFDGDRNVEVPYLLQCTMNDVL  758

         6899**********************9875.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aee+     +++  ++++ ++Fl ++++l       ++ +k G +a +++i+++

Q: 759   AEEIH----KTKSEEDYMIHTFLVMQRKL------GTAGQKLGGSAALCHIRHDptdpsg  808

         ***99....9999999*************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG+++avLcr+gk+++ls  H++  e+E++R++++ + v++++  +v+Gv+

Q: 809   cfTLTAANVGKCKAVLCRDGKPLSLSLLHNVGLEEEYRRVRQHRAIVTEDN--KVNGVTD  866

         **************************************************9..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R +G  +l+p v+p P v+ ++lt++def+iL+s Glwd vs+ eav++vr+v +

Q: 867   STRIMGYSFLYPSVIPCPYVQTVTLTPQDEFFILGSRGLWDAVSPAEAVEAVRNVPD---  923

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

            +aakkL++la+ +g++d++ a+vv

Q: 924   -GLAAAKKLCTLAQGYGCTDSLCAVVV  949

         .*********************99997

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VSSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDVLAEEIH 60

KTKSEEDYMI HTFLVMQRKL GTAGQKLGGS AALCHIRHDP TDPSGCFTLT AANVGKCKAV 120

LCRDGKPLSL SLLHNVGLEE EYRRVRQHRA IVTEDNKVNG VTDSTRIMGY SFLYPSVIPC 180

PYVQTVTLTP QDEFFILGSR GLWDAVSPAE AVEAVRNVPD GLAAAKKLCT LAQGYGCTDS 240

LCAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>