EKS-GAA-00537

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00537

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	456.3	4.4E-137	74	339	266

Status

Unreviewed

Ensembl Protein

ENSGACP00000018110

UniProt Accession

G3PKI0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013698	ENSGACP00000018110	ENSGACT00000018145
ENSGACG00000013698	ENSGACP00000018117	ENSGACT00000018152

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

1691

Protein Sequence
(FASTA)

MSAQARLKRL EELLLEQKAA GCLSVEALLD LLLCFYTEVS HSPLKREKHV TDFLEWVKPF 60

TTTVKDMRLH RDDFEMLKVI GRGAFGEVAV VKMKHTERVY AMKILNKWEM LKRAETACFR 120

EERDVLVKGD SQWITTLHYA FQDDNYLYLV MDYYVGGDLL TLLSKFEDRL PEDMSKFYVA 180

EMVLAVHSIH QQRYIHRDIK PDNVLLDVNG HIRLADFGSC LRMMEDGTVQ SSVAVGTPDY 240

ISPEILQAME DGMGRYGPEC DWWSLGVCVY EMLYGETPFY AESLVETYGK IMNHENTFQF 300

PSHGTDVSRG RQDLTQRLPG PGELLGLNGI SDFKSHAFFS GIDWENIRSA EAPYIPDVSS 360

PTDTSNFDVD DDVLKNPEIS PPMSHSGFTG QHLPFVGFTY TTDSCFADRS SVRQTGLGQE 420

EAGAGGGGQE VEAFERRIRR LEQEKQELNR KLQGETCSTQ ALQAPPRGGT LTRDKEIKKL 480

NEEIERLKKK LADSDRLEHQ LEEAVTLRQD YESSASKLKS LERQVKTLRQ EKEEVHKQLA 540

DSLERLRSHG KELKEAHAQR KVALQEFSDL SERMVDLRSS KQRLSRQLRD KEEEMDTLLQ 600

KMDAMRQEIR KTEKNRKELE GQLDDAKAEA QKEKKLREHI EVHSKQLETE LQNLKAQQGR 660

GAVAGGADFQ QELSRMKADL DTKSLFYEEE LLRRDSSHSS EIKKLRKDLQ ESEGAQLTAN 720

KELLQLREKL DKAKRDRQAE MDEAVSVVKE KSEREKNLLT EENRKLTAET DKLCSFVDQL 780

TAQNRQLEDD LQDLSSKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAT KMTEELETLR 840

SSSLGPRTLV TTSVTHTHTG NMHTHTHTHT LIRAKQMVQE ELRKVKAANI NMESKLKESE 900

ERSREMGEQV ESLKKEMEDS RSRSDKGLKL PDFQDSIFEY FNTSPLAPDL TFRVSHLSTT 960

DIDSTPLKSE ATPPSPSTTS EQEEVKAASV PASPSPTYQS SALTTPKPKA HQLSIKTFSS 1020

PTQCTHCTSL MVGLLRQGYA CEVCSFICHV SCKDHAPLVC PIPAEHTKRP QGIDVQRGIG 1080

TAYKGYVRIP KPSGVKKGWQ RAFALVSDCK LFLYDVPEGK STQPGVGASL VLDLRDEEFS 1140

VSSVLASDVI HATRKDIPCI FRVSSSQLIS QLSAVSLLVL AESEVEKRKW VRILEGLQGI 1200

LTKNLLKNQQ VHILHEAYDA SLPLIKTALS AAVLDRERIA LGTEDGLFVV EVTRDVIVRA 1260

ADSKKIHQID LIPKEKIVAL LCGRNRHVHL HHWGALEGAE SAFDLKLTDT KGCQALTTGV 1320

LRPGGPSCLL AAVKRQVLCY EISRVKPYHK KLWEVQAPGG VQWLGMVRDR LCVGYPSGFA 1380

LLALQGESSP ISLVNPADPS LAFLAQQSLD ALHALQVGPT ELLLCFSQLG VYVDGQGRRS 1440

RTQELMWPAT PLACSSNSTH LTVYSENGLD VFDIHTTEWV QTISLRKIRP LNIEGTLNLL 1500

SSEPPRLIYF SNTSSERDLT IPETSDQSRK LMVRTRSKRK FLFKVPEEER LQQRREMLRD 1560

PELRSKMISN PTNFNHVAHM GPGDGMQVLM DLPLSVMPSS QDDPVKDKPR PLSSISRQQR 1620

SKTHITRTAS DFGGGASSRS VSELDPDLDR EPDSDSTKHS TPSNSSNPSS PPSPNSPHRS 1680

QLTLDGLEMD P 1691

Nucleotide Sequence
(FASTA)

ATGTCGGCTC AGGCCCGTCT GAAGCGGCTG GAGGAGCTGC TGCTGGAGCA GAAGGCTGCG 60

GGCTGTTTGA GTGTGGAGGC GCTGCTCGAC CTGCTGCTCT GCTTCTACAC GGAGGTCTCA 120

CACTCTCCGC TGAAGAGGGA GAAGCACGTC ACCGACTTCC TGGAGTGGGT GAAGCCGTTC 180

ACCACCACAG TGAAGGACAT GCGGCTGCAC AGAGACGACT TCGAGATGCT GAAGGTGATT 240

GGACGCGGAG CTTTTGGAGA GGTCGCCGTG GTGAAGATGA AGCACACAGA GAGAGTTTAC 300

GCCATGAAGA TCCTCAATAA GTGGGAGATG CTGAAGAGAG CTGAGACGGC GTGTTTCCGA 360

GAAGAACGTG ACGTGCTGGT GAAAGGAGAC AGCCAGTGGA TCACTACCCT GCACTACGCC 420

TTCCAGGACG ACAACTACCT GTACCTGGTG ATGGATTACT ACGTGGGGGG GGACCTGCTG 480

ACACTGCTCA GTAAATTTGA GGATCGTCTT CCAGAGGACA TGTCCAAGTT CTACGTTGCT 540

GAGATGGTGC TCGCCGTCCA CTCCATCCAC CAGCAGCGCT ACATCCACAG AGACATTAAA 600

CCGGACAATG TCCTGCTGGA TGTCAACGGT CACATTCGCC TGGCTGACTT CGGGTCTTGT 660

CTCCGTATGA TGGAGGACGG CACGGTGCAG TCCTCCGTAG CCGTGGGTAC TCCGGACTAC 720

ATCTCCCCAG AGATTCTGCA GGCCATGGAG GACGGGATGG GGCGCTACGG TCCAGAGTGT 780

GACTGGTGGT CTCTGGGAGT CTGCGTGTAC GAGATGCTCT ACGGAGAGAC GCCCTTCTAC 840

GCTGAGTCTC TGGTTGAGAC CTACGGCAAG ATCATGAACC ATGAGAACAC GTTTCAGTTC 900

CCCTCCCATG GGACCGACGT GTCCCGAGGA CGCCAAGACC TGACCCAGCG CCTGCCTGGC 960

CCTGGGGAAC TACTCGGCCT CAACGGGATC TCTGACTTCA AGAGCCACGC CTTCTTCAGT 1020

GGCATCGACT GGGAGAACAT CCGATCCGCT GAGGCCCCGT ACATCCCTGA CGTGTCCTCG 1080

CCCACCGACA CCTCCAACTT CGACGTGGAC GACGACGTCC TCAAGAATCC GGAGATCAGC 1140

CCTCCGATGT CTCACAGCGG TTTCACTGGT CAGCACCTCC CATTTGTCGG CTTTACTTAC 1200

ACCACTGACA GCTGCTTCGC AGACCGCAGC TCCGTCAGGC AGACCGGCCT CGGCCAGGAG 1260

GAGGCGGGGG CGGGAGGAGG AGGGCAGGAG GTGGAGGCCT TCGAGAGGAG GATTCGCCGA 1320

CTGGAGCAAG AGAAGCAGGA GCTGAACCGC AAACTCCAGG GTGAGACATG CTCAACTCAG 1380

GCCCTGCAGG CTCCACCCCG AGGGGGAACT CTTACCCGAG ACAAGGAGAT CAAGAAGCTA 1440

AACGAGGAGA TTGAACGTCT TAAGAAGAAG CTGGCAGACT CTGATCGGCT GGAGCACCAG 1500

CTAGAGGAGG CTGTCACACT CCGACAGGAC TACGAGAGCT CTGCTTCCAA ACTGAAGAGC 1560

CTGGAGAGGC AGGTGAAGAC TCTGAGACAG GAGAAAGAAG AAGTTCACAA GCAGCTGGCC 1620

GACTCCCTGG AGCGTCTGAG GAGTCACGGC AAGGAGCTCA AAGAGGCTCA CGCACAGAGG 1680

AAAGTGGCCC TGCAAGAGTT CTCCGATCTG TCGGAGAGGA TGGTCGACCT GCGCTCCTCC 1740

AAACAGCGTC TGTCCCGTCA GCTCCGAGAC AAAGAGGAGG AGATGGACAC GCTCCTGCAG 1800

AAGATGGACG CCATGAGACA GGAGATCCGT AAGACTGAGA AGAACCGCAA GGAGCTGGAG 1860

GGTCAGCTGG ACGATGCCAA AGCAGAAGCG CAGAAGGAGA AGAAGTTAAG GGAGCACATT 1920

GAGGTTCACT CCAAACAGCT GGAGACGGAG CTGCAGAACC TGAAGGCCCA GCAGGGTCGG 1980

GGAGCAGTCG CCGGCGGGGC GGACTTCCAG CAGGAGCTGT CCCGTATGAA AGCCGATCTG 2040

GATACAAAGA GTCTGTTCTA CGAGGAGGAG CTGCTGAGGA GAGACTCGTC CCACTCCTCC 2100

GAGATCAAGA AGCTCCGCAA AGACCTGCAA GAGTCGGAGG GGGCGCAGCT CACCGCCAAC 2160

AAGGAGCTGC TGCAGCTACG AGAGAAACTG GACAAGGCCA AGAGGGACCG ACAAGCCGAG 2220

ATGGATGAAG CTGTTTCAGT TGTAAAAGAG AAATCTGAAC GGGAGAAAAA CCTTTTGACC 2280

GAAGAAAACC GAAAACTTAC GGCTGAAACA GACAAGCTCT GCTCCTTCGT GGATCAGCTG 2340

ACTGCTCAGA ACCGTCAGCT AGAGGACGAC CTGCAGGACC TGTCCTCTAA GAAGGAGAGC 2400

GTAGCTCACT GGGAGGCGCA GATCGCAGAG ATCATCCAGT GGGTGAGCGA TGAGAAGGAC 2460

GCTCGAGGAT ACCTTCAGGC TCTGGCCACC AAGATGACAG AAGAGCTGGA AACACTCCGC 2520

AGCTCCAGTC TAGGACCCAG AACTCTGGTA ACAACTAGTG TGACACACAC ACACACTGGT 2580

AACATGCACA CACACACACA CACACACACA CTGATCAGAG CCAAGCAGAT GGTTCAGGAG 2640

GAGCTGCGCA AAGTCAAGGC TGCCAACATT AACATGGAAA GTAAGCTAAA GGAGTCTGAG 2700

GAGAGGAGTC GGGAGATGGG GGAGCAGGTG GAGAGTCTGA AGAAGGAGAT GGAGGACAGC 2760

CGCTCCCGCT CGGACAAAGG TCTGAAGCTT CCAGACTTTC AAGACTCCAT TTTTGAATAT 2820

TTCAACACGT CTCCTCTGGC TCCTGATCTC ACCTTCAGAG TGAGTCACCT GTCTACCACG 2880

GACATTGACT CCACCCCCCT AAAATCGGAG GCCACGCCCC CGTCACCCTC CACCACCTCA 2940

GAGCAGGAGG AAGTAAAAGC TGCGTCCGTC CCAGCGAGCC CCTCCCCCAC TTACCAGAGC 3000

TCAGCACTGA CCACGCCAAA GCCCAAAGCT CACCAGCTGA GCATCAAGAC CTTCTCCAGC 3060

CCCACTCAGT GCACACACTG CACCTCCCTG ATGGTCGGAC TCCTCCGACA AGGATACGCC 3120

TGTGAAGTCT GCTCCTTCAT CTGTCACGTT TCCTGTAAAG ACCACGCCCC CTTGGTCTGT 3180

CCAATCCCAG CCGAGCACAC CAAGAGGCCA CAGGGCATAG ACGTCCAGAG AGGCATTGGC 3240

ACCGCCTACA AGGGCTACGT CAGAATCCCC AAACCCAGCG GTGTGAAGAA GGGATGGCAG 3300

CGCGCCTTCG CCTTGGTCTC TGACTGTAAG CTGTTCCTCT ACGACGTCCC GGAGGGGAAG 3360

TCGACACAGC CGGGGGTTGG TGCAAGTCTG GTTCTGGATC TCAGAGACGA GGAGTTTTCC 3420

GTCAGCTCAG TCTTGGCGTC GGATGTGATC CACGCCACCA GAAAGGATAT CCCCTGCATC 3480

TTTAGAGTGT CGTCGTCACA ACTGATCTCA CAGCTCTCGG CAGTGTCTCT GCTGGTGCTG 3540

GCGGAGAGCG AGGTGGAGAA AAGGAAGTGG GTCCGGATCC TGGAGGGTCT GCAGGGCATC 3600

CTGACCAAGA ACCTCCTGAA AAACCAACAG GTCCACATCC TGCACGAGGC CTACGACGCA 3660

TCGCTGCCCC TCATCAAGAC TGCGCTGTCT GCTGCTGTCC TTGACCGGGA GAGGATCGCT 3720

TTGGGAACCG AAGACGGGCT GTTTGTGGTG GAGGTCACCA GAGATGTGAT CGTACGGGCA 3780

GCGGACAGCA AGAAGATTCA TCAGATCGAT TTGATCCCGA AGGAGAAGAT CGTTGCTCTT 3840

CTCTGCGGTC GGAATCGCCA CGTTCACCTC CACCACTGGG GGGCGCTGGA GGGAGCAGAG 3900

TCCGCCTTCG ACCTCAAGCT CACTGACACC AAAGGCTGCC AGGCTCTGAC AACGGGGGTG 3960

CTGCGACCCG GAGGCCCATC CTGCCTGCTG GCTGCTGTCA AACGTCAGGT TCTGTGCTAC 4020

GAGATCTCCC GGGTGAAACC CTACCACAAG AAGCTGTGGG AGGTGCAGGC CCCCGGCGGG 4080

GTGCAGTGGT TGGGCATGGT CAGGGACCGG CTGTGCGTGG GTTATCCTTC GGGCTTCGCT 4140

CTGCTGGCCC TGCAGGGGGA GTCGTCCCCC ATCAGCCTGG TGAACCCGGC CGACCCGTCG 4200

CTCGCCTTTT TGGCTCAGCA GTCGCTGGAC GCCCTCCACG CCCTGCAGGT GGGCCCCACC 4260

GAACTGCTGC TGTGCTTCAG CCAGCTCGGA GTCTACGTGG ACGGGCAAGG CCGCCGCTCC 4320

AGGACCCAGG AGCTGATGTG GCCCGCCACG CCGCTGGCAT GCAGCTCCAA CTCCACCCAC 4380

TTGACCGTCT ACAGTGAGAA TGGACTGGAC GTTTTCGACA TTCACACCAC CGAGTGGGTC 4440

CAGACCATCT CCCTCCGCAA GATCAGACCT CTGAATATTG AAGGGACTTT GAACCTGCTG 4500

AGCTCAGAAC CTCCTCGACT CATCTACTTC AGCAACACCT CCTCAGAGCG AGACCTCACC 4560

ATCCCGGAGA CGTCGGACCA GAGCAGGAAG TTGATGGTTC GAACGCGCAG CAAGAGGAAG 4620

TTCCTGTTTA AGGTTCCAGA GGAGGAGCGT CTTCAGCAAA GGAGGGAGAT GCTGAGGGAT 4680

CCGGAGCTCA GATCAAAGAT GATCTCCAAT CCCACTAACT TTAACCACGT GGCCCACATG 4740

GGACCAGGAG ACGGCATGCA GGTCCTCATG GACCTCCCTC TGAGTGTGAT GCCTTCCTCT 4800

CAAGATGACC CAGTTAAAGA TAAGCCCCGC CCACTTTCCA GCATCTCCCG ACAACAGAGG 4860

AGTAAGACTC ACATCACACG CACAGCTTCA GATTTTGGGG GAGGAGCTTC ATCGCGCAGC 4920

GTCTCTGAAC TGGACCCGGA CCTGGACCGA GAGCCGGACT CTGACTCCAC CAAACACTCG 4980

ACCCCATCCA ACAGCTCTAA TCCCAGCAGC CCCCCCAGTC CCAACTCCCC CCACCGCAGC 5040

CAGCTCACCC TGGATGGCCT TGAGATGGAT CCG 5073

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fe+lkviGrGafgevavv++k+te+vyamkil+k+e+lkrae+a+freerdvlvk+ds+w

Q: 74    FEMLKVIGRGAFGEVAVVKMKHTERVYAMKILNKWEMLKRAETACFREERDVLVKGDSQW  133

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd++ylylvm+y+vGGdlltllsk+ed+lpe++ +fy+ae+vla++s+h+ +

Q: 134   ITTLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMSKFYVAEMVLAVHSIHQQR  193

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         y+hrdikpdn+lld++Ghi+ladfGscl+++edgtv+ssvavGtpdyispe+l+a+e+g+

Q: 194   YIHRDIKPDNVLLDVNGHIRLADFGSCLRMMEDGTVQSSVAVGTPDYISPEILQAMEDGM  253

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+++++fp++  +vs+  +d

Q: 254   GRYGPECDWWSLGVCVYEMLYGETPFYAESLVETYGKIMNHENTFQFPSHGtDVSRGRQD  313

         *************************************************987********

S: 240   likklltsreerlgregiedlkkhpff  266

         l ++l   + e lg +gi+d+k+h+ff

Q: 314   LTQRL-PGPGELLGLNGISDFKSHAFF  339

         *9997.567789**************9

Domain Sequence
(FASTA)

FEMLKVIGRG AFGEVAVVKM KHTERVYAMK ILNKWEMLKR AETACFREER DVLVKGDSQW 60

ITTLHYAFQD DNYLYLVMDY YVGGDLLTLL SKFEDRLPED MSKFYVAEMV LAVHSIHQQR 120

YIHRDIKPDN VLLDVNGHIR LADFGSCLRM MEDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GRYGPECDWW SLGVCVYEML YGETPFYAES LVETYGKIMN HENTFQFPSH GTDVSRGRQD 240

LTQRLPGPGE LLGLNGISDF KSHAFF 266

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013