EKS-GAA-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAA-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	403.9	3.8E-121	64	316	253

Status

Unreviewed

Ensembl Protein

ENSGACP00000018222

UniProt Accession

G3PKU2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGACG00000013777	ENSGACP00000018222	ENSGACT00000018257

Organism

Gasterosteus aculeatus

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MDTGCFTAAQ RLSCHAMNAD LFKPAPERGP QQSSAPVKTG RNKPEQPKAE LAQVVTDSKT 60

GRCYSKGKLL GKGGFARCYE MTDLSSNKMY AVKVIPQSRV SKPHQRDKIT NEIELHKTLS 120

HKHVVKFSHH FEDQENIYIF LELCSRKSLA HIWKARHTLT EPEVRYYLRH IISGLKYIHS 180

RGILHRDLKL GNFFVNENME LRLGDFGLAA KLETVELRKK TICGTPNYLA PEVLNRQGHG 240

TESDVWSLGC VMYTLMCGSP PFETLDLKET YKCIKDVRYN LPASLPPAAQ KLISGILQKN 300

PSDRLSLDQI LNHEFFTKGF TPDKLPPSSC VMVPELHPPS PAKKFFTKMA KSFFGKKKAK 360

VEKIPCEEKD DKDISKLVSG IVKCSINRQI SYKTVGANEV PPPMAPVVGS APLEQTPAEE 420

ESRKSISRSF KGTTASSTEP CEDVLTPAAV SESALKVLNS CLANMPAATR NPPCLSSPQS 480

FLWVTKWVDY SNKYGFGYQL SNQSIGVLFN EGTRLSLCDQ RKTVHYRFPN NKHFTFAANS 540

LPEQLRGQKQ IVDLMANYME QNLMEGGDLH CEDQVSGCPP LLLQWVKTDH ALVMLFNNGT 600

LQVNFYADHT KIILCKSSDS YLLTYISRER VSCTYLLSML NEMGCTSELR HRLRYVVQLL 660

QHHADE 666

Nucleotide Sequence
(FASTA)

ATGGATACCG GTTGTTTCAC CGCGGCGCAG CGCCTTTCGT GCCACGCCAT GAATGCGGAT 60

TTATTTAAGC CTGCTCCGGA ACGCGGACCC CAGCAGTCCT CCGCCCCGGT GAAAACCGGC 120

AGGAATAAAC CCGAACAGCC CAAAGCGGAG CTGGCTCAGG TGGTGACAGA CTCCAAAACG 180

GGACGGTGCT ACAGTAAAGG GAAGCTTTTG GGAAAGGGCG GCTTCGCTCG ATGCTACGAG 240

ATGACGGACC TCTCCAGCAA CAAGATGTAT GCCGTGAAGG TGATTCCACA GAGCCGAGTG 300

TCCAAGCCCC ACCAACGGGA CAAGATCACG AACGAGATCG AGCTCCACAA AACCCTGTCG 360

CACAAGCATG TGGTGAAATT CTCCCATCAT TTCGAAGACC AAGAGAACAT CTACATCTTC 420

CTCGAGCTCT GCAGTCGTAA GTCGCTGGCA CACATTTGGA AGGCGAGACA CACGCTCACG 480

GAGCCAGAAG TGCGATATTA CCTCCGACAC ATCATATCCG GCCTCAAGTA CATCCACAGC 540

AGAGGGATCC TGCACCGAGA CCTCAAGCTG GGCAACTTCT TTGTCAACGA GAACATGGAG 600

CTGCGGCTGG GAGACTTTGG CCTCGCCGCC AAGCTGGAGA CGGTCGAGCT GAGGAAAAAA 660

ACGATCTGCG GGACTCCAAA CTACTTGGCC CCCGAGGTGC TCAACAGGCA GGGCCACGGC 720

ACGGAGTCCG ACGTCTGGTC CCTGGGATGC GTCATGTACA CCCTGATGTG CGGCAGCCCT 780

CCTTTTGAGA CCCTCGACCT GAAGGAGACC TACAAGTGTA TAAAAGACGT CCGGTACAAC 840

CTGCCGGCGT CGCTGCCCCC CGCTGCACAG AAACTCATCT CCGGCATCCT GCAGAAAAAC 900

CCCAGCGACA GACTTTCGCT GGATCAAATC CTCAACCACG AGTTCTTCAC CAAAGGTTTC 960

ACCCCCGATA AGCTTCCACC CAGCAGCTGT GTGATGGTGC CGGAGCTCCA CCCCCCCAGC 1020

CCTGCAAAGA AATTCTTTAC TAAAATGGCA AAGAGCTTCT TTGGCAAGAA GAAAGCCAAA 1080

GTGGAGAAGA TCCCATGCGA GGAAAAAGAT GACAAAGATA TTTCCAAGCT TGTGTCGGGC 1140

ATCGTTAAAT GTTCCATCAA CCGGCAAATC AGCTACAAGA CGGTGGGAGC CAACGAGGTG 1200

CCCCCTCCAA TGGCCCCGGT CGTCGGCTCT GCGCCACTGG AACAAACTCC TGCTGAGGAG 1260

GAATCCAGGA AGTCAATCTC TCGTTCCTTC AAGGGAACAA CGGCCAGCAG CACAGAACCA 1320

TGTGAGGACG TGCTGACCCC TGCAGCGGTG TCTGAATCGG CCTTGAAAGT CCTCAACAGC 1380

TGCCTGGCCA ACATGCCTGC AGCCACTAGA AACCCGCCTT GTTTGTCCAG CCCCCAGTCC 1440

TTCCTGTGGG TGACCAAGTG GGTCGACTAC TCGAATAAAT ATGGTTTCGG CTACCAGCTC 1500

TCGAACCAAA GCATCGGCGT GCTCTTCAAT GAGGGCACGC GTCTGAGCCT CTGTGATCAA 1560

CGCAAGACCG TCCACTACCG CTTTCCCAAC AACAAACACT TCACATTCGC TGCCAACTCT 1620

CTACCTGAGC AGCTTCGTGG CCAGAAACAG ATTGTGGACC TCATGGCCAA CTACATGGAG 1680

CAAAACCTTA TGGAGGGTGG AGATCTTCAT TGTGAGGATC AAGTATCCGG GTGTCCTCCT 1740

CTGCTGCTCC AGTGGGTGAA GACGGACCAT GCTCTGGTCA TGCTCTTCAA CAACGGCACA 1800

TTACAGGTCA ACTTCTACGC CGACCACACA AAGATCATCC TGTGCAAGTC ATCGGACTCT 1860

TATTTACTCA CCTACATCAG CCGGGAGCGC GTCTCGTGCA CGTACCTCCT CAGCATGCTG 1920

AATGAGATGG GCTGCACCTC TGAGCTGAGA CACCGGCTGC GATACGTGGT CCAGCTTCTC 1980

CAACACCATG CTGATGAGTG A 2001

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++gkllGkGgfa+cye++dl++++++avkv+p+s++ k++qr+k+++eie+h++l+hk+

Q: 64    YSKGKLLGKGGFARCYEMTDLSSNKMYAVKVIPQSRVSKPHQRDKITNEIELHKTLSHKH  123

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +vk++++fed+en+y++lelcsr+sla+++k+r++ltepevryylr i+sglky+h++ i

Q: 124   VVKFSHHFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRHIISGLKYIHSRGI  183

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+++gdfGla++le+ e rkkt+cGtPny+aPevl+++gh++e+

Q: 184   LHRDLKLGNFFVNENMELRLGDFGLAAKLETVELRKKTICGTPNYLAPEVLNRQGHGTES  243

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytl++G+PPfet +lkety++ik+ +y+lP+sl ++a++li+ +l+k+P++

Q: 244   DVWSLGCVMYTLMCGSPPFETLDLKETYKCIKDVRYNLPASLPPAAQKLISGILQKNPSD  303

         ************************************************************

S: 241   rpsleevlkdefl  253

         r+sl+++l++ef+

Q: 304   RLSLDQILNHEFF  316

         ************8

Domain Sequence
(FASTA)

YSKGKLLGKG GFARCYEMTD LSSNKMYAVK VIPQSRVSKP HQRDKITNEI ELHKTLSHKH 60

VVKFSHHFED QENIYIFLEL CSRKSLAHIW KARHTLTEPE VRYYLRHIIS GLKYIHSRGI 120

LHRDLKLGNF FVNENMELRL GDFGLAAKLE TVELRKKTIC GTPNYLAPEV LNRQGHGTES 180

DVWSLGCVMY TLMCGSPPFE TLDLKETYKC IKDVRYNLPA SLPPAAQKLI SGILQKNPSD 240

RLSLDQILNH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013