EKS-GAA-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	354.0	7.3E-106	40	312	273

Status

Unreviewed

Ensembl Protein

ENSGACP00000018093

UniProt Accession

G3PKG3;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013690	ENSGACP00000018093	ENSGACT00000018128

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1308

Protein Sequence
(FASTA)

MSLFQSALDF LAGPGSLGAA SRDQNDFVGQ VVELGDMKLR IKRVIAEGGF AFVYEAQDMS 60

SGKDYALKRL LSNEEEKNKE IIQEVCFMKK LSGHPNMVQF CSAASISKEE SDTGQAEFLI 120

LTELCKGQLV DFIKRVEQRA LLSCDTVLKI FYQSCRAVQH MHKQKPPIIH RDLKIENLLI 180

SNQGTIKLCD FGSSTTVSHY PDYSWSAQKR SMVEDEITRN TTPAYRTPEM IDLYSNFPIN 240

DKQDIWALGC ILYLLCFKQH PFEDGAKLQI VNGKYSIPQN DVKYTVYHNL IRSMLKVNPE 300

ERLSITELVN QLQEIAAARN VNPKSPITEL LEQNGGFGNN GAQPPTQIHN AQNNSGTYDP 360

DQAGSGILDI LRGGTERFLT NIKDTSSKVI QSVASYAKGD LDISYITSRI AVMSFPAEGV 420

ESAIKNNIED VRLFLDSRHA GHYAVYNLSK RSYRPSRFHN RVSECNWQVR RAPNLRSLYS 480

VCKNMHLWLK QDQRNICIVH CLDGRAASAV AVCSFLCFCR LFTTAEAAVY MFSMKRCPPG 540

IAPSHKRYIE YMCDMMAEEP IVPHSKPIMV RSIAMTPLPL FNKQRSGCRP FCEVYVGDER 600

VLTTSQEYDK MRDFKMEDGR AEIPLNVTVQ GDVLVVIYHA RSTLGGRLQA KMASMKMFQI 660

QFHTGFVPRN ATTVKFAKYD LDACDIQEKY PDLFQVTLDI EVEPRDRPST KTPPWEGFQN 720

KGLNPKILFS SRDEQQEVLS KFGKPELPRQ PAFYDSESPQ PAQTPEGSNA TEPESPGSTD 780

GNANNFFQTL DWEDVSGLQD SADSQGGGSM NDPEDLSDQS EGESYSYSAP GGEPLSRDPS 840

EPLFDADFQS APPAAQESPI GDTADLLGLN SDPSVSSTSS SSAAHPGVQA GIKAASSNSD 900

LLNDLFAPPA GQTAAAQEDL FYGGPPGGAT PDSKRTILPP PAAAGDLFDP FGMGSGSGAG 960

VTVGSSRQAS GPDLFGDLLG SDRSAPSNPA PASNASLFNL NKPVNDPPKM TSSASQPDLL 1020

GGWDSWAAST TASMSASASK PSYTSTGEGT SGGASMSKAK SQTFDPFADL GNLGSNLPAS 1080

SNGNFSEPKA KAPSSSTKAQ AQPWQAGRPA SAQKKPWLPG SGPGTAPKAS SASQAAGPQH 1140

TKPNYNLNFS SVIGGREDRG VRGPSFGAKP KVKEDDFEDL LSTQGFASRP DRKGPRTIAE 1200

MRRQEITKDI DPLKLQILDW IEGKERNIRA LLSTLNTVLW EGETRWRPVG MADLVTPDQV 1260

KKYYRKAVLI VHPDKATGQP YEHYAKMIFM ELNDAWSEFE NQGSKALF 1308

Nucleotide Sequence
(FASTA)

ATGTCCCTGT TCCAGTCGGC ACTGGATTTC CTAGCCGGGC CCGGCTCGCT GGGGGCGGCC 60

AGCCGGGACC AGAACGACTT CGTCGGACAG GTCGTGGAGC TCGGCGACAT GAAGCTGAGG 120

ATCAAGAGGG TGATCGCGGA AGGTGGTTTT GCTTTTGTTT ATGAAGCCCA GGACATGAGC 180

AGCGGTAAAG ACTATGCCCT CAAGAGGCTG CTGTCCAACG AGGAAGAGAA GAACAAGGAA 240

ATCATACAGG AAGTCTGCTT CATGAAAAAG CTGTCCGGTC ACCCCAACAT GGTCCAGTTC 300

TGCTCGGCTG CCTCCATCAG TAAGGAGGAG TCTGACACCG GGCAGGCCGA GTTCTTGATC 360

CTCACCGAGT TGTGCAAAGG TCAGCTGGTG GACTTCATCA AGCGGGTGGA GCAGAGGGCT 420

CTTCTGTCGT GTGACACCGT GCTGAAAATC TTCTACCAGT CGTGTCGCGC CGTGCAGCAC 480

ATGCACAAGC AGAAGCCCCC GATCATACAC CGGGACCTCA AGATTGAGAA CCTCTTGATT 540

AGTAACCAGG GCACCATCAA GCTGTGTGAC TTTGGCAGCT CCACCACCGT GTCGCATTAC 600

CCCGACTACA GCTGGTCGGC ACAGAAGAGG TCCATGGTGG AGGATGAGAT CACAAGGAAC 660

ACCACTCCGG CGTACCGAAC GCCAGAGATG ATTGATCTCT ACTCCAACTT CCCCATCAAT 720

GACAAACAGG ACATCTGGGC GCTGGGGTGC ATCCTCTACC TGCTGTGTTT CAAGCAGCAC 780

CCGTTCGAGG ACGGGGCCAA GCTGCAAATC GTCAACGGAA AATACTCCAT CCCTCAGAAC 840

GACGTCAAGT ACACCGTGTA CCACAACCTC ATCCGTTCCA TGTTGAAAGT GAACCCAGAG 900

GAGCGTCTGT CCATTACAGA GTTGGTCAAC CAGCTCCAGG AGATAGCAGC CGCACGCAAC 960

GTCAACCCCA AGTCCCCCAT TACCGAGCTG CTGGAGCAGA ACGGAGGTTT CGGCAACAAC 1020

GGAGCCCAGC CGCCCACGCA GATCCACAAC GCGCAGAACA ACTCAGGCAC ATACGACCCC 1080

GATCAGGCCG GCAGCGGGAT CTTGGACATC TTAAGGGGAG GAACGGAGCG CTTCCTGACC 1140

AACATAAAGG ACACTTCCTC TAAAGTCATC CAGTCAGTGG CCAGCTACGC CAAAGGGGAC 1200

CTAGATATTT CGTACATCAC CTCCAGAATA GCAGTCATGT CCTTTCCAGC AGAGGGGGTG 1260

GAGTCAGCGA TCAAGAACAA CATTGAGGAC GTCCGTCTGT TCCTGGACTC GCGTCACGCC 1320

GGCCACTACG CCGTCTACAA CCTCTCCAAG CGCTCCTACA GGCCGTCTCG ATTCCACAAC 1380

AGGGTTTCAG AGTGCAACTG GCAAGTGCGC CGCGCCCCCA ACCTCCGCAG CCTTTACAGT 1440

GTGTGTAAGA ACATGCATTT GTGGCTCAAG CAAGACCAGC GGAACATCTG TATAGTACAC 1500

TGTCTGGACG GCAGGGCGGC GTCGGCGGTG GCCGTTTGCT CCTTCCTGTG TTTCTGTCGC 1560

CTCTTCACCA CAGCCGAGGC CGCCGTCTAC ATGTTCTCCA TGAAGCGCTG CCCGCCGGGC 1620

ATAGCGCCCT CACACAAGAG GTACATAGAG TACATGTGCG ACATGATGGC AGAGGAGCCA 1680

ATCGTCCCCC ACAGCAAACC CATCATGGTT CGCTCCATCG CCATGACGCC CTTGCCGCTG 1740

TTCAACAAGC AGCGCAGCGG CTGCCGGCCG TTCTGCGAGG TTTACGTCGG GGACGAGAGA 1800

GTCCTCACCA CGTCGCAGGA GTACGACAAG ATGAGGGATT TCAAGATGGA GGACGGAAGA 1860

GCAGAGATTC CCCTCAATGT GACGGTCCAA GGAGATGTGC TGGTGGTGAT CTACCATGCA 1920

AGATCTACAC TGGGTGGACG CCTACAGGCC AAGATGGCGT CAATGAAGAT GTTTCAGATC 1980

CAGTTCCACA CAGGTTTCGT CCCCCGAAAC GCCACCACCG TCAAGTTTGC CAAGTACGAC 2040

CTGGATGCCT GTGACATCCA GGAGAAGTAC CCGGACCTGT TCCAGGTCAC CTTGGACATC 2100

GAGGTGGAAC CCAGAGACAG ACCGAGCACC AAGACTCCTC CTTGGGAGGG CTTCCAAAAC 2160

AAGGGCCTCA ACCCCAAAAT CCTCTTCTCG TCTCGCGATG AGCAGCAGGA GGTCCTCAGC 2220

AAATTTGGTA AGCCAGAGTT GCCTCGTCAG CCAGCATTTT ATGACTCCGA GTCCCCCCAG 2280

CCGGCTCAGA CCCCGGAGGG CTCCAATGCA ACAGAACCAG AATCTCCTGG CAGCACCGAT 2340

GGCAACGCCA ACAACTTCTT CCAGACACTG GATTGGGAAG ATGTGAGTGG CCTTCAGGAT 2400

TCCGCGGACA GTCAAGGAGG GGGATCGATG AATGACCCGG AGGACCTAAG TGACCAGTCA 2460

GAGGGAGAGT CCTACTCTTA CTCCGCCCCC GGTGGGGAGC CGCTGTCACG TGACCCCAGC 2520

GAACCGCTGT TTGATGCTGA CTTCCAGAGC GCCCCACCTG CAGCCCAGGA GTCTCCTATC 2580

GGGGACACAG CTGACCTACT GGGGTTGAAC TCTGACCCGT CGGTGTCGTC GACCTCCTCC 2640

TCCTCTGCAG CTCATCCAGG AGTCCAGGCA GGAATCAAAG CTGCATCCAG CAACAGCGAC 2700

CTCCTCAACG ACCTGTTTGC CCCCCCTGCT GGTCAGACGG CAGCAGCGCA GGAGGACTTG 2760

TTCTACGGTG GGCCGCCGGG CGGGGCCACA CCGGACTCCA AACGCACTAT TCTCCCTCCG 2820

CCTGCAGCCG CCGGCGACCT GTTTGACCCG TTTGGGATGG GGTCTGGCTC CGGTGCGGGC 2880

GTCACTGTGG GTTCCTCTCG ACAGGCCTCC GGACCGGATC TGTTTGGAGA CCTGTTGGGT 2940

TCTGACCGCT CTGCCCCCAG TAACCCTGCC CCTGCTTCCA ACGCGAGTCT CTTCAACCTC 3000

AATAAACCAG TGAACGATCC TCCTAAGATG ACCTCATCAG CCAGCCAGCC GGACCTGCTG 3060

GGCGGGTGGG ACAGCTGGGC AGCGAGCACC ACCGCCAGCA TGAGCGCCTC CGCCAGCAAA 3120

CCCAGCTACA CCAGCACAGG TGAGGGAACT TCGGGTGGTG CATCTATGTC CAAGGCCAAG 3180

TCTCAGACCT TTGACCCCTT TGCTGACCTG GGAAACCTGG GTTCCAACTT ACCAGCTTCC 3240

TCCAACGGCA ATTTTTCGGA GCCAAAAGCC AAAGCTCCGT CCTCCTCCAC TAAAGCTCAA 3300

GCACAGCCCT GGCAGGCCGG AAGACCCGCC TCCGCCCAGA AAAAACCTTG GCTGCCCGGA 3360

TCAGGACCCG GGACAGCGCC TAAAGCATCC TCTGCCTCTC AGGCTGCAGG TCCGCAGCAC 3420

ACGAAACCCA ACTACAACCT CAACTTCTCC AGTGTCATCG GCGGGAGAGA GGACCGAGGG 3480

GTTCGGGGGC CTAGTTTCGG CGCCAAGCCG AAGGTAAAGG AGGATGATTT TGAGGACCTG 3540

CTGTCCACTC AGGGTTTTGC CTCCCGGCCG GATAGGAAGG GACCAAGAAC CATCGCCGAA 3600

ATGAGGAGAC AGGAGATCAC GAAGGACATC GATCCACTTA AATTGCAGAT CTTGGACTGG 3660

ATTGAGGGGA AGGAGCGAAA CATCCGAGCG CTGCTGTCCA CTCTAAACAC TGTGCTGTGG 3720

GAGGGGGAGA CCCGCTGGAG GCCCGTGGGC ATGGCCGACT TGGTGACTCC CGACCAGGTG 3780

AAGAAGTACT ACAGGAAGGC CGTGCTGATA GTCCACCCGG ATAAGGCGAC GGGCCAACCT 3840

TACGAACATT ACGCTAAGAT GATCTTCATG GAATTGAACG ACGCCTGGTC AGAGTTCGAG 3900

AACCAGGGTT CCAAAGCACT CTTCTAA 3927

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         ri++v+aeGGfa+vy a+d+s+g+ yalKr+l+neee+++ei++E+++mkklsgh+n+v+

Q: 40    RIKRVIAEGGFAFVYEAQDMSSGKDYALKRLLSNEEEKNKEIIQEVCFMKKLSGHPNMVQ  99

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+l+l+e+ck g+lvd++++ +++  ls++++lki+++ +rav

Q: 100   FCsaASISKEESDTGQAEFLILTELCK-GQLVDFIKRVEQRALLSCDTVLKIFYQSCRAV  158

         **7667789999999************.8**********9988*****************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlk+eN+l+s++g+++lcD+GS tt ++ ++   s+q++s++++ei+

Q: 159   QHMHKQKPPIIHRDLKIENLLISNQGTIKLCDFGSSTTVSHYPDyswSAQKRSMVEDEIT  218

         *******************************************99999************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt+ yr+PE+idlysn++i++k+DiWaLGc+lY lcf ++Pfe+++kl i+ngkysiP

Q: 219   RNTTPAYRTPEMIDLYSNFPINDKQDIWALGCILYLLCFKQHPFEDGAKLQIVNGKYSIP  278

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +n+  ++  ++li++ml+v+peeR++i++++++l

Q: 279   QNDVKYTVYHNLIRSMLKVNPEERLSITELVNQL  312

         ******************************9986

Domain Sequence
(FASTA)

RIKRVIAEGG FAFVYEAQDM SSGKDYALKR LLSNEEEKNK EIIQEVCFMK KLSGHPNMVQ 60

FCSAASISKE ESDTGQAEFL ILTELCKGQL VDFIKRVEQR ALLSCDTVLK IFYQSCRAVQ 120

HMHKQKPPII HRDLKIENLL ISNQGTIKLC DFGSSTTVSH YPDYSWSAQK RSMVEDEITR 180

NTTPAYRTPE MIDLYSNFPI NDKQDIWALG CILYLLCFKQ HPFEDGAKLQ IVNGKYSIPQ 240

NDVKYTVYHN LIRSMLKVNP EERLSITELV NQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013